Dental caries is caused by the interaction of four main factors: the tooth, dental plaque, diet, and time. Dental plaque is a soft biofilm containing bacteria like Streptococcus mutans that produce acid from sugars in the diet, causing demineralization of tooth enamel and leading to cavities. Diet plays a key role, as frequent consumption of fermentable carbohydrates like sucrose promotes acid production. Other factors like saliva, fluoride, socioeconomic status, and education can also influence risk. Dental caries is diagnosed visually, tactilely, and radiographically and can be classified based on location, extent, and rate of progression. Prevention focuses on reducing sugar intake, maintaining oral hygiene to
INCLUDES DEFINITION, CAUSATIVE AGENT, CURRENT CONCEPT OF DENTAL CARIES, KEY'S TRIANGLE, CLASSIFICATION OF DENTAL CARIES BASED ON ANATOMICAL SITE, SEVERITY AND RATE OF PROGRESSION, CLINICAL VARIANTS AND SEQUELAE OF DENTAL CARIES, MANAGEMENT AND TREATMENT OF DENTAL CARIES
Hume- “caries is essentially a progressive loss by acid dissolution of the apatite component of the enamel then the dentin or of the cementum then dentin.”
According to location:
Pit or Fissure caries
Smooth Surface caries
According to rapidity:
Acute
Chronic
Arrested
According to occurrence:
Primary (Virgin) caries
Secondary (Recurrent) caries
According to the site of occurrence:
Enamel caries
Cemental caries.
Acidogenic [ Miller’s Chemico-parasitic] theory.
Proteolytic theory.
Proteolysis- chelation theory.
Indian Dental Academy: will be one of the most relevant and exciting training center with best faculty and flexible training programs for dental professionals who wish to advance in their dental practice,Offers certified courses in Dental implants,Orthodontics,Endodontics,Cosmetic Dentistry, Prosthetic Dentistry, Periodontics and General Dentistry.
Dental caries /certified fixed orthodontic courses by Indian dental academy Indian dental academy
Welcome to Indian Dental Academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy has a unique training program & curriculum that provides students with exceptional clinical skills and enabling them to return to their office with high level confidence and start treating patients
State of the art comprehensive training-Faculty of world wide repute &Very affordable.
We in Chinthamani Laser Dental Clinic & Implant Centre ,cover every speciality and subspeciality in dentistry so that all kind of your dental problems can be treated efficiently and effectively.
Contact us:
Chinthamani Laser Dental Clinic & Implant Centre
1/464,Mount Poonamallee High Road,
Iyyapanthangal,
Chennai-56
Phone no.044-43800059 , 92 83 786776
Email:
chinthamanidental@gmail.com,
Website:
www.chinthamanilaserdentalclinic.com
INCLUDES DEFINITION, CAUSATIVE AGENT, CURRENT CONCEPT OF DENTAL CARIES, KEY'S TRIANGLE, CLASSIFICATION OF DENTAL CARIES BASED ON ANATOMICAL SITE, SEVERITY AND RATE OF PROGRESSION, CLINICAL VARIANTS AND SEQUELAE OF DENTAL CARIES, MANAGEMENT AND TREATMENT OF DENTAL CARIES
Hume- “caries is essentially a progressive loss by acid dissolution of the apatite component of the enamel then the dentin or of the cementum then dentin.”
According to location:
Pit or Fissure caries
Smooth Surface caries
According to rapidity:
Acute
Chronic
Arrested
According to occurrence:
Primary (Virgin) caries
Secondary (Recurrent) caries
According to the site of occurrence:
Enamel caries
Cemental caries.
Acidogenic [ Miller’s Chemico-parasitic] theory.
Proteolytic theory.
Proteolysis- chelation theory.
Indian Dental Academy: will be one of the most relevant and exciting training center with best faculty and flexible training programs for dental professionals who wish to advance in their dental practice,Offers certified courses in Dental implants,Orthodontics,Endodontics,Cosmetic Dentistry, Prosthetic Dentistry, Periodontics and General Dentistry.
Dental caries /certified fixed orthodontic courses by Indian dental academy Indian dental academy
Welcome to Indian Dental Academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy has a unique training program & curriculum that provides students with exceptional clinical skills and enabling them to return to their office with high level confidence and start treating patients
State of the art comprehensive training-Faculty of world wide repute &Very affordable.
We in Chinthamani Laser Dental Clinic & Implant Centre ,cover every speciality and subspeciality in dentistry so that all kind of your dental problems can be treated efficiently and effectively.
Contact us:
Chinthamani Laser Dental Clinic & Implant Centre
1/464,Mount Poonamallee High Road,
Iyyapanthangal,
Chennai-56
Phone no.044-43800059 , 92 83 786776
Email:
chinthamanidental@gmail.com,
Website:
www.chinthamanilaserdentalclinic.com
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Hemodialysis: Chapter 3, Dialysis Water Unit - Dr.Gawad
Dental caries
1.
2. Dental caries is a post eruptive localised
pathological process of external origin
involving the softening of dental hard tissues
and progressing to cavity formation due to
demineralization of the inorganic components
and destruction of the organic portion.
3.
4. There are four major factors responsible for
the aetiology of Dental Caries namely;
The tooth
The diet
Dental plaque
Time
5.
6. Although these four factors are the major aetiological
factors of Dental caries, there are also some sub-
factors that also aid the afore mentioned factors.
They are;
Saliva
Fluoride
Socioeconomic status
Education/knowledge
Immune system
7.
8. DENTAL PLAQUE: This is a soft tenacious material found on
the tooth surface and can’t be easily rinsed or washed away with
water. They are formed as a result adherence of saliva pellicle
which are soft cell free, structure less material which after
adherence, are invaded by microorganism colonies such as the
Streptococcus mutans . This bacteria accounts for 70-80% of the
bacteria in the plaque before it is now joined by other
filamentous microbes (Lactobacillus and Actinomyses spp).
These microbes altogether secrete extracellular polysaccharide
which assists in further adherence and thickness of the plaque.
9. THE DIET: The diet basically means the kind of food we eat. This has
been more or less the most important risk factor for DC, it can also
affect DC either positively or negatively. The most common substrate
that is acted upon by the bacteria is usually Carbohydrate to release
acid and mucopolyssacharide which demineralizes the tooth and
eventually leads to DC. There are some things to note when we talk
about the diet with regards to DC;
The physical nature of the diet: the physical nature of the food we eat
also increases the susceptibility of a man to caries. For example, a
sticky meal are more susceptible to be acted on by the dental plaque
bacteria than the liquid or solid substrates.
Chemical composition of the food: the chemical composition of the
food substrate also goes a long way in telling the suseptibility of one to
caries, it is known that monosaccharaides are more cariogenic than
disaccharides and polysaccharides.
10. Frequency of intake: this is also important, because the
number of times a particular substrate is taken also gives us
an idea of the person being caries prone.
Presence of other diets: the presence of other diets such as protein
and fats have been found out to reduce the cariogenic effects of
carbohydrates.
NB :- Sucrose is the most cariogenic sugar and is the most
abundantly consumed sugar.
11. THE TOOTH FACTOR: We all know that the teeth are important
tissues that are found in the oral cavity(mouth). Therefore, there were
investigations carried out to determine whether there is a relationship
between the chemical composition of the tooth and a carious tooth. It
was discovered that there was no difference in CA+, Phosphorus,
Carbonate and Magnesium ion in either enamel of both sound tooth
and carious tooth, but there was a difference in the their fluoride
content.
it was found that fluoride in sound enamel of the tooth was
higher than in carious tooth and it inhibits demineralization.
there are some factors that must be taken into consideration
when talking about the tooth factor they are;
MORPHOLOGICAL CHARACTERISTICS OF THE TOOTH:- the
form and structure of the tooth also affects the susceptibility of a tooth
to caries for example,
12. The presence of deep pits and fissures on the occlusal surface of the
tooth serve as stagnation areas for food which are then acted upon
by the bacterial plaque, leading to caries formation.
The proximal surfaces of contact areas also serve as stagnation
areas.
TOOTH POSITIONING:- Malpositioned or malrotated teeth can
produce stagnation areas which may become difficult to clean,
thereby increasing the chances of caries attack on the teeth.
DISTURBANCES IN THE FORMATION OF TOOTH
STRUCTURE:- a disturbance in the formation of tooth structure
such as amelogenesis imperfecta and other disturbances also
influence the progression of Dental Caries.
13.
14. There are various side-effects that Dental caries cause they are;
Pain
Tooth loss
Infections
15. Dental caries are classified clinically according to the following;
Sight of caries attack
Extent of caries
Rate of spread
Caries attacking intact surfaces or margin of restorations
Others e.g. active or arrested caries.
16.
17. Dental caries is diagnosed using the following methods;
Visual:- This is by inspection with the eyes, they appear as white
spot lesion or as frank cavitations on tooth surface.
Tactile:- The cavitations that are present on the pits and fissures on
the occlusal surface of the tooth can be detected by tactile sensation,
using the tip of a blunt explorer.
Radiographic:- Dental caries appear as radiolucent areas on
periapical or bite wing radiographs.
NB:- Mouth mirrors, explorers, good light and radiographs are still the
commonest and most reliable methods of caries diagnosis.
18.
19. Since dental caries formation is a condition that progresses or regresses
as a result of both demineralization and remineralization respectively,
its necessary to educate people and then gain control by either reducing
the demineralization factor and enhancing the remineralization factor
Reducing the demineralizing factors
Enhancing protective Factors
Preventive measures provided by dental professionals.
20. Frequency of intake of fermented CHO:- This is the most
common and significant cariogenic factor. Therefore dietary
counseling is essential in controlling such etiological factors.
Effective Oral Hygiene:- The first oral hygiene routine
should be carried out before or after breakfast. This is
because the primary objective is removal of plaque rather
than demineralization of food debris. Also topical fluoride
application by brushing with a fluoride containing toothpaste
should be carried out twice daily.
21.
22. Basically this has to do with the saliva since it’s a significant
protective factor because it bathes the entire dentition constantly. It
is a great buffer of the oral cavity because of its great calcium,
phosphorus and also to a minimal extent the fluoride ions. Therefore
a condition such as xerostomia also known as dry mouth would
favor demineralization and therefore saliva stimulants are
prescribed.
23. Pits and Fissure sealants:- Use of flow able resin bounded
firmly to the enamel surface which then isolates the pits and
fissures from the cariogenic environs. They are used to seal
deep pits and fissures.
Restorations:- filling of deep pits and fissures with amalgam
to prevent caries.
Extraction of carious teeth/tooth.
Fluoride therapy:- this is the use of topical fluoride
application in the dental clinic to strengthen the teeth. This is
done for younger people rather than teenagers and adults.