Low back pain is one of the most common musculoskeletal complaints encountered in clinical practice. It is the leading cause of disability in the developed world and accounts for billions of dollars in healthcare costs annually. Although epidemiological studies vary, the incidence of low back pain is estimated to be anywhere between 5% to more than 30% with a lifetime prevalence of 60% to 90%. Most occurrences of low back pain are self-limited and resolve without intervention. Approximately 50% of cases will resolve within one to two weeks. 90% of cases will resolve in six to 12 weeks. The differential for low back pain is broad, and amongst other diagnoses, should include lumbosacral radiculopathy. Lumbosacral radiculopathy is a term used to describe a pain syndrome caused by compression or irritation of nerve roots in the lower back. It can be caused by lumbar disc herniation, degeneration of the spinal vertebra, and narrowing of the foramen from which the nerves exit the spinal canal. Symptoms include low back pain that radiates into the lower extremities in a dermatomal pattern. Other accompanying symptoms can include numbness, weakness, and loss of reflexes, although the absence of these symptoms does not exclude a diagnosis of lumbosacral radiculopathy.
Presentation contain etiology, blood supply of femoral head & neck,pathogenesis ,classification system ,clinical features,diagnosis,managment, pelvic & femoral osteotomies in detail
Low back pain is one of the most common musculoskeletal complaints encountered in clinical practice. It is the leading cause of disability in the developed world and accounts for billions of dollars in healthcare costs annually. Although epidemiological studies vary, the incidence of low back pain is estimated to be anywhere between 5% to more than 30% with a lifetime prevalence of 60% to 90%. Most occurrences of low back pain are self-limited and resolve without intervention. Approximately 50% of cases will resolve within one to two weeks. 90% of cases will resolve in six to 12 weeks. The differential for low back pain is broad, and amongst other diagnoses, should include lumbosacral radiculopathy. Lumbosacral radiculopathy is a term used to describe a pain syndrome caused by compression or irritation of nerve roots in the lower back. It can be caused by lumbar disc herniation, degeneration of the spinal vertebra, and narrowing of the foramen from which the nerves exit the spinal canal. Symptoms include low back pain that radiates into the lower extremities in a dermatomal pattern. Other accompanying symptoms can include numbness, weakness, and loss of reflexes, although the absence of these symptoms does not exclude a diagnosis of lumbosacral radiculopathy.
Presentation contain etiology, blood supply of femoral head & neck,pathogenesis ,classification system ,clinical features,diagnosis,managment, pelvic & femoral osteotomies in detail
Deformities observed with Pes cavus includes :
*clawing of the toes
*posterior hind foot deformity (described as an increased calcaneal angle)
*contracture of the plantar fascia
*cock-up deformity of the great toe
Following References were used to prepare this powerpoint presentation which makes the slides accurate and relaible for studying purpose; Therapeutic Exrercise – Carolyn Kisner
Orthopaedic Physical Assessment – Magee
Orthopaedic Medicine – L. Ombregt
Campbell’s Operative Orthopaedics
Slides includes following headings;
DEFINITION
TYPES
ORTHOPAEDIC ASSESSMENT
MEDICAL MANAGGEMENT
PHYSIOTHERAPY MANAGEMENT
SURGICAL MANAGEMENT
hip osteoarthritis is most disabling condition and surgery is a consequence of the same. but if this condition can assess on time so it can be manageable with conservative treatment and decrease the prevalence of AVN. further life of an individual become better.
Deformities observed with Pes cavus includes :
*clawing of the toes
*posterior hind foot deformity (described as an increased calcaneal angle)
*contracture of the plantar fascia
*cock-up deformity of the great toe
Following References were used to prepare this powerpoint presentation which makes the slides accurate and relaible for studying purpose; Therapeutic Exrercise – Carolyn Kisner
Orthopaedic Physical Assessment – Magee
Orthopaedic Medicine – L. Ombregt
Campbell’s Operative Orthopaedics
Slides includes following headings;
DEFINITION
TYPES
ORTHOPAEDIC ASSESSMENT
MEDICAL MANAGGEMENT
PHYSIOTHERAPY MANAGEMENT
SURGICAL MANAGEMENT
hip osteoarthritis is most disabling condition and surgery is a consequence of the same. but if this condition can assess on time so it can be manageable with conservative treatment and decrease the prevalence of AVN. further life of an individual become better.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
3. Definition:
• The term "Spondylolisthesis" refers to a
condition where one of the vertebrae (usually
L5) becomes misaligned anteriorly (slips
forward) in relation to the vertebra below. This
forward slippage is caused by a problem or
defect within the pars interarticularis.
• Greek word spondylos- Spine and olisthanein-
to slip.
6. HISTORY:
• Herbiniaux:- first described spondylolisthesis.
• Term coined by:- Killian.
• FIRST DESCRIBED AS
PSUEDOSPONDYLOLISTHESIS BY
JUNGHANNS.
• Newman in 1963:- coined the phrase
Degenerative spondylolisthesis.
7. INCIDENCE:
• PATIENTS OLDER THAN 40 YEARS.
• L4-L5 MORE THAN OTHER LUMBAR LEVELS
• L3-L4 MORE AFFECTED THAN L5-S1.
• WOMEN> MEN.
• SAGGITAL FACET ANGLES OF MORE THAN 45
DEGRESS.
• DIABETES – ROLE UNCLEAR.
• ESTROGEN – ROLE UNCLEAR.
8. THEORIES:
The first theory proposed a failure of ossification during
embryonic development, leading to a pars interarticularis
defect at birth
The second theory demonstrated that the pars defect
began to appear around age six and became progressively
more common till age 16. After age 16, the incidence fell
and rarely developed after adolescence
Saggital Facet theory predilection of slippage because of
facet orientation that does not resist anterior translation.
Disc degeneration theory disc narrows-> overloading of
facets -> secondary remodelling -> anterolisthesis.
It is currently thought that the defect develops from
small stress fractures that fail to heal and form a
chronic nonunion.
10. Type Name Description
I Congenital Dysplastic abnormalities
II Isthmic
A Lytic (stress fracture)
B Healed fracture (elongated, intact)
C Acute high energy fracture
III Degenerative Segmental instability
IV Traumatic Fracture of hook other than pars
V Pathologic Underlying pathology
VI Iatrogenic Surgical excision of posterior
elements
WILTSE,NEWMAN AND MC NAB
CLASSIFICATION:-
13. Dysplastic pathway Traumatic pathway
Weakness in the hook &
catch mechanism
Body weight
transmitted through
weak zone
Soft tissue restraints:
plastic deformation
Growth plate
overloaded
Repetitive cyclic loads
(sports)
Stress fracture of a
Normal pars
Hard cortical pars pre-
disposes to fatigue
fracture and non-union
Predisposes to a vertical
subluxation
14. Dysplastic changes
• Proximal sacral rounding
• Trapezoidal L5
• Vertical sacrum
• Junctional kyphosis
• Compensatory hyper-lordosis
Contributes to the mechanics of
progression, but not causation
16. CLINICAL EVALUATION:
• Mostly asymptomatic ,
• LEG PAIN,
• Tiredness and
• NEUROGENIC CLAUDICATION.
• Unilateral sciatica,
• Sense of instability.
17. CLINICAL SIGNS:
• Gait:- pelvic waddle gait.
• Above slip level- Lordotic posture,
• Below slip-Kyphosis of lumbosacral junction,
• Heart shaped buttocks,
• Shortening of trunk with complete absence of waist
line,
• Z deformity,
• Step sign,
• Hamstring tightness,
• Objective signs of motor weakness, reflex change and
sensory deficit only seen with Severe slips.
18.
19. DIAGNOSTIC IMAGING:
• XRAYS- FERGUSON AP VIEW
(By angling the x-ray beam parallel to the L5-S1 disc.
With this view, the profile of the L5 pedicles,
transverse processes, and sacral ala is more easily
seen. )
• LATERAL VIEW.
• OBLIQUE VIEWS.
• FLEXION AND EXTENSION VIEWS IN LATERAL
VIEWS.
20.
21.
22. MEYERDING GRADING SYSTEM:
GRADING
GRADE 1 displacement of 25% or less;
GRADE 2 between 25% and 50%
GRADE 3 between 50% and 75%;
GRADE 4 more than 75%
GRADE 5 the position of L5 completely
below the top of the sacrum -
SPONDYLOPTOSIS.
23.
24.
25. ULLMANS SIGN
A LINE DRAWN UPWARD FROM THE
ANTERIOR SURFACE OF SACRUM
NORMALLY IS PROJECTED AT OR IN
FRONT OF THE ANTEROINFERIOR
ANGLE OF BODY OF LAST LUMBAR
VERTEBRA.
WHEN ITS INTERSETED IT SHOWS
FORWARD DISPLACEMENT.
26. PERCENTAGE SLIP:
DISTANCE FROM LINE DRAWN
PARALLEL TO POSTERIOR PORTION OF
FIRST SACRAL VERTEBRAE TO LINE
PARALEL TO POSTERIOR PORTION OF
BODY OF L5.
27. SLIP ANGLE:
BY INTERSECTION OF A LINE DRAWN
PARALLEL TO INFERIOR ASPECT OF L5
BODY AND LINE DRAWN
PERPENDICULAR TO POSTERIOR
ASPECT OF BODY OF S1.
BOXALL ET AL
Are the best predictors of instability or
progression of the spondylolisthesis
deformity.
30. RISK FACTORS FOR PROGRESSION OF
SPONDYLOLISTHESIS:
RISK FACTORS RISK FACTORS
Clinical Roentgenographic Risk factors
9 to 15 years Dysplastic
Girls > Boys Dome shaped, vertical sacrum
Episodes of back pain Trapezoid shaped L5
Postural deformity or gait
deformity due to hamstring
spasms
more than 50% slip(grade3
and 4)
Increasing slip angle
Instability
31. SURGICAL TREATMENT :
• Guidelines:
• For most patients with back pain and leg pain
with spondylolisthesis.
• For patients with failure of previous posterior
fusion.
• For patients over age 60 years with good
stability of the L5 vertebrae body but with
signs and symptoms of nerve root
compression.
32. Operative treatment for DEG.
Spondylolisthesis:
• For unremitting back and leg pain after
adequate Non operative treatment.
*(only 10-15% require surgery).
• Decompression,
• Decompression With Fusion,
• PLIF and TLIF,
• Anterior spinal fusion,
• Decompression and combined fusion.
34. DECOMPRESSION WITH FUSION:
• CLAUDICTORY PAIN AND LEG PAIN,
• PRESERVED DISC HEIGHT,
• OSTEOPOROSIS(PARS FRACTURE),
• ABSENCE OF OSTEOPHYTE AND DYNAMIC
MOTION PRESENT.
*(Fusion status and presence
or absence of comorbid disease.)
35. PLIF AND TLIF:
• Discographically concordant single level axial back
pain with radiculopathy,
• Minimal disc degenerative changes,
• Preserved disc height,
• For revison surgeries with inadequate posterior
fusion,
• For patients with hypermobile levels,
• For small or absent transverse process at the
levels to be fused.
36. ANTERIOR SPINAL FUSION:
• Only if some indirect spinal decompression is
provided by eradication of disc , restoration of
disc height and ligamentotaxis by placement
of structural bone grafts or cage after
distraction of disc space and tensioning of
posterior ligamentous structures.
37. DECOMPRESSION AND COMBINED
FUSION:
• For Anterior interbody fusion:
• Kyphosis and
• Posterior saggital vertical axis,
• For posterior interbosy fusion:
• For saggitally neutral or lordotic spines with
intac disc
38. Developmental
Less than 50% slip
PL fusion
Spondylotic defect VAN DAM Technique
More than 50% slip • Bilateral PL fusion
• Reduction with anterior spinal
fusion
• Reduction with posterior spinal
instrumentation
In children Cast reduction and fusion by Scagleitti
technique
Neurological less than 50% slip L5-S1 PL fusion
Neurological with more than 50% slip L4-S1 PL fusion
For spondyloptosis or grade 5 Vertebrectomy with posterior spinal
instrumentaion with L4-S1 fusion.
39. • Broadly divided into two categories:
– Direct repair of the pars defects
– Arthrodesis of the involved segments
OPERATIVE TREATMENT OF PARS INTARARTICULARIS
40. Pseudarthrosis Repair /Direct Repair
Area of soft-tissue
removal without
decortication
Area of
decortication
Location
of pedicle
Spondylolytic
defect
Recipient bed prepared for autogenous cancellous bone graft
41. Pseudarthrosis Repair /Direct Repair
Area of excision of
Posterior elements
Ligamentum
flavum not to
be excised
Nerve root before
decompression
Posterior elements overlying affected nerve root are excised.
42. Pseudarthrosis Repair /Direct Repair
Head of variableangle
screw
Area of
bone graft
Starting point of
screw insertion
Variable-angle pedicle screw and bone graft inserted
43. Pseudarthrosis Repair /Direct Repair
Rod
Laminar
hook
Rod attached to head of screw with variable angle eyebolt. Laminar hook attached to rod.
44. L 5 VERTEBRECTOMY:
Resection of the L5 vertebra with reduction of L4 onto S1 described by Gaines
and Nichols in 1985
Editor's Notes
Occasionally, facet joint and/or posterior neural arch defects may also cause this syndrome as well.
The forward slippage does NOT always occur. This non-slipped pars defect is called a "Spondylolysis" and is almost always a precursor to the actual forward slippage
Chronic muscle spasm (protective):
‘painful’ pars
Annular tears
Root compression / traction
LEG PAIN AND CLAUDICTORY PAIN MOST COMMON 68%.
CAUSES OF LEG PAIN:
L5 compression / traction
Abnormal motion
Facet joint arthrosis
Pars scar
The disc above far-lateral