Jeff Dean presents designs, lessons, and advice from building large distributed systems at Google. He discusses how computing is shifting to small devices and large consolidated computing farms. Google's data centers contain thousands of servers organized into racks and clusters. MapReduce is introduced as a programming model that applies to many large-scale computing problems by hiding details like parallelization, load balancing, and fault tolerance in a runtime library. It involves mapping data, shuffling and sorting, then reducing to produce output.