The document discusses cleaning validation for detergents used in pharmaceutical settings, focusing on formulation disclosure and the importance of consistent components. It highlights key cleaning parameters such as time, action, chemistry, temperature, water quality, and rinsing. Additionally, it addresses the notification of changes and the requirement for very low residue levels that are easily rinsable.

1. CLEANING
VALIDATION

8. Detergents
• Formulation disclosure
• Consistent components
• Notification of changes
• Very low levels remain, readily
rinsable

9. Cleaning parameters
• Time
• Action (agitation or impingement)
• Chemistry (includes concentration)
• Temperature
• Water quality
• Rinsing

33. Pharmaceutical Cleaning Validation