The document discusses the shikimic acid pathway, which is a metabolic pathway that synthesizes the aromatic amino acids phenylalanine, tyrosine, and tryptophan. Shikimic acid is an intermediate product in this pathway that occurs in plants, fungi, and bacteria, but not animals or humans. The pathway combines phosphoenolpyruvate and erythrose-4-phosphate with nitrogen to produce the aromatic amino acids, which are essential for animals and humans. These amino acids then go on to act as precursors for other important compounds like flavonoids, alkaloids, and aromatic metabolites.

1. Shikimic acid pathway
Introduction
ASST.PROF ROHIT PRADIP MALI
NGSPM COP, NASHIK.

2. Content
• About Shikimic acid
• Shikimic acid pathway
• Biosynthetic precursors
• Role of shikimic acid pathway

3. About Shikimic acid
• Common name – Shikimi.
• Shikimic acid is first isolated By Johan Fredrik Eykman in 1885.
• Shikimic acid is a cyclohexenecarboxylic acid that is
cyclohex-1-ene-1-carboxylic acid substituted by
hydroxy groups at positions 3, 4 and 5 (the 3R,4S,5R
stereoisomer).

4. Shikimic acid pathway
• It is a metabolic pathway for biosynthesis of Aromatic Amino acids
• This 3 amino acid are synthesised phenylalanine,
tyrosine, and tryptophan
• Shikimic acid is key intermediate product of carbohydrates In chain
reaction
• phenylalanine, and tryptophan are essential amino acid
produce by shikimic pathway.
• This are essential amino acid means they can’t form in
animal bodies, human bodies but animal and human
have need of this so they called as essential amino
acids.

5. • Shikimic acid pathway occurs in plants, fungi,bacteria it is not
occurring in animals, humans
• Biosynthetic precursors- (Precursors means starting Material)
1. Phospo-enol- pyruvate (From Glycolysis pathway)
+
2. Erythrose-4-phosphate (Pentose phosphate pathway)
(1+2)+3
3. Nitrogen from amine group (Glutamate,glycine, serine)

6. Role of shikimic acid pathway
• Precursors of different biosynthetic pathways like Phenolic, Phenyl
propane derivatives(flavonoids, coumarin, Tannin,lignin)
• Tryptophan produce from shikimic acid is a precursor of indole,indole
derivatives(e.g reserpine,vincristine vinblastin)and many alkaloids
(e.g Quinine, papaverine) and other aromatic metabolites(e.g
Vanilline, arbutine)
• As a intermediate in Gallic acid synthesis pathway.

7. Thank you