This document summarizes the key aspects of evaluating clinical trials. In 3 sentences: Clinical trials aim to determine if new treatments are safe and effective by testing them on people after promising laboratory and animal studies. Different types of clinical trials exist, from uncontrolled to randomized controlled trials, with RCTs being the gold standard as they randomly assign participants to interventions to reduce bias. Properly evaluating trials involves assessing their design, limitations, and results to determine the risk of bias and whether the trial's conclusions are valid and applicable to a specific patient.