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P A U L H S I E N - L I K A O , M D
P R O F E S S O R O F M E D I C I N E
N A T I O N A L T A I W A N U N I V E R S I T Y H O S P I T A L
Reverse CART is not RDR
HLK2109
Disclosure
 I have nothing to disclose relevant to the following presentation
HLK2109
Goal of CTO PCI – no argument
 Re-open the occluded segment, maintaining patency of pertinent side
branches and outflow vessels, and re-perfuse the ischemic bed, with
safety and efficiency
 Success should provide anginal relief, improve exercise tolerance and
LV function, reduce need for CABG, and even long-term survival
 Not just TIMI3 flow with <20% residual diameter stenosis!!
HLK2109
Terminology
 RDR: retrograde dissection re-entry
 r-CART: reverse controlled antegrade and retrograde tracking
HLK2109
My argument 1
 r-CART is not RDR
HLK2109
Are they the same ideas?
 Very frequently used interchangeably in the “HTBRID universe”
Riley RF, et al. Cathet Cardiovasc Interv 2019
Brilakis ES, et al. JACC Intv 2012
HLK2109
But RWE and RDR are mutually exclusive
Brilakis ES, et al. J Am Coll Cardiol Intv 2012 Sianos G, et al. EuroIntervention 2018
HLK2109
RDR the violent way: intentional knuckling
DeMartini TJ, et al. Intervent Cardiol Clin 2012
HLK2109
And r-CART is based on RWE
 Aim to preserve
distal cap, and space
creation within
plaque
 Theoretically less
side branch loss,
especially in-
segment and distal
ones
Joyal D, et al. J Am Coll Cardiol Intv 2012
HLK2109
APCTO and EuroCTO only knuckle conditionally
Wu EB, et al. AsiaIntervention 2018 Galassi A, et al. Eurointervention 2019
HLK2109
We want r-CART even less traumatic when plausable
Matsuno S, et al. Eurointervention 2018
HLK2109
r-CART
 Should be wire-based and started with RWE, different from RDR
 Minimal space (intentionally only within the plaque) creation for wire
connection
 “The most commonly used method to connect the proximal and distal
true lumen … if retrograde true lumen crossing attempts are
unsuccessful.”
 We should try to stay within the plaque from cap to cap, and knuckle
should only be done within the occluded segment when necessary
HLK2109
Brilakis ES, et al. JACC Intv 2012
My argument 2
 r-CART (especially wire-based) is better than RDR
 Because by staying within the plaque and in between the caps, we can
have better outcome
 And that’s why we should differentiate r-CART from RDR
HLK2109
SI tracking related to bad outcome
Florence CTO Registry data
Valenti R, et al. J Am Coll Cardiol 2013
HLK2109
And procedural complications
Sabbah M, et al. Cathet Cardiovasc Interv 2019
Kurashiki data
HLK2109
Up to 40% retrograde will result in SI tracking
Tsujita K, et al. J Am Coll Cardiol Intv 2012
NYPH/CUMC data J-PROCTOR data
Muramatsu T, et al. EuroIntervention 2014
HLK2109
RDR: more SI tracking and longer stents
Song L, et al. J Am Coll Cardiol Intv 2017
NYPH/CUMC data
HLK2109
And SI tracking means trouble
Song L, et al. J Am Coll Cardiol Intv 2017
NYPH/CUMC data
HLK2109
SI in retrograde means more stent and TVR
Hasekawa K, et al. EuroIntervention 2017
J-PROCTOR 2 data
HLK2109
25/81
=31%
Conclusions
 RDR and r-CART are different
 Staying intraplaque gives you the best procedural and long term
outcomes
 Don’t win the battle (TIMI 3, <20% RS) while losing the whole war
(TVR, ischemic relief)!
 Remember the non-CTO community is asking seriously for evidence for
clinical benefits over OMT!
HLK2109
But r-CART not necessarily means knuckle
Brilakis ES, et al. Catheter Cardiovasc Interv 2012
But r-CART not necessarily means knuckle
Brilakis ES, et al. Catheter Cardiovasc Interv 2012

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Debate: Is there a difference between RDR and reverse CART? – Yes

  • 1. P A U L H S I E N - L I K A O , M D P R O F E S S O R O F M E D I C I N E N A T I O N A L T A I W A N U N I V E R S I T Y H O S P I T A L Reverse CART is not RDR HLK2109
  • 2. Disclosure  I have nothing to disclose relevant to the following presentation HLK2109
  • 3. Goal of CTO PCI – no argument  Re-open the occluded segment, maintaining patency of pertinent side branches and outflow vessels, and re-perfuse the ischemic bed, with safety and efficiency  Success should provide anginal relief, improve exercise tolerance and LV function, reduce need for CABG, and even long-term survival  Not just TIMI3 flow with <20% residual diameter stenosis!! HLK2109
  • 4. Terminology  RDR: retrograde dissection re-entry  r-CART: reverse controlled antegrade and retrograde tracking HLK2109
  • 5. My argument 1  r-CART is not RDR HLK2109
  • 6. Are they the same ideas?  Very frequently used interchangeably in the “HTBRID universe” Riley RF, et al. Cathet Cardiovasc Interv 2019 Brilakis ES, et al. JACC Intv 2012 HLK2109
  • 7. But RWE and RDR are mutually exclusive Brilakis ES, et al. J Am Coll Cardiol Intv 2012 Sianos G, et al. EuroIntervention 2018 HLK2109
  • 8. RDR the violent way: intentional knuckling DeMartini TJ, et al. Intervent Cardiol Clin 2012 HLK2109
  • 9. And r-CART is based on RWE  Aim to preserve distal cap, and space creation within plaque  Theoretically less side branch loss, especially in- segment and distal ones Joyal D, et al. J Am Coll Cardiol Intv 2012 HLK2109
  • 10. APCTO and EuroCTO only knuckle conditionally Wu EB, et al. AsiaIntervention 2018 Galassi A, et al. Eurointervention 2019 HLK2109
  • 11. We want r-CART even less traumatic when plausable Matsuno S, et al. Eurointervention 2018 HLK2109
  • 12. r-CART  Should be wire-based and started with RWE, different from RDR  Minimal space (intentionally only within the plaque) creation for wire connection  “The most commonly used method to connect the proximal and distal true lumen … if retrograde true lumen crossing attempts are unsuccessful.”  We should try to stay within the plaque from cap to cap, and knuckle should only be done within the occluded segment when necessary HLK2109 Brilakis ES, et al. JACC Intv 2012
  • 13. My argument 2  r-CART (especially wire-based) is better than RDR  Because by staying within the plaque and in between the caps, we can have better outcome  And that’s why we should differentiate r-CART from RDR HLK2109
  • 14. SI tracking related to bad outcome Florence CTO Registry data Valenti R, et al. J Am Coll Cardiol 2013 HLK2109
  • 15. And procedural complications Sabbah M, et al. Cathet Cardiovasc Interv 2019 Kurashiki data HLK2109
  • 16. Up to 40% retrograde will result in SI tracking Tsujita K, et al. J Am Coll Cardiol Intv 2012 NYPH/CUMC data J-PROCTOR data Muramatsu T, et al. EuroIntervention 2014 HLK2109
  • 17. RDR: more SI tracking and longer stents Song L, et al. J Am Coll Cardiol Intv 2017 NYPH/CUMC data HLK2109
  • 18. And SI tracking means trouble Song L, et al. J Am Coll Cardiol Intv 2017 NYPH/CUMC data HLK2109
  • 19. SI in retrograde means more stent and TVR Hasekawa K, et al. EuroIntervention 2017 J-PROCTOR 2 data HLK2109 25/81 =31%
  • 20. Conclusions  RDR and r-CART are different  Staying intraplaque gives you the best procedural and long term outcomes  Don’t win the battle (TIMI 3, <20% RS) while losing the whole war (TVR, ischemic relief)!  Remember the non-CTO community is asking seriously for evidence for clinical benefits over OMT! HLK2109
  • 21. But r-CART not necessarily means knuckle Brilakis ES, et al. Catheter Cardiovasc Interv 2012
  • 22. But r-CART not necessarily means knuckle Brilakis ES, et al. Catheter Cardiovasc Interv 2012