The document defines dental caries as a disease caused by bacteria in the mouth that ferment dietary carbohydrates, producing acid that demineralizes tooth enamel and destroys tooth structure. The major factors contributing to dental caries are certain bacteria like Streptococcus mutans; dental plaque that allows bacteria to adhere to teeth; saliva, which can increase the cariogenic effect while also helping to clean teeth; and consumption of fermentable carbohydrates like sugars, which feed the bacteria. The microbiology section notes that the main bacteria involved are streptococci and lactobacilli, while other bacteria like actinomyces may also play a role.