The document provides guidance on performing an oral cholecystography procedure to visualize the gallbladder. It begins by explaining that oral cholecystography involves administering a radiopaque contrast agent by mouth that is then excreted by the liver and collects in the gallbladder. The examination involves three stages - a control radiograph, administration of the contrast agent the evening before, and imaging the following day. Factors like diet, contrast agent dose, and imaging after a fatty meal are discussed to optimize visualization of the gallbladder and any gallstones. Contraindications to the procedure and different contrast agents used are also mentioned.
MDCT Principles and Applications- Avinesh ShresthaAvinesh Shrestha
Multidetector CT (MDCT) is one of the most commonly used imaging modality in the field of Radiology. Development and advancement in MDCT has made it's application as a major component in diagnosis and treatment planning of multitude of disease across the planet. This presentation briefly describes its basic principle and it's wide variety of application in medical imaging.
MDCT Principles and Applications- Avinesh ShresthaAvinesh Shrestha
Multidetector CT (MDCT) is one of the most commonly used imaging modality in the field of Radiology. Development and advancement in MDCT has made it's application as a major component in diagnosis and treatment planning of multitude of disease across the planet. This presentation briefly describes its basic principle and it's wide variety of application in medical imaging.
IVU is the radiographic examination of urinary tract including renal parenchyma, calyces and pelvis after intravenous injection of contrast media. Study was carried out at UCMS, Bhairawa, Nepal.
This presention is about gastroscopy and colonoscopy. Detailed explanations are give along with two videos that shows the procedure. The slide also explains about how the procedure is done and for who it is done.
Colorectal Surgeon Sydney provides you insights on causes of colorectal cancer, stages of colorectal cancer, colorectal cancer stories, blogs, communities.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
The prostate is an exocrine gland of the male mammalian reproductive system
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Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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ASA GUIDELINE
NYSORA Guideline
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Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Couples presenting to the infertility clinic- Do they really have infertility...
Contrast media 4
1. IN THE NAME Of GOD
Amir al-Muminin, peace be upon him, said:
There is no wealth like wisdom, no destitution like ignorance, no
inheritance like refinement and no support like consultation.
املومنينرامي(ع)فرمودند:
هيچينيازيبنچو،عقلوهيچيفقرنچوناداني،نيستهيچثيرانچو،ادبوهيچ
پشتيبانينچوترمشونيست.
4. In vertebrates the gallbladder (Cholecyst, Biliary Vesicle) is a small organ that
aids mainly in fat digestion and concentrates bile produced by the liver.
Human anatomy
5. Human anatomy
The gallbladder is a hollow system that sits just beneath the liver. In adults, the
gallbladder measures approximately 8 centimetres (3.1 in) in length and 4
centimetres (1.6 in) in diameter when fully distended.
It is divided into three sections: fundus, body and neck.
The neck tapers and connects to the biliary tree via the cystic duct, which then
joins the common hepatic duct to become the common bile duct.
At the neck of the gall bladder is a mucosal fold called Hartmann's pouch, where
gallstones commonly get stuck. The angle of the gallbladder is located between
the costal margin and the lateral margin of the rectus abdominis muscle.
7. Function
When food containing fat enters the digestive tract, it stimulates the secretion of
cholecystokinin (CCK).
In response to CCK, the adult human gallbladder, which stores about 50
millilitres (1.7 U.S. fl oz; 1.8 imp fl oz) of bile, releases its contents into the
duodenum. The bile, originally produced in the liver, emulsifies fats in partly
digested food.
cholecystokinin (CCK) is a peptide hormone of the gastrointestinal system
responsible for stimulating the digestion of fat and protein
8. Oral cholecystography (O.C.G)
Oral cholecystography is a procedure used to visualize the gallbladder by
administering, by mouth, a radiopaque contrast agent that is excreted by the
liver.
This excreted material will collect in the gallbladder, where reabsorption of
water concentrates the excreted contrast.
Since only 10% of gallstones are radiopaque, the remaining 90% will appear as
translucent on an opaque background in an abdominal x-ray
9. • Proven hypersensitivity to iodinated contrast agents
• Sever hepatic renal disease
• Dehydration
• Cholecystectomy
• Malabsorption syndrome
• Diarrhea
• Drug Vomiting
• Bilirubin higher than 3 milligram
Contraindications
11. Contrast media Dose
Telepaque or Biloptin:
Normal patient
6 (Tablet) × 0/5 (gram iodine) = 3 gram iodine
Fat patient
12 (Tablet) × 0/5 (gram iodine) = 6 gram iodine
Higher Dose is danger and to be affected with kidney .
12. Exam Stages
The examination is a three stage process :
1) Day 1 the patient takes a laxative for two days prior to the examination days,
(check contraindications to laxative preparation, care with diabetics, and
conditions like Crohns disease)
13. 2) Day 2 a single control radiograph of the whole abdomen or the right side of
the abdomen.
(This film is then examined to determine, the position of the gallbladder (level with
the upper margin of the hepatic flexure of the colon, to demonstrate any radio
opaque calculi, evaluate the efficacy of the laxative preparation and judge the
exposure for the second part of the examination.)
The evening before the examination the patient takes the oral contrast agent
tablets as directed by the manufacturer, typically 3 grams of Calcium Ipodate
(Biloptin) with plenty of water, the patient remains nil by mouth except for water
until the examination 14 hours after taking the contrast medium.
Exam Stages
14. 3) The day of the examination check the patient has taken the tablets as directed,
followed the dietary instructions and not been sick or had diarrhea.
The evening of the day before the examination the patient is encouraged to have
a high fat meal to empty the gall bladder. It can help to better absorb Telepaque
but it is not affect on Bilopaque and Biloptin.
AFM or After Fatty Meal Film. If the gall bladder is adequately demonstrated
with obvious calculi then a fatty meal is given, either a proprietary product such
as "Prosperol" or a glass of full fat milk or two eggs , 40 minutes later the gall
bladder is imaged in whichever projection best demonstrated .
Exam Stages
16. Gallstone
A gallstone is a crystalline concretion formed within the gallbladder by
accretion of bile components. These calculi are formed in the gallbladder, but
may pass distally into other parts of the biliary tract such as the cystic duct,
common bile duct, pancreatic duct, or the ampulla of Vater.
On the basis of their composition, gallstones can be divided into the following
types:
Cholesterol stones
Cholesterol stones vary in color from light-yellow to dark-green or brown and are
oval 2 to 3 cm in length, often having a tiny dark central spot. To be classified as
such, they must be at least 80% cholesterol by weight.
17. Gallstone
2. Pigment stones
Pigment stones are small, dark stones made of bilirubin and calcium salts that are
found in bile. They contain less than 20% of cholesterol (or 30%, according to
the Japanese classification system).
3. Mixed
75 % people have mixed stones.
19. Intra venous cholangiography (I.V.C)
X-ray examination of the bile ducts, using a radiopaque dye as a contrast
medium. In the intravenous method, the dye is administered intravenously and is
excreted by the liver into the bile ducts.
Preparation of the patient for the intravenous method requires restriction of
fluids to concentrate the dye and may also include cleansing of the intestinal
tract on the day prior to the examination with a laxative or enema so that fecal
material and gas will not obscure the biliary tract.
X-ray films are taken at 10-minute intervals as the dye is excreted via the cystic,
hepatic, and common bile ducts into the intestinal tract. The excretion is usually
completed within 4 hours.
20. I.V.C Application
• Cholecystectomy
• O.C.G is not satisfactory
• Coldo-colelitiasis
• Bilirubin higher than 3 milligram
Contraindications :
• Sever hepatic renal disease
• Bilirubin higher than 5 milligram
22. T-tube Cholangiogram
A T-tube cholangiogram is a fluoroscopic procedure in which contrast medium
is injected through a T-tube into the patient's biliary tree. The T-tube is most
commonly inserted during a cholecystectomy operation when there is a
possibility of residual gall stones within the biliary tree.
23. Indications & Contraindications
Indications
Patient must have T-Tube insitue
Patient's with possibility of residual small gallstones post cholecystectomy
Obstructive Jaundice
Bile duct Stricture
Surgeon unable to explore Bile duct during cholecystectomy surgery
Contraindications
Contrast or iodine allergy
Pregnancy ( pregnancy test required)
Barium study within last 3 days
24. Examination
1. The drainage tube is clamped the day preceding the examination to let the tube
fill with bile as a preventive measure against air bubbles entering the ducts,
where they would simulate cholesterol stones.
2. The preceding meal is withheld.
3. When indicated, a cleansing enema is administered about 1 hour before the
examination.
Premedication is not required.
25. Examination
The patient is positioned supine on the X-ray table than a slightly RPO position
20ْ can help to ensure the CBD is not superimposed over the patient's spine.
A preliminary/scout image of the RUQ should be acquired.
Injection should continue until the entire biliary tree is opacified and there is
passage of contrast into the duodenum.
If the Intra Hepatic ducts do not fill, the patient can be tilted Trendelenburg and
further contrast injected into the T-tube.
The patient may need to lie on their left hand side to fill the left hepatic duct.
26. Contrast media
The density of the contrast medium used in postoperative
cholangiograms is recommended to be no more than 25% to 30%
because small stones may be obscured with a higher concentration.
Urografin 60%
Conray 280
Omnipaque
28. Endoscop Retrograde Cholangio paceratography (E.R.C.P)
Endoscopic retrograde cholangiopancreatography is an endoscopic procedure
that involves the use of fiberoptic endoscopes. You will be lightly sedated and
your doctor will insert an endoscope through the mouth, down the esophagus,
and into the stomach and small bowel. A smaller tube or catheter is passed
through the endoscope and into the bile ducts. Dye is injected into the ducts,
and the doctor takes X-rays that can show whether a tumor is present in the bile
ducts.
31. Arthrogrphy
An arthrogram is a series of images, often X-rays, of a joint after
injection of a contrast medium
An arthrogram is used to:
Find problems in your joint capsule, ligaments, cartilage (including tears,
degeneration, or disease), and the bones in the joint. In your shoulder, it may be
used to help find rotator cuff tears or a frozen shoulder.
Find abnormal growths or fluid-filled cysts.
Confirm that a needle has been placed correctly in your joint before joint fluid
analysis, a test in which a sample of joint fluid is removed with a thin needle.
Check needle placement before a painkilling injection, such as a corticosteroid
injection.
32. Arthrogrphy
The joint area will be cleaned and a local anesthetic will be injected into the
tissues around the joint to reduce pain.
Next, if fluids are present in the joint, the physician may suction them out
(aspirate) with a needle. These fluids may be sent to a laboratory for further
study.
Contrast agents are then injected into the joint through the same location by
attaching the aspirating needle to a syringe containing the contrast medium.
The purpose of contrast agents in x-ray procedures is to help highlight details of
areas under study by making them opaque.
33. Contrast media
Agents for arthrography are generally air and water-soluble dyes, the most
common containing iodine. Air and iodine may be used together or
independently. After the contrast agent is administered, the site of injection will
be sealed and the patient may be asked to move the joint around to distribute the
contrast.
Radiolucent Contrast media :
Air
Carbon dioxide
Oxygen
Radioopaque Contrast media :
Urografin 60% - Conray 240 – Hexabrix
Omnipaque - Visipaque - Ultravist
35. Radiographic examination involving opacification of pathological tracks or
extravasation of contrast medium from hollow organs (gastrointestinal tract,
bladder) or tubular structures (bile ducts, ureter) .
One of the main indications of fistulography is to look for postoperative
anastomotic leaks or injuries of the bile ducts and ureters.
Fistulous tracks may also develop from infections, inflammatory or tumour
lesions and may brake through to the skin (abscesses, osteomyelitis). In these
cases the fistulous track may be demonstrated by inserting a blunt needle or
small catheter into the mouth of the fistula.
Fistulography
36. Contrast media
Oily Contrast media :
lipiodol
Ethiodol
Myodile
Water soluble Contrast media :
Urografin 76% - Conray 240 – Hypaque
Omnipaque - Visipaque - Niopam