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Jan	
  H.	
  Jensen	
  
                                Office:	
  C314B	
  

                   Teaching:	
  Nanoterm,	
  Molecular	
  
                      Sta0s0cs	
  (Nano),	
  KemiF1,	
  
                      Computa0onal	
  Chemistry	
  	
  
Research:	
  Protein	
  design,	
  Bio-­‐catalysis,	
  Nano-­‐biosensors,	
  Quantum	
  
chemistry	
  and	
  structural	
  bioinforma0cs	
  soDware	
  development	
  	
  

Group:	
  Postdocs:	
  Mats	
  Olsson,	
  Chresten	
  Søndergaard,	
  Michal	
  	
  
Rostkowski,	
  Luca	
  De	
  Vico.	
  	
  Ph.D.:	
  Casper	
  Steinmann,	
  Mar0n	
  Hediger	
  
Anders	
  Christensen,	
  MS:	
  Kasper	
  ThoDe,	
  	
  

Book:	
  Molecular	
  Modeling	
  Basics,	
  2010	
  
Blog:	
  molecularmodelingbasics.blogspot.com	
  
                                  Jan	
  H.	
  Jensen	
  University	
  of	
  Copenhagen	
  
Research	
  Interests	
  at	
  a	
  glance	
  
                    Quantum	
                       Structural	
  
                    Chemistry	
                   Bioinforma0cs	
  	
  
                                   Con0nuum	
  
                                  Electrosta0cs	
  
                                                                                     So?ware/Webservers	
  
             ApplicaFons	
  
           Ra0onal	
  Design	
  
           Enzyme	
  catalysis	
  
           Protein	
  Stability	
  
Protein	
  Structure	
  Determina0on	
  
          Nano	
  BioSensors	
  
             Drug	
  Design	
  
                         Jan	
  H.	
  Jensen	
  University	
  of	
  Copenhagen	
  
Currently	
  Funded	
  Projects/Local	
  CollaboraFons	
  

      Computa0onal	
  Design	
  of	
  Stable	
  Enzymes	
  (NABIIT	
  –	
  DSF)	
  Leila	
  Lo	
  Leggio/NZ	
  

                   In	
  Silico	
  Ra0onal	
  Engineering	
  of	
  Novel	
  Enzymes	
  (EU)	
  NZ	
  

     Enzyme	
  design:	
  shaping	
  substrate	
  specificity	
  using	
  computa0onal	
  chemistry	
  	
  
   and	
  novel	
  screening	
  methodology	
  (FTP)	
  MarFn	
  Willemöes/Jakob	
  Winther	
  (BIO)	
  

          Development	
  of	
  Electrochemical	
  Reactors	
  Using	
  Dehydrogenases	
  for	
  
                Enan0opure	
  Synthon	
  Prepara0ons	
  (EU)	
  Leila	
  Lo	
  Leggio	
  

      Protein	
  Structure	
  Determina0on	
  Using	
  Chemical	
  ShiDs	
  (Novo	
  Nordisk	
  Ph.D.	
  	
  
           Scholarship	
  to	
  Anders	
  Christensen)	
  Thomas	
  Hamelryck	
  (BIO),	
  NN	
  

     Quan0ta0ve	
  Predic0on	
  of	
  Nano-­‐Wire	
  Based	
  FET	
  Biosensors	
  (UNIK	
  Synthe0c	
  
Biology	
  Ph.D.	
  Scholarship	
  to	
  Mar0n	
  Hediger)	
  Karen	
  MarFnez/Jesper	
  Nygaard	
  (Nano)	
  

                                         Jan	
  H.	
  Jensen	
  University	
  of	
  Copenhagen	
  
Using	
  Molecular	
  SimulaFons	
  and	
  VisualizaFon	
  in	
  Chemical	
  EducaFon	
  

    A	
  200,000	
  Kr	
  grant	
  from	
  Educa0on	
  at	
  its	
  Best	
  (Den	
  Gode	
  Uddannelse)	
  




               h^p://molecularmodelingbasics.blogspot.com/	
  
      h^p://proteinsandwavefunc0ons.blogspot.com/search/label/DGU	
  	
  
                                   Jan	
  H.	
  Jensen	
  University	
  of	
  Copenhagen	
  
Center	
  for	
  ComputaFonal	
  Molecular	
  Sciences	
  
      Science	
                                                            Pharma	
  
  Kurt	
  Mikkelsen	
                                              Flemming	
  Steen	
  Jørgensen	
  
    Jan	
  Jensen	
                                                       Lars	
  Olsen	
  
   Sten	
  Re^rup	
  
                                                                                          Life	
  
Henrik	
  Kjærgaard	
                                                            Peter	
  Thulstrup	
  
 Stephan	
  Sauer	
                                                             Lars	
  Hemmingsen	
  
Solvejg	
  Jørgensen	
  

 Gemma	
  Solomon	
  

 Mingjun	
  Yang	
  
Mar0n	
  Andersson	
  



        h^ps://sites.google.com/site/ccomsatuc/home	
  
       h^p://proteinsandwavefunc0ons.blogspot.com/	
  	
  
                    Jan	
  H.	
  Jensen	
  University	
  of	
  Copenhagen	
  

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Brief intro to my research

  • 1. Jan  H.  Jensen   Office:  C314B   Teaching:  Nanoterm,  Molecular   Sta0s0cs  (Nano),  KemiF1,   Computa0onal  Chemistry     Research:  Protein  design,  Bio-­‐catalysis,  Nano-­‐biosensors,  Quantum   chemistry  and  structural  bioinforma0cs  soDware  development     Group:  Postdocs:  Mats  Olsson,  Chresten  Søndergaard,  Michal     Rostkowski,  Luca  De  Vico.    Ph.D.:  Casper  Steinmann,  Mar0n  Hediger   Anders  Christensen,  MS:  Kasper  ThoDe,     Book:  Molecular  Modeling  Basics,  2010   Blog:  molecularmodelingbasics.blogspot.com   Jan  H.  Jensen  University  of  Copenhagen  
  • 2. Research  Interests  at  a  glance   Quantum   Structural   Chemistry   Bioinforma0cs     Con0nuum   Electrosta0cs   So?ware/Webservers   ApplicaFons   Ra0onal  Design   Enzyme  catalysis   Protein  Stability   Protein  Structure  Determina0on   Nano  BioSensors   Drug  Design   Jan  H.  Jensen  University  of  Copenhagen  
  • 3. Currently  Funded  Projects/Local  CollaboraFons   Computa0onal  Design  of  Stable  Enzymes  (NABIIT  –  DSF)  Leila  Lo  Leggio/NZ   In  Silico  Ra0onal  Engineering  of  Novel  Enzymes  (EU)  NZ   Enzyme  design:  shaping  substrate  specificity  using  computa0onal  chemistry     and  novel  screening  methodology  (FTP)  MarFn  Willemöes/Jakob  Winther  (BIO)   Development  of  Electrochemical  Reactors  Using  Dehydrogenases  for   Enan0opure  Synthon  Prepara0ons  (EU)  Leila  Lo  Leggio   Protein  Structure  Determina0on  Using  Chemical  ShiDs  (Novo  Nordisk  Ph.D.     Scholarship  to  Anders  Christensen)  Thomas  Hamelryck  (BIO),  NN   Quan0ta0ve  Predic0on  of  Nano-­‐Wire  Based  FET  Biosensors  (UNIK  Synthe0c   Biology  Ph.D.  Scholarship  to  Mar0n  Hediger)  Karen  MarFnez/Jesper  Nygaard  (Nano)   Jan  H.  Jensen  University  of  Copenhagen  
  • 4. Using  Molecular  SimulaFons  and  VisualizaFon  in  Chemical  EducaFon   A  200,000  Kr  grant  from  Educa0on  at  its  Best  (Den  Gode  Uddannelse)   h^p://molecularmodelingbasics.blogspot.com/   h^p://proteinsandwavefunc0ons.blogspot.com/search/label/DGU     Jan  H.  Jensen  University  of  Copenhagen  
  • 5. Center  for  ComputaFonal  Molecular  Sciences   Science   Pharma   Kurt  Mikkelsen   Flemming  Steen  Jørgensen   Jan  Jensen   Lars  Olsen   Sten  Re^rup   Life   Henrik  Kjærgaard   Peter  Thulstrup   Stephan  Sauer   Lars  Hemmingsen   Solvejg  Jørgensen   Gemma  Solomon   Mingjun  Yang   Mar0n  Andersson   h^ps://sites.google.com/site/ccomsatuc/home   h^p://proteinsandwavefunc0ons.blogspot.com/     Jan  H.  Jensen  University  of  Copenhagen