This document discusses the challenges in treating diabetic foot problems. It notes that neuropathy, deformity, trauma, ulceration, infection, ischemia and limb loss are common complications. A thorough assessment is needed to determine if the foot problem is neuropathic, ischemic, involves osteomyelitis, Charcot neuroarthropathy or a combination. Treatment depends on the underlying issues but may include offloading, antibiotics, debridement, revascularization procedures like angioplasty or bypass. Multidisciplinary care with specialists like vascular surgeons is important for managing the complex challenges of the diabetic foot.