The major arteries supplying the brain and spinal cord are the internal carotid arteries, vertebral arteries, and their branches. The internal carotid arteries enter the cranium and give rise to the anterior and middle cerebral arteries. The vertebral arteries join to form the basilar artery, which branches into the posterior cerebral arteries. These arteries anastomose to form the Circle of Willis, supplying different regions of the brain. The vertebral and basilar arteries also give rise to branches that supply the brainstem and cerebellum. The spinal cord receives blood from the anterior and posterior spinal arteries as well as segmental arteries originating from nearby vessels. Occlusion of cerebral arteries can cause strokes with deficits corresponding to the territory of the occluded vessel
4 th ventricle- Anatomical and surgical perspectivesuresh Bishokarma
4th ventricle connects the entire ventricular system of brain. Its connection with cisterns magna and cerebella pontine cistern via foramen of magenta and Luschka. CSF absorbs into the arachnoid granulation.
4 th ventricle- Anatomical and surgical perspectivesuresh Bishokarma
4th ventricle connects the entire ventricular system of brain. Its connection with cisterns magna and cerebella pontine cistern via foramen of magenta and Luschka. CSF absorbs into the arachnoid granulation.
arteries of human body including head and neck, upper extremities, lower extremities
different between the veins and arteries. common carotid arteries, internal carotid arteries, external carotid arteries, subclavian arteries
circle of Willis
The carotid arteries are the primary vessels supplying blood to the brain and face. The right common carotid artery (RCCA) originates in the neck from the brachiocephalic artery while the left common carotid artery (LCCA) arises in the thorax from the arch of the aorta.
The origin, course, branches, and distribution of internal carotid artery.
The origin, course, branches, and distribution of basilar artery.
Describe the formation, branches and distribution of circulus arteriosus.
Outline the venous drainage of the brain.
Similar to Blood supply of the brain & spinal cord cns- (20)
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stockrebeccabio
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stock
Telegram: bmksupplier
signal: +85264872720
threema: TUD4A6YC
You can contact me on Telegram or Threema
Communicate promptly and reply
Free of customs clearance, Double Clearance 100% pass delivery to USA, Canada, Spain, Germany, Netherland, Poland, Italy, Sweden, UK, Czech Republic, Australia, Mexico, Russia, Ukraine, Kazakhstan.Door to door service
Hot Selling Organic intermediates
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Couples presenting to the infertility clinic- Do they really have infertility...
Blood supply of the brain & spinal cord cns-
1. BLOOD SUPPLY OF THE
BRAIN & SPINAL CORD
Marami binti Mustapa
Anatomy Unit
FMDH NDUM
2. DESIRED LEARNING OUTCOMES
This lecture will enable you to:
• list the arteries supplying the brain and spinal cord
• explain the different cerebral arteries supplying the different areas of
the cerebral cortex
• describe blood supply of cerebellum
• describe the blood supply of brain stem
• describe the blood supply of spinal cord
3. CONTENTS
• Internal carotid artery & its branches
• Vertebral artery, basilar artery & their branches
• Cerebral arterial circle of Willis, its cortical & striate branches
• Effects of lesion of cerebral arteries
• Blood supplies to the spinal cord
5. • Derives from:
• Internal carotid arteries
• Vertebral arteries
Lies within subarachnoid
space
6. INTERNAL CAROTID ARTERIES
• Arises from the common carotid artery
• Ascends vertically from the neck to the base of the
skull
• Enter cranial cavity through carotid canals (temporal
bone)
• Passes through cavernous sinus
• Terminal branches:
• Anterior cerebral arteries
• Middle cerebral arteries
8. VERTEBRAL ARTERIES
• Begins in the root of the neck
• 1st branch of the subclavian arteries
• Passes through the transverse foramina of the 1st six
cervical vertebrae
• At the suboccipital region, it pierce the dura and
arachnoid and pass through foramen magnum
• Unite at the caudal part of the pons to form basilar
artery (VERTEBROBASILAR CIRCULATION)
12. Territories of the Major Cerebral
Arteries: Lateral View
Branches of the
Anterior Cerebral
Artery
Branches of the Posterior
Cerebral Artery
Branches of the Middle
Cerebral Artery
16. Central Arteries
4 Groups of Central
Arteries penetrate the
deep brain tissue in the
region of the Circle of
Willis:
Anteromedial group
Anterolateral group
Posterolateral group
Posteromedial group
In addition to the central arteries, the medial striate artery, which is a branch of
the anterior cerebral artery, also supplies many of the anterior deep structures
of the brain (importantly, anterior part of the internal capsule).
18. Arterial Supply: Brain Stem and
Cerebellum
Cerebellum: 3 Arteries
From vertebral arteries:
•Posterior Inferior
Cerebellar artery
From basilar artery:
•Anterior Inferior
Cerebellar Artery
•Superior Cerebellar
Artery
19. Arterial Supply: Brain Stem and
Cerebellum
Brain Stem:
Midbrain: branches
from the termination of
the basilar artery and
initial segment of the
posterior cerebral artery.
Pons: Pontine arteries
Medulla: branches from
anterior inferior
cerebellar artery and
posterior inferior
cerebellar artery.
20. Arterial Supply: Choroid Plexus
From: 4
Lateral view of brain,
including ventricles
View of brain from below,
including circle of Willis
One anterior and two posterior
choroidal arteries on each side
supply the choroid plexus of the
lateral and 3rd ventricles.
Branches from the anterior inferior
cerebellar artery and posterior
inferior cerebellar artery supply the
choroid plexus of the 4th ventricle.
22. Venous drainage follows a
similar pattern
Arterial Supply includes:
A. Three major longitudinal
arteries: one anterior spinal and
two posterior spinal arteries that
originate from the vertebral
arteries. These run the length of
the cord.
Anterior Posterior
B. Supplemented by Segmental
arteries derived from vertebral,
deep cervical, intercostal and
lumbar arteries.
C. Radicular arteries that run with
the dorsal and ventral spinal nerve
roots.
23. Anterior Posterior
In most people, a particularly large
radicular artery arises from an
intercostal artery on the left between
T9 and T11. It is called the “great
anterior segmental medullary artery”
or the artery of Adamkiewicz. It often
supplies much of the blood for the
lower spinal cord.
24. The anterior spinal artery supplies approximately
2/3 of the cross-sectional area of the spinal cord.
25. Venous Drainage
• 3 anterior and 3 posterior spinal
veins
• Drained by medullary and
radicular veins
• Join the internal vertebral
venous plexuses in epidural
space
26. CLINICAL RELATIONS
sudden occlusion of a cerebral artery/ rupture of a blood vessel causes bleeding
(cerebral haemorrhage)
Cerebrovascular Accident (Stroke)
Related to carotid artery n its
cerebral branches:
• Contralateral
sensory/motor deficit
• Aphasia (loss of language)
Related to vertebrobasilar
circulation:
• Focal brain stem syndrome (eg:
hypereflexia, ipsilateral
incoordination, contralateral
hemisensory loss etc)
brain infarction (death of brain tissue)