Differentiated instruction is an approach to teaching that aims to meet the needs of diverse learners by creating multiple paths to learning. Teachers can differentiate the content, process, and products based on students' readiness levels, interests, and learning profiles. Key strategies for differentiation include tiered instruction, anchoring activities, flexible grouping, and compacting the curriculum. While differentiation aims to be fair to all students, it recognizes that fairness is not about treating all students the same, but rather creating appropriately challenging learning experiences for each student.