3. Textbook and Materials
Main text : Cell biology, 2nd edition, Pollard & Earnshaw
Most of lecture material will be provided as ppt at
http://www.slideshare.net/suknamgoong
* Book is in my Office
4. Course Objectives
• To understand the molecular basis of life at
the cellular level
• Focusing on general principles and
molecular mechanisms.
• Therefore, we assume general knowledge of
Macromolecular structures and Chemical
bonds, equilibrium constants, and rate
constants
8. Evolution of Life
Prebiotic origin of life:
Details are uncertain; RNA may have dominated early biochemistry.
Common ancestor of all modern cells existed ~3.5 billion years ago with
about 600 genes.
Life diverged from this common origin by natural selection of favorable
random mutations.
Lateral transfer of genes among species has contributed to genetic
diversity during evolution.
13. Main difference with Eukaryotic and Procaryotic Cells
- Compartmentation by inner cell membrane
Nucleus
Mitochondria
Lysosome
14. What is difference betweeen
complicated machine and living
cell?
Both are composed with various ‘component’
Performed as ‘defined’ task
What is difference between them?
29. Three-dimensional Structure of Protein determine their functions
What is main driving force for Three-dimensional structure of Protein folding?
30. Main driving force for tertiary structure formation : Van der waals interactions
Most protein are in water
Hydrophilic (charged, polar) amino acid residues tend to be in protein surface
Hydrophobic residues avoids water (core packing)
36. It is difficult to understand how horse can run with this
single frame of picture..
But if we have series of still images of horse running,
we can figure out how horse can run..
37.
38. To understand how to protein do their jobs, we need
Series of ‘snapshot’ structure.
GDP or GTP mediated
Conformational change of
Rab28 GTPase
