Heart disease is the leading cause of death in the United States, responsible for over 600,000 deaths yearly. Risk factors include high blood pressure, high cholesterol, diabetes, obesity, smoking, and lack of physical activity. Symptoms of heart disease can include chest pain or pressure, pain or cramping in the legs with exercise, and numbness or coldness in the feet or legs. Maintaining a healthy lifestyle through diet, exercise, not smoking, and managing conditions like high blood pressure or diabetes can help prevent and manage heart disease.