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Similar to Chapter i, 2nd point, shikimic acid pathway
Chapter i, 2nd point, shikimic acid pathway
- 1. Shikimic acid pathway Introduction ASST.PROFROHIT PRADIP MALI NGSPM COP, NASHIK.
- 2. Content • About Shikimicacid • Shikimic acid pathway • Biosynthetic precursors • Role of shikimic acid pathway
- 3. About Shikimic acid •Common name – Shikimi. • Shikimic acid is first isolated By Johan Fredrik Eykman in 1885. • Shikimic acid is a cyclohexenecarboxylic acid that is cyclohex-1-ene-1-carboxylic acid substituted by hydroxy groups at positions 3, 4 and 5 (the 3R,4S,5R stereoisomer).
- 4. Shikimic acid pathway •It is a metabolic pathway for biosynthesis of Aromatic Amino acids • This 3 amino acid are synthesised phenylalanine, tyrosine, and tryptophan • Shikimic acid is key intermediate product of carbohydrates In chain reaction • phenylalanine, and tryptophan are essential amino acid produce by shikimic pathway. • This are essential amino acid means they can’t form in animal bodies, human bodies but animal and human have need of this so they called as essential amino acids.
- 5. • Shikimic acidpathway occurs in plants, fungi,bacteria it is not occurring in animals, humans • Biosynthetic precursors- (Precursors means starting Material) 1. Phospo-enol- pyruvate (From Glycolysis pathway) + 2. Erythrose-4-phosphate (Pentose phosphate pathway) (1+2)+3 3. Nitrogen from amine group (Glutamate,glycine, serine)
- 6. Role of shikimicacid pathway • Precursors of different biosynthetic pathways like Phenolic, Phenyl propane derivatives(flavonoids, coumarin, Tannin,lignin) • Tryptophan produce from shikimic acid is a precursor of indole,indole derivatives(e.g reserpine,vincristine vinblastin)and many alkaloids (e.g Quinine, papaverine) and other aromatic metabolites(e.g Vanilline, arbutine) • As a intermediate in Gallic acid synthesis pathway.
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