Cancer is characterized by uncontrolled cell growth that can spread to other parts of the body. It arises from existing tissues and the cancer cells have lost contact inhibition and regulation of growth. Some causes of cancer include chronic irritation, atmospheric pollution, smoking, radiation, and chemicals. Cancers are classified as either malignant tumors, which grow rapidly and spread, or benign tumors, which are confined to their origin. Diagnosis involves examining cell and tissue samples under a microscope to identify abnormal cancer cells.
ANTI CANCER DRUGS[ANTI-NEOPLASTIC DRUGS] MEDICINAL CHEMISTRY BY P. RAVISANKAR.Dr. Ravi Sankar
what is cancer?, History,Malignent tumor, non-malignent tumor(benign tumor),Largest tumor ever removed, tumour growth kinitics, doubling tume, angiogenesis, causes of cancer, drugs, treatment of cancer, classification of anti-cancer agents, mechanism of actions,alkylating agents,anti metabolites, vinka alkaloids, best ways to reducing cancer.
BY P. RAVISANKAR
VIGNAN PHARMACY COLLEGE
VADLAMUDI
GUNTUR
ANDHRA PRADESH
INDIA.
ANTI CANCER DRUGS[ANTI-NEOPLASTIC DRUGS] MEDICINAL CHEMISTRY BY P. RAVISANKAR.Dr. Ravi Sankar
what is cancer?, History,Malignent tumor, non-malignent tumor(benign tumor),Largest tumor ever removed, tumour growth kinitics, doubling tume, angiogenesis, causes of cancer, drugs, treatment of cancer, classification of anti-cancer agents, mechanism of actions,alkylating agents,anti metabolites, vinka alkaloids, best ways to reducing cancer.
BY P. RAVISANKAR
VIGNAN PHARMACY COLLEGE
VADLAMUDI
GUNTUR
ANDHRA PRADESH
INDIA.
Multicellular organisms coordinate their functions for the proper survival of the individual. Cells send, receive and interpret an elaborate set of extracellular signals that serve as social controls. Resting, growing dividing, differentiating and dying all depend on these signals.
Mutations tend to disrupt these social controls. Mutations give single cells a selective advantage of more prolific growth and division as compared to other cells.
Cancer develops when an individual mutant clone of cells begins prospering at the expense of its neighbours.
So, Cancer is a genetic disease characterized by uncontrolled division of abnormal cells leading to a malignant and invasive growth or tumor.
TUMORS may be benign or malignant.
BENIGN TUMORS: These, such as a common skin wart, remains confined to their original location, neither invade surrounding normal tissue nor spread to distant body sites.
MALIGNANT TUMORS: These are capable of both invading surrounding normal tissue and spreading throughout the body via the circulatory or lymphatic systems (Metastasis).
Delve into the complex world of tumors with our insightful presentation. From benign growths to malignant masses, we'll navigate through the intricacies of tumor biology, diagnosis, and treatment. Through a comprehensive exploration of key concepts and cutting-edge research, discover how tumors develop, evade the body's defenses, and influence health outcomes. Join us as we decode the language of oncology, examining tumor types, classifications, and the latest advancements in therapeutic interventions. Whether you're a healthcare professional, researcher, or simply curious about the science behind tumors, this presentation promises to enlighten and inspire.
Cancer
Cancer is one of the most common diseases in the developed world:
1 in 4 deaths are due to cancer
1 in 17 deaths are due to lung cancer
Lung cancer is the most common cancer in men
Breast cancer is the most common cancer in women
There are over 100 different forms of cancer
Cancer
The division of normal cells is precisely controlled. New cells are only formed for growth or to replace dead ones.
Cancerous cells divide repeatedly out of control even though they are not needed, they crowd out other normal cells and function abnormally. They can also destroy the correct functioning of major organs.
What causes cancer?
Cancer arises from the mutation of a normal gene.
Mutated genes that cause cancer are called oncogenes.
It is thought that several mutations need to occur to give rise to cancer
Cells that are old or not functioning properly normally self destruct and are replaced by new cells.
However, cancerous cells do not self destruct and continue to divide rapidly producing millions of new cancerous cells.
A factor which brings about a mutation is called a mutagen.
A mutagen is mutagenic.
Any agent that causes cancer is called a carcinogen and is described as carcinogenic.
So some mutagens are carcinogenic.
Carcinogens
Ionising radiation – X Rays, UV light
Chemicals – tar from cigarettes
Virus infection – papilloma virus can be responsible for cervical cancer.
Hereditary predisposition – Some families are more susceptible to getting certain cancers. Remember you can’t inherit cancer its just that you maybe more susceptible to getting it.
Benign or malignant?
Benign tumours do not spread from their site of origin, but can crowd out (squash) surrounding cells eg brain tumour, warts.
Malignant tumours can spread from the original site and cause secondary tumours. This is called metastasis. They interfere with neighbouring cells and can block blood vessels, the gut, glands, lungs etc.
Why are secondary tumours so bad?
Both types of tumour can tire the body out as they both need a huge amount of nutrients to sustain the rapid growth and division of the cells.
The Development of Cancer
Within every nucleus of every one of the human body's 30 trillion cells exists DNA, the substance that contains the information needed to make and control every cell within the body. Here is a close-up view of a tiny fragment of DNA.
1. DNA of a normal cell
This piece of DNA is an exact copy of the DNA from which it came. When the parent cell divided to create two cells, the cell's DNA also divided, creating two identical copies of the original DNA.
2. Mutation of DNA
Here is the same section of DNA but from another cell. If you can imagine that DNA is a twisted ladder, then each rung of the ladder is a pair of joined molecules, or a base pair. With this section of DNA, one of the base pairs is different from the original. This DNA has suffered a mutation, either through mis-copying (when its parent cell divided), or through the damaging effects
Cancer basically starts with uncontrolled growth level of cells and goes beyond the blood lymph or healthy tissues to create tumor in their targeted organ(s).
Introduction
Tumours
Types of Tumours
Formation of Tumours
How cancer cell differ from normal cells
Classification of cancer
The causes of cancer
Viruses and Cancer
Cancer and Gene: A. Oncogene
B. Tumours suppressor gene
Detection and Diagnosis
Therapy of cancer
How can cancer are prevented
Conclusion
References
Multicellular organisms coordinate their functions for the proper survival of the individual. Cells send, receive and interpret an elaborate set of extracellular signals that serve as social controls. Resting, growing dividing, differentiating and dying all depend on these signals.
Mutations tend to disrupt these social controls. Mutations give single cells a selective advantage of more prolific growth and division as compared to other cells.
Cancer develops when an individual mutant clone of cells begins prospering at the expense of its neighbours.
So, Cancer is a genetic disease characterized by uncontrolled division of abnormal cells leading to a malignant and invasive growth or tumor.
TUMORS may be benign or malignant.
BENIGN TUMORS: These, such as a common skin wart, remains confined to their original location, neither invade surrounding normal tissue nor spread to distant body sites.
MALIGNANT TUMORS: These are capable of both invading surrounding normal tissue and spreading throughout the body via the circulatory or lymphatic systems (Metastasis).
Delve into the complex world of tumors with our insightful presentation. From benign growths to malignant masses, we'll navigate through the intricacies of tumor biology, diagnosis, and treatment. Through a comprehensive exploration of key concepts and cutting-edge research, discover how tumors develop, evade the body's defenses, and influence health outcomes. Join us as we decode the language of oncology, examining tumor types, classifications, and the latest advancements in therapeutic interventions. Whether you're a healthcare professional, researcher, or simply curious about the science behind tumors, this presentation promises to enlighten and inspire.
Cancer
Cancer is one of the most common diseases in the developed world:
1 in 4 deaths are due to cancer
1 in 17 deaths are due to lung cancer
Lung cancer is the most common cancer in men
Breast cancer is the most common cancer in women
There are over 100 different forms of cancer
Cancer
The division of normal cells is precisely controlled. New cells are only formed for growth or to replace dead ones.
Cancerous cells divide repeatedly out of control even though they are not needed, they crowd out other normal cells and function abnormally. They can also destroy the correct functioning of major organs.
What causes cancer?
Cancer arises from the mutation of a normal gene.
Mutated genes that cause cancer are called oncogenes.
It is thought that several mutations need to occur to give rise to cancer
Cells that are old or not functioning properly normally self destruct and are replaced by new cells.
However, cancerous cells do not self destruct and continue to divide rapidly producing millions of new cancerous cells.
A factor which brings about a mutation is called a mutagen.
A mutagen is mutagenic.
Any agent that causes cancer is called a carcinogen and is described as carcinogenic.
So some mutagens are carcinogenic.
Carcinogens
Ionising radiation – X Rays, UV light
Chemicals – tar from cigarettes
Virus infection – papilloma virus can be responsible for cervical cancer.
Hereditary predisposition – Some families are more susceptible to getting certain cancers. Remember you can’t inherit cancer its just that you maybe more susceptible to getting it.
Benign or malignant?
Benign tumours do not spread from their site of origin, but can crowd out (squash) surrounding cells eg brain tumour, warts.
Malignant tumours can spread from the original site and cause secondary tumours. This is called metastasis. They interfere with neighbouring cells and can block blood vessels, the gut, glands, lungs etc.
Why are secondary tumours so bad?
Both types of tumour can tire the body out as they both need a huge amount of nutrients to sustain the rapid growth and division of the cells.
The Development of Cancer
Within every nucleus of every one of the human body's 30 trillion cells exists DNA, the substance that contains the information needed to make and control every cell within the body. Here is a close-up view of a tiny fragment of DNA.
1. DNA of a normal cell
This piece of DNA is an exact copy of the DNA from which it came. When the parent cell divided to create two cells, the cell's DNA also divided, creating two identical copies of the original DNA.
2. Mutation of DNA
Here is the same section of DNA but from another cell. If you can imagine that DNA is a twisted ladder, then each rung of the ladder is a pair of joined molecules, or a base pair. With this section of DNA, one of the base pairs is different from the original. This DNA has suffered a mutation, either through mis-copying (when its parent cell divided), or through the damaging effects
Cancer basically starts with uncontrolled growth level of cells and goes beyond the blood lymph or healthy tissues to create tumor in their targeted organ(s).
Introduction
Tumours
Types of Tumours
Formation of Tumours
How cancer cell differ from normal cells
Classification of cancer
The causes of cancer
Viruses and Cancer
Cancer and Gene: A. Oncogene
B. Tumours suppressor gene
Detection and Diagnosis
Therapy of cancer
How can cancer are prevented
Conclusion
References
In the Present scenario, the total mushroom production in India is approximately 0.13 million tons.
From 2010-2017, the mushroom industry in India has registered an average growth rate of 4.3% per annum.
By considering the production statistics, the spawn demand in India is estimated about 8000-10000 tons per annum.
Spirulina-Single cell protein (SCP) refers to dead and dry cells of microorganisms like yeast, bacteria, fungi, and algae.
These SCPs serve as a food or feed supplement and can be an alternative to conventional protein sources. SCP includes a high content of protein with all essential amino acids.
Strep throat is caused by infection with a bacterium known as Streptococcus pyogens, also called group A Streptococcus. They are contagious. They can spread through droplets when someone with the infection coughs or sneezes or through shared food or drinks.
It is a technology of growing mushrooms using plant, animal and industrial waste. This technology has gained importance worldwide because of its dietary fibres andproteins value.
A Strategic Approach: GenAI in EducationPeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...Dr. Vinod Kumar Kanvaria
Exploiting Artificial Intelligence for Empowering Researchers and Faculty,
International FDP on Fundamentals of Research in Social Sciences
at Integral University, Lucknow, 06.06.2024
By Dr. Vinod Kumar Kanvaria
Francesca Gottschalk - How can education support child empowerment.pptxEduSkills OECD
Francesca Gottschalk from the OECD’s Centre for Educational Research and Innovation presents at the Ask an Expert Webinar: How can education support child empowerment?
Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
4. INTRODUCTION
Cancer is a tumour. It is an abnormal overgrowth or
enlargement of tissue.
It has no co-0rdination with the normal tissue.
Cancers now cause the second largest number of
deaths in most countries.
Definition
Cancer is an independent, autonomous,
uncontrolled growth of a tissue containing a mass
of aberrant or abnormal cells
5.
6.
7. PROPERTIES OF CANCER
1. It arises from an existing tissue or cells of the body.
2. The growth of the tumour is autonomous. It follows its own laws of
growth.
3. It is not regulated by those governing the tissues or cells.
4. The tumour cells are undifferentiated and anaplasdtic in nature.
Anaplasia
It refers to the reversion of differentiated cells into undifferentiated
or embryonic cells.
5. They have a greater potentiality for growth and multiplication.
6.They carry out none of the functions of normal adult cells.
7.They have large and irregular nuclei.
8.They lose their contact inhibition.
8. CONTACT INHIBITION
Normal cells stop movement and division when they make
contact with each other. This phenomenon is called contact
inhibition.
Cancer cells have no contact inhibition, it becomes
cancerous.
NUCLEUS
It is larger in size and irregular in shape.
The nucleolus is also large in size and it exhibits
hypertrophy (The enlargement of organ or tissue……..)
CHROMOSOMAL ABNORMALITY
This is due to abnormal mitosis.
The misbehaviour of centrioles is another characteristic
feature of cancer cells.
9. • Plasma membrane becomes leaky.
Growth promoting factors
1.The cancer cells release an excessive amount of
growth promoting factors.
2. They escape by leakage through the cell
membranes.
3.After, it has leaked out, it acts on the surface of the
neighbouring cells.
4. Thus inducing abnormal growth and multiplication
of the normal cells.
10. CAUSES OF CANCER
I.CHRONIC IRRITATION
• Chronic irritation causes cancers.
• Ex. Irritation caused to the tongue by broken or malformed
teeth has often led to the cancer of the tongue.
• Cancers of the lip were quite common when clay pipes
were in use.
II. ATMOSPHERIC POLLUTION
• Reports says that, people living in the city sides are eaily
prone to cancers than country sides.
• It is true that the atmosphere of the cities are polluted with
the products of the combustion of coal and oil and with
motor exhaust gases.
11. • The increase in th industrilization caused a corresponding
increase in cancer cells.
III. SMOKING
Heavy smoking of cigarettes cause and increase in the
number of lung cancer cases.
Positive evidence that cigerette smoking alone cause lung
cancer
IV.RADIATION
Excessive radiation also causes cancers(x rays, cosmic rays).
X rays without appropriate shielding and other protective
devices make patient to the direct exposure of rays and
cause cancers.
13. TYPES
Classified into 2 ways. They are
1.Basis of pain
2.Basis of tissues
Based on the pain, the cancers are classified into
1.Malignant tumour and 2. nnon-malignant tumour.
MALIGNANT TUMOUR
1. It gives pain, grows rapidly and spreads from the
place of its origin to other parts of the body, nearby
or away.
14. NON-MALIGNANT TUMOUR(BENIGN TUMOUR)
1.This cancer do or do not harm the possessor. It is
confined to the area in which it originated.
2.Its growth is always slow.
Cancers on the basis of the tissues they originate , classified
into 8 types. They are,
1.CARCINOMA
a. It arises from epithelial cells.
b. It occurs on the skin, in the lining membrane of internal
organs.
2.SARCOMA
a. Arising from any connective tissue and mesenchymal cells.
22. 3.OSTEOMA – Tumors of bone.
4.FIBROMA – Tumour arising from fibrous tissues.
5.GLIOMA – These cancers develop in the network of
supporting connective tissues in the brain and the central
nervous system.
6.MELANOMA
A. This is a pigmented tumour.
B. It originates from the pigmented moles on the skin.
C. If theses moles are irritated, they rapidly become
malignant.
7. LYMPHOMA – Cancer from lymph nodes and other tissues
of the lymphatic system.
8.TERATOMA – Arises from the morula stage itself.
23. Cancer Cell
It is an abnormal cell that doesn't follow this cycle.
Instead of dying off as they should, cancer
cells reproduce more abnormal cells that can
invade nearby tissue. They can also travel
throughout the blood and lymph systems to other
parts of the body.
FORMATION
Cancer develops when the body's normal control
mechanism stops working. Old cells do not die and
instead grow out of control, forming new,
abnormal cells. These extra cells may form a mass
of tissue, called a tumor.
24. • CARCINOGENESIS
It also called oncogenesis or tumorigenesis, is
the formation of a cancer, whereby normal
cells are transformed into cancer cells. The
process is characterized by changes at the
cellular, genetic, and epigenetic levels and
abnormal cell division.
25. DIAGNOSIS
• Cancer is nearly always diagnosed by an expert who
has looked at cell or tissue samples under a
microscope.
• In some cases, tests done on the cells' proteins,
DNA, and RNA can help tell doctors if
there's cancer.
• These test results are very important when
choosing the best treatment options
26. Signs of Cancer
• Change in bowel or bladder habits.
• A sore that does not heal or heal and returns
• Unusual bleeding or discharge.
• Thickening or lump in the breast or elsewhere.
• Indigestion or difficulty in swallowing.
• Obvious change in a wart or mole.
• Nagging cough or hoarseness.
• Alternating constipation and diarrhoea
• Unexpectable loss of weight.
27. BIOPSY
• It is a technique by which a suspected cancer tissue
can be tested. It consists microscopic examination.
X RAY
It is used to diagnose digestive tract, kidney and
chest.