Bone is a dynamic and highly vascularized tissue that continues to remodel throughout the lifetime. It plays an integral role in locomotion, load-bearing capacity, and acts as a protective casing for the internal organs of the body. Current challenges include the engineering of materials that can match both the mechanical and biological context of real bone tissue matrix and support the vascularization of large tissue constructs. Scaffolds with new levels of biofunctionality that attempt to recreate nanoscale topographical and biofactor cues from the extracellular environment are emerging as interesting candidate biomimetic materials.

1. Biomaterials in Bone
Regeneration
Presented by
M R Khan

2.  Bone is a dynamic and highly vascularized tissue that
continues to remodel throughout the lifetime.
 It plays an integral role in locomotion, load-bearing
capacity, and acts as a protective casing for the internal
organs of the body.
 Current challenges include the engineering of materials
that can match both the mechanical and biological context
of real bone tissue matrix and support the vascularization
of large tissue constructs.
 Scaffolds with new levels of biofunctionality that attempt
to recreate nanoscale topographical and biofactor cues
from the extracellular environment are emerging as
interesting candidate biomimetic materials.
Introduction

3.  The gold standard for reconstruction of large bone defects
is the use of
Autogenous bone grafts, Allografts or synthetic grafting,
Alloplastic. But this method lack of sufficient
transplantable materials, donor site morbidity,
inflammation, and resorption of the implanted bone.
 The current therapies for bone regeneration and
perspectives in the field of stem cell-based regenerative
medicine addressing sources of stem cells and growth
factors to develop an efficient and high-quality bone
derivation without any immunorejection and
tumorigenesis.
Introduction

4. Biological concept of using bone regeneration
 Contains bone forming cell (osteogenesis))
 Serve as scaffold for bone formation (osteoconduction)
 Matrix of bone regeneration materials contains bone inductive
substance (osteoinduction)
Cell
mediators at
the defect
(BMP)
stimulation of
osteoprogenitor
cells
Osteoblasts
new bone
formation
Osteoblasts in the transplanted bone
having adequate blood supply &
cellular viability.
forms new centers of
ossification within the graft
Osteoinduction
Osteogenesis

5. Bioactive
Inorganic
Materials
 Tricalcium Phosphate
 Calcium Phosphates
 Hydroyapatite (HA)
 Bioactive Glasses
 Their Combinations
Polymers  Biological Polymers  Collagen
 Hyaluronic Acid
 Synthetic Polymers o Poly-hydroxylethyl-
methacrylate (PHEMA)
o Polyfumarates
o Polylactic Acid (PLA)
o Polyglycolic Acid (PGA)
o Co-polymers Of PLA And
PGA (PLGA)
o Polycaprolactone
Biomaterials Bone Regenaration

6. Biomaterials Bone Regenaration

7. Enhancing
material
biofunctionality.
Control over
cellular
interaction for
bone and
cartilage repair
can be achieved
through scaffold
material design.

8. How to Work Biomaterials in Bone Regeneration

9. The End