This document discusses differentiated instruction for teaching mixed-ability classrooms. It begins by comparing differentiated instruction to teaching in a one-room schoolhouse. It then defines what differentiated instruction is and is not, emphasizing that it is a blend of whole group, small group, and individual instruction that is qualitative and adapts assignments based on student differences in readiness, interests, and learning needs. It also provides examples of classroom layouts and discussions of strategies for struggling and advanced learners that could support differentiated instruction.