Cancer of the oral cavity are associated with the use of tobacco and alcohol as they seems to have a synergistic carcinogenic effect. More common after the age of 35 years, with 65 years behind the average age of diagnosis. Oral cavity cancer is two times more common in men than in women. The common sites of oral malignant lesions are lower lip (mostly), lateral border and undersurface of tongue, labial commissure and buccal mucosa. According to NATIONAL CANCER INSTITUTE, ‘Oral cancer is defined as the cancer that forms in tissues of the oral cavity (the mouth) or the oropharynx (the part of the throat at the back of the mouth).’ According to FDI World Dental Federation, ‘Oral cancer is a type of head and neck cancer and is any cancerous tissue growth located in the oral cavity.’ Oral cancer is defined as the abnormal uncontrolled growth of cells in the oral cavity, characterized by lesions, thickened mass and dysphagia. There are two types of oral cancer:- Oral cavity cancer (cancer that starts in mouth) Oropharyngeal cancer (cancer that starts in throat behind the mouth) Head and Neck Squamous Cell Carcinoma (HNSCC) is a term used for the cancers of oral cavity, pharynx and larynx, accounts 90% malignant tumors. The exact cause is unknown Long term use of tobacco History of frequent alcohol consumption Prolong sunlight exposure may lead to lip cancer Irritation from the pipe stem resting on the lip in Pipe smokers HPV contributes 25% of oral cancer cases Multiple oral sex partners Low serum Vitamin A, C and E levels Smoked meat ingestion Poor oral hygiene Recurrent herpetic lesion may lead to lip cancer Immunosuppression Syphilis Chronic irritation (jagged tooth, ill fitting prosthesis, chemical or mechanical irritants) TNM CLASSIFICATION OF ORAL CANCER T- Primary tumor TX Primary tumor cannot be assessed T0 No evidence of primary tumor Tis Carcinoma in situ T1 Tumor 2 cm or less in greatest dimension T2 Tumor more than 2 cm but not more than 4 cm in greatest dimension T3 Tumor more than 4 cm in greatest dimension T4a Tumor invades through cortical bone, into deep/ extrinsic muscle of tongue, maxillary sinus, or skin of face T4b Tumor invades masticator space, pterygoid plates, or skull base, or encases internal carotid artery N- Regional Lymph nodes NX Regional lymph node cannot be assessed N0 No regional lymph node metastasis N1 Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension N2 Metastasis in lymph node, more than 3 cm but not more than 6 cm in greatest dimension N3 Metastasis in a lymph node more than 6 cm in greatest dimension M- Distant Metastasis M0 No distant metastasis M1 Distant metastasis Lip Cancer Indurated Painless ulcer Tongue Cancer Ulcer or area of thickening Soreness or pain Increased salivation Slurred speech Dysphagia Toothache Earache(later sign) Oral Cavity Cancer Leukoplakia Also known as Smoker's patch, white patch