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Challenges in
the Diabetic
Foot
Diabetic Foot Protection Service
Tallaght Hospital, Dublin, Ireland
Sean Tierney
October 2016
Vascular surgery @ Tallaght
Vascular disease
Neuropathy
Deformity
Trauma
UlcerHealing Limb loss
Vascular surgery @ Tallaght
Vascular disease
Neuropathy
Deformity
Trauma
UlcerHealing Limb loss
Ischaemia
Infection/Osteomyelitis
Vascular surgery @ Tallaght
The challenges
• Is it neuropathic?
• Is it ischaemic? or both
• Is there osteomyelitis?
• Is it Charcot?
• What can we do about it?
Vascular surgery @ Tallaght
Is there neuropathy?
Sensory
Motor
Autonomic
Vascular surgery @ Tallaght
Sensory neuropathy
• -ve predictive value =
90%-98%
• +ve predictive value =
18%-36%
• 80% of foot ulcers and
100% of amputations
occur in those with loss of
sensation 32 mo followup
J Fam Pract. 2000;49:S30
Diabetes Care. 1992;15:1386
Vascular surgery @ Tallaght
Ipswich Touch test
• If ≥2 (of 6) missed
• Sensitivity 77%
• Equivalent to
SWMF
Rayman G. Diabetes Care. Jul 2011; 34(7): 1517–1518.
Vascular surgery @ Tallaght
Autonomic neuropathy
Vascular surgery @ Tallaght
Autonomic neuropathy
Vascular surgery @ Tallaght
Motor neuropathy
Diabetes Care. 2001;24:1442
Diabetes Metab. 2003;29:261
Vascular surgery @ Tallaght
Is it ischaemic?
Vascular surgery @ Tallaght
Arterial supply
Poitier et al, Eur J Vasc Endovasc 2011
• PAOD prevalence
9.5% - 13.6%
• ~ 50% with ulcer
• distal > proximal
• Medial artery
calcification more
common
Vascular surgery @ Tallaght
Is palpation of pulses reliable?
DP only PT only Both
Sensitivity 64 70 73
Specificity 81 83 92
NPV * 91 92 94
PPV 43 49 81
Accuracy 77 81 95
absent pulses
• Negative predictive value of palpable pulses in excluding PAOD
is 94% (vs ABI <0.9 as gold standard)
Armstrong et al. Can J Cardiol 2010
Vascular surgery @ Tallaght
ABI in Diabetes
Poitier et al, Eur J Vasc Endovasc 2011
Vascular surgery @ Tallaght
ABI in Diabetes
Poitier et al, Eur J Vasc Endovasc 2011
Vascular surgery @ Tallaght
<120s
60o
<120s
Beurger’s test
-ve +ve
Vascular surgery @ Tallaght
Toe pressure
P>SBP
Vascular surgery @ Tallaght
Toe pressure measurements
• Less affected by medial calcification
(neuropathy, CRF)
• absolute toe pressure of <30 mmHg =
critical ischemia
• 1o healing of DFU
– 85% TP >45 mmHg
– 36% ≤45 mmHg (p < .001) *
Brooks et al. Diabetic Medicine 2001, 18(12):528-532.
* Apelqvist et al. Diabetes Care June 1989 12:6 373-378
Vascular surgery @ Tallaght
Tissue oxygenation
Vascular surgery @ Tallaght
Tissue oximetry & healing
Londahl et al. Diabetolgia 2011
Vascular surgery @ Tallaght
Tissue oximetry (summary)
• tissue hypoxia is defined as “a TcPO2 <40 mm Hg”
• associated with reduced likelihood of amputation
healing
• in critical limb ischemiaTcPO2 typically < 30 mm Hg
Oxygen response
• TcPO2 increases by > 40 mm Hg on 100% O2
usually associated with subsequent healing
Fife et al. Undersea and Hyperbaric Medicine. 2009
Vascular surgery @ Tallaght
• TcPO2 best in comparative
analysis
• Poor methodology
• More research required
Vascular surgery @ Tallaght
Is there osteomyelitis?
Vascular surgery @ Tallaght
Clinical assessment
• Debride –
diagnostic and
therapeutic
• Probe wound -
?probes to bone
• ?Bone biopsy
• Imaging
Vascular surgery @ Tallaght
Probes to bone
Malhotra et al Diabet Foot Ankle. 2014
Vascular surgery @ Tallaght
Plain XRay
• osteopenia
• periosteal thickening
• cortical erosions
• new bone formation
• sequestrum
• 30–50% bone loss required (2–3
weeks)
• ? OM vs Charcot
sensitivity 54% specificity 68%
But NPV?
Malhotra et al Diabet Foot Ankle. 2014
Vascular surgery @ Tallaght
MRI
Kapoor A et al. Arch Intern Med. 2007
• Early
• Bone oedema
(overdiagnosis)
• vs Charcot ??
• “investigation of choice”
sensitivity 90% specificity 80%
Vascular surgery @ Tallaght
Scintigraphy
• Tc-99m-Medronic
Acid
Bisphosphonate
• sensitivity 80-90%
specificity < 50%
• inflammatory or
trauma
Vascular surgery @ Tallaght
Spect
• CT
• Isotope
• Tc-99m + CT or MRI
• ↑ specificity
Vascular surgery @ Tallaght
Probes to bone
Malhotra et al Diabet Foot Ankle. 2014
Vascular surgery @ Tallaght
Is it Charcot?
Vascular surgery @ Tallaght
Is it Charcot?
• Swelling
• Erythema
• Neuropathy 100%
• Pain 75%
vs cellulitis
vs osteomyelitis
Vascular surgery @ Tallaght
Is it Charcot?
• Xray – normal
• MRI
• Antibiotics ↓
Vascular surgery @ Tallaght
What to do?
Structural &
neuropathy
Vascular surgery @ Tallaght
Neuropathic ulcer
Structural &
neuropathy
Offload
Lewis J et al. Cochrane Database Syst Rev. 2013
Vascular surgery @ Tallaght
Neuropathic ulcer
Vascular surgery @ Tallaght
What to do?
Structural &
neuropathy
Offload
Ischaemia
Osteomyelitis
Acute Charcot
Vascular surgery @ Tallaght
Osteomelitis – antibiotics tx
• No sequestrum on Xray
• No systemic sepsis
+/- bone debridement/bx
• 4 studies highly selected
• 6/52 – 3/12 therapy + offloading
• Healing in 60-80%
• Urgent Sx in 1/3
• Recurrence in 1/3
Malhotra et al Diabet Foot Ankle. 2014
Vascular surgery @ Tallaght
Osteomelitis - surgery
• Antibiotics
• Sliding scale
• Surgical
Debridement – all
infected bone
• Drainage
Vascular surgery @ Tallaght
Infection
• Multiple
procedures
• VAC closure
• Offloading
Vascular surgery @ Tallaght
What to do?
Structural &
neuropathy
Offload
Ischaemia
Osteomyelitis
Drain,
debride, ABx
Acute Charcot
Vascular surgery @ Tallaght
Acute Charcot
• Offload
• Non-wt bearing
• Assess stability
clinical & Xray
• Wait
• 9-12 months
Vascular surgery @ Tallaght
What to do?
Structural &
neuropathy
Offload
IschaemiaOsteomyelitis
Drain,
debride, ABx
Acute Charcot
Offload
Vascular surgery @ Tallaght
Vascular Intervention
Ischaemia
Revascularisation
Vascular surgery @ Tallaght
Imaging
• Popliteal pulse
– Angio
• Femoral pulse
– Duplex
• ? Femoral pulse
– CT
Popposelli F. JVS 2010
Vascular surgery @ Tallaght
Pedal Bypass surgery
0
20
40
60
80
100
0 6 12 18 24 30 36 42 48 54 60
Limbsurvivalasapercentage
Time after surgery (months)
Limb Salvage
Good et al Ir J Med Sci 2010
Vascular surgery @ Tallaght
Meta-analysis (pop pedal bypass)
• N=1,2320 (79 studies)
• @ 5 years
• 1o patency 63%
• 2o patency 71%
• Limb salvage 78%
• * 5 yr mortality ~50%
Albers et al J Vasc Surg. 2006 43:498-503.
*Hinchcliffe et al Diabetes Metab Res Review 2012
Vascular surgery @ Tallaght
Patient Survival after Popliteo-pedal bypass
0
20
40
60
80
100
0 6 12 18 24 30 36 42 48 54 60
Time after surgery (months)
Survivalasapercentage
Pedal Bypass surgery
Good et al Ir J Med Sci 2010
Vascular surgery @ Tallaght
Options
Vascular surgery @ Tallaght
Technical considerations
• Consent
• Ipsilateral
(antegrade)
• Local
• ? 4/5Fr
• ? ultrasound
Vascular surgery @ Tallaght
Tibial angioplasty - results
• 40 mo
• 61 limbs in 53 patients
(41 male, median age
73)
• Rest pain /tissue loss)
• TASC D
O Connor et al ASGBI 2014
Vascular surgery @ Tallaght
Tibial angioplasty – results 2
• Technical success
81.3% (49/61 limbs)
• 2o procedure
n=12 (4 distal bypass)
• Survival (3 y) 72%
• AFS (3 yr) 64%
O Connor et al ASGBI 2014
Vascular surgery @ Tallaght
Tibial angioplasty – meta-analysis
• N = 2653
• Technical success = 90%
@ 3 years
• 1o patency 49%
• 2o patency 63%
• Limb salvage 80%
• Survival 68%
Romiti et al J Vas Surg 2008
Vascular surgery @ Tallaght
Tibial angioplasty – meta-analysis
• N = 2653
• Technical success = 90%
• @ 3 years
• 1o patency 49%
• 2o patency 63%
• Limb salvage 80%
• Survival 68%
Romiti et al J Vas Surg 2008
vs Bypass (@5 years)
63%
71%
78%
50%
Albers et al J Vasc Surg. 2006 43:498-503.
Vascular surgery @ Tallaght
Tibial artery disease
• Sub-intimal vs luminal
• Target vessels
• 50% better healing
rates
• Re-assessment
Lida O et al. J Vasc Surg. 2012; 55(2):363-370
Vascular surgery @ Tallaght
The evidence?
Vascular surgery @ Tallaght
Multidisciplinary care
Nason et al. Ir J Med Sci 2013
Vascular surgery @ Tallaght
www.perfuse.net
@theseant
http://www.slideshare.net/stierney/diabetic-foot-2016

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Challenges in the diabetic foot 2016

  • 1. Challenges in the Diabetic Foot Diabetic Foot Protection Service Tallaght Hospital, Dublin, Ireland Sean Tierney October 2016
  • 2. Vascular surgery @ Tallaght Vascular disease Neuropathy Deformity Trauma UlcerHealing Limb loss
  • 3. Vascular surgery @ Tallaght Vascular disease Neuropathy Deformity Trauma UlcerHealing Limb loss Ischaemia Infection/Osteomyelitis
  • 4. Vascular surgery @ Tallaght The challenges • Is it neuropathic? • Is it ischaemic? or both • Is there osteomyelitis? • Is it Charcot? • What can we do about it?
  • 5. Vascular surgery @ Tallaght Is there neuropathy? Sensory Motor Autonomic
  • 6. Vascular surgery @ Tallaght Sensory neuropathy • -ve predictive value = 90%-98% • +ve predictive value = 18%-36% • 80% of foot ulcers and 100% of amputations occur in those with loss of sensation 32 mo followup J Fam Pract. 2000;49:S30 Diabetes Care. 1992;15:1386
  • 7. Vascular surgery @ Tallaght Ipswich Touch test • If ≥2 (of 6) missed • Sensitivity 77% • Equivalent to SWMF Rayman G. Diabetes Care. Jul 2011; 34(7): 1517–1518.
  • 8. Vascular surgery @ Tallaght Autonomic neuropathy
  • 9. Vascular surgery @ Tallaght Autonomic neuropathy
  • 10. Vascular surgery @ Tallaght Motor neuropathy Diabetes Care. 2001;24:1442 Diabetes Metab. 2003;29:261
  • 11. Vascular surgery @ Tallaght Is it ischaemic?
  • 12. Vascular surgery @ Tallaght Arterial supply Poitier et al, Eur J Vasc Endovasc 2011 • PAOD prevalence 9.5% - 13.6% • ~ 50% with ulcer • distal > proximal • Medial artery calcification more common
  • 13. Vascular surgery @ Tallaght Is palpation of pulses reliable? DP only PT only Both Sensitivity 64 70 73 Specificity 81 83 92 NPV * 91 92 94 PPV 43 49 81 Accuracy 77 81 95 absent pulses • Negative predictive value of palpable pulses in excluding PAOD is 94% (vs ABI <0.9 as gold standard) Armstrong et al. Can J Cardiol 2010
  • 14. Vascular surgery @ Tallaght ABI in Diabetes Poitier et al, Eur J Vasc Endovasc 2011
  • 15. Vascular surgery @ Tallaght ABI in Diabetes Poitier et al, Eur J Vasc Endovasc 2011
  • 16. Vascular surgery @ Tallaght <120s 60o <120s Beurger’s test -ve +ve
  • 17. Vascular surgery @ Tallaght Toe pressure P>SBP
  • 18. Vascular surgery @ Tallaght Toe pressure measurements • Less affected by medial calcification (neuropathy, CRF) • absolute toe pressure of <30 mmHg = critical ischemia • 1o healing of DFU – 85% TP >45 mmHg – 36% ≤45 mmHg (p < .001) * Brooks et al. Diabetic Medicine 2001, 18(12):528-532. * Apelqvist et al. Diabetes Care June 1989 12:6 373-378
  • 19. Vascular surgery @ Tallaght Tissue oxygenation
  • 20. Vascular surgery @ Tallaght Tissue oximetry & healing Londahl et al. Diabetolgia 2011
  • 21. Vascular surgery @ Tallaght Tissue oximetry (summary) • tissue hypoxia is defined as “a TcPO2 <40 mm Hg” • associated with reduced likelihood of amputation healing • in critical limb ischemiaTcPO2 typically < 30 mm Hg Oxygen response • TcPO2 increases by > 40 mm Hg on 100% O2 usually associated with subsequent healing Fife et al. Undersea and Hyperbaric Medicine. 2009
  • 22. Vascular surgery @ Tallaght • TcPO2 best in comparative analysis • Poor methodology • More research required
  • 23. Vascular surgery @ Tallaght Is there osteomyelitis?
  • 24. Vascular surgery @ Tallaght Clinical assessment • Debride – diagnostic and therapeutic • Probe wound - ?probes to bone • ?Bone biopsy • Imaging
  • 25. Vascular surgery @ Tallaght Probes to bone Malhotra et al Diabet Foot Ankle. 2014
  • 26. Vascular surgery @ Tallaght Plain XRay • osteopenia • periosteal thickening • cortical erosions • new bone formation • sequestrum • 30–50% bone loss required (2–3 weeks) • ? OM vs Charcot sensitivity 54% specificity 68% But NPV? Malhotra et al Diabet Foot Ankle. 2014
  • 27. Vascular surgery @ Tallaght MRI Kapoor A et al. Arch Intern Med. 2007 • Early • Bone oedema (overdiagnosis) • vs Charcot ?? • “investigation of choice” sensitivity 90% specificity 80%
  • 28. Vascular surgery @ Tallaght Scintigraphy • Tc-99m-Medronic Acid Bisphosphonate • sensitivity 80-90% specificity < 50% • inflammatory or trauma
  • 29. Vascular surgery @ Tallaght Spect • CT • Isotope • Tc-99m + CT or MRI • ↑ specificity
  • 30. Vascular surgery @ Tallaght Probes to bone Malhotra et al Diabet Foot Ankle. 2014
  • 31. Vascular surgery @ Tallaght Is it Charcot?
  • 32. Vascular surgery @ Tallaght Is it Charcot? • Swelling • Erythema • Neuropathy 100% • Pain 75% vs cellulitis vs osteomyelitis
  • 33. Vascular surgery @ Tallaght Is it Charcot? • Xray – normal • MRI • Antibiotics ↓
  • 34. Vascular surgery @ Tallaght What to do? Structural & neuropathy
  • 35. Vascular surgery @ Tallaght Neuropathic ulcer Structural & neuropathy Offload Lewis J et al. Cochrane Database Syst Rev. 2013
  • 36. Vascular surgery @ Tallaght Neuropathic ulcer
  • 37. Vascular surgery @ Tallaght What to do? Structural & neuropathy Offload Ischaemia Osteomyelitis Acute Charcot
  • 38. Vascular surgery @ Tallaght Osteomelitis – antibiotics tx • No sequestrum on Xray • No systemic sepsis +/- bone debridement/bx • 4 studies highly selected • 6/52 – 3/12 therapy + offloading • Healing in 60-80% • Urgent Sx in 1/3 • Recurrence in 1/3 Malhotra et al Diabet Foot Ankle. 2014
  • 39. Vascular surgery @ Tallaght Osteomelitis - surgery • Antibiotics • Sliding scale • Surgical Debridement – all infected bone • Drainage
  • 40. Vascular surgery @ Tallaght Infection • Multiple procedures • VAC closure • Offloading
  • 41. Vascular surgery @ Tallaght What to do? Structural & neuropathy Offload Ischaemia Osteomyelitis Drain, debride, ABx Acute Charcot
  • 42. Vascular surgery @ Tallaght Acute Charcot • Offload • Non-wt bearing • Assess stability clinical & Xray • Wait • 9-12 months
  • 43. Vascular surgery @ Tallaght What to do? Structural & neuropathy Offload IschaemiaOsteomyelitis Drain, debride, ABx Acute Charcot Offload
  • 44. Vascular surgery @ Tallaght Vascular Intervention Ischaemia Revascularisation
  • 45. Vascular surgery @ Tallaght Imaging • Popliteal pulse – Angio • Femoral pulse – Duplex • ? Femoral pulse – CT Popposelli F. JVS 2010
  • 46. Vascular surgery @ Tallaght Pedal Bypass surgery 0 20 40 60 80 100 0 6 12 18 24 30 36 42 48 54 60 Limbsurvivalasapercentage Time after surgery (months) Limb Salvage Good et al Ir J Med Sci 2010
  • 47. Vascular surgery @ Tallaght Meta-analysis (pop pedal bypass) • N=1,2320 (79 studies) • @ 5 years • 1o patency 63% • 2o patency 71% • Limb salvage 78% • * 5 yr mortality ~50% Albers et al J Vasc Surg. 2006 43:498-503. *Hinchcliffe et al Diabetes Metab Res Review 2012
  • 48. Vascular surgery @ Tallaght Patient Survival after Popliteo-pedal bypass 0 20 40 60 80 100 0 6 12 18 24 30 36 42 48 54 60 Time after surgery (months) Survivalasapercentage Pedal Bypass surgery Good et al Ir J Med Sci 2010
  • 49. Vascular surgery @ Tallaght Options
  • 50. Vascular surgery @ Tallaght Technical considerations • Consent • Ipsilateral (antegrade) • Local • ? 4/5Fr • ? ultrasound
  • 51. Vascular surgery @ Tallaght Tibial angioplasty - results • 40 mo • 61 limbs in 53 patients (41 male, median age 73) • Rest pain /tissue loss) • TASC D O Connor et al ASGBI 2014
  • 52. Vascular surgery @ Tallaght Tibial angioplasty – results 2 • Technical success 81.3% (49/61 limbs) • 2o procedure n=12 (4 distal bypass) • Survival (3 y) 72% • AFS (3 yr) 64% O Connor et al ASGBI 2014
  • 53. Vascular surgery @ Tallaght Tibial angioplasty – meta-analysis • N = 2653 • Technical success = 90% @ 3 years • 1o patency 49% • 2o patency 63% • Limb salvage 80% • Survival 68% Romiti et al J Vas Surg 2008
  • 54. Vascular surgery @ Tallaght Tibial angioplasty – meta-analysis • N = 2653 • Technical success = 90% • @ 3 years • 1o patency 49% • 2o patency 63% • Limb salvage 80% • Survival 68% Romiti et al J Vas Surg 2008 vs Bypass (@5 years) 63% 71% 78% 50% Albers et al J Vasc Surg. 2006 43:498-503.
  • 55. Vascular surgery @ Tallaght Tibial artery disease • Sub-intimal vs luminal • Target vessels • 50% better healing rates • Re-assessment Lida O et al. J Vasc Surg. 2012; 55(2):363-370
  • 56. Vascular surgery @ Tallaght The evidence?
  • 57. Vascular surgery @ Tallaght Multidisciplinary care Nason et al. Ir J Med Sci 2013
  • 58. Vascular surgery @ Tallaght