Dalibor Jajcevic, SES-Tec, AT (CloudFlow)

CLOUD-BASED MULTIPHASE FLOW
SIMULATION OF A BIOREACTOR
PROJECT: CLOUDFLOW
23rd and 24th of June – Amsterdam

USE-CASE: BIOREACTOR
I4MS 2016: FOSTERING DIGITAL INDUSTRIAL INNOVATION IN EUROPE · 23rd and 24th of June · Amsterdam
 Bioreactor is a device, which supports a
biologically active environment
 It is used for the production of different
organisms, which are used in pharmaceutical,
chemical and food industries
 Pharma companies: Bayer, Pfizer, etc.
 Food & drink manufactures: Nestle, Paulaner
Brewery, etc.
 Manufacturer of the bioreactors are
equipment manufacturer: ZETA, VTU, Vogel-
Busch Biopharma, Eppendorf etc.
Source: http://www.sanisure.com/

 What is the problem and for whom?
 Long calculation time (about a week - caused by the need to run transient simulations up to 20
seconds) without a highly optimized workflow and huge computational resources
 Industry requires a calculation time not longer than one week
 These computational resources are often not affordable for SME
 Why simulation?
 Product improvement (e.g. higher cell density, number of viable cells etc.)
 Process understanding (e.g. scale up, new impeller design or number of impellers etc.)
 Improvement of process criteria (kLa, shear rate, homogenization etc.)
 Why Cloud computing for a bioreactor simulation?
 Peak demands can be covered
 Huge number of CPUs are available on demand
 Possibility to perform DoE analysis (e.g. up to 25 parallel variants)
 Full cost control
 Already developed and proven workflow
ACTUAL PROBLEM AND WHY
CAN CLOUD COMPUTING HELP?

 SES-Tec OG, Austria
 Leading partner and End-User
 Simulation technology consulter and service
provider
 SME*
 AVL LIST GmbH, Austria
 Software vendor
 Large enterprise**
 Arctur računalniški inženiring d.o.o., Slovenia
 HPC Provider
 SME*
* fewer than 250 employees
** more than 250 employees
EXPERIMENT CONSORTIUM

EXPERIMENT DESIGN AND
TECHNICALAPPROACH
 Simulation model
Vessel
Impeller
Baffles
Sparger
Rotor cell
selection
Stator cell
selection
Fill level

CURRENT PROCESS WITHOUT
USING CLOUD COMPUTATION
MISSING
COMPUTATIONAL
RESOURCES

EXPERIMENT DESIGN AND
TECHNICALAPPROACH
 Implementation
 Solution
 Access to computational resources via Cloud - thus full cost control,
shorter calculation time and affordable for SME
 Highly optimized workflow for this kind of application
WEB BROWSER AND CLOUDFLOW PORTAL

3D RESULTS POST-
PROCESSING IN CLOUD
 2D and 3D data post-processing in
Cloud
 Full integrated 2D/3D post-
processing application in
Cloud
 No data transfer through
network
 Simulation and residuals
monitoring

ECONOMIC IMPACT AND
BUSINESS OPPORTUNITIES
 In house costs
 45.000€ (12-16CPUs + License for
a year)
 Utilization: about 80% per year
 Cloud costs: 1,2 [€ / CPU h]
 Real advantage of Cloud for an
end-user
 Huge number of variants in short
calculation time, e.g. 25 variants in
one week (no investment costs).
 Variant simulation (e.g. DoE) is
not direct comparable with in-
house calculation, due to very high
investment costs (e.g. 25*45.000€,
practically not possible for SMEs)
0
20000
40000
60000
80000
100000
120000
0 20 40 60 80 100
Costs[€]
Nr. of Variants
Cloud costs
In house costs
 Cost saving

ECONOMIC IMPACT AND
BUSINESS OPPORTUNITIES
 Time saving
 Actual impact for SES-Tec
 In the next three years SES-Tec is planning to increase the actual turnover by 15%
of the actual turnover only due to Cloud computing. SES-Tec
 We will contact potential customers (e.g. Vision Pharma (2016) and CPHI (2016))
and increase the market in the are of pharma and bio technology
 Furthermore, SES-Tec is planning to hire a new employee, which deals exclusively
with cloud computation.

CONCLUSION AND
FURTHER PLANS
 Cloud computing advantages
 No investment and service costs
 Available 24/7
 Benefits from CloudFlow project
 Cloud computing knowledge and integration of a workflow
 Results of a DoE analysis in Cloud
 Experience and basis knowledge for other applications and integrations
 New services offer new application areas and new job positions
 How I4MS helped SES-Tec
 With the help of I4MS it was possible to create a new tested application – in order to keep up also as an SME
 Provided a large network
 A SME is forced to economize differently as a large enterprise and therefore it is pretty tough to develop a
cloud-based platform for a CFD simulation during the daily work
 Dissemination and exploitation activities
 Contact with potential customers
 Usability test with SES-Tec customers (live demonstrations for potential new applications)

Dalibor Jajcevic, SES-Tec, AT (CloudFlow)

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