The document summarizes two scientific articles about proteins that regulate the cell cycle. The JNK protein, previously known to help cells respond to stress, was found to also control the cell cycle by regulating the APC/C protein complex. Histone H1, a protein that DNA winds around, was found to regulate gene activity throughout the cell cycle by controlling transcription when phosphorylated. Understanding the roles of these proteins may provide insights into diseases caused by cell cycle dysregulation.
it gives detail or you can say brief introduction of iPS cells , what are they , how can be obtained , what are the future possibilities of iPS cells what promise it made to upcoming future technology to medical health
Pluripotent Stem Cells and their applications in disease modelling, drug disc...tara singh rawat
This ppt gives an insight of the potential and possibilities of pluripotent stem cells research in disease modelling, drug discovery and regenerative medicine
Does dying help us to survive?
Would immortality kill you?
Often troubled by the secrets of death?
Why do we die?
Secrets of death
1. Reduction theory of death
2. Apoptosis
3. Necrosis
4. Undying cells kill you
5. Telomeric castration
6.Apoptosis and mitotic relation
7. Werner Syndrome
8. SPITZ of life
it gives detail or you can say brief introduction of iPS cells , what are they , how can be obtained , what are the future possibilities of iPS cells what promise it made to upcoming future technology to medical health
Pluripotent Stem Cells and their applications in disease modelling, drug disc...tara singh rawat
This ppt gives an insight of the potential and possibilities of pluripotent stem cells research in disease modelling, drug discovery and regenerative medicine
Does dying help us to survive?
Would immortality kill you?
Often troubled by the secrets of death?
Why do we die?
Secrets of death
1. Reduction theory of death
2. Apoptosis
3. Necrosis
4. Undying cells kill you
5. Telomeric castration
6.Apoptosis and mitotic relation
7. Werner Syndrome
8. SPITZ of life
Pathophysiology of TBI is complex and consists of acute and delayed injury. In the acute phase, brain tissue destroyed upon impact includes neurons, glia, and endothelial cells, the latter of which makes up the blood-brain barrier. In the delayed phase, “toxins” released from damaged cells set off cascades in neighboring cells eventually leading to exacerbation of primary injury. As researches further explore pathophysiology and molecular mechanisms underlying this debilitating condition, numerous potential therapeutic strategies, especially those involving stem cells, are emerging to improve recovery and possibly reverse damage. In addition to elucidating the most recent advances in the understanding of TBI pathophysiology, this review explores two primary pathways currently under investigation and are thought to yield the most viable therapeutic approach for treatment of TBI: manipulation of endogenous neural cell response and administration of exogenous stem cell therapy.
Biology, genetics, nanotechnology, neuroscience, materials science, biotech, ...Brian Russell
Over the past two years I've done a lot of interesting research which I've decided to aggregate. My research pertains to the following: Biology, Genetics, Nanotechnology, Neuroscience, Materials Science, Biotechnology, Chemical Engineering, All Things 3-D, Super Computing, Quantum Physics, Energy, Design, & Sustainability.
4. INTRODUCTION The cell cycle is a process necessary for the humans cells, which is controlled in some phases by specific proteins. When the proteins in check points doesn’t stop the process of division when the cell isn’t ready, is possible that the cellular growth can get out of control and mutate. The latest researches is looking for alterations, diseases and cancer with origin in the wrong cell division.
5. NEW ROLE FOR THE JNK PROTEIN: LONG KNOWN TO HELP CELLS RESPOND TO STRESS, JNK ALSO CONTROLS CELL CYCLE Science Daily July 16, 2010
6. JNK protein was known for helps cells respond to stress, produced by ultraviolet radiation, JNK had made a little bit easy repair the damages caused… NEW ROLE FOR THE JNK PROTEIN: LONG KNOWN TO HELP CELLS RESPOND TO STRESS, JNK ALSO CONTROLS CELL CYCLE … Although, The research revealed something…
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8. NEW ROLE FOR THE JNK PROTEIN: LONG KNOWN TO HELP CELLS RESPOND TO STRESS, JNK ALSO CONTROLS CELL CYCLE The role of JNK was the most unexpected result: JNK protein regulates to the protein complex APC/C , which is active during mitosis and it allows that the sister chromatids can separate through the destruction of cohesins. The Cdh1 phosphorylation activates APC/C.
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10. HISTONE H1 REGULATES GENE ACTIVITY THROUGHOUT THE CELL CYCLE Science Daily July 6, 2010
11. HISTONE H1 REGULATES GENE ACTIVITY THROUGHOUT THE CELL CYCLE The DNA contained in all the human’s cells is very long, and sometimes is necessary that DNA winds around specialized proteins named histones. The histones(H1, H2A, H2B, H3 and H4) provides different levels of DNA, and one of them is the nucleosome (without H1) and chromatosome ( with H1)
12. The new study found that when the H1 histone is phosphorylated, the RNA polymerase I and II is more active, making more easy the transcription of some parts the genome. HISTONE H1 REGULATES GENE ACTIVITY THROUGHOUT THE CELL CYCLE
13. Using fluorescence microscopy, they discovered that H1 phosphorylated was inside the nucleolus, the place where are transcripted the ribosomal RNA. At final, the estudy found that H1 phosphorylated has functions in mitosis and interphase, and a interesting role in hormonal treatments , through the association with the regulatory regions of hormone responsive genes. HISTONE H1 REGULATES GENE ACTIVITY THROUGHOUT THE CELL CYCLE
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16. NEW ROLE FOR THE JNK PROTEIN: LONG KNOWN TO HELP CELLS RESPOND TO STRESS, JNK ALSO CONTROLS CELL CYCLE It can bring new ideas and causes about the behavior of metastatic process, mutations and diseases, and also, it can be one more reason for create and think about a effective treatments, which can prevent and cure one of the most common problems of the actuality
17. HISTONE H1 REGULATES GENE ACTIVITY THROUGHOUT THE CELL CYCLE The latest advances of the functions of the H1 allows us investigate and discover what kind of diseases and alterations of the cell cycle are relacionated with de H1 phosphorylated’s function.
18. This information can be useful for produce metods and treatments that stimulates the H1 action and create responses more faster from the cell and so, make more easy the expression of the specific parts of the genome.