Conduct outside reading on Salla disease. Explain its underlying molecular biology, cause,
signs, symptoms and progression of the disease. Address whether any cures have been found. If
yes describe them. If no explain why this is the case.
Solution
Salla disease is a type of allelic disorder which falls under sialic acid storage disease
characterized by a delay in development, ataxia, and some dysmorphic features. Additional signs
are hypopigmentation of skin and hair, mild skeletal dysplasias, and course facial features.There
is an accumulation of the charged monosaccharide sialic acid (N-acetylneuraminic acid) in
lysosomes as a result of which sialic acid cannot be transported out of lysosomes.The mode of
inheritence is autosomal recessive disease. The diagnosis is dependent upon the raised excretion
of sialic acid in urine. Electron microscopic studies of reveal a lot about it.
There is actually a homozygous missense mutation in SLC17A5 which codes for the transport
protein called sialin. People with salla disease have normal life span but remain differently abled.
There is no cure for this disease as its a homozygous missense mutation which is having dual
mode of action-either altering the amino acids in translated proteins or else remaining silent.
References
1. Gorlin, R,J., Cohen, M,M., & Hennekam, R,C,M. (2001). Syndromes of the head and
neck.New York: Oxford university press.
2. Barness, E,G., Barness,L,A., & Farrell, P,M. (2017). Metabolic diseases. Amsterdam:IOS
press BV..
Thalassemia is an inherited blood disorder that causes your body to have less hemoglobin than normal. Hemoglobin enables red blood cells to carry oxygen. Thalassemia can cause anemia, leaving you fatigued.
Disorders of amino acid metabolism
Disorders of renal amino acid transport
Disorders of carbohydrate metabolism and transport
Carbohydrate-deficient protein syndromes
carbohydrate metabolism and transport
Disorders of fatty acid oxidation
Disorders of purine and pyrimidine metabolism
Disorders of lipid and lipoprotein metabolism
Ceroid lipofuscinosis and other lipidoses.
Disorders of serum lipoproteins
Lysosomal disorders
Peroxisomal disorders
Disorders of metal metabolism
Porphyrias
FETAL ALCOHOL SYNDROME (FAS) is the leading known cause of mental retardation
and birth defects in the world. Fetal alcohol syndrome is a pattern of physical, behavioral and
cognitive abnormalities seen in individuals exposed to alcohol in uterus. Because alcohol is a
known teratogen and the damage done to a fetus by alcohol exposure is permanent, public
education about the dangers of prenatal alcohol exposure has been extensive. Many of the
features of the fetal alcohol syndrome are secondary to the effect of alcohol on brain
development. These include microcephaly, short palpebral fissures, the long smooth philtrum
and thin vermilion of the upper lip, joint anomalies, altered palmar crease pattern, and mental
retardation. Animal studies as well as a limited amount of human data also show that
maternal genotype is a key player : Advances in the development of novel antioxidant
therapies as an approach for fetal alcohol syndrome prevention. Peptides NAPVSIPQ (NAP)
and SALLRSIPA (SAL), related to activity-dependent neuroprotective protein (ADNP),
prevent alcohol-induced damage in a mouse model of FAS. In a recent study, the thyroxin
reversed the deficit both in the level of their genes and their social behaviour, research is
going on how the prenatal thyroid hormone supplementation reverses the behavioural deficits
in the fetal alcohol spectrum disorder model. Another study used a priori approach to assess
molecular phenotype in the cranial neural folds (head fold) of early mouse embryos soon
after maternal alcohol treatment. FAS can be modulated pharmacologically with PK11195, a
potent ligand with specific binding to the mitochondrial peripheral-type benzodiazepine
receptor recognition site. PK11195 has been shown to protect early mouse embryos from eye
and brain defects induced with diverse teratogens and to protect adult tissues from some
inflammatory lesions. Microarray transcript profiling of the embryonic head fold at 3.0 hr
after alcohol exposure or PK11195 counter-exposure enabled prioritization of candidate
pathways that integrate the genomic response with genetic susceptibility of the system. These
findings are consistent with the growing view that developmental exposure to alcohol alters
common signalling pathways linking receptor activation to cytoskeletal reorganization. The
programmatic shift in cell motility and metabolic capacity further implies cell signals and
responses that are integrated by the mitochondrial recognition site for PK11195.
CONCLUSIONS: Until the advent of effective prevention measures, it will remain
necessary to seek ways to treat the life-long neurobehavioral consequences of prenatal
alcohol exposure. Nevertheless, alcohol is a widely accepted and legal social drug, and many
pregnant mothers continue to drink it while pregnant. Whereas, FAS is totally preventable by
avoiding alco
Sickle cell anemia is one of a group of inherited disorders known as sickle cell disease.
It affects the shape of red blood cells, which carry oxygen to all parts of the body.
One brain area in which neurogenesis is especially apparent is the.pdferremmfab
One brain area in which neurogenesis is especially apparent is the:
A.amygdala
B.thalamus
c.hypothalamus
D.hippocampus
Solution
The adult neurogenesis among mammals was initially found majorly in the dentate gyrus (DG)
part of the hippocampus. Lately, the minimal contribution of amygdala and hypothalamus has
been also studied.
Therefore, the correct option is: D-hippocampus.
Ive used op amps as comparators a number of times because of the e.pdferremmfab
I\'ve used op amps as comparators a number of times because of the easy availability (they can
be purchased 4 op amps to the IC package) so one was used as a comparator while the other
three for other purposes. But there are units made that are actually called comparators. Is there
something different about these - not just ordinary op amps?
Solution
there is no difference it is just ordinary op amps.
More Related Content
Similar to Conduct outside reading on Salla disease. Explain its underlying mole.pdf
Thalassemia is an inherited blood disorder that causes your body to have less hemoglobin than normal. Hemoglobin enables red blood cells to carry oxygen. Thalassemia can cause anemia, leaving you fatigued.
Disorders of amino acid metabolism
Disorders of renal amino acid transport
Disorders of carbohydrate metabolism and transport
Carbohydrate-deficient protein syndromes
carbohydrate metabolism and transport
Disorders of fatty acid oxidation
Disorders of purine and pyrimidine metabolism
Disorders of lipid and lipoprotein metabolism
Ceroid lipofuscinosis and other lipidoses.
Disorders of serum lipoproteins
Lysosomal disorders
Peroxisomal disorders
Disorders of metal metabolism
Porphyrias
FETAL ALCOHOL SYNDROME (FAS) is the leading known cause of mental retardation
and birth defects in the world. Fetal alcohol syndrome is a pattern of physical, behavioral and
cognitive abnormalities seen in individuals exposed to alcohol in uterus. Because alcohol is a
known teratogen and the damage done to a fetus by alcohol exposure is permanent, public
education about the dangers of prenatal alcohol exposure has been extensive. Many of the
features of the fetal alcohol syndrome are secondary to the effect of alcohol on brain
development. These include microcephaly, short palpebral fissures, the long smooth philtrum
and thin vermilion of the upper lip, joint anomalies, altered palmar crease pattern, and mental
retardation. Animal studies as well as a limited amount of human data also show that
maternal genotype is a key player : Advances in the development of novel antioxidant
therapies as an approach for fetal alcohol syndrome prevention. Peptides NAPVSIPQ (NAP)
and SALLRSIPA (SAL), related to activity-dependent neuroprotective protein (ADNP),
prevent alcohol-induced damage in a mouse model of FAS. In a recent study, the thyroxin
reversed the deficit both in the level of their genes and their social behaviour, research is
going on how the prenatal thyroid hormone supplementation reverses the behavioural deficits
in the fetal alcohol spectrum disorder model. Another study used a priori approach to assess
molecular phenotype in the cranial neural folds (head fold) of early mouse embryos soon
after maternal alcohol treatment. FAS can be modulated pharmacologically with PK11195, a
potent ligand with specific binding to the mitochondrial peripheral-type benzodiazepine
receptor recognition site. PK11195 has been shown to protect early mouse embryos from eye
and brain defects induced with diverse teratogens and to protect adult tissues from some
inflammatory lesions. Microarray transcript profiling of the embryonic head fold at 3.0 hr
after alcohol exposure or PK11195 counter-exposure enabled prioritization of candidate
pathways that integrate the genomic response with genetic susceptibility of the system. These
findings are consistent with the growing view that developmental exposure to alcohol alters
common signalling pathways linking receptor activation to cytoskeletal reorganization. The
programmatic shift in cell motility and metabolic capacity further implies cell signals and
responses that are integrated by the mitochondrial recognition site for PK11195.
CONCLUSIONS: Until the advent of effective prevention measures, it will remain
necessary to seek ways to treat the life-long neurobehavioral consequences of prenatal
alcohol exposure. Nevertheless, alcohol is a widely accepted and legal social drug, and many
pregnant mothers continue to drink it while pregnant. Whereas, FAS is totally preventable by
avoiding alco
Sickle cell anemia is one of a group of inherited disorders known as sickle cell disease.
It affects the shape of red blood cells, which carry oxygen to all parts of the body.
One brain area in which neurogenesis is especially apparent is the.pdferremmfab
One brain area in which neurogenesis is especially apparent is the:
A.amygdala
B.thalamus
c.hypothalamus
D.hippocampus
Solution
The adult neurogenesis among mammals was initially found majorly in the dentate gyrus (DG)
part of the hippocampus. Lately, the minimal contribution of amygdala and hypothalamus has
been also studied.
Therefore, the correct option is: D-hippocampus.
Ive used op amps as comparators a number of times because of the e.pdferremmfab
I\'ve used op amps as comparators a number of times because of the easy availability (they can
be purchased 4 op amps to the IC package) so one was used as a comparator while the other
three for other purposes. But there are units made that are actually called comparators. Is there
something different about these - not just ordinary op amps?
Solution
there is no difference it is just ordinary op amps.
Is there any reason that mitosis could not occur in a cell whose gen.pdferremmfab
Is there any reason that mitosis could not occur in a cell whose genome is haploid? Why or why
not? Relate your answer to the way chromosomes line up for metaphase in mitosis.
Solution
Answer:
Haploid cells can undergo mitosis. It is beneficial for some plants and protists, the end result is
two identical haploid cells (nn).
Some plants use the alternation of generations reproductive cycle. A haploid gamete is
mitotically reproduced. Mitosis is much quicker than meiosis, allowing for many haploid
gametes to be produced. Example: Gametophyte of Bryophyte plants. It is produced from mitotic
cell division of spores, which are produced by meiosis in sporophytes.
During S-phase, DNA gets duplicated with each chromosome containing 4 chromatids. The
chromosomes line up at the center of the cell during metaphase. The centromeres split and divide
each chromosome into two which migrate to the opposite poles during anaphase..
In fruit flies, the brown gene, which controls eye color, is located .pdferremmfab
In fruit flies, the brown gene, which controls eye color, is located on an autosome. Brown
mutants (bw) have brown eyes, while wild-type flies (bw^+) have red eyes. A gene on the X
chromosome, miniature, controls wing size. Miniature wings are caused by the m allele, which is
recessive to the allele for normal wings (m^+). True-breeding miniature-winged, red-eyed
females are crossed to true-breeding normal-winged, brown-eyed males. Predict the phenotypes
(including their ratios of the F1 flies. If the F1 flies are intercrossed with each other, what
phenotypes will appear in the F2 and in what proportions?
Solution
1.
Phenotype
Normal wings Red Eyes 4418
Miniature wings Brown eyes 4330
Normal wings Brown eyes 610
Miniature wings Red eyes 590
2. The F1 was self-crossed to give rise to the F2 generation. Of these offspring, 3/4 had brown
eyes while 1/4 had Red eyes. Phenotypic ratio is 3:1.
In a population of Gouldian Finches, 1200 have a white breast colora.pdferremmfab
In a population of Gouldian Finches, 1200 have a white breast coloration and 800 have purple
breast coloration. The population is at Hardy-Weinberg equilibrium and breast color is
determined by a single mutation at one locus. What is the frequency of the dominant genotype if
purple is the dominant trait?
Solution
1200 have white. Let the symbol for recessive trait be \"p\" and that for dominant trait be \"P\".
So, genotype of 1200 finches will be \"pp\".
Total finches=1200+800=2000
According to HW equilibrium, q^2=pp=1200/2000=0.6
q= 0.6
p=(1-q)=(1-.77)=0.23=frequency of dominant phenotype.
IL 0 Group II Group I Select GP I Select GP II Solution Basic P.pdferremmfab
IL 0 Group II Group I Select GP I Select GP II
Solution
Basic Pneumatic Circuitry For control and automation 2. Contents Introduction Symbols
Circuit layout Actuator control 2/2 Valve Actuator control 3/2 Valve Actuator control 5/2 Valve
Sequential control Sequence solution 5/3 Valves Poppet/spool logic Balanced spool logic
Feedback Click the section to advance directly to it 3. Introduction This module shows the
methods of application of pneumatic valves and components for control and automation The
methods of pure pneumatic sequential control are confined to simple examples The majority of
modern systems are controlled electronically and is the subject of electropneumatic modules A
message to pneumatic circuit designers: Use proven and reliable design techniques Produce
circuits and documentation that are clear to read Design for safety Do not try to be too clever, the
circuit will be difficult for others to read and maintain 4. Symbols The standard for fluid
power symbols is ISO 1219-1. This is a set of basic shapes and rules for the construction of fluid
power symbols Cylinders can be drawn to show their extreme or intermediate positions of stroke
and any length above their width Valves show all states in the one symbol. The prevailing state is
shown with the port connections Other components are single state symbols 5. Symbols single
acting actuators Single acting, sprung instroked Single acting, sprung outstroked Single acting,
sprung instroked, magnetic Single acting, sprung outstroked, magnetic 6. Symbols double acting
actuators Double acting, noncushioned Double acting, adjustable cushions Double acting,
through rod, adjustable cushions Double acting, magnetic, adjustable cushions Double acting,
rodless, magnetic, adjustable cushions 7. Symbols rotary actuators Semi-rotary double acting
Rotary motor single direction of rotation Rotary motor bidirectional 8. Symbols valves 2/2
Valve push button / spring 3/2 Valve detented lever operated 1 3/2 Valve push button / spring 2
10 12 2 10 12 3 2 10 12 3 1 1 9. Symbols valves 3/2 Valve differential pressure operated 2 12 3
10 1 5/2 Valve push button / spring 5/3 Valve double pressure operated spring centre 14 4 5 4 2 5
1 3 2 12 1 3 10. Symbols valves A valve function is known by a pair of numbers e.g. 3/2. This
indicates the valve has 3 main ports and 2 states The valve symbol shows both of the states Port
numbering is to CETOP RP68P and shows: when the valve is operated at the 12 end port 1 is
connected to port 2 when reset to the normal state at the 10 end port 1 is connected to nothing (0)
2 12 10 3 1 11. Symbols valves A valve function is known by a pair of numbers e.g. 3/2. This
indicates the valve has 3 main ports and 2 states The valve symbol shows both of the states Port
numbering is to CETOP RP68P and shows: when the valve is operated at the 12 end port 1 is
connected to port 2 when reset to the normal state at the 10 end port 1 is connected to nothing (0)
2 12 10 3 1 12. Symbols val.
If noncovalent interactions such as hydrogen bonds are so weak , how.pdferremmfab
If noncovalent interactions such as hydrogen bonds are so weak , how are they able to hold
molecules in a particular conformation and hold two molecules (such as enzyme and substrate)
together?
Solution
The non-covalent interactions are weak forces like hydrogen bonds, hydrophobic interactions,
electrostatic interactions, and Vander Waals forces. Conformations in the structure of proteins at
secondary and tertiary level are due to extensive hydrogen bonding. Though individually weak,
these non-covalent interactions are able to hold molecules in a particular conformation because,
they occur in large numbers. When a substrate binds to an enzyme, the attractive forces between
the substrate and the enzyme alter the enzyme\'s conformation. As the substrate approaches the
active site, these non-covalent interactions cause the active site to bend into such a shape that the
substrate molecule closely fits into it. As the shape of the active site changes, it produces changes
in the shape of other regions of the enzyme molecule altering the overall conformation of the
enzyme. The conformational change in the enzyme allows the formation of more non-covalent
interactions, which hold the two molecules together..
How is the address of the individual of an array foundSolution.pdferremmfab
How is the address of the individual of an array found?
Solution
An array is a type of variable in C programming, one that you can examine for its size and
address. Now you uncover the deep, dark secret of beholding an array’s address.
The source code from Where the Array Lurks shows a teensy program that declares an int array
and then displays that array’s location in memory..
Given the following information (ignore the top posts on the LEGO br.pdferremmfab
Given the following information (ignore the top posts on the LEGO bricks):
The short blocks have a thickness of 3.20±.01 mm
The tall blocks have a thickness of 9.60±.01 mm
When the stack is the TALLEST: What would the maximum size of these gaps be?
Solution
I a little confuse with this, but with the gaps I think that you are talking about the separation
between them? if you put the tallest form, the tolerance is 0.02 mm, so this would be, but I don´t
really sure.
Gene Splicing -1. DNA is made up of two separate strands of base s.pdferremmfab
Gene Splicing -
1. DNA is made up of two separate strands of base sequences. The same sequence is found on
both strands, but running in opposite directions. What word describes this characteristic?
2. What does the term “sticky ends” refer to in gene splicing?
3. What is a plasmid? How is a plasmid used in gene splicing?
4. What types of vectors are used to carry DNA from one species into the DNA of another
species? Give examples.
5. What is a “transgenic organism”? Give examples
6. Why is it essential that the same restriction enzyme be used to cleave (cut) the DNA of both
organisms used to create a transgenic organism?
7. Are there any factors other than technical ones that might slow — or even prevent — the use
of bioengineering?
Solution
1, The sequences present in both the strands of DNA running in opposite direction are called
ANTIPARALLEL AND COMPLEMENTARY STRANDS.
2. STICKY ENDS refer to the DNA which has some extra nucleotides in one strand and
overhangs extra than another strand. The nucleotides of the sticly ends are unpaired.
3. PLASMID : plasmid is an extrachromosomal materia present in the bacteris. These are
autonoously replication circular genetic materials, characteristic of bacteris. Plasmids are used as
vectors in recombinant DNA technology. Plasmids carry genes for antibiotic resistance and some
other colony selection traits.
4. VECTORS:
following types of vectors are used:.
For each of these functions, is it one-to-one Is it onto For each .pdferremmfab
For each of these functions, is it one-to-one? Is it onto? For each of these functions, is it one-to-
one? Is it onto? For each of these functions, is it one-to-one? Is it onto? (recall that the range [0.
infinite) is the non-negative real numbers)
Solution
all functions are onto function because all functions have square operation..
Find all roots of Re(arcsinh(z)) = 0, where z is the complex number,.pdferremmfab
Find all roots of Re(arcsinh(z)) = 0, where z is the complex number, z = x + iy.
Solution
a) Write z = x + iy and separate sin(z) into real and imaginary parts: sin(z) = sin(x + iy) = sin(x)
cos(iy) + cos(x) sin(iy) = sin(x) cosh(y) + i cos(x) sinh(y) = i ? ( sin(x) cosh(y) = 0 cos(x) sinh(y)
= 1 The first equation gives x = n?, n = 0,.
Discuss the history of operations, information, systems, and conting.pdferremmfab
Discuss the history of operations, information, systems, and contingency management.
Solution
Answer 1. History of Operation Management
History of Operation Management has undergone many stages that shows shifts in thinking with
the evolution of management.
a. Pre-Industrial Stage:
This stage was prior to Industrial revolution. It was cotton-based guild system. The production of
goods took place in homes or cottages. The craftsmen guided apprentices to perform better hand
work.
b. Post-Industrial Revolution Era
An Industrial Revolution came into existence during 18th century and its impact spread to all
European nations and United States. Industrial Revolution led to two major developments in
Operation Management. First is widespread replacement of human power with machine power.
Secondly, the factories were established everywhere for operations. Lot of inventions were made
during that period.Gasoline and electricity were invented in 1800s. Old cottage systems were
replaced by factory system. Mass production came into existence.
The operation management history can be divided into five stages
Answer 2. History of Information Management
Information management has its history, its origin dated back to post-industrial era. With mass
production all over, the people were feeling the need for information exchange in more
formalized manner. In those days the information management was only in germ phase i.e. the
records were maintained properly handwritten on papers in the files.
Not later after, the writing machines were replaced by computers. In 1970s, the computers could
all do was file management. But the employees were able to retrieve information accurately and
speedily.
During 1990s, the information management was dealt only by high qualified employees of the
companies. It maintained important documents of the company. After 2000, the information
management itself became a profession. The companies specializing in data protection are
outsourced with the file management job. During these years, the information management has
become more efficient, more accurate with high speed of process..
Dr. Butthead received a new cell line and he wants to see which cult.pdferremmfab
Dr. Butthead received a new cell line and he wants to see which culture media grows the cells
the best. He cultures them in a supplemented (s) and complete (c) media. After 2 days he dilutes
a sample from each flask 1/2 (100uL of cells + 100 uL of trypan blue) His hemacytometer counts
for S are 15,14,19,12 and C are 92,100,95,and 84.
1. Which is the concentration of cells in each flask? (cell per mL)
2. Which media works best? explain why?
3. cells must be fed if they are too concentrated (ie 1x10^6 cells/ml). Does either flask need to be
fed? if yes why and describe how to dilute the cells to 5x10^4 cell/ml in a volume of 10 mL.
Thank you for your help
Solution
1. Which is the concentration of cells in each flask? (cell per mL)
Dilution factor =2
Supplemented (s)
Cell/mL=(15+14+19+12)/4 x dilution factor x 10^ 4
=30 x 10^ 4 cells/mL
Complete (c) media
Cell/mL=(92+100+95+84)/4 x dilution factor x 10^ 4
=185.5 x 10^ 4 cells/mL
2. Which media works best? explain why?
Complete (c) media works best since it promotes cell proliferation better than supplemented
media.
3. cells must be fed if they are too concentrated (ie 1x10^6 cells/ml). Does either flask need to be
fed? if yes why and describe how to dilute the cells to 5x10^4 cell/ml in a volume of 10 mL.
Cells in the Complete (c) media needs to be fed since the it is too concentrated
Stock of cells = 185.5 x 10^ 4 cells/mL
Required = 5 x10^4 cell/ml
Volume = 10 mL
C1V1= C2V2
(stock) (required)
V1=C2V2/C1
V1 = ( 5 x10^4 X 10 mL )/ 185.5 x 10^ 4
=0.27 mL
0.27 mL of stock + 9.73 mL of media gives 10 mL of media with 5 x10^4 cell/ml concentration.
Describe or explain how SNPs in gens at evolutionary conserved break.pdferremmfab
Describe or explain how SNPs in gens at evolutionary conserved breakpoints can lead to
dramatic phenotypic differences between species like chimpanzees and humans even though
their genomes are 98% similar? Provide and describe or explain an example of one gene with
SNP differences between gorillas and humans that might have resulted changes between humans
and apes.
Solution
A DNA sequence is a linear combination of four nucleotides. The two sequences when compared
position by position, and wherever a different nucleotides at the same position occurs, that\'s a
SNP. SNPs reflect past mutations that were mostly (but not exclusively) unique events, and two
individuals sharing a variant allele are thereby marked with a common evolutionary heritage.
Analysis of shared pattern of SNP variation can identify the genes similar to our ancestors.
Although humans and chimps have many identical genes, they often use them in different ways.
Same gene can be expressed more in humans and less in chimps. The same genes are expressed
in the same brain regions in human, chimp and gorilla, but in different amounts thereby resulting
in difference in brain activity. Thousands of differences like these affect brain development and
function, and help explain why the human brain is larger and smarter.
The chimpanzee immune system is surprisingly similar to ours. Most viruses that cause diseases
like AIDS and hepatitis in human can also infect chimpanzees. In case of malaria parasite which
can be transmitted by mosquito bite in human does not infect chimps. A small DNA difference
makes human red blood cells vulnerable to this parasite, while chimp blood cells are resistant.
Also the characteristic of speech in human is the result of SNP which is absent in chimps or apes..
Data Analysis correlation. A correlation R in regression analysis t.pdferremmfab
Data Analysis correlation. A correlation R in regression analysis that would he generated if
only one independent variable were considered at a time. You will recall that the Multiple R is
just the square root of R square. So the correlations shown in figure 13.21 are essentially the
square roots of the amount of variance shared between each of the variables shown.
Solution
The tables shows the multicollinearity among the variables only. The table does not reveals
anything. In the sense we cannnot make any predictions. So, the correlation coefficients in this
table represents only positive or negative association between the predictor variable..
Can we accept mobile apps as a part of data communication networks.pdferremmfab
Can we accept mobile apps as a part of data communication networks?
Solution
Answer:
Yes, we accept mobile apps as a part of data communication because mobile computing involves
mobile communication. It allows transmission of data like texts , audio , vedio and now a days
VoIP calls are made through the mobile apps. There are many mobiles apps which gives the
services like voice over the internet. Thus mobile apps play a very important role in data
communication network..
At absolute temperature T, a black body radiates its peak intensity a.pdferremmfab
At absolute temperature T, a black body radiates its peak intensity at wavelength lambda At
absolute temperature 2T, what would be the wavelength of the peak intensity?
Solution
For a particular black body, accoring to wein law
T=Constant
When Temperature equal to 2T,
(2T)= constant . this is possible only when =/2
/2 (2T)= T= constant
Answer :=/2.
An unsaturated solution of Na2SO4 is present in equilibrium with its.pdferremmfab
An unsaturated solution of Na2SO4 is present in equilibrium with its vapor in a closed vessel. (a)
How many phases and components are present? (b) What is the number of degrees of freedom of
the system? Identify the independent variables
Solution
No. of components = 2 (Na2SO4 and water - as each phase can be described by these two
components only)
No. of phases = 3 ( solid and liquid and vapor)
degrees of freedom = 2-3+2 = 1.
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
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Conduct outside reading on Salla disease. Explain its underlying mole.pdf
1. Conduct outside reading on Salla disease. Explain its underlying molecular biology, cause,
signs, symptoms and progression of the disease. Address whether any cures have been found. If
yes describe them. If no explain why this is the case.
Solution
Salla disease is a type of allelic disorder which falls under sialic acid storage disease
characterized by a delay in development, ataxia, and some dysmorphic features. Additional signs
are hypopigmentation of skin and hair, mild skeletal dysplasias, and course facial features.There
is an accumulation of the charged monosaccharide sialic acid (N-acetylneuraminic acid) in
lysosomes as a result of which sialic acid cannot be transported out of lysosomes.The mode of
inheritence is autosomal recessive disease. The diagnosis is dependent upon the raised excretion
of sialic acid in urine. Electron microscopic studies of reveal a lot about it.
There is actually a homozygous missense mutation in SLC17A5 which codes for the transport
protein called sialin. People with salla disease have normal life span but remain differently abled.
There is no cure for this disease as its a homozygous missense mutation which is having dual
mode of action-either altering the amino acids in translated proteins or else remaining silent.
References
1. Gorlin, R,J., Cohen, M,M., & Hennekam, R,C,M. (2001). Syndromes of the head and
neck.New York: Oxford university press.
2. Barness, E,G., Barness,L,A., & Farrell, P,M. (2017). Metabolic diseases. Amsterdam:IOS
press BV.
