The document discusses the cell cycle, cancer, and cancer treatment. It describes the five phases of the cell cycle - G0, G1, S, G2, and M phase. Cancer occurs when cells divide uncontrollably and avoid checkpoints that normally stop division. The hallmarks of cancer allow cells to proliferate, avoid death, and develop blood vessels to grow. Common cancer treatments include chemotherapy, radiation therapy, targeted therapy, and surgery. Statistics show the number of new cancer cases in Iraq has increased dramatically since the 1991 Gulf War due to environmental toxins from warfare.
This file is about cancer knowledge of initial level along with its cycle that shows how a cell change into cancerous one.
It's given cell cycle also help one in getting idea about what and how is it going on.
Carcinogenesis
Theories of carcinogenesis
Hallmarks of cancer
Important Oncogenes
RB & p53 genes
Metastasis
Aetiology and Pathogenesis of cancer
Tests for carcinogenicity
How to repair damaged DNA?
Basic DNA repair mechanism
Repair of double stranded break
This file is about cancer knowledge of initial level along with its cycle that shows how a cell change into cancerous one.
It's given cell cycle also help one in getting idea about what and how is it going on.
Carcinogenesis
Theories of carcinogenesis
Hallmarks of cancer
Important Oncogenes
RB & p53 genes
Metastasis
Aetiology and Pathogenesis of cancer
Tests for carcinogenicity
How to repair damaged DNA?
Basic DNA repair mechanism
Repair of double stranded break
Carcinogenesis refers to the process by which a normal cell is transformed into a malignant cell and repeatedly divides to become a cancer
Chemicals which initiate this process is called chemical carcinogens
Chemicals which increase the effectiveness of carcinogens is called co-carcinogens
REGULATORY BACKGROUND
ROLE OF PROTO-ONCOGENES AND TUMOR SUPPRESSOR GENES
ACTIVATION OF PROTO ONCOGENES
OXIDATIVE STRESS IN CARCINOGENESIS
OECD guidelines
451- Carcinogenecity studies
453- Combined chronic toxicity/carcinogenecity
ICH guidelines
S1A- Guideline on the need for carcinogenicity studies of
pharmaceuticals
S1B- Testing for carcinogenicity of pharmaceuticals
S1C- Dose selection for carcinogenicity studies of pharmaceuticals
Cancer is disease where cells grows out of control and invade, erode and destroy normal tissues
Normal body cells grow, divide and die in orderly fashion
Cancer cell does not obey this path
Cancer cells don't die (Immortality). They just continue to grow and divide in disorderly fashion
This makes it hard for the body to work the way it should
Carcinogenesis refers to the process by which a normal cell is transformed into a malignant cell and repeatedly divides to become a cancer
Chemicals which initiate this process is called chemical carcinogens
Chemicals which increase the effectiveness of carcinogens is called co-carcinogens
REGULATORY BACKGROUND
ROLE OF PROTO-ONCOGENES AND TUMOR SUPPRESSOR GENES
ACTIVATION OF PROTO ONCOGENES
OXIDATIVE STRESS IN CARCINOGENESIS
OECD guidelines
451- Carcinogenecity studies
453- Combined chronic toxicity/carcinogenecity
ICH guidelines
S1A- Guideline on the need for carcinogenicity studies of
pharmaceuticals
S1B- Testing for carcinogenicity of pharmaceuticals
S1C- Dose selection for carcinogenicity studies of pharmaceuticals
Cancer is disease where cells grows out of control and invade, erode and destroy normal tissues
Normal body cells grow, divide and die in orderly fashion
Cancer cell does not obey this path
Cancer cells don't die (Immortality). They just continue to grow and divide in disorderly fashion
This makes it hard for the body to work the way it should
define the cancer, types of tumor cells, TNM classification, staging, cancer cells in different area, etiology, carcinogenesis, sign of cancer, diagnosis, prevention - radiation therapy, chemotherapy, surgical management
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
1. Prepared by:
Zaid wa’ael Dagher
Abdul Aziz Ali Ammar
Manar Sabar Gadbhan
Safa Saade Abbas
Ruqaya Dhafer Ogaidy
Abdul Rahman Mohammed Alwan
Mohammed Nabeel Barhan
2. What is Cell Cycle?
Cancer
Cancer treatment
Statistics on cancer
3. Cell Cycle : Is a series of events, which include cellular
division and involves the processes occurring during
interphase. It’s divided into five phases :
G0 :cells are programmed to perform specialized
functions.
G1 :protein synthesis,organelles produced,increase
volume of the cytoplasm.
S : cell duplicates its DNA.
G2 :same the G1.
M phase: a process of cells duplication or reproduction .
This process last 12 hours
5. Cells that are capable of reproducing are normally stopped
at specific phases they are :
end of G1 ,G2 and during metaphase ,The most important of
these are immediately preceding the initiation of DNA
synthesis and immediately preceding the act of mitosis.
The first checkpoint :occurs in the late G1 phase, just
before cells enter the S phase, the DNA must be in an
acceptable state, with no lesions, before the cell can
leave G1 .
The second checkpoint: occurs just before the cell enters
the M phase, determined whether the new progenies are
worthy successors with accurate genetic copies of the
parent, contain full complement of proteins and other
materials to complete mitosis.
6. metaphase–anaphase transition during mitosis is
carefully regulated in order to assure high-fidelity
transmission of genetic information to the daughter
cells.
spindle-assembly checkpoint
monitors the attachment of kinetochores to the
spindle microtubules, and inhibits anaphase onset until
all chromosomes have achieved a proper bipolar
orientation on the spindle
Check points are regulated by Cyclins , CDKs (Cyclin
dependent kinase) the master regulators and tumor
suppressors gene.
7. Cancer is a disorder of uncontrolled cell division.
All cancers originate from normal cells of the host.
Hence, a normal cell must undergo a series of
changes in order to become tumorigenic and
finally malignant.
The tumor is not only composed of malignant cells
but also contains a number of normal cells that
were recruited; they are required for tumor growth
9. The hallmarks Of cancer are a list of properties that
cancerous cells all have in common that achieving the
growth advantage by cancerous cell and of tumorigenesis.
A. Sustaining proliferative signaling.
B. Evading growth suppressors
C. Resisting cell death.
D. Enabling replicative immortality.
E. Inducing angiogenesis.
F. Activating invasion and metastasis.
G. Reprogramming energy metabolism.
H. Evading immune destruction.
10. A. Sustaining proliferative signaling: Cancers use multiple
mechanisms to sustain their proliferation:
1. Tumors may produce growth factors for which they have
receptors in an autocrine fashion.
2. Tumors may stimulate surrounding normal tissues and these
normal tissues provide growth factors for the tumor.
3. Tumor may become hypersensitive to growth factors through
up regulation of growth receptors or alterations of the
structure of these receptors
4. Finally, they may become independent of growth factors by
the presence of somatic mutations activating downstream
pathways
11. B. Evading growth suppressors : Normal cells use
multiple mechanisms to regulate negatively cell
proliferation; most of these processes occur through
the products of activation of tumor suppressor genes.
Loss of function of these gene products allows tumor
cells to evade the inhibitory mechanisms.
C. Evading immune destruction :The immune cells
continue surveying the body and eliminate pathogens
and potentially cancerous cells. For cancer cells to
survive, they have to evade this surveillance and they
can achieve it by disabling 33 components of the
immune system
12. Hallmarks
D. Resisting cell death: cell death process take place in three cases:
1. Apoptosis. Under normal conditions, cells that get damaged undergo
programmed cell death in the process of apoptosis. Cancer cells have
ability to avoid this process despite apoptosis-inducing stressors such
as DNA damage or oncogene hypersignaling.
2. Autophagy is a natural process that allows cells to break down
intracellular organelles upon exposure to stressors with help of
lysosomes and recycle nutrients. Cancer cells may use autophagy to
recycle their nutrients and escape damaging agents
3. Necrosis is another process of cell death in which cells increase in size
and break, releasing multiple proinflammatory cytokines. Immune
cells are attracted to the areas of necrosis to eliminate the remnants
of cells. Cancer can use this process to induce an inflammatory
proneoplastic environment, stimulate angiogenesis, and even use
these cytokines to stimulate its own growth.
13. II. Chemotherapy:
- major categories of medical treatments for cancer
- The aim is to prolong life and to reduce symptoms by
inhabiting the process of cell division
II. Radiation therapy:
- Using ionization radiation to kill our control malignant
cells and normally delivered by a linear accelerator .
- Used to treat cancer that is localized and also after
surgery to prevent tumor recurrence.
- Damaging the DNA of cancerous cells
14. II. Targeted therapy:
- Major modalities Of medical treatment for cancer
- Successful target therapies are chemical entities
that target or preferentially target protein or
enzyme that carries a mutation.
II. Surgical Interference
- Surgical intervention is performed to remove the
swollen area for fear of spreading to the rest of the
body and to reduce the number of cancer cells to as
little as possible and thus also facilitate chemical
treatment
15. Common side effects:
Fatigue: feeling tired or exhausted all most all time
Skin problems: dryness , itching red and sore
Nausea: unpleasant feeling
chemotherapy and radiation therapy will cause
hair loss while loss of hair color in targeted therapy
16. Year NO. of new cases
registered
Male Female
2003 11248 5698 5550
2004 14520 7525 6995
2005 15172 7505 7667
2012 25566 11489 14177
2018 25320 11300
14020
17. The most common causes that increase the rate of cancer
cases are:
Lifestyle :Smoking , alcohol consumption, diet and the
physical activity.
Environment: Air and water pollution, damaged ozone
and viruses
War: In Iraq the use of DU and explosives for military
purposes is related to cause cancer cases throughout
much of Iraq. in 1991, the rate of cancer cases in Iraq
was 40 out of 100,000 people. By 1995, it had increased
to 800 out of 100,000 people, and, by 2005, it had
doubled to at least 1,600 out of 100,000 people
18. Wikipedia
Atlas of plant and animal histology
Wiki Med
Lippincott manual of clinical oncology
Globocan