This study compared the effectiveness of Custodiol-HTK crystalloid cardioplegia solution versus conventional blood cardioplegia for myocardial protection in 100 patients undergoing early coronary artery bypass grafting (CABG) within one month of a ST-elevation myocardial infarction (STEMI). The study found that while the Custodiol group had a significantly shorter duration of mechanical ventilation and ICU stay, they also experienced a higher rate of post-operative arrhythmias compared to the blood cardioplegia group. Overall, both cardioplegia solutions provided similar outcomes for mortality and complications, with Custodiol associated with lower troponin levels but higher lactate levels in the first six hours after CABG.