Ha Phuong TA has extensive experience in microfluidics applications, protein structure and toxicity research. She holds a doctorate in physical chemistry and doctorate in pharmacy. Her research interests include microfluidics in medical science, amyloid protein toxicity, and structure-toxicity relationships in pharmaceutical proteins. She has received several awards for her research posters and held positions as a postdoctoral researcher and assistant professor studying protein analysis using microfluidics and mass spectrometry.

1. Resume
Ha Phuong TA
Doctor in pharmacy
Doctor in physical chemistry
ha-phuong.ta@espci.fr
thphuong29@gmail.com
Tel : +33 6 34 46 09 75
RESEARCH INTERESTS
Microfluidics applications in medical science
Toxicity of amyloid proteins
Structure – toxicity relationship of pharmaceutical proteins
Keywords: microfabrication, microfluidics, mass spectrometry, infrared spectroscopy (PMIRRAS, ATR), SRCD,
Ellipsometry, Fluorescence, protein characterization, protein separation, HPLC, SEC, Plasmon Waveguide Resonance
spectroscopy, amyloids, toxicity, secondary structure
EDUCATION
• 2011: Doctorate in Physical Chemistry, Bordeaux 1 University, Talence, France
• 2008: Master in Pharmaceutical chemistry, Faculty of Pharmacy, Paris 11 University, Châtenay – Malabry, France
• 2006: Diploma of pharmacist, Hanoi University of Pharmacy, Hanoi, Vietnam
AWARDS, FELLOWSHIPS, GRANTS
Price of best posters, Amyloid protein – membrane interaction studies, 8th
European Biophysics Congress, August
2011, Budapest, Hungary.
Price of best posters, Amyloid proteins – membrane interaction studies, ISM Scientist Symposium (The Institute of
Molecular Sciences), July 2010, Talence, France.
French Embassy scholarship for Master Program, 2007
Olympiad Prizes on Physics, Vietnam (<2006)
SUPERVISORY EXPERIENCES
Teaching in molecular biology, physical chemistry
Supervising student’s internships
PROFESSIONNAL EXPERIENCES
• Since 09/2015: Assitant Professor in Molecular Biology, ESPCI Paris, France
o Research project: Coupling of the mass spectrometry and the microfluidics for the protein analysis
• 09/2013 – 08/2015 : Postdoctoral researcher in physical chemistry / biophysics, CEA Saclay, Gif-sur-Yvette,
France
o Research project: Diagnostics of biomarker proteins by coupling of the mass spectrometry and the
microfluidics
• 12/2011 – 08/2013: Postdoctoral researcher in physical chemistry / biophysics, Synchrotron Soleil (the French
national Synchrotron facility), Gif-sur-Yvette, France
o Research project 1: Studies of the folding of the pharmaceutical proteins (Synchrotron Soleil –Servier
Institute collaboration)
o Research project 2: Automatisation and high-throughput sampling for the protein conformational
determination by coupling of the microfluidics and the synchrotron radiation circular dichroism (SRCD).
• 10/2008 – 11/2011: PhD student in physical chemistry, The institute of Chemistry and Biology of Membranes
and Nano-objects (CBMN), CNRS, UMR 5248, Talence, France
o Thesis: Studies of structure – toxicity relationship of amyloid proteins in interaction with membrane
models
• 09/2006 – 09/2007: Research Analyst, The National Institute of Drug Quality Control of Vietnam (NIDQC),
Hanoi, Vietnam

2. SKILLS
TECHNICS TRANSVERSAL EXPERIENCES
o Analysis:
- Infrared spectroscopy (FTIR, PMIRRAS, ATR),
MS, SRCD, PWR (Plasmon Waveguide Resonance
spectroscopy), Fluorescence
- Ellipsometry
- Chromatography (HPLC, flash, TLC)
- Extraction and isolation of natural products
o Microfluidics:
Fabrication of microfluidics devices compatible with
specific detection methods (IR, UV, SRCD, MS) for the
protein analysis
o Biology:
Expression and purification of recombinant proteins, cell
culture.
o Problem solving:
- Targeting the goal and made analytical & logical approaches.
o Management:
- Management of multidisciplinary projects (chemistry /
biology / physics): Planning/ conducting experiments,
Processing data / analyzing results
- Team working skills
- Scientific communications (papers, talks, posters)
o Languages:
- English : scientific
- French : fluent
- Vietnamese : mother tongue
o Informatics:
- Matlab, Origin, Igor
- OMNIC, GRAMS32, Kaleidagraph, GraphPad Prism
- Photoshop, MS Office
REFERENCES
1. Pr Laurent Servant, Bordeaux University, 0540006416, l.servant@ism.u-bordeaux1.fr
2. Dr Matthieu Réfrégiers, team leader, Disco beamline, Synchrotron Soleil, 0169359655,
matthieu.refregiers@synchrotronsoleil.fr
3. Dr Robert Thai, Ingenieer, Service d’Ingénierie moléculaire des protéines – SIMOPRO, CEA Saclay, 0169089961,
robert.thai@cea.fr,
PUBLICATIONS
1. Réfrégiers M, Wien F, Ta HP., Premvardhan L, Bac S, Jamme F, Rouam V, Lagarde B, Polack F, Giorgetta JL,
Ricaud JP, Bordessoule M, Giuliani A. DISCO synchrotron-radiation circular-dichroism endstation at SOLEIL. J
Synchrotron Radiat. 2012, 19(Pt 5):831-5.
2. Ta HP., Berthelot K, Coulary-Salin B, Castano S, Desbat B, Bonnafous P, Lambert O, Alves I, Cullin C, Lecomte
S. A yeast toxic mutant of HET-s amyloid disrupts membrane integrity. Biochim Biophys Acta. 2012, 1818(9):2325-
34.
3. Belbachir K, Lecomte S, Ta HP., Petibois C, Desbat B., Orientation of molecular groups of fibers in nonoriented
samples determined by polarized ATR-FTIR spectroscopy. Anal Bioanal Chem. 2011, 401(10):3263-8.
4. Berthelot K, Ta HP., Géan J, Lecomte S, Cullin C., In vivo and in vitro analyses of toxic mutants of HET-s:FTIR
antiparallel signature correlates with amyloid toxicity. J Mol Biol. 2011, 412(1):137-52.
5. Ta HP., Berthelot K., Coulary-Salin B., Desbat B., Géan J., Servant L., Cullin C., Lecomte S., Comparative studies
of nontoxic and toxic amyloids interacting with membrane models at the air-water interface. Langmuir. 2011,
27(8):4797-807.
CONFERENCE PRESENTATIONS
Proceedings conferences
1. HP. Ta, M. Antoine, A. Giuliani, F. Wien, V. Rouam, G. Ferry, M. Refregiers, “High-throughput microfluidic
SRCD for proteins studies”, 11th International Conference on Synchrotron Radiation Instrumentation (SRI 2012),
July 9–13, Lyon, France, Journal of Physics, Vol 425 (2013)
2. HP. Ta, K. Berthelot, C. Cullin, S. Lecomte, J. Géan “Structure/toxicity relationship of amyloids by infrared
spectroscopy” 7th EBSA European Biophysics Congress, July 11-15, Genevo, Italy, European Biophys. J., Vol 38
Supplement 1, p S105 (2009).
3. S. Lecomte, HP. Ta, J. Géan, K. Berthelot, C. Cullin “Interaction Het-S Prion / Membrane to get a Better Insight of
Amyloid Toxicity” 54th Biophysical Society Meeting February 20-24, San Fransisco, Biophys. J. 98(3) p459a
(2010).

3. 4. HP. Ta, K. Berthelot, B. Coulary-Salin, B. Desbat, L. Servant, C. Cullin, S. Lecomte “Amyloid protein-membrane
interactions and structure-toxicity relationship study” 8th EBSA, August 23-28 Budapest, Hungary European
Biophys. J., Vol 40 Supplement 1, p S94 (2011).
5. K. Berthelot, HP. Ta, B. Coulary-Salin, C. Cullin, S. Lecomte “What makes an amyloid toxic: morphology,
structure or interaction with membranes?” 8th EBSA European Biophysics Congress, 23-28 august Budapest,
Hungary European Biophys. J., Vol 40 Supplement 1, p S90 (2011).
6. HP. Ta, A. Maciuk, S. Vautier, A. Milane, S. Welti, P. Champy, IW. Wainer, C. Fernandez, B. Figadère “High-
resolution bioguided screening of Ganoderma capense for P-gp modulating activity” 7th Joint Meeting of AFERP,
ASP, GA, PSE & SIF natural products with pharmaceutical, nutraceutical, cosmetic and agrochemical interest
Athenaeum Intercontinental, August 3-8, Athens Greece, Planta Med. 74 - PC85 (2008).
Talk presentations
1. Structure/toxicity relationship study of amyloid proteins, 11th
Journée Francophone des Jeunes Physico-Chimistes,
Oct. 2010, Autrans, France.
2. Structure/toxicity of prion proteins study - an approach by vibrational spectroscopy and ellipsometry, 16th
Congress
of French group of peptides and proteins (GFPP), May 2009, Albéville, France.
Poster presentations
1. High-throughput microfluidic – SRCD for protein studies, 11th
International conference on Synchrotron Radiation,
July 2012, Lyon, France.
2. Amyloid protein-membrane interaction studies, 8th
European Biophysics Congress, August 2011, Budapest,
Hungary.
3. Amyloid proteins: a structure/toxicity relationship study, 13th
International Conference on Organized Molecular
Films, July 2010, Quebec, Canada.
4. Amyloid proteins/membrane interaction studies, ISM Scientist Symposium (The Institute of Molecular
Sciences), July 2010, Talence, France.
5. Amyloid proteins/membrane interaction studies, 3th
IECB Young Scientist Symposium, Mai 2010, Pessac,
France.
6. High-resolution bioguided screening of Ganoderma capense for P-gp modulating activity. 7th
Joint Meeting of GA,
AFERP, ASP, PSE & SIF, Août 2008, Athens, Greece.