The document discusses various radiographic clues that can help determine the nature of bone lesions. It describes clues provided by the appearance of lesions, including patterns of bone destruction (geographic, moth-eaten, permeative) and periosteal reactions. Certain appearances provide clues about benign versus malignant lesions. Location of lesions and lesion density also provide clues. Characteristic locations are described for several lesions. Sclerotic, lytic and blastic lesions have different potential underlying causes in children versus adults. Soft tissue extension is also a potential clue.