Children differ from adults both physically and mentally in several key ways important for nurses to understand. Physically, children have proportionately larger body surfaces, thinner skin, smaller airways, less developed organs and excretory systems. Mentally, children's brains develop rapidly, their cognition and behaviors change with age, and they rely more on social bonding and are prone to separation anxiety. Understanding these anatomical, physiological, cognitive and social differences is necessary for nurses to appropriately care for children of all ages.