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CASE REPORT
Supervised by: dr. Arie Adrianus Polim,D.MAS, SpOG(K)
Presented by:
Belinda Anabel (2015-061-002)
Christiandi Budiman (2015-061-007)
Anastasia Limanto (2015-061-008)
Patient’s Identity
• Name : Ms. E
• Date of birth/age : December 18, 1980 / 37 years old
• Ethnic : Javanese
• Nationality : Indonesian
• Address : Muara Baru
• Education : elementary school
• Marital status : married
• Occupation : - (housewife)
• Religion : moslem
• Date of admission : February 21, 2017
Anamnesis
• Chief complaint: vaginal bleeding 1 day prior to
admission
• Present illness
• Patient complained of sudden vaginal bleeding 1 day prior to
admission, then decided to go to the nearest primary
healthcare center and referred afterwards. Vaginal bleeding
was not heavy, only occured once, and was only blotches of
fresh red blood on the undergarments of the patient. Mucus
was present along with blood, but contractions were not
present. This was the first time vaginal bleeding happened
since the start of pregnancy. There was also a complaint of
worsening abdominal pain since 8 hours prior to admission.
Ingested medication at the time of admission, medicine taken
Anamnesis
History of past illness
• No history of hypertension
• No history of diabetes mellitus
• No history of allergy
• No history of heart disease
• No history of liver disease
• No history of kidney disease
• No history of epilepsy
• No history of hematological disease
• No history of asthma
• No history of surgery
• No history of curettage
• No history of smoking
• No history of trauma
Anamnesis
• Contraception history : never used
• Antenatal care
• Antenatal care was done 3 times at the nearest midwife from
home. The first visit was on around the second month of
pregnancy, the second around the sixth month of pregnancy,
and the third was around the eighth month of pregnancy.
There was no maternal or fetal abnormality detected one the
first visit. There was high blood pressure recorded on the sixth
month and eighth month of pregnancy, however patient was
not sure about the blood pressure measurement, only
remembered it was about 160/100. USG was not performed.
Further data cannot be completed as the patient loses her
pregnancy book, and can not remember data accurately.
Anamnesis
• Menstruation history
• Menarche : 14 years old
• Menstrual cycle: regular cycle every 35 days, duration of 7
days, dysmennorhea (-)
• Total pads : 2-3 pads (50-75 mL)
• First day of last menstrual period : 16th May 2016
• Marital history
• Married twice:
• 1st marriage lasts for 14 years
• 2nd marriage until now (9 years)
Anamnesis
• Gestational history
No. Year
Gestational
Age
Labor History Sex
Birth
Weight
Breast
Feeding
1 1995 34 weeks
Spontaneous
vaginal delivery
Femal
e
2500
grams
Breastfed
until 2.5
months old
2 2000 34 weeks
Spontaneous
vaginal delivery
Femal
e
3800
grams
Breastfed
until 2.5
months old
3 Current pregnancy (40 weeks)
Physical Examination
• General condition: moderately ill
• Consciousness : compos mentis
• Blood pressure : 140/90 mmHg
• Heart rate: 100 bpm
• Respiratory rate : 24 x/minute
• Temperature: 36,5°C
• Weight : 70 kg
• Height: 159 cm
• BMI : 26 kg/m2 (Overweight)
General Examination
• Eyes : anemic conjunctiva -/-, icteric sclera -/-
• Mouth : wet oral mucosa membrane
• Thorax
• Heart :regular 1st and 2nd heart sounds, murmur -, gallop -
• Lung
• Inspection : symmetric chest expansion in both static and dynamic
breathing
• Percussion : sonor on both lungs
• Auscultation : vesicular breath sounds +/+ regular, rhonchi -/-,
wheezing -/-
• Mammae : hyperpigmentation of areola +/+, nipple retraction -/- breast
milk -/-
General Examination
• Abdomen
• Inspection : convex, striae gravidarum +, linea nigra +
• Palpation : supple in all abdominal region, tenderness -
• Auscultation : bowel sound +, 5x/minute
• Extremities
• warm, edema -/-/-/-
• physiological reflex +/+/+/+
• pathological reflex -/-/-/-
Obstetric Examination
• ANC : 3 times at midwife clinic
• First day of last menstrual period: May 16th, 2016
• Expected day of delivery : February 21st, 2017
• Fundal height : 32 cm
• Expected birth weight : (32-11) x 155 = 3255 gram
• Fetal heart rate : 144 bpm
• Fetal presentation : head presentation
• His : 4x/10 minutes, 35 seconds each, medium intensity
• Leopold I : buttocks (on right side of upper abdomen)
• Leopold II : back on the right, extremity on the left
• Leopold III : head
• Leopold IV : divergent, 4/5
Obstetric Examination
• Inspection : vulva edema -, secrete +, blood +, cicatrix -
• Inspeculo : not performed
• Digital vaginal examination
• Vulvovagina: normal
• Portio: anterior position, cervical dilatation 8-9 cm, effacement 80%, soft cervix consistency, intact
amniotic membrane, Hodge III, head presentation
• Cardiotocography
• Baseline : 140 bpm
• Variable : normal
• Acceleration : (-)
• Deceleration : (+) once in 20 minutes
• Fetal movement : (-)
• His : (+) 3 times in 20 minutes
• Result : suspicious
Laboratory Test
• Hematological
Test Result Normal Values Unit
Hemoglobin 10.5 12.0 - 15.6 g/dL
Hematocrite 32 36 - 48 %
Platelet 383 165 - 415 thousands/uL
Leukocyte 18.2 3.54 - 9.06 thousands/uL
Erythrocyte 4.01 4.0 - 5.2 fL
MCV 76.6 79 - 93.3 pg
MCH 26.1 26.7 - 31.9 g/dL
MCHC 33.2 32.3 - 35.9 -
Laboratory Test
• Urinalysis
Test Result Normal Values Unit
Complete Urine
Test
     
Glucose Negative Negative mg/dL
Protein Negative Negative mg/dL
Bilirubin Negative Negative -
Urobilinogen Negative Negative -
pH 7.0 5.0 - 9.0 -
Density 1,010 1003 - 1025 -
Occult blood + Negative -
Ketone +++ Negative mg/dL
Nitrite Negative Negative -
Diagnosis
• Differential Diagnosis
• Gestational hypertention
• Chronic hypertention
• Working Diagnosis
G3P2A0, 36 years old, gestational age 40 weeks old
according to first day of last menstrual period, in partu
active first stage, with gestational hypertension, with
single living intrauterine fetus, head presentation
Therapy
• Observation of parturition
• IVFD RL 500 mL + 1 amp, initial treatment is 8 dpm
then observe contractions per 15 minutes, if
contractions are inadequate, add up the dose by 4 tpm
every timem with the maximum dose of 40 dpm.
• Methyldopa tab 3 x 500 mg
Delivery Report
1. Patient was positione in a lithotomy pisition, and a sterile doek was
placed in the mother’s abdomen.
2. If the baby’s head had reached the vulva with a diameter of 5-6 cm,
place a sterile doek beneath the mother’s behind.
3. Place a hand layered with sterile doek on the perineal area of the
mother, while the other hand keeping the baby’s deflected position
and helping the delivery of the head.
4. Guide the mother to do Valsava maneuver, breathe shortly and
quickly, checking if there is any placental cord around the baby’s
neck. If it is strangling the baby, put 2 clamps on the cord and cut
between the 2 clamps, then wait for the baby to do external rotation.
Delivery Report
5. After the baby did external rotation, hold the baby biparietally. Guide the
mother to do Valsava maneuver while contractions happened.
6. Gently point the head inferiorly and distally until the front shoulders
appears in the pubic arc, and then point the body part superiorly and
distally to deliver the back part of the shoulders.
7. After both shoulders are delivered, displace the helper’s lower hand to
the mother’s perineum to support the baby’s head and upper arm on
the down side. Use the upper hand to hold the upper arm on the upper
side.
8. After the body and the arms are delivered, proceed to help the delivery
of the backside, behind, extremities and foot. Dry the baby and place it
on the mother’s body.
Delivery Report
9. Check if there is any other baby inside the uterus, and
give necessary medication.
10.Around 2 minutes after the delivery, clamp the
placental cord 2 cm distally from the first clamp, and
hold it with one hand.
11.Expand and the placental cord, then push it dorsally
and cranially until the placenta deattach. When the
placenta appears in the vaginal introitus, hold and
twist the placenta until the sac is separated, and
deliver it.
Final Diagnosis
• Final working diagnosis
• P3A0, 36 years old, post-partus maturus with spontaneous vaginal
delivery with gestational hypertension.
• Neonatal diagnosis
• Female term neonate, appropriate for gestational age, birth weight
2.820 grams, birth length, APGAR score 7/9, gestational age 38-39
weeks according to New Ballard Score, healthy neonate.
• Placenta
• Placental measurement 18 x 18 x 2 cm, intact membrane, hematoma
(-), stöll cell (+), calcification (-), umbilical cord length 48 cm, marginal
implantatopm, blood 780 cc, weight 860 grams.
Post-delivery Therapy
•Cefadroxil tab 3 x 500 mg
•Methyldopa tab 3 x 250 mg
•Methyl ergometrin tab 3 x 0.125 mg
•Mefenamic acid tab 3 x 500 mg
•Diet high in protein and calories
•Gradual increase in mobilization
•Vital sign observation
Follow-up
February 21, 2017 (16.00)
• Subjective
Post partum pain VAS 2/10, no complaints
• Objective
• General condition: mildly ill appearance
• Consciousness: compos mentis
• Blood pressure : 140/100 mmHg
• Heart rate : 88 bpm
• Respiratory rate : 16 x/minute
• Temperature : 36,5ºC
Follow-up
February 21, 2017 (16.00)
• Assessment
P3A0, 36 years old, post-partus maturus with spontaneous vaginal
delivery with gestational hypertension.
• Planning
• Nifedipine as needed (if the blood pressure 140/100 mmHg)
• Captopril tab 2 x 12.5 mg
• Mefenamic acid tab 3 x 500 mg
• Ferrous sulfate tab 1 x
• Cefixime tab 3 x 200 mg
Follow-up
February 22, 2017 (05.00)
• Subjective
Post partum pain VAS 2/10, no complaints
• Objective
• General condition: mildly ill appearance
• Consciousness: compos mentis
• Blood pressure : 140/100 mmHg
• Heart rate : 88 bpm
• Respiratory rate : 16 x/minute
• Temperature : 36,5ºC
Follow-up
February 22, 2017 (05.00)
• Assessment
P3A0, 36 years old, post-partus maturus with spontaneous vaginal
delivery with gestational hypertension.
• Planning
• Nifedipine as needed (if the blood pressure 140/100 mmHg)
• Captopril tab 2 x 12.5 mg
• Mefenamic acid tab 3 x 500 mg
• Ferrous sulfate tab 1 x 300 mg
• Cefixime tab 3 x 200 mg
Analysis
Comparison Theory Case
Definition  New onset of blood pressure
after 20 weeks of gestation in
the absence of accompanying
proteinuria.
 Blood pressure comes back to
normal after 12 weeks post-
partum.
It was discovered that the patient
had a high blood pressure about
150/100 at her second visit to the
midwife, at her gestational age of
about 24 weeks. For return to
normal values, more time is
needed to observe the patient in
the next 12 weeks.
Risk Factor  Older maternal ages (> 40
years old)
 High BMI (> 29.0/30.0)
 Primiparity
 Renal disease
 Diabetes mellitus
 History of pre-eclampsia on
previous pregnancy(ies)
 Young maternal age (38 years
old)
 Multiparity
 No renal disease, or diabetes
mellitus
 No history of pre-eclampsia on
previous pregnancies
Clinical
presentation
Asymptomatic Asymptomatic
Diagnosis  New onset of blood pressure
after 20 weeks of gestation in
the absence of accompanying
proteinuria.
 Blood pressure comes back to
normal after 12 weeks post-
partum.
 No new-onset proteinuria
 No thrombocytopenia
 No elevated blood levels of liver
transaminase to twice the
normal concentration
 No new development of renal
insufficiency (elevated serum
creatinine greater than 1.1
mg/dL or a doubling of serum
creatinine in the absence of
other renal disease)
 New onset of blood pressure
after 20 weeks of gestation in
the absence of accompanying
proteinuria.
 No thrombocytopenia
 No new-onset proteinuria
 No new-onset cerebral or visual
disturbances
 Liver transaminase and kidney
function were not tested
 Chest x-ray was not taken to
exclude pulmonary edema
Management Methyldopa 0.5–3 g/d orally
in two to three divided
doses
 Observation of parturition
 IVFD RL 500 mL + 1 amp
oxytocin, initial treatment
is 8 dpm then observe
contractions per 15
minutes, if contractions
are inadequate, add up
the dose by 4 tpm every
time (maximum dose 40
dpm)
 Methyldopa tab 3 x 500
mg
Literature Review
GESTATIONAL HYPERTENSION
• Blood pressure (BP) in normotensive pregnant women
is dynamic, varying throughout the day and over the
course of the pregnancy.
• Normal circadian fluctuations seen in non-pregnancy
patients = pregnant population, daily blood pressures
being lowest in the morning and peaking during the late
afternoon and evening.
• Diastolic BP reaches its nadir around 18–22 weeks of
gestation.
• Systolic blood pressure gradually demonstrates a slight
GESTATIONAL HYPERTENSION
• In labor, blood pressure can transiently increase up to
35 mmHg systolic and 25 mmHg diastolic.
• Hypertensive disorders are becoming increasingly
common in pregnancy, primarily because of the
increase in the number of patients with chronic
hypertension who become pregnant.
• Gestational hypertension is characterized most often by
new-onset elevations of blood pressure after 20 weeks
of gestation, often near term, in the absence of
accompanying proteinuria. The failure of blood pressure
to normalize postpartum requires changing the
DEFINITION
• It is defined as the finding of hypertension (blood
pressure at least 140 mmHg systolic and/or 90 mmHg
diastolic) without proteinuria on at least two occasions
at least 6 hours apart after the 20th
week of gestation in
women known to be normotensive before pregnancy
and before 20 weeks of gestation.
EPIDEMIOLOGY
• Prevalence between 6 and 15% in nulliparas and 2–4%
in multiparas.
• New-onset hypertension during pregnancy—termed
gestational hypertension—is followed by signs and
symptoms of preeclampsia almost half the time, and
preeclampsia is identified in 3.9 percent of all
pregnancies.
• WHO : 16 percent of maternal deaths were reported to
be due to hypertensive disorders.
CLASSIFICATION
• Mild or severe
• Severe : sustained blood pressure elevations of systolic
blood pressure to 160 mmHg or more and/or diastolic
blood pressure to 110 mmHg or more.
• A rigorous definition of severe gestational hypertension
requires that the elevated blood pressure should be
observed for at least 6 hours.
PATHOPHYSIOLOGY
• Similar to preeclampsia
• Gestational hypertension before 30 weeks frequently is severe, advances to preeclampsia,
and has a guarded perinatal prognosis.
• Gestational hypertension after 34 weeks is usually a benign condition that rarely becomes
severe, progresses to preeclampsia, and results in uniformly good perinatal outcome.
• Early gestational hypertension shares with preeclampsia a high incidence of poor placentation
with histologic evidence of placental ischemia and hemodynamic changes characterized by
vasoconstriction and decreased cardiac output (CO).
• Late gestational hypertension occurs more frequently in obese women and in multiple
pregnancies, and the placentas do not show histologic changes consistent with ischemia.
• In late gestational hypertension, the fundamental hemodynamic changes are increased
plasma volume, increased CO, and normal peripheral vascular resistance (PVR). The
fundamental problem behind early gestational hypertension is poor placentation, while late
gestational hypertension corresponds to a poor maternal adaptation to the physiologic
changes of pregnancy.
Diagnosis
• Hypertension is diagnosed empirically when BP is >140 mmHg
systolic or >90 mmHg diastolic.
• Previously, incremental 30 mm Hg systolic or 15 mm Hg diastolic from
midpregnancy blood pressure values had also been used as diagnostic
criteria, even when absolute values were < 140/90 mm Hg.
• These incremental changes are no longer recommended criteria because
evidence shows that such women are not likely to experience increased
adverse pregnancy outcomes.
• That said, women who have a rise in pressure of 30 mmHg systolic or
15 mmHg diastolic should be observed more closely because
eclamptic seizures develop in some of these women whose BP have
stayed < 140/90 mmHg.
Diagnosis
• A woman must have an elevated BP >20th week of
gestation without proteinuria or other laboratory
abnormalities.
• Elevated BP during pregnancy is defined as a systolic BP
>140 mmHg or a diastolic blood pressure >90 mmHg.
• Women diagnosed with gestational hypertension do not
have a history of elevated blood pressure prior to the
20th week of gestation and their blood pressure
normalizes within the first 12 weeks of the postpartum
period.
Diagnosis
• This diagnosis is made in women whose BP reach 140/90 mm Hg or
greater for the first time after mid pregnancy, but in whom
proteinuria is not identified.
• Almost half of these women subsequently develop preeclampsia
syndrome, which includes findings such as headaches or epigastric
pain, proteinuria, and thrombocytopenia.
• Even so, when blood pressure increases appreciably, it is dangerous
to both mother and fetus to ignore this rise only because
proteinuria has not yet developed.
• Finally, gestational hypertension is reclassified by some as transient
hypertension if evidence for preeclampsia does not develop and the
blood pressure returns to normal by 12 weeks postpartum.
Maternal and Perinatal Outcome
• Maternal and perinatal morbidity are increased in
women with gestational hypertension.
• In the study of Gofton et al. (2001) induction of labor
and cesarean section in women with gestational
hypertension were almost double as those in the control
group and were similar to preeclampsia and chronic
hypertension.
• However, this study did not differentiate between mild
and severe or between early and late gestational
hypertension.
Maternal and Perinatal Outcome
• Barton et al. (2002) found differences in outcome
depending on ethnicity with African-American women,
exhibiting a higher incidence of placental abruption,
stillbirth, and neonatal deaths than in White women.
• Also, women with mild gestational hypertension have an
increased incidence of obstetrical interventions such as
induction of labor and cesarean section.
• Women with severe gestational hypertension have a
higher incidence of preterm birth and small-for-
gestational-age newborns than in those with normal
pregnancy and with mild preeclampsia.
Maternal and Perinatal Outcome
• The most frequent complication of gestational hypertension is its progress to
preeclampsia that is heralded by the development of proteinuria (300 or more
mg of protein in a 24-hour urine collection or at least 30 mg/dl or 1+ in
dipstick in at least two random urine samples collected at least 6 hours, but no
more than 7 days apart).
• Approximately 15–25% of women with gestational hypertension develop
preeclampsia and this risk varies with the gestational age. Approximately one-
third of women with gestational hypertension present with a severe form of
the condition.
• They have a substantial increase in poor maternal and perinatal outcome
when compared with normotensive women. They have increased incidence of
preterm delivery and small-for-gestational-age infants.
• They also have an increased incidence of abruptio placentae and admissions
to the neonatal intensive care nursery.
• Overall, their outcome is quite similar to that in women with severe
preeclampsia.
Management – Initial Evaluation
• Women with elevated blood pressure (≥140 systolic or ≥90 diastolic)
and no proteinuria by qualitative urine examination require an initial
evaluation to determine whether or not they are at significant risk for a
poor pregnancy outcome.
• There are major and minor risk factors. The first and most important
major risk factor to be considered in such evaluation is the degree of
blood pressure elevation.
• If the hypertension is severe (≥160 systolic or ≥110 diastolic) the
patient has a risk similar to a severe preeclamptic and should be
admitted to the hospital to complete her evaluation and start medical
treatment.
• If the blood pressure is not in the severe range, the other components of
the initial evaluation can be assessed on an outpatient basis.
Management – Initial Evaluation
• Another major risk factor is the gestational age at the
onset of the disease, and the earlier the presentation,
the greater the likelihood of complications and poor
outcomes.
• From the fetal side, major risk factors for a poor
outcome are the presence of fetal growth restriction and
abnormal uterine and umbilical Doppler assessment.
• Minor factors include Black ethnicity, multiparity,
decreased fluid volume, and significant changes in
placental echographic morphology (grade III placenta,
infarcts).
Management - Gestational
hypertension without risk factors
• Women with gestational hypertension and no risk
factors can be managed as outpatients.
• The objectives of their prenatal care are the early
detection of preeclampsia and of progression of the
condition to a severe form.
• They need to be instructed in the correct way to obtain
their blood pressure at home and are asked to record
their readings and bring this information to each office
visit.
• They are given a blood pressure threshold, usually
systolic ≥ 150 or diastolic ≥100, that requires office or
hospital evaluation.
Management - Gestational
hypertension without risk factors
• They also need to be instructed in the correct way to perform
qualitative examination of their urine for protein, using dipsticks,
and are asked to test the first urine voided every morning and to
call or come to the office or hospital if the result is ≥ 2+.
• These women need to be instructed about how to perform daily
fetal movement counts.
• No dietary restrictions are necessary and normal activities are
allowed; however, they should be excused from work if it
involves strenuous physical activities, significant stress, or
standing up for prolonged periods of time.
• They should have office visits every week.
Management - Gestational
hypertension without risk factors
• Performance of nonstress test (NST) is probably unnecessary if
the fetal growth and the uterine, umbilical, and cerebral fetal
Dopplers, as determined in the initial evaluation, are normal and
there is no change in the weekly clinical assessment of the
maternal and fetal condition.
• The weekly assessment of patients with gestational hypertension
and no risk factors must include a systematic review of the
maternal and fetal status.
• From the maternal side the review includes the levels of blood
pressure at home, the presence or absence of symptoms
suggestive of end-organ damage (blurred vision, epigastric pain),
and the presence of proteinuria.
Management - Gestational
hypertension without risk factors
• From the fetal side the review includes daily charting of
fetal movements and measurement of the uterine
fundal height.
• Proteinuria (≥2+) in a random urine sample is
diagnostic of preeclampsia.
• When the proteinuria is trace or 1+ it is necessary to
send the random sample to the lab for determination of
the protein/ creatinine and calcium/creatinine ratio.
• A protein/creatinine ratio > 0.30 is indicative of
preeclampsia and a value less than 0.20 rules out
significant proteinuria.
Management - Gestational
hypertension without risk factors
• Patients with preeclampsia have hypocalciuria and the finding of a
calcium/creatinine ratio < 0.06 strongly suggests that this condition is
present.
• The calcium/creatinine ratio in normotensive women is 0.44 ± 0.32, in
chronic hypertension is 0.20 ± 0.18, and in preeclampsia is 0.03 ± 0.03.
• The development of proteinuria, elevation of the blood pressure above the
threshold, decreased fetal movements, abnormal fundal growth, or
development of maternal symptoms suggestive of end-organ damage
require admission to the hospital for further evaluation and perhaps
delivery.
• Patients with negative evaluations in their weekly assessment may
continue with the pregnancy until they reach 38 weeks. At this time labor
may be induced using cervical ripening agents when the cervix is not ripe.
Gestational HTN with Risk Factors
• Objective:
• pharmacologic control of BP
• early detection of pre-eclampsia, end-organ damage, fetal decompensation
• Avoid complication
• Initial evaluation (repeat 1-2x/week):
• 24-h urine collection (check for protein)
• Platelet count: if not normal check for PT, PTT, fibrinogen
• LDH, liver enzyme
Gestational HTN with Risk Factors
• Fetal assessment:
• NST twice per week
• Umbilical, cerebral Doppler weekly
• Fetal movement count
• BP should not exceed 150/100
• If BP exceed ≥160 / ≥110 : require anti-hypertensive,
beta-blocker, diuretic
• Beta-blocker:
• Labetalol 3-4x/day (600-2400 mg/hr)
• Diuretic
• Furosemide: 20-40 mg every 6-12 hr
• Hydrochlorothiazide: 25-50 mg daily
• Termination of pregnancy if HTN is uncontrolled or there is
evidence of end-organ damage, abruptio placentae, arrest of
fetal growth
Management - Delivery
• Gestational hypertension is not by itself an indication for cesarean
section except in severe cases unresponsive to treatment or with fetal
growth restriction before 32 weeks.
• Women with gestational hypertension who develop preeclampsia should
be managed as described under preeclampsia.
• The route of delivery in women with severe gestational hypertension who
require delivery depends on the results of the digital pelvic examination
and on the cervical length by endovaginal ultrasound examination. If the
cervix is unripe and the cervical length is ≥ 2.5 cm it is better to deliver
by cesarean and avoid a prolonged induction.
• If the cervix is ripe vaginal delivery will be the best option. For women
with mild gestational hypertension delivered after 37 weeks, induction of
labor and vaginal delivery will be the first choice.
Figure 2. Management of gestational hypertension

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case-report-gestational-hypertension_compress (1).pdf

  • 1. CASE REPORT Supervised by: dr. Arie Adrianus Polim,D.MAS, SpOG(K) Presented by: Belinda Anabel (2015-061-002) Christiandi Budiman (2015-061-007) Anastasia Limanto (2015-061-008)
  • 2. Patient’s Identity • Name : Ms. E • Date of birth/age : December 18, 1980 / 37 years old • Ethnic : Javanese • Nationality : Indonesian • Address : Muara Baru • Education : elementary school • Marital status : married • Occupation : - (housewife) • Religion : moslem • Date of admission : February 21, 2017
  • 3. Anamnesis • Chief complaint: vaginal bleeding 1 day prior to admission • Present illness • Patient complained of sudden vaginal bleeding 1 day prior to admission, then decided to go to the nearest primary healthcare center and referred afterwards. Vaginal bleeding was not heavy, only occured once, and was only blotches of fresh red blood on the undergarments of the patient. Mucus was present along with blood, but contractions were not present. This was the first time vaginal bleeding happened since the start of pregnancy. There was also a complaint of worsening abdominal pain since 8 hours prior to admission. Ingested medication at the time of admission, medicine taken
  • 4. Anamnesis History of past illness • No history of hypertension • No history of diabetes mellitus • No history of allergy • No history of heart disease • No history of liver disease • No history of kidney disease • No history of epilepsy • No history of hematological disease • No history of asthma • No history of surgery • No history of curettage • No history of smoking • No history of trauma
  • 5. Anamnesis • Contraception history : never used • Antenatal care • Antenatal care was done 3 times at the nearest midwife from home. The first visit was on around the second month of pregnancy, the second around the sixth month of pregnancy, and the third was around the eighth month of pregnancy. There was no maternal or fetal abnormality detected one the first visit. There was high blood pressure recorded on the sixth month and eighth month of pregnancy, however patient was not sure about the blood pressure measurement, only remembered it was about 160/100. USG was not performed. Further data cannot be completed as the patient loses her pregnancy book, and can not remember data accurately.
  • 6. Anamnesis • Menstruation history • Menarche : 14 years old • Menstrual cycle: regular cycle every 35 days, duration of 7 days, dysmennorhea (-) • Total pads : 2-3 pads (50-75 mL) • First day of last menstrual period : 16th May 2016 • Marital history • Married twice: • 1st marriage lasts for 14 years • 2nd marriage until now (9 years)
  • 7. Anamnesis • Gestational history No. Year Gestational Age Labor History Sex Birth Weight Breast Feeding 1 1995 34 weeks Spontaneous vaginal delivery Femal e 2500 grams Breastfed until 2.5 months old 2 2000 34 weeks Spontaneous vaginal delivery Femal e 3800 grams Breastfed until 2.5 months old 3 Current pregnancy (40 weeks)
  • 8. Physical Examination • General condition: moderately ill • Consciousness : compos mentis • Blood pressure : 140/90 mmHg • Heart rate: 100 bpm • Respiratory rate : 24 x/minute • Temperature: 36,5°C • Weight : 70 kg • Height: 159 cm • BMI : 26 kg/m2 (Overweight)
  • 9. General Examination • Eyes : anemic conjunctiva -/-, icteric sclera -/- • Mouth : wet oral mucosa membrane • Thorax • Heart :regular 1st and 2nd heart sounds, murmur -, gallop - • Lung • Inspection : symmetric chest expansion in both static and dynamic breathing • Percussion : sonor on both lungs • Auscultation : vesicular breath sounds +/+ regular, rhonchi -/-, wheezing -/- • Mammae : hyperpigmentation of areola +/+, nipple retraction -/- breast milk -/-
  • 10. General Examination • Abdomen • Inspection : convex, striae gravidarum +, linea nigra + • Palpation : supple in all abdominal region, tenderness - • Auscultation : bowel sound +, 5x/minute • Extremities • warm, edema -/-/-/- • physiological reflex +/+/+/+ • pathological reflex -/-/-/-
  • 11. Obstetric Examination • ANC : 3 times at midwife clinic • First day of last menstrual period: May 16th, 2016 • Expected day of delivery : February 21st, 2017 • Fundal height : 32 cm • Expected birth weight : (32-11) x 155 = 3255 gram • Fetal heart rate : 144 bpm • Fetal presentation : head presentation • His : 4x/10 minutes, 35 seconds each, medium intensity • Leopold I : buttocks (on right side of upper abdomen) • Leopold II : back on the right, extremity on the left • Leopold III : head • Leopold IV : divergent, 4/5
  • 12. Obstetric Examination • Inspection : vulva edema -, secrete +, blood +, cicatrix - • Inspeculo : not performed • Digital vaginal examination • Vulvovagina: normal • Portio: anterior position, cervical dilatation 8-9 cm, effacement 80%, soft cervix consistency, intact amniotic membrane, Hodge III, head presentation • Cardiotocography • Baseline : 140 bpm • Variable : normal • Acceleration : (-) • Deceleration : (+) once in 20 minutes • Fetal movement : (-) • His : (+) 3 times in 20 minutes • Result : suspicious
  • 13. Laboratory Test • Hematological Test Result Normal Values Unit Hemoglobin 10.5 12.0 - 15.6 g/dL Hematocrite 32 36 - 48 % Platelet 383 165 - 415 thousands/uL Leukocyte 18.2 3.54 - 9.06 thousands/uL Erythrocyte 4.01 4.0 - 5.2 fL MCV 76.6 79 - 93.3 pg MCH 26.1 26.7 - 31.9 g/dL MCHC 33.2 32.3 - 35.9 -
  • 14. Laboratory Test • Urinalysis Test Result Normal Values Unit Complete Urine Test       Glucose Negative Negative mg/dL Protein Negative Negative mg/dL Bilirubin Negative Negative - Urobilinogen Negative Negative - pH 7.0 5.0 - 9.0 - Density 1,010 1003 - 1025 - Occult blood + Negative - Ketone +++ Negative mg/dL Nitrite Negative Negative -
  • 15. Diagnosis • Differential Diagnosis • Gestational hypertention • Chronic hypertention • Working Diagnosis G3P2A0, 36 years old, gestational age 40 weeks old according to first day of last menstrual period, in partu active first stage, with gestational hypertension, with single living intrauterine fetus, head presentation
  • 16. Therapy • Observation of parturition • IVFD RL 500 mL + 1 amp, initial treatment is 8 dpm then observe contractions per 15 minutes, if contractions are inadequate, add up the dose by 4 tpm every timem with the maximum dose of 40 dpm. • Methyldopa tab 3 x 500 mg
  • 17. Delivery Report 1. Patient was positione in a lithotomy pisition, and a sterile doek was placed in the mother’s abdomen. 2. If the baby’s head had reached the vulva with a diameter of 5-6 cm, place a sterile doek beneath the mother’s behind. 3. Place a hand layered with sterile doek on the perineal area of the mother, while the other hand keeping the baby’s deflected position and helping the delivery of the head. 4. Guide the mother to do Valsava maneuver, breathe shortly and quickly, checking if there is any placental cord around the baby’s neck. If it is strangling the baby, put 2 clamps on the cord and cut between the 2 clamps, then wait for the baby to do external rotation.
  • 18. Delivery Report 5. After the baby did external rotation, hold the baby biparietally. Guide the mother to do Valsava maneuver while contractions happened. 6. Gently point the head inferiorly and distally until the front shoulders appears in the pubic arc, and then point the body part superiorly and distally to deliver the back part of the shoulders. 7. After both shoulders are delivered, displace the helper’s lower hand to the mother’s perineum to support the baby’s head and upper arm on the down side. Use the upper hand to hold the upper arm on the upper side. 8. After the body and the arms are delivered, proceed to help the delivery of the backside, behind, extremities and foot. Dry the baby and place it on the mother’s body.
  • 19. Delivery Report 9. Check if there is any other baby inside the uterus, and give necessary medication. 10.Around 2 minutes after the delivery, clamp the placental cord 2 cm distally from the first clamp, and hold it with one hand. 11.Expand and the placental cord, then push it dorsally and cranially until the placenta deattach. When the placenta appears in the vaginal introitus, hold and twist the placenta until the sac is separated, and deliver it.
  • 20. Final Diagnosis • Final working diagnosis • P3A0, 36 years old, post-partus maturus with spontaneous vaginal delivery with gestational hypertension. • Neonatal diagnosis • Female term neonate, appropriate for gestational age, birth weight 2.820 grams, birth length, APGAR score 7/9, gestational age 38-39 weeks according to New Ballard Score, healthy neonate. • Placenta • Placental measurement 18 x 18 x 2 cm, intact membrane, hematoma (-), stöll cell (+), calcification (-), umbilical cord length 48 cm, marginal implantatopm, blood 780 cc, weight 860 grams.
  • 21. Post-delivery Therapy •Cefadroxil tab 3 x 500 mg •Methyldopa tab 3 x 250 mg •Methyl ergometrin tab 3 x 0.125 mg •Mefenamic acid tab 3 x 500 mg •Diet high in protein and calories •Gradual increase in mobilization •Vital sign observation
  • 22. Follow-up February 21, 2017 (16.00) • Subjective Post partum pain VAS 2/10, no complaints • Objective • General condition: mildly ill appearance • Consciousness: compos mentis • Blood pressure : 140/100 mmHg • Heart rate : 88 bpm • Respiratory rate : 16 x/minute • Temperature : 36,5ºC
  • 23. Follow-up February 21, 2017 (16.00) • Assessment P3A0, 36 years old, post-partus maturus with spontaneous vaginal delivery with gestational hypertension. • Planning • Nifedipine as needed (if the blood pressure 140/100 mmHg) • Captopril tab 2 x 12.5 mg • Mefenamic acid tab 3 x 500 mg • Ferrous sulfate tab 1 x • Cefixime tab 3 x 200 mg
  • 24. Follow-up February 22, 2017 (05.00) • Subjective Post partum pain VAS 2/10, no complaints • Objective • General condition: mildly ill appearance • Consciousness: compos mentis • Blood pressure : 140/100 mmHg • Heart rate : 88 bpm • Respiratory rate : 16 x/minute • Temperature : 36,5ºC
  • 25. Follow-up February 22, 2017 (05.00) • Assessment P3A0, 36 years old, post-partus maturus with spontaneous vaginal delivery with gestational hypertension. • Planning • Nifedipine as needed (if the blood pressure 140/100 mmHg) • Captopril tab 2 x 12.5 mg • Mefenamic acid tab 3 x 500 mg • Ferrous sulfate tab 1 x 300 mg • Cefixime tab 3 x 200 mg
  • 27. Comparison Theory Case Definition  New onset of blood pressure after 20 weeks of gestation in the absence of accompanying proteinuria.  Blood pressure comes back to normal after 12 weeks post- partum. It was discovered that the patient had a high blood pressure about 150/100 at her second visit to the midwife, at her gestational age of about 24 weeks. For return to normal values, more time is needed to observe the patient in the next 12 weeks. Risk Factor  Older maternal ages (> 40 years old)  High BMI (> 29.0/30.0)  Primiparity  Renal disease  Diabetes mellitus  History of pre-eclampsia on previous pregnancy(ies)  Young maternal age (38 years old)  Multiparity  No renal disease, or diabetes mellitus  No history of pre-eclampsia on previous pregnancies Clinical presentation Asymptomatic Asymptomatic
  • 28. Diagnosis  New onset of blood pressure after 20 weeks of gestation in the absence of accompanying proteinuria.  Blood pressure comes back to normal after 12 weeks post- partum.  No new-onset proteinuria  No thrombocytopenia  No elevated blood levels of liver transaminase to twice the normal concentration  No new development of renal insufficiency (elevated serum creatinine greater than 1.1 mg/dL or a doubling of serum creatinine in the absence of other renal disease)  New onset of blood pressure after 20 weeks of gestation in the absence of accompanying proteinuria.  No thrombocytopenia  No new-onset proteinuria  No new-onset cerebral or visual disturbances  Liver transaminase and kidney function were not tested  Chest x-ray was not taken to exclude pulmonary edema
  • 29. Management Methyldopa 0.5–3 g/d orally in two to three divided doses  Observation of parturition  IVFD RL 500 mL + 1 amp oxytocin, initial treatment is 8 dpm then observe contractions per 15 minutes, if contractions are inadequate, add up the dose by 4 tpm every time (maximum dose 40 dpm)  Methyldopa tab 3 x 500 mg
  • 31. GESTATIONAL HYPERTENSION • Blood pressure (BP) in normotensive pregnant women is dynamic, varying throughout the day and over the course of the pregnancy. • Normal circadian fluctuations seen in non-pregnancy patients = pregnant population, daily blood pressures being lowest in the morning and peaking during the late afternoon and evening. • Diastolic BP reaches its nadir around 18–22 weeks of gestation. • Systolic blood pressure gradually demonstrates a slight
  • 32. GESTATIONAL HYPERTENSION • In labor, blood pressure can transiently increase up to 35 mmHg systolic and 25 mmHg diastolic. • Hypertensive disorders are becoming increasingly common in pregnancy, primarily because of the increase in the number of patients with chronic hypertension who become pregnant. • Gestational hypertension is characterized most often by new-onset elevations of blood pressure after 20 weeks of gestation, often near term, in the absence of accompanying proteinuria. The failure of blood pressure to normalize postpartum requires changing the
  • 33. DEFINITION • It is defined as the finding of hypertension (blood pressure at least 140 mmHg systolic and/or 90 mmHg diastolic) without proteinuria on at least two occasions at least 6 hours apart after the 20th week of gestation in women known to be normotensive before pregnancy and before 20 weeks of gestation.
  • 34. EPIDEMIOLOGY • Prevalence between 6 and 15% in nulliparas and 2–4% in multiparas. • New-onset hypertension during pregnancy—termed gestational hypertension—is followed by signs and symptoms of preeclampsia almost half the time, and preeclampsia is identified in 3.9 percent of all pregnancies. • WHO : 16 percent of maternal deaths were reported to be due to hypertensive disorders.
  • 35. CLASSIFICATION • Mild or severe • Severe : sustained blood pressure elevations of systolic blood pressure to 160 mmHg or more and/or diastolic blood pressure to 110 mmHg or more. • A rigorous definition of severe gestational hypertension requires that the elevated blood pressure should be observed for at least 6 hours.
  • 36. PATHOPHYSIOLOGY • Similar to preeclampsia • Gestational hypertension before 30 weeks frequently is severe, advances to preeclampsia, and has a guarded perinatal prognosis. • Gestational hypertension after 34 weeks is usually a benign condition that rarely becomes severe, progresses to preeclampsia, and results in uniformly good perinatal outcome. • Early gestational hypertension shares with preeclampsia a high incidence of poor placentation with histologic evidence of placental ischemia and hemodynamic changes characterized by vasoconstriction and decreased cardiac output (CO). • Late gestational hypertension occurs more frequently in obese women and in multiple pregnancies, and the placentas do not show histologic changes consistent with ischemia. • In late gestational hypertension, the fundamental hemodynamic changes are increased plasma volume, increased CO, and normal peripheral vascular resistance (PVR). The fundamental problem behind early gestational hypertension is poor placentation, while late gestational hypertension corresponds to a poor maternal adaptation to the physiologic changes of pregnancy.
  • 37. Diagnosis • Hypertension is diagnosed empirically when BP is >140 mmHg systolic or >90 mmHg diastolic. • Previously, incremental 30 mm Hg systolic or 15 mm Hg diastolic from midpregnancy blood pressure values had also been used as diagnostic criteria, even when absolute values were < 140/90 mm Hg. • These incremental changes are no longer recommended criteria because evidence shows that such women are not likely to experience increased adverse pregnancy outcomes. • That said, women who have a rise in pressure of 30 mmHg systolic or 15 mmHg diastolic should be observed more closely because eclamptic seizures develop in some of these women whose BP have stayed < 140/90 mmHg.
  • 38. Diagnosis • A woman must have an elevated BP >20th week of gestation without proteinuria or other laboratory abnormalities. • Elevated BP during pregnancy is defined as a systolic BP >140 mmHg or a diastolic blood pressure >90 mmHg. • Women diagnosed with gestational hypertension do not have a history of elevated blood pressure prior to the 20th week of gestation and their blood pressure normalizes within the first 12 weeks of the postpartum period.
  • 39. Diagnosis • This diagnosis is made in women whose BP reach 140/90 mm Hg or greater for the first time after mid pregnancy, but in whom proteinuria is not identified. • Almost half of these women subsequently develop preeclampsia syndrome, which includes findings such as headaches or epigastric pain, proteinuria, and thrombocytopenia. • Even so, when blood pressure increases appreciably, it is dangerous to both mother and fetus to ignore this rise only because proteinuria has not yet developed. • Finally, gestational hypertension is reclassified by some as transient hypertension if evidence for preeclampsia does not develop and the blood pressure returns to normal by 12 weeks postpartum.
  • 40. Maternal and Perinatal Outcome • Maternal and perinatal morbidity are increased in women with gestational hypertension. • In the study of Gofton et al. (2001) induction of labor and cesarean section in women with gestational hypertension were almost double as those in the control group and were similar to preeclampsia and chronic hypertension. • However, this study did not differentiate between mild and severe or between early and late gestational hypertension.
  • 41. Maternal and Perinatal Outcome • Barton et al. (2002) found differences in outcome depending on ethnicity with African-American women, exhibiting a higher incidence of placental abruption, stillbirth, and neonatal deaths than in White women. • Also, women with mild gestational hypertension have an increased incidence of obstetrical interventions such as induction of labor and cesarean section. • Women with severe gestational hypertension have a higher incidence of preterm birth and small-for- gestational-age newborns than in those with normal pregnancy and with mild preeclampsia.
  • 42. Maternal and Perinatal Outcome • The most frequent complication of gestational hypertension is its progress to preeclampsia that is heralded by the development of proteinuria (300 or more mg of protein in a 24-hour urine collection or at least 30 mg/dl or 1+ in dipstick in at least two random urine samples collected at least 6 hours, but no more than 7 days apart). • Approximately 15–25% of women with gestational hypertension develop preeclampsia and this risk varies with the gestational age. Approximately one- third of women with gestational hypertension present with a severe form of the condition. • They have a substantial increase in poor maternal and perinatal outcome when compared with normotensive women. They have increased incidence of preterm delivery and small-for-gestational-age infants. • They also have an increased incidence of abruptio placentae and admissions to the neonatal intensive care nursery. • Overall, their outcome is quite similar to that in women with severe preeclampsia.
  • 43. Management – Initial Evaluation • Women with elevated blood pressure (≥140 systolic or ≥90 diastolic) and no proteinuria by qualitative urine examination require an initial evaluation to determine whether or not they are at significant risk for a poor pregnancy outcome. • There are major and minor risk factors. The first and most important major risk factor to be considered in such evaluation is the degree of blood pressure elevation. • If the hypertension is severe (≥160 systolic or ≥110 diastolic) the patient has a risk similar to a severe preeclamptic and should be admitted to the hospital to complete her evaluation and start medical treatment. • If the blood pressure is not in the severe range, the other components of the initial evaluation can be assessed on an outpatient basis.
  • 44. Management – Initial Evaluation • Another major risk factor is the gestational age at the onset of the disease, and the earlier the presentation, the greater the likelihood of complications and poor outcomes. • From the fetal side, major risk factors for a poor outcome are the presence of fetal growth restriction and abnormal uterine and umbilical Doppler assessment. • Minor factors include Black ethnicity, multiparity, decreased fluid volume, and significant changes in placental echographic morphology (grade III placenta, infarcts).
  • 45. Management - Gestational hypertension without risk factors • Women with gestational hypertension and no risk factors can be managed as outpatients. • The objectives of their prenatal care are the early detection of preeclampsia and of progression of the condition to a severe form. • They need to be instructed in the correct way to obtain their blood pressure at home and are asked to record their readings and bring this information to each office visit. • They are given a blood pressure threshold, usually systolic ≥ 150 or diastolic ≥100, that requires office or hospital evaluation.
  • 46. Management - Gestational hypertension without risk factors • They also need to be instructed in the correct way to perform qualitative examination of their urine for protein, using dipsticks, and are asked to test the first urine voided every morning and to call or come to the office or hospital if the result is ≥ 2+. • These women need to be instructed about how to perform daily fetal movement counts. • No dietary restrictions are necessary and normal activities are allowed; however, they should be excused from work if it involves strenuous physical activities, significant stress, or standing up for prolonged periods of time. • They should have office visits every week.
  • 47. Management - Gestational hypertension without risk factors • Performance of nonstress test (NST) is probably unnecessary if the fetal growth and the uterine, umbilical, and cerebral fetal Dopplers, as determined in the initial evaluation, are normal and there is no change in the weekly clinical assessment of the maternal and fetal condition. • The weekly assessment of patients with gestational hypertension and no risk factors must include a systematic review of the maternal and fetal status. • From the maternal side the review includes the levels of blood pressure at home, the presence or absence of symptoms suggestive of end-organ damage (blurred vision, epigastric pain), and the presence of proteinuria.
  • 48. Management - Gestational hypertension without risk factors • From the fetal side the review includes daily charting of fetal movements and measurement of the uterine fundal height. • Proteinuria (≥2+) in a random urine sample is diagnostic of preeclampsia. • When the proteinuria is trace or 1+ it is necessary to send the random sample to the lab for determination of the protein/ creatinine and calcium/creatinine ratio. • A protein/creatinine ratio > 0.30 is indicative of preeclampsia and a value less than 0.20 rules out significant proteinuria.
  • 49. Management - Gestational hypertension without risk factors • Patients with preeclampsia have hypocalciuria and the finding of a calcium/creatinine ratio < 0.06 strongly suggests that this condition is present. • The calcium/creatinine ratio in normotensive women is 0.44 ± 0.32, in chronic hypertension is 0.20 ± 0.18, and in preeclampsia is 0.03 ± 0.03. • The development of proteinuria, elevation of the blood pressure above the threshold, decreased fetal movements, abnormal fundal growth, or development of maternal symptoms suggestive of end-organ damage require admission to the hospital for further evaluation and perhaps delivery. • Patients with negative evaluations in their weekly assessment may continue with the pregnancy until they reach 38 weeks. At this time labor may be induced using cervical ripening agents when the cervix is not ripe.
  • 50. Gestational HTN with Risk Factors • Objective: • pharmacologic control of BP • early detection of pre-eclampsia, end-organ damage, fetal decompensation • Avoid complication • Initial evaluation (repeat 1-2x/week): • 24-h urine collection (check for protein) • Platelet count: if not normal check for PT, PTT, fibrinogen • LDH, liver enzyme
  • 51. Gestational HTN with Risk Factors • Fetal assessment: • NST twice per week • Umbilical, cerebral Doppler weekly • Fetal movement count • BP should not exceed 150/100 • If BP exceed ≥160 / ≥110 : require anti-hypertensive, beta-blocker, diuretic
  • 52. • Beta-blocker: • Labetalol 3-4x/day (600-2400 mg/hr) • Diuretic • Furosemide: 20-40 mg every 6-12 hr • Hydrochlorothiazide: 25-50 mg daily • Termination of pregnancy if HTN is uncontrolled or there is evidence of end-organ damage, abruptio placentae, arrest of fetal growth
  • 53. Management - Delivery • Gestational hypertension is not by itself an indication for cesarean section except in severe cases unresponsive to treatment or with fetal growth restriction before 32 weeks. • Women with gestational hypertension who develop preeclampsia should be managed as described under preeclampsia. • The route of delivery in women with severe gestational hypertension who require delivery depends on the results of the digital pelvic examination and on the cervical length by endovaginal ultrasound examination. If the cervix is unripe and the cervical length is ≥ 2.5 cm it is better to deliver by cesarean and avoid a prolonged induction. • If the cervix is ripe vaginal delivery will be the best option. For women with mild gestational hypertension delivered after 37 weeks, induction of labor and vaginal delivery will be the first choice.
  • 54. Figure 2. Management of gestational hypertension