Here are the answers to 4 questions from the list:
1. Methods to determine interfacial tension:
- Drop weight method: In this method, a drop of liquid is formed at the end of a capillary tube immersed in another liquid medium. The weight of the drop is measured which is directly proportional to the interfacial tension.
- Du Nouy ring method: In this method, a platinum ring is immersed in the liquid and then pulled out. The force required to detach the ring from the liquid surface is measured which is directly proportional to the interfacial tension.
2. Factors influencing rate of reaction: The factors that influence the rate of a chemical reaction include concentration, temperature, pressure
DIFFUSION PRINCIPLES IN BIOLOGICAL SYSTEMSAMAR RAVAL
DIFFUSION,
diffusion principles in biological systems
PHYSICAL PHARMACEUTICS-I
DIFFUSION
USE OF DIFFUSION CONCEPT
TYPES OF DIFFUSION
LAWS OF DIFFUSION
FICK’S FIRST LAW OF DIFFUSION
FICK’S SECOND LAW OF DIFFUSION
LAWS OF DIFFUSION
LAWS OF DIFFUSION APPLICATIONS
Definition of drying
Importance of drying
Difference between drying and evaporation
Drying is defined as removal of the liquid from a material by application of heat & is accomplished by transfer of a liquid from the surface into an unsaturated vapor phase .
Drying is the final removal of water from material (usually by heat)
Drying is commonly the last stage in a manufacture process
Non-thermal drying
1- As Squeezing wetted sponge
2- Adsorption by desiccant (desiccation)
3- Extraction.
Preservation of drug products
Preparation of bulk drugs
Improved handling
Improved characteristics
Equipments
Drying is necessary in order to avoid deterioration. A few examples are…
--blood products, tissues… undergo microbial growth
--effervescent tablets, synthetic & semi synthetic drugs undergo…. chemical decomposition.
DIFFUSION PRINCIPLES IN BIOLOGICAL SYSTEMSAMAR RAVAL
DIFFUSION,
diffusion principles in biological systems
PHYSICAL PHARMACEUTICS-I
DIFFUSION
USE OF DIFFUSION CONCEPT
TYPES OF DIFFUSION
LAWS OF DIFFUSION
FICK’S FIRST LAW OF DIFFUSION
FICK’S SECOND LAW OF DIFFUSION
LAWS OF DIFFUSION
LAWS OF DIFFUSION APPLICATIONS
Definition of drying
Importance of drying
Difference between drying and evaporation
Drying is defined as removal of the liquid from a material by application of heat & is accomplished by transfer of a liquid from the surface into an unsaturated vapor phase .
Drying is the final removal of water from material (usually by heat)
Drying is commonly the last stage in a manufacture process
Non-thermal drying
1- As Squeezing wetted sponge
2- Adsorption by desiccant (desiccation)
3- Extraction.
Preservation of drug products
Preparation of bulk drugs
Improved handling
Improved characteristics
Equipments
Drying is necessary in order to avoid deterioration. A few examples are…
--blood products, tissues… undergo microbial growth
--effervescent tablets, synthetic & semi synthetic drugs undergo…. chemical decomposition.
Solid State of matter,
Crystalline, Amorphous & Polymorphism Forms,
Classification of solid state of matter On the basis of Internal Structure,
PHYSICAL PHARMACEUTICS-I,
Habet,
B.Pharm,
State of matter and properties of matter (Part-2) (Latent Heat, Vapour pressu...Ms. Pooja Bhandare
Latent Heat, Vapour pressure, Factor affecting vapour pressure, Surface area, Types of molecule, Temperature and Intermolecular forces, Sublimation Critical point
State of matter and properties of matter (Part-6)(Relative humidity, Liquid ...Ms. Pooja Bhandare
RELATIVE HUMIDITY, Humidity, Wet and Dry Hygrometer, LIQUID COMPLEX, LIQUID CRYSTALS, Types of liquid crystals, GLASSY STATES, Characteristics glassy state, Types of glassy state, What is the Glass Transition Temperature?
Sanjo College of Pharmaceutical Studies, Physical Pharmaceutics I , 3rd semester B.Pharm, Complexation & protein binding, Classification in detail, determination methods, application of complexes in pharmacy.
Solid State of matter,
Crystalline, Amorphous & Polymorphism Forms,
Classification of solid state of matter On the basis of Internal Structure,
PHYSICAL PHARMACEUTICS-I,
Habet,
B.Pharm,
State of matter and properties of matter (Part-2) (Latent Heat, Vapour pressu...Ms. Pooja Bhandare
Latent Heat, Vapour pressure, Factor affecting vapour pressure, Surface area, Types of molecule, Temperature and Intermolecular forces, Sublimation Critical point
State of matter and properties of matter (Part-6)(Relative humidity, Liquid ...Ms. Pooja Bhandare
RELATIVE HUMIDITY, Humidity, Wet and Dry Hygrometer, LIQUID COMPLEX, LIQUID CRYSTALS, Types of liquid crystals, GLASSY STATES, Characteristics glassy state, Types of glassy state, What is the Glass Transition Temperature?
Sanjo College of Pharmaceutical Studies, Physical Pharmaceutics I , 3rd semester B.Pharm, Complexation & protein binding, Classification in detail, determination methods, application of complexes in pharmacy.
The Art of the Pitch: WordPress Relationships and SalesLaura Byrne
Clients don’t know what they don’t know. What web solutions are right for them? How does WordPress come into the picture? How do you make sure you understand scope and timeline? What do you do if sometime changes?
All these questions and more will be explored as we talk about matching clients’ needs with what your agency offers without pulling teeth or pulling your hair out. Practical tips, and strategies for successful relationship building that leads to closing the deal.
Transcript: Selling digital books in 2024: Insights from industry leaders - T...BookNet Canada
The publishing industry has been selling digital audiobooks and ebooks for over a decade and has found its groove. What’s changed? What has stayed the same? Where do we go from here? Join a group of leading sales peers from across the industry for a conversation about the lessons learned since the popularization of digital books, best practices, digital book supply chain management, and more.
Link to video recording: https://bnctechforum.ca/sessions/selling-digital-books-in-2024-insights-from-industry-leaders/
Presented by BookNet Canada on May 28, 2024, with support from the Department of Canadian Heritage.
Builder.ai Founder Sachin Dev Duggal's Strategic Approach to Create an Innova...Ramesh Iyer
In today's fast-changing business world, Companies that adapt and embrace new ideas often need help to keep up with the competition. However, fostering a culture of innovation takes much work. It takes vision, leadership and willingness to take risks in the right proportion. Sachin Dev Duggal, co-founder of Builder.ai, has perfected the art of this balance, creating a company culture where creativity and growth are nurtured at each stage.
Securing your Kubernetes cluster_ a step-by-step guide to success !KatiaHIMEUR1
Today, after several years of existence, an extremely active community and an ultra-dynamic ecosystem, Kubernetes has established itself as the de facto standard in container orchestration. Thanks to a wide range of managed services, it has never been so easy to set up a ready-to-use Kubernetes cluster.
However, this ease of use means that the subject of security in Kubernetes is often left for later, or even neglected. This exposes companies to significant risks.
In this talk, I'll show you step-by-step how to secure your Kubernetes cluster for greater peace of mind and reliability.
Dev Dives: Train smarter, not harder – active learning and UiPath LLMs for do...UiPathCommunity
💥 Speed, accuracy, and scaling – discover the superpowers of GenAI in action with UiPath Document Understanding and Communications Mining™:
See how to accelerate model training and optimize model performance with active learning
Learn about the latest enhancements to out-of-the-box document processing – with little to no training required
Get an exclusive demo of the new family of UiPath LLMs – GenAI models specialized for processing different types of documents and messages
This is a hands-on session specifically designed for automation developers and AI enthusiasts seeking to enhance their knowledge in leveraging the latest intelligent document processing capabilities offered by UiPath.
Speakers:
👨🏫 Andras Palfi, Senior Product Manager, UiPath
👩🏫 Lenka Dulovicova, Product Program Manager, UiPath
Kubernetes & AI - Beauty and the Beast !?! @KCD Istanbul 2024Tobias Schneck
As AI technology is pushing into IT I was wondering myself, as an “infrastructure container kubernetes guy”, how get this fancy AI technology get managed from an infrastructure operational view? Is it possible to apply our lovely cloud native principals as well? What benefit’s both technologies could bring to each other?
Let me take this questions and provide you a short journey through existing deployment models and use cases for AI software. On practical examples, we discuss what cloud/on-premise strategy we may need for applying it to our own infrastructure to get it to work from an enterprise perspective. I want to give an overview about infrastructure requirements and technologies, what could be beneficial or limiting your AI use cases in an enterprise environment. An interactive Demo will give you some insides, what approaches I got already working for real.
Neuro-symbolic is not enough, we need neuro-*semantic*Frank van Harmelen
Neuro-symbolic (NeSy) AI is on the rise. However, simply machine learning on just any symbolic structure is not sufficient to really harvest the gains of NeSy. These will only be gained when the symbolic structures have an actual semantics. I give an operational definition of semantics as “predictable inference”.
All of this illustrated with link prediction over knowledge graphs, but the argument is general.
Smart TV Buyer Insights Survey 2024 by 91mobiles.pdf91mobiles
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LF Energy Webinar: Electrical Grid Modelling and Simulation Through PowSyBl -...DanBrown980551
Do you want to learn how to model and simulate an electrical network from scratch in under an hour?
Then welcome to this PowSyBl workshop, hosted by Rte, the French Transmission System Operator (TSO)!
During the webinar, you will discover the PowSyBl ecosystem as well as handle and study an electrical network through an interactive Python notebook.
PowSyBl is an open source project hosted by LF Energy, which offers a comprehensive set of features for electrical grid modelling and simulation. Among other advanced features, PowSyBl provides:
- A fully editable and extendable library for grid component modelling;
- Visualization tools to display your network;
- Grid simulation tools, such as power flows, security analyses (with or without remedial actions) and sensitivity analyses;
The framework is mostly written in Java, with a Python binding so that Python developers can access PowSyBl functionalities as well.
What you will learn during the webinar:
- For beginners: discover PowSyBl's functionalities through a quick general presentation and the notebook, without needing any expert coding skills;
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From Siloed Products to Connected Ecosystem: Building a Sustainable and Scala...
Diffusion final
1. Diffusion
• Diffusion is defined as a process of mass
transfer of individual molecules of a substance
• Diffusion is Migration of solute molecules
from higher concentration to lower
concentration to achieve equilibrium
• In case of osmosis escaping tendency of
solvent molecules is measured
• In case of diffusion escaping tendency of
solute molecule is measured
• In pharmacy diffusion through natural barrier
or polymeric barrier is important
2. • membrane is film separating the phases which
may be porous or non porous
• Diffusant or permeant orpenetrant is The
material that undergoes the transport by
passive diffusion
Application
• Controlled and sustained release follows
diffusion controlled
• Molecular weight of polymer can be
estimated
• Transport of drug from GIT can be predicted
through diffusion studies
3. • Diffusion of drugs into tissues and their
excretion through kidney can be studied
through diffusion
• Dialysis,micronisation,ultrafiltration,haemodia
lysis,osmosis use the principle of diffusion
4. STEADY STATE DIFFUSION
• At Steady state - conditions do not vary with
time
• In case of diffusion mass transfer remains
constant with time OR mass transfer takes
place at constant rate through the study and
diffusion process is not allowed to attain
equilibrium
• If condition vary with time then the system is
under unsteady state
5. Transport cell
• Transport cell is used to study the diffusion
• Which consists of donor and receptor
compartment separated by membrane
• Permeant dissolved in solvent and placed in
donor compartment
• Vehicle is placed in receptor compartment
• The permeant get transported in to receptor
comportment through membrane
• At steady state mass transfer remains constant
6. SINK CONDITION
• It is the state in which the concentration in the
receptor compartment is maintained at lower
level compared to its concentration in the donor
compartment
• This can be maintained by connecting receptor
compartment to a large reservoir from which
solution is reticulated
• It is easy to maintain sink condition than steady
state condition due to maintaining constant
gradient in donor compartment is difficult
7. Flux
• Rate of mass transfer (dM/dt) expressed as of
flux(J)
• Flux (J) is rate of mass transfer across unit
surface area of a barrier and mathematically
expressed as: J ≡ atoms / area / time
1 dM dM = change in mass of material, g
J= S = surface area.cm2
S dt d t = change in time.sec
Units for flux are g.cm -2sec -1 OR kg .meter -2sec -1
Flux is always positive quantity because it
increases continuously during process
8. Fick’s I law
• Fick’s first law states that the flux is directly proportional
to the concentration gradient
J ≡ atoms / area / time ∝ concentration gradient
dc OR dc Negative sign indicates
J∝ J = − D ...( 2) a decrease in concentration
dx dx But flux is positive quantity
flux in steady state flow
dc=change in conc. of material g/cm 3.
D=diffusion coefficient of a penetrant, cm/sec2.
Dx=change in the distance, cm.
1 dM dc
J= J = −D 1 dM dc
S dt dx J= = −D
Combining equation and i.e. S dt dx
dM dc
...(3)
Eqn 3 explains Rate of
We get = −DS mass transfer as per fick’s first law
dt dx
D is effected by temperature, pressure etc hence it is not constant it is coefficient
9. Fick’s I law
Diffusion coefficient/ diffusivity
No. of atoms dM dc
crossing area A = − DS Cross-sectional area
per unit time dt dx Concentration gradient
Mass transport is down the concentration gradient
Flow direction
A
10. Application of fick’s first law
• Used to explain drug diffusion across
biomembranes with desirable parameters
• Applied in the design of sustained and
controlled release systems
11. Fick’s Second Law ; Non-steady state Diffusion
It explains the change in conc. at definite location
with respect to x , y and z axes(or direction)
Fick’s second law states that the change in y J
y
concentration With time in a particular region
is proportional to the change In the concentration Jx
gradient at that point of time Jz x
z
∆c
The concentration ∂c i.e.
∆t
changes with time due to
∆J
change in amount or flux ∂J i.e. of diffusing
∆x
molecules with in the x direction
12. • The relationship can be expressed w.r.t -x ,y and z
as: = − ∂J
∂c ∂c ∂J ∂c ∂J
=− =−
∂t ∂x ∂t ∂y ∂t ∂z
Partial derivatives notation used due to
concentration is a function of both x or y or z and t
dc dc dc
J = −D J = −D J = −D
dx dy dz
Differentiating above equation w.r.t x ,y and z respectively
∂J ∂C 2 ∂J ∂ 2C ∂J ∂ 2C
= −D 2 = −D = −D 2
∂x ∂x ∂y ∂ y2 ∂z ∂z
substituting for ∂C , ∂C and ∂C in above equation for ∂J , ∂J and ∂J
∂t ∂t ∂t ∂x ∂y ∂z
∂C ∂C 2 ∂C ∂ 2C ∂C ∂ 2C
= −D 2 = −D = −D 2
∂t ∂x ∂t ∂ y2 ∂t ∂z
13. ∂C ∂ C ∂ C ∂ C
2 2 2
= −D 2 + + 2
∂t ∂ x ∂y 2
∂z
Fick’s second law refers to change in concentration
of diffusant with time at any distance x i.e. non
steady state flow
14. DIFFUSION CONTROLLED RELEASE
HIGUCHI’S EQUATION
• Sustained and controlled release of a drug
form a table has been obtained by
incorporating the drug in insoluble matrix
such as plastic ,resin, wax and fatty alcohol
• In this matrix model ,outside layer of the drug
is exposed to the bathing solution
• Then the drug diffuses out of the matrix
• The rate of dissolution of drug particle within
the matrix must be faster than that of
diffusion rate of drug leaving the matrix
15. The rate of release of drugs dispersed in an inert
matrix system has been derived by higuchi
dM Cs
= C0 dx − ........(1)
dt 2
where
dM = change in the amount of drug released per unit time
dx = change in the thickness of the zone of matrix
that has been depleted of drug
C 0 = total amount of drug in unit volume in the matrix
Cs = saturated conc of the drug in the matrix
16. Dm Cs
From diffusion theory dM = dt........( 2 )
x
Where Dm is diffusion coefficient in the matrix
Equating eqn 1 and 2 ,integrating and solving for x gives
M = [ Cs Dm ( 2C0 − C s ) t ]
1
2
When the amount of drug in excess of saturation concentration
that is Co>Cs
M = [ C s Dm 2C0t ] 2 ......( 3)
1
Eqn 3 indicates that the amount drug released is a function of square root time
M = kt
1
OR 2
17. Methods and procedures
• Two types
• A) horizontal transport cell
wurester cell
Viles chein permeation cell
• B) vertical transport cell
Aquair and weiner diffusion cell
biber and rhodes cell
franz diffusion cell
18. Horizontal Transport Cell
wurester cell
Receptor and donor
compartment made of pyrex glass
material
Animal or human skin acts as semi
permeable cell and barrier may be
supported on a perforated plate
Drug sample solution taken in donor
compartment and solvent in the
receptor compartment
Whole set up placed in constant
temperature bath to maintain the
temp of 37±0.2
The liquid in receptor stirred by
using magnetic beads to obtain
19. vertical Transport Cell
Viles chein skin permeation cell
Receptor and donor compartment
made of pyrex glass or glass or
plexi glass material
Animal or human skin acts as semi
permeable cell
This system used for as in vitro
models for drug absorption and used
to test drug diffusion from
ointments ,transdermal patches etc
Drug sample solution taken in donor
compartment and solvent in the
receptor compartment
Whole set up placed in constant The liquid in receptor stirred by using
temperature bath to maintain the magnetic beads to obtain uniform
distribution
temp of 37±0.2
20. Horizontal Transport Cell
Aquair and weiner diffusion cell
Receptor and donor compartment
made of pyrex glass or plastic
material
Animal or human skin acts as semi
permeable cell and barrier may be
supported on a perforated plate
Drug sample solution taken in upper
compartment and solvent in the
lower compartment
Whole set up placed in constant
temperature bath to maintain the
temp of 37±0.2
The liquid in receptor stirred by
using magnetic beads to obtain
21. Horizontal Transport Cell
biber and rhodes cell
This is three compartment cell
Two Receptor and one donor
compartment
Synthetic or isolated biological
membrane can be used
Drug sample solution allowed to
diffuse from two donor
compartment to inner receptor
compartment
liquid in receptor stirred by
using magnetic beads to
obtain uniform distribution
22. Horizontal Transport Cell
scheuplein cell
Receptor and donor compartment
made of pyrex glass material
Animal or human skin acts as semi
permeable cell and barrier may be
supported on a perforated plate
Drug sample solution taken in donor
compartment and solvent in the
receptor compartment
Whole set up placed in constant
temperature bath to maintain the
temp of 37±0.2
The liquid in receptor stirred by
using magnetic beads to obtain
uniform distribution
23. Horizontal Transport Cell
franz diffusion cell
modified version of
different cell for in-vitro studies
Excised human cell membrane acts
as semi permeable membrane
Animal or human skin acts as semi
permeable cell and barrier may be
supported on a perforated plate
Drug sample solution filled in donor
compartment and solvent in the
receptor compartment
Whole set up placed in constant
temperature bath to maintain the The liquid in receptor stirred by using
temp of 37±0.2 magnetic beads to obtain uniform
distribution
24. Transport across GI tract
• Most of drugs ,when administered ,have to
pass through GI membrane to reach blood
• The structure and nature of GI tract decide
the transport of drugs
• These barrier are highly complex structure
composed of lipids ,proteins , lipoproteins and
polysaccharides and lipoidal in nature
25. Polar heads Fluid Mosaic
love water Model of the
& dissolve. cell membrane
Non-polar
tails hide
from water.
Carbohydrate cell
markers
Proteins
26.
27. Types of diffusion
• Passive diffusion
• Active transport
• Facilitated diffusion
• pinocytosis
39. Answer any Four Questions
Each question carries 5 marks
1) List out the method to determine interfacial tension
explain any one method
2) Write a note on factors influencing rate of reaction
3) What are chelates give its application
4) What are adsorption isotherms explain different
types
5) Explain chemical degradation by oxidation
6) Write a note on size distribution curves
7) Explain-how particle sizes are expressed
8) Define and differentiate order and molecularity of a
reaction