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Unit - I
Composition and Structure of Plasma
Membrane
Prepared by:
Nikhil A. Borode
Assistant Professor
Department of Zoology
I. Membrane Structure:
A. Membrane models have evolved to fit new
data: Science as Process
B. A membrane is a Fluid Mosaic of lipids,
proteins, carbos
II. Traffic Across Membranes
a. Molecular organization of membrane=selective permeability
b. Passive Transport=Diffusion across a membrane
c. Osmosis=passive transport of water
d. Balancing water uptake/loss=cell survival
e. Specific proteins facilitate transport of selected solutes
f. Active transport=pumping solutes against gradient
g. Some ion pumps generate voltage across membranes
h. Cotransport: A membrane protein couples the transport of one
solute to another
i. Exocytosis/Endocytosis transport large molecules
Fluid Mosaic Model
General Membrane Characteristics
• Held together by hydrophobic interactions
• Most lipids/proteins can drift laterally
• Molecules rarely flip transversely
• Phospholipids move faster than proteins
• Some proteins are connected to the cytoskeleton, can’t move
far
• Unsaturated Hydrocarbon tails on lipids increase fluidity
• Cholesterol decreases fluidity at warmer temps, more fluid at
colder temps. (plant survival adaptation)
The Fluidity of Membranes
MOSAICISM
• Membranes are mosaics of floating proteins in a lipid
bilayer. 2 ways:
•Integral Proteins: trans membrane, have both
hydrophilic and hydrophobic parts
•Peripheral Proteins: Attached to membrane’s
surface by:
• Attachment to integral proteins or ECM fibers (outside)
• Attachment to filaments of cytoskeleton (inside)
The Structure of a Transport Protein

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Compostion and structure of plasma membrane.pptx

  • 1. Unit - I Composition and Structure of Plasma Membrane Prepared by: Nikhil A. Borode Assistant Professor Department of Zoology
  • 2. I. Membrane Structure: A. Membrane models have evolved to fit new data: Science as Process B. A membrane is a Fluid Mosaic of lipids, proteins, carbos
  • 3. II. Traffic Across Membranes a. Molecular organization of membrane=selective permeability b. Passive Transport=Diffusion across a membrane c. Osmosis=passive transport of water d. Balancing water uptake/loss=cell survival e. Specific proteins facilitate transport of selected solutes f. Active transport=pumping solutes against gradient g. Some ion pumps generate voltage across membranes h. Cotransport: A membrane protein couples the transport of one solute to another i. Exocytosis/Endocytosis transport large molecules
  • 4.
  • 6. General Membrane Characteristics • Held together by hydrophobic interactions • Most lipids/proteins can drift laterally • Molecules rarely flip transversely • Phospholipids move faster than proteins • Some proteins are connected to the cytoskeleton, can’t move far • Unsaturated Hydrocarbon tails on lipids increase fluidity • Cholesterol decreases fluidity at warmer temps, more fluid at colder temps. (plant survival adaptation)
  • 7. The Fluidity of Membranes
  • 8. MOSAICISM • Membranes are mosaics of floating proteins in a lipid bilayer. 2 ways: •Integral Proteins: trans membrane, have both hydrophilic and hydrophobic parts •Peripheral Proteins: Attached to membrane’s surface by: • Attachment to integral proteins or ECM fibers (outside) • Attachment to filaments of cytoskeleton (inside)
  • 9. The Structure of a Transport Protein