2. USE-CASE: BIOREACTOR
I4MS 2016: FOSTERING DIGITAL INDUSTRIAL INNOVATION IN EUROPE · 23rd and 24th of June · Amsterdam
Bioreactor is a device, which supports a
biologically active environment
It is used for the production of different
organisms, which are used in pharmaceutical,
chemical and food industries
Pharma companies: Bayer, Pfizer, etc.
Food & drink manufactures: Nestle, Paulaner
Brewery, etc.
Manufacturer of the bioreactors are
equipment manufacturer: ZETA, VTU, Vogel-
Busch Biopharma, Eppendorf etc.
Source: http://www.sanisure.com/
3. What is the problem and for whom?
Long calculation time (about a week - caused by the need to run transient simulations up to 20
seconds) without a highly optimized workflow and huge computational resources
Industry requires a calculation time not longer than one week
These computational resources are often not affordable for SME
Why simulation?
Product improvement (e.g. higher cell density, number of viable cells etc.)
Process understanding (e.g. scale up, new impeller design or number of impellers etc.)
Improvement of process criteria (kLa, shear rate, homogenization etc.)
Why Cloud computing for a bioreactor simulation?
Peak demands can be covered
Huge number of CPUs are available on demand
Possibility to perform DoE analysis (e.g. up to 25 parallel variants)
Full cost control
Already developed and proven workflow
ACTUAL PROBLEM AND WHY
CAN CLOUD COMPUTING HELP?
I4MS 2016: FOSTERING DIGITAL INDUSTRIAL INNOVATION IN EUROPE · 23rd and 24th of June · Amsterdam
4. SES-Tec OG, Austria
Leading partner and End-User
Simulation technology consulter and service
provider
SME*
AVL LIST GmbH, Austria
Software vendor
Large enterprise**
Arctur računalniški inženiring d.o.o., Slovenia
HPC Provider
SME*
* fewer than 250 employees
** more than 250 employees
EXPERIMENT CONSORTIUM
I4MS 2016: FOSTERING DIGITAL INDUSTRIAL INNOVATION IN EUROPE · 23rd and 24th of June · Amsterdam
5. EXPERIMENT DESIGN AND
TECHNICALAPPROACH
I4MS 2016: FOSTERING DIGITAL INDUSTRIAL INNOVATION IN EUROPE · 23rd and 24th of June · Amsterdam
Simulation model
Vessel
Impeller
Baffles
Sparger
Rotor cell
selection
Stator cell
selection
Fill level
6. CURRENT PROCESS WITHOUT
USING CLOUD COMPUTATION
I4MS 2016: FOSTERING DIGITAL INDUSTRIAL INNOVATION IN EUROPE · 23rd and 24th of June · Amsterdam
MISSING
COMPUTATIONAL
RESOURCES
7. EXPERIMENT DESIGN AND
TECHNICALAPPROACH
I4MS 2016: FOSTERING DIGITAL INDUSTRIAL INNOVATION IN EUROPE · 23rd and 24th of June · Amsterdam
Implementation
Solution
Access to computational resources via Cloud - thus full cost control,
shorter calculation time and affordable for SME
Highly optimized workflow for this kind of application
WEB BROWSER AND CLOUDFLOW PORTAL
8. 3D RESULTS POST-
PROCESSING IN CLOUD
I4MS 2016: FOSTERING DIGITAL INDUSTRIAL INNOVATION IN EUROPE · 23rd and 24th of June · Amsterdam
2D and 3D data post-processing in
Cloud
Full integrated 2D/3D post-
processing application in
Cloud
No data transfer through
network
Simulation and residuals
monitoring
9. ECONOMIC IMPACT AND
BUSINESS OPPORTUNITIES
I4MS 2016: FOSTERING DIGITAL INDUSTRIAL INNOVATION IN EUROPE · 23rd and 24th of June · Amsterdam
In house costs
45.000€ (12-16CPUs + License for
a year)
Utilization: about 80% per year
Cloud costs: 1,2 [€ / CPU h]
Real advantage of Cloud for an
end-user
Huge number of variants in short
calculation time, e.g. 25 variants in
one week (no investment costs).
Variant simulation (e.g. DoE) is
not direct comparable with in-
house calculation, due to very high
investment costs (e.g. 25*45.000€,
practically not possible for SMEs)
0
20000
40000
60000
80000
100000
120000
0 20 40 60 80 100
Costs[€]
Nr. of Variants
Cloud costs
In house costs
Cost saving
10. ECONOMIC IMPACT AND
BUSINESS OPPORTUNITIES
I4MS 2016: FOSTERING DIGITAL INDUSTRIAL INNOVATION IN EUROPE · 23rd and 24th of June · Amsterdam
Time saving
Actual impact for SES-Tec
In the next three years SES-Tec is planning to increase the actual turnover by 15%
of the actual turnover only due to Cloud computing. SES-Tec
We will contact potential customers (e.g. Vision Pharma (2016) and CPHI (2016))
and increase the market in the are of pharma and bio technology
Furthermore, SES-Tec is planning to hire a new employee, which deals exclusively
with cloud computation.
11. CONCLUSION AND
FURTHER PLANS
I4MS 2016: FOSTERING DIGITAL INDUSTRIAL INNOVATION IN EUROPE · 23rd and 24th of June · Amsterdam
Cloud computing advantages
No investment and service costs
Available 24/7
Benefits from CloudFlow project
Cloud computing knowledge and integration of a workflow
Results of a DoE analysis in Cloud
Experience and basis knowledge for other applications and integrations
New services offer new application areas and new job positions
How I4MS helped SES-Tec
With the help of I4MS it was possible to create a new tested application – in order to keep up also as an SME
Provided a large network
A SME is forced to economize differently as a large enterprise and therefore it is pretty tough to develop a
cloud-based platform for a CFD simulation during the daily work
Dissemination and exploitation activities
Contact with potential customers
Usability test with SES-Tec customers (live demonstrations for potential new applications)