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Biotechnology- Antisense Technology
This document provides an overview of antisense technology for inhibiting gene expression. It discusses how antisense oligonucleotides are complementary to mRNA and can bind to prevent translation. The mechanisms of hybridization arrest and RNaseH activation are described. Different approaches using antisense oligonucleotides that do and do not activate RNaseH are covered. Applications in agriculture and medicine are mentioned, including the development of the Flavr Savr tomato that used antisense technology to delay fruit ripening. The role of antisense oligonucleotides in drug discovery is also briefly discussed.
