This document provides guidance on assessing and diagnosing a patient presenting with vaginal bleeding in early pregnancy. It outlines taking a history including details of bleeding and pain and performing a physical exam. Key differential diagnoses are listed as miscarriage, molar pregnancy, ectopic pregnancy, pregnancy of unknown location, and local causes. If a urine pregnancy test is positive, further evaluation includes blood tests, ultrasound, and examining the cervix and products of conception for signs of intrauterine pregnancy. An ectopic pregnancy should be suspected if the pregnancy test is positive but no intrauterine gestation is seen on ultrasound.