1. Xuan Chen
17 Marshall Ter, Lowell, MA, 01854
Cell: 503-915-4418, email: xuanchen1985@gmail.com
Authorized to work in the US for any employer and start immediately
Profile
Ph. D. in chemistry with 6+ years of experience in organic/polymer synthesis and analysis; 5+
years of experience in nanomaterial synthesis, functionalization and characterization; 3+ years
of experience in drug/biomolecule delivery system.
 Strong background in material science and engineering.
 Extensive knowledge in design, synthesis and characterization of novel small molecules and
polymers/lipids based on applications.
 Proficient in advanced drug/biomolecule delivery system to meet specific requirements such
as controlled-release, active-targeting and long-circulation time.
 Experience in technical report writing, SOPs and instrument maintenance.
I am seeking a research scientist position in material science and engineering for pharmaceutical
applications.
Education
Ph. D. University of Massachusetts, Lowell, MA, (Polymer chemistry) Sept. 2011–May 2016
M. Sc. Chinese Academy of Sciences, China, (Polymer chemistry and physics) Sept. 2007–Jul. 2010
B. Sc. Nanjing University, China, (Inorganic Chemistry) Sept. 2003–Jul. 2007
Research Experience
University of Massachusetts, Lowell, MA, USA
Department of Chemistry, Polymer Science
Advisor: Prof. Mingdi Yan
Dissertation: Synthesis of polylactide-based glycopolymers and their applications in bacteria
detection and inhibition.
 Synthesized small molecules (carbohydrate derivatives, bio-molecular vectors) and identified
their structures by FT-IR and 1D/2D NMR.
 Designed and synthesized a series of carbohydrate-functionalized biodegradable
monomers/polymers (homo-/block-/star-polymers) using a combination of anionic/ring-
opening polymerization and click chemistry.
 Determined the polymer structures and properties by GPC, FT-IR, NMR, TGA and DSC.
 Formulated and characterized organic/inorganic nanomaterials (polymers and iron oxide
nanoparticles/quantum dots) by TEM, SEM, AFM, XPS and DLS.
 Discovered the selective interactions of nanomaterials with protein/bacteria (Escherichia coli
and mycobacteria) by optical microscope and TEM (a new platform for bacteria detection).
 Optimized formulation of hydrophobic and hydrophilic antibiotics/anti-cancer drugs by
emulsion and nanoprecipitation to reach higher encapsulation efficiency.
 Performed micelle (nano-/micro-particles) characterizations by DLS/TEM/SEM and studied the
in-vitro drug-release behavior by HPLC /UV-vis.
 Evaluated the potentials of drug-loaded micelles for overcoming multidrug resistance.

2. Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS)
China State Key Laboratory of Polymer Physics and Chemistry
 Synthesized and characterized a number of biodegradable polymers using ring-opening
polymerization.
 Studied their self-assembly properties in solvent mixtures using GPC equipped with refractive
index (RI)/dynamic light scattering (DLS)/UV-vis/viscometer detectors.
Nanjing University, China
Kuang Yaming Honors School
 Prepared ligand-metal complexes and studied their crystal structures/fluorescent properties
by XRD/fluorometer.
Presentation
Synthesis of biodegradable glycopolymers and their uses in antibiotic formulation.
Chen, X.; King, M.; Wu, B.; Kurt-Jones, E.A.; Wang, J.; Finberg R.; Yan, M.
American Chemical Society National Meeting & Exposition, 2015, Boston.
Skills
 Organic synthesis and purification (organic molecules and functionalized monomers)
 Polymer synthesis using radical (including ATRP and RAFT), anionic and ring-opening
polymerization
 Bio-conjugation
 Polymer functionalization and characterization
 Nano-/micro-particle formulation
 Polymer coating
 Synthesis and functionalization of inorganic nanomaterials (quantum dots, iron oxide, silica,
gold and silver nanoparticles)
 Bacteria/cell culture
 Biomolecular assay
Instruments:
 Nuclear Magnetic Resonance NMR (Bruker), Fourier Transmission Infrared FT-IR (Thermo
Fisher), GC-MS (Shimadzu), Column Chromatography HPLC-MS (Waters with Empower and
Shimadzu), UV/vis Spectroscopy (Thermo Fisher), X-ray Powder Diffraction XRD (Scintag),
Gel Permeation Chromatography GPC-MALLS (Waters with Empower), Dynamic Light
Scattering DLS (Waters), Transmission Electron Microscopy TEM-EDS (Phillips), Laser
Scanning Confocal Microcopy LSCM (Olympus), Scanning Electron Microscopy SEM (Zeiss),
X-ray Photoelectron Spectroscopy XPS (VG Scientific), Thermogravimetric Analysis TGA (TA),
Differential Scanning Calorimetry (TA), Atomic Force Microscopy (PSIA), Surface Plasmon
Resonance (Bio-Red), Quartz Crystal Microbalance QCM (Q-Sense), Matrix-assisted Laser
Desorption/ionization MALDI-TOF (Waters), Contact Angle (First Ten Angstroms), Fluorometer
(Agilent) and microarray (Arrayit)
Computer Skills:
 Microsoft office, Mathematics, Matlab, Origin, ChemOffice, Mestrenova, Adobe photoshop,
3ds Max, Endnote, Empower.

3. Awards
Outstanding graduate student in the Polymer Program for 2015
Department of Chemistry, University of Massachusetts, Lowell
Publications
1. Chen, X.; Ramström, O.; Yan, M. Glyconanomaterials: Emerging Applications in Biomedical
Research, Nano Res. 2014, 10, 1381-1403.
2. Chen, X.; Wu, B.; Jayawadana, K.; Hao, N.; Jayawardena, K.; Langer, R.; Jaklenec, A.; Yan, M.
Magnetic Multivalent Trehalose glycopolymer nanoparticles for the detection of mycobacteria. Adv.
Healthcare Mat, in press.
3. Sundhoro, M.; Wang, H.; Boiko, S.; Chen, X.; Jayawadena, S.; Park. J.; Yan, M. Fabrication of
carbohydrate microarrays on a poly(2-hydroxyethyl methacrylate)-based photoactive substrate.
Org. Biomol. Chem. 2016, 14, 1124-1130.
4. Hao, N.; Chen, X.; Jayawadena, K.; Wu, B.; Sundhoro, M.; Yan, M. Shape Control of Mesoporous
silica nanomaterials Templated with Dual Cationic Surfactants and Their Antibacterial activities.
Biomater. Sci. 2015, 4, 87-91.
5. Hao, N.; Chen, X.; Jeon, S.; Yan, M. Trehalose-Conjugated Hollow Oblate Mesoporous Silica
Nanoparticles as Nanoantibiotics to Target Mycobacteria, Adv. Healthcare Mat. 2015, 4,
2797-2801.
6. Hao, N; Jayawrdana, K. W.; Chen, X.; Yan, M. One-Step synthesis of Amine-functionalized
Hollow Mesoporous Silica Nanoparticles as Effcient Antibacterial and Anticancer Materials, ACS
Appl. Mater. Interfaces 2015, 7, 1040-1045.
7. Park, J, Jayawardena, H. S. N,; Chen, X.; Jayawardana, K. W.; Sundhoro, M.; Ada E.; Yan, M. A
General Method for the Fabrication of Graphene-nanoparticle Hybrid Material, Chem. Commun.
2015, 51, 2882-2885.
8. Jayawardena, H. S. N.; Jayawardana, K. W.; Chen, X.; Yan, M. Maltoheptaose promotes
nanoparticle internalization by Escherichia coli. Chem. Commun. 2013, 49, 3034-3036.
9. Chen, X.; Liu, G.; Ji, X.; Bo, S. Synthesis and Solution Properties of Two Polyphosphazenes.
Chemical Journal of Chinese Universities 2011, 2, 032.
10. Xie, J.; Chen, X.; Liu, G., and Sun, W. Synthesis and Crystal Structure of Cu (II) Complex with
Two-dimensional Network Structure Chinese Journal of Inorganic Chemistry 2007, 7, 1295-1298.
Patents
1. Glucose Enhances Cellular Uptake of Nanoparticles in Mammalian Cells. US Provisional Patent
USSN 61781017, 2013.
2. Maltoheptaose Promotes Internalization of Nanoparticles in Escherichia coli. US Povisional
Patent USSN 61766176, 2012.