Cardiovascular disease is the leading cause of death in the United States. It refers to conditions affecting the heart and blood vessels, such as atherosclerosis, arteriosclerosis, and hypertension. Atherosclerosis is a narrowing of the arteries due to plaque buildup, which can lead to heart attack if a blood clot forms. Lifestyle changes like quitting smoking, exercising, and following a low-fat diet can help prevent cardiovascular disease.