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Classification of anticancer
drugs
Lecture by Farah Javaid
Assistant professor
Pharm.D
M.Phil (Pharmacology)
Ph.D (Scholar)
Classification type a:
Cell specific and nonspecific anticancer drugs
b) Classification of anticancer drugs (main
classification)
1) ALKYLATING AGENTS
• Acronym used to memorize it is (NEAT-N)
• (1) the nitrogen mustards (Mechlorethamine, cyclophosphamide, ifosphamide,
melphalan, chlorambucil)
• (2) the ethyleneimines, (thiotepa)
• (3) the alkyl sulfonates, (busulfan)
• (4) the triazenes. (dacarbazine, temozolomide)
• (5) the nitrosoureas, (carmustine, Streptozocin )
• The methylhydrazine and platinum complexes also are included here, even though
they do not formally alkylate DNA and use a different means to form covalent
adducts with DNA.
2) Antimetabolites
Class of analog Name of drugs
1. Folic acid analog i) Methotrexate
2. Pyrimidine analog
• (cytosine & thymine in case of DNA )
• (Cytosine & uracil in case of RNA)
i) 5-FU
ii) Floxuridine
iii) Capecitabine
iv) Cytarabine (cytosine arabinoside)
v) Gemcitabine
3. Purine analog
• (adenine & guanine)
i) 6-MP
ii) 6-Thioguanine
iii) Cladribine
iv) Fludarabine
3) Antibiotics
• A) Anthracycline Antibiotics (CCND)(class of drugs used in cancer chemotherapy
derived from Streptomyces bacterium)
• Dactinomycin (actinomycin D)
• Daunorubicin (daunomycin, rubidomycin)
• Doxorubicin
• Idarubicin
• Mitoxantrone
• Epirubicin
• B) Anthraquinone, also called anthracenedione or dioxoanthracene (CCD)
(quinone derivative of anthracene and the parent substance of a large class of dyes )
• Bleomycin
,
4) Natural & Semi-synthetic products of
Plants
• A) VINCA ALKALOIDS
• Vincristine
• Vinblastine
• B) TAXANES
• Paclitaxel
• Docetaxel
• C) EPIPODOPHYLLOTOXINS
• Etoposide
• D) CAMPTOTHECIN ANALOGUES
• Topotecan
• Irinotecan
Microtubule
inhibitors(natural
products)
Topoisomerase
inhibitors
(semi-synthetic
products)
5) Steroidal hormones and their antagonists
Classes of hormones Examples of drugs
1) Glucocorticoids Prednisolone
2) Selective estrogen receptor modulators
(SERM)
Tamoxifen
3) Aromatase inhibitors Aminoglutethimide
Anastrozole & Letrozole
Exemestane
4) Progestins Hydroxyprogesterone acetate
Megestreol
5) GnRH analogues Leuprolide
Goserelin
6) Estrogens Ethinyl estradiol or Diethylstilbestrol
7) Synthetic Nonsteroidal Antiandrogen Flutamide,
Nilutamide
6) Monoclonal antibodies
• Currently, several monoclonal antibodies are available in the United
States for the treatment of cancer.
• Examples of monoclonal antibodies:
1. Trastuzumab,
2. rituximab,
3. bevacizumab, and
4. cetuximab.
7) Platinum coordination complexes:
1. Cisplatin ,
2. carboplatin,
3. Oxaliplatin
8) Tyrosine kinase inhibitor
• i) Imatinib
• ii) Gefitinib
9) Miscellaneous
• i) Procarbazine
• ii)L-Asparaginase
• iii) interferons
Good luck 

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classification of anticancer drugs-1.pptx

  • 1. Classification of anticancer drugs Lecture by Farah Javaid Assistant professor Pharm.D M.Phil (Pharmacology) Ph.D (Scholar)
  • 2. Classification type a: Cell specific and nonspecific anticancer drugs
  • 3.
  • 4.
  • 5.
  • 6. b) Classification of anticancer drugs (main classification)
  • 7. 1) ALKYLATING AGENTS • Acronym used to memorize it is (NEAT-N) • (1) the nitrogen mustards (Mechlorethamine, cyclophosphamide, ifosphamide, melphalan, chlorambucil) • (2) the ethyleneimines, (thiotepa) • (3) the alkyl sulfonates, (busulfan) • (4) the triazenes. (dacarbazine, temozolomide) • (5) the nitrosoureas, (carmustine, Streptozocin ) • The methylhydrazine and platinum complexes also are included here, even though they do not formally alkylate DNA and use a different means to form covalent adducts with DNA.
  • 8. 2) Antimetabolites Class of analog Name of drugs 1. Folic acid analog i) Methotrexate 2. Pyrimidine analog • (cytosine & thymine in case of DNA ) • (Cytosine & uracil in case of RNA) i) 5-FU ii) Floxuridine iii) Capecitabine iv) Cytarabine (cytosine arabinoside) v) Gemcitabine 3. Purine analog • (adenine & guanine) i) 6-MP ii) 6-Thioguanine iii) Cladribine iv) Fludarabine
  • 9. 3) Antibiotics • A) Anthracycline Antibiotics (CCND)(class of drugs used in cancer chemotherapy derived from Streptomyces bacterium) • Dactinomycin (actinomycin D) • Daunorubicin (daunomycin, rubidomycin) • Doxorubicin • Idarubicin • Mitoxantrone • Epirubicin • B) Anthraquinone, also called anthracenedione or dioxoanthracene (CCD) (quinone derivative of anthracene and the parent substance of a large class of dyes ) • Bleomycin ,
  • 10. 4) Natural & Semi-synthetic products of Plants • A) VINCA ALKALOIDS • Vincristine • Vinblastine • B) TAXANES • Paclitaxel • Docetaxel • C) EPIPODOPHYLLOTOXINS • Etoposide • D) CAMPTOTHECIN ANALOGUES • Topotecan • Irinotecan Microtubule inhibitors(natural products) Topoisomerase inhibitors (semi-synthetic products)
  • 11. 5) Steroidal hormones and their antagonists Classes of hormones Examples of drugs 1) Glucocorticoids Prednisolone 2) Selective estrogen receptor modulators (SERM) Tamoxifen 3) Aromatase inhibitors Aminoglutethimide Anastrozole & Letrozole Exemestane 4) Progestins Hydroxyprogesterone acetate Megestreol 5) GnRH analogues Leuprolide Goserelin 6) Estrogens Ethinyl estradiol or Diethylstilbestrol 7) Synthetic Nonsteroidal Antiandrogen Flutamide, Nilutamide
  • 12. 6) Monoclonal antibodies • Currently, several monoclonal antibodies are available in the United States for the treatment of cancer. • Examples of monoclonal antibodies: 1. Trastuzumab, 2. rituximab, 3. bevacizumab, and 4. cetuximab.
  • 13. 7) Platinum coordination complexes: 1. Cisplatin , 2. carboplatin, 3. Oxaliplatin
  • 14. 8) Tyrosine kinase inhibitor • i) Imatinib • ii) Gefitinib
  • 15. 9) Miscellaneous • i) Procarbazine • ii)L-Asparaginase • iii) interferons

Editor's Notes

  1. CCS:cell cycle specific drugs CCNS: cell cycle nonspecific drugs