The document discusses recent advances in understanding DNA regulation and replication. A key finding was the discovery of an enzyme thought to reside only in mitochondria, but is also found in the nucleus and may be involved in epigenetic regulation of DNA. Additionally, researchers created the first model of the eukaryotic DNA replication fork using yeast enzymes. This model allows study of the replication process and its regulation in fine detail. These discoveries provide insights into normal biological functions and disease states, aiding medical research and potential new treatments.
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Molecular Biologist Academic CV for Industry or Private Sector Consideration Sirie Godshalk
Molecular Biologist with over thirteen years of hands-on research experience, impactful writer and presenter, dynamic leader and enthusiastic team player with an eye for great ideas and a passion to move science in new directions seeks challenging opportunities beyond the bench.
Third Natural Eukaryotic Epigenetic Mark Found.pdfCreative BioMart
A group at the Marine Biology Laboratory (MBL) now found a third epigenetic mark in this freshwater invertebrate, Adineta vaga, which has previously been found only in bacteria. For the first time, a horizontally transferred gene has been shown to remodel gene regulatory systems in eukaryotes.
This lecture covers key findings to the development of genomics as a field. This first part covers briefly Mendel to knowing that DNA is the genetic material by Hershey and Chase
Introduction to Synthetic Genome
SYNTHETIC GENOMICS Study of Invitro chemical synthesis of genetic material i.e., DNA in the form of oligonucleotides, genes, or genomes with Computational techniques for its design. SYNTHETIC GENOME Artificially synthesised genome (invitro)
genetic engineering, future perspectives and QC validationSana Rubab
this ppt will help you in studying genetic engineering, its introduction, history, basics, methods and procedures, QC validation, future perspectives and applications.
This lecture covers some nice stories about the origins of the words "genome" and the derived word "genomics". the lecture also introduces viral, bacterial, and eukaryotic genomes.
Method for physiologic phenotype characterization at the single-cell level in...Shashaanka Ashili
Intercellular heterogeneity is a key factor in a variety of core cellular processes including proliferation, stimulus response, carcinogenesis, and drug resistance. However, cell-to-cell variability studies at the single-cell level have been hampered by the lack of enabling experimental techniques. We present a measurement platform that features the capability to quantify oxygen consumption rates of individual, non-interacting and interacting cells
under normoxic and hypoxic conditions. It is based on real-time concentration measurements of metabolites of
interest by means of extracellular optical sensors in cell-isolating microwells of subnanoliter volume. We present the results of a series of measurements of oxygen consumption rates (OCRs) of individual non-interacting and interacting human epithelial cells. We measured the effects of cell-to-cell interactions by using the system’s capability to isolate two and three cells in a single well. The major advantages of the approach are: 1. ratiometric, intensity-based characterization of the metabolic phenotype at the single-cell level, 2. minimal invasiveness due to the distant positioning of sensors, and 3. ability to study the effects of cell-cell interactions on cellular respiration rates.
Molecular Biologist Academic CV for Industry or Private Sector Consideration Sirie Godshalk
Molecular Biologist with over thirteen years of hands-on research experience, impactful writer and presenter, dynamic leader and enthusiastic team player with an eye for great ideas and a passion to move science in new directions seeks challenging opportunities beyond the bench.
Third Natural Eukaryotic Epigenetic Mark Found.pdfCreative BioMart
A group at the Marine Biology Laboratory (MBL) now found a third epigenetic mark in this freshwater invertebrate, Adineta vaga, which has previously been found only in bacteria. For the first time, a horizontally transferred gene has been shown to remodel gene regulatory systems in eukaryotes.
This lecture covers key findings to the development of genomics as a field. This first part covers briefly Mendel to knowing that DNA is the genetic material by Hershey and Chase
Introduction to Synthetic Genome
SYNTHETIC GENOMICS Study of Invitro chemical synthesis of genetic material i.e., DNA in the form of oligonucleotides, genes, or genomes with Computational techniques for its design. SYNTHETIC GENOME Artificially synthesised genome (invitro)
genetic engineering, future perspectives and QC validationSana Rubab
this ppt will help you in studying genetic engineering, its introduction, history, basics, methods and procedures, QC validation, future perspectives and applications.
This lecture covers some nice stories about the origins of the words "genome" and the derived word "genomics". the lecture also introduces viral, bacterial, and eukaryotic genomes.
Method for physiologic phenotype characterization at the single-cell level in...Shashaanka Ashili
Intercellular heterogeneity is a key factor in a variety of core cellular processes including proliferation, stimulus response, carcinogenesis, and drug resistance. However, cell-to-cell variability studies at the single-cell level have been hampered by the lack of enabling experimental techniques. We present a measurement platform that features the capability to quantify oxygen consumption rates of individual, non-interacting and interacting cells
under normoxic and hypoxic conditions. It is based on real-time concentration measurements of metabolites of
interest by means of extracellular optical sensors in cell-isolating microwells of subnanoliter volume. We present the results of a series of measurements of oxygen consumption rates (OCRs) of individual non-interacting and interacting human epithelial cells. We measured the effects of cell-to-cell interactions by using the system’s capability to isolate two and three cells in a single well. The major advantages of the approach are: 1. ratiometric, intensity-based characterization of the metabolic phenotype at the single-cell level, 2. minimal invasiveness due to the distant positioning of sensors, and 3. ability to study the effects of cell-cell interactions on cellular respiration rates.
DNA is a long polymer of simple units called nucleotides. Each one contains a phosphate group (acid component), a sugar group (neutral component) and a nitrogen base (basic component).
4. The discovery of new mechanisms of
cellular function and it’s process is a
great aid to all researchers specially
community health as an great progress
in etiology understanding and
development of treatments of
different organic entities
The discovery of new mechanisms of
cellular function and it’s process is a
great aid to all researchers specially
community health as an great progress
in etiology understanding and
development of treatments of
different organic entities
The development of new tools in
medical genetics study are of great
importance for the understanding and
learning the different processes
involved, thus facilitating its study
and accessibility
5. SWEET GENES: new way found by which
metabolism is linked to the regulation of DNA
(July 3, 2014)
The DNA has a special
configuration, which allows not
only the maintenance and
stability but also conducive to
the different processes to be
performed for proper operation.
The DNA has a special
configuration, which allows not
only the maintenance and
stability but also conducive to
the different processes to be
performed for proper operation.
6. Among the fate of the DNA to its
operation is the relaxation of
chromatin which consists of genetic
material and proteins mainly histones,
this relaxation promotes replication
and development of the central
dogma of molecular biology
Among the fate of the DNA to its
operation is the relaxation of
chromatin which consists of genetic
material and proteins mainly histones,
this relaxation promotes replication
and development of the central
dogma of molecular biology
SWEET GENES: new way found by which
metabolism is linked to the regulation of
DNA
7. This process is made by a molecule
known acetyl-CoA. This relaxes the
DNA, allowing for DNA replication and
gene expression. This mechanism is
called "epigenetic regulation of DNA" is
very important for normal functions
This process is made by a molecule
known acetyl-CoA. This relaxes the
DNA, allowing for DNA replication and
gene expression. This mechanism is
called "epigenetic regulation of DNA" is
very important for normal functions
The way which the nucleus generates
acetyl-CoA for histone acetylation and
DNA relaxation had remained elusive,
until these days
The way which the nucleus generates
acetyl-CoA for histone acetylation and
DNA relaxation had remained elusive,
until these days
SWEET GENES: new way found by which
metabolism is linked to the regulation of
DNA
8. SWEET GENES: new way found by which
metabolism is linked to the regulation of
DNA
A research team discovered of an
enzyme which thought to reside
only with in mitochondria for energy
production by acetil CoA, called
Pyruvate Dehydrogenase Complex
(PDC), actually also has been find it
into the nucleus and maybe have
responsibility in epigenetic
regulation
A research team discovered of an
enzyme which thought to reside
only with in mitochondria for energy
production by acetil CoA, called
Pyruvate Dehydrogenase Complex
(PDC), actually also has been find it
into the nucleus and maybe have
responsibility in epigenetic
regulation
9. This work bring to us different implications for many
physiological and pathological conditions with this enzyme
discovered into the nucleus is comprehended the way what
is produced and can participate in the regulation of DNA
specifically epigenetic
STUDENT OBSERVATION
SWEET GENES: new way found by which
metabolism is linked to the regulation of
DNA
10. DNA 'replication fork' reconstituted for the
first time
(July 9, 2014)
The genetic material undergoes
different processes of great
importance to properly perform
its functions, including DNA
replication, the first step of the
central molecular biology dogma
The genetic material undergoes
different processes of great
importance to properly perform
its functions, including DNA
replication, the first step of the
central molecular biology dogma
11. DNA 'replication fork' reconstituted for the
first time
Replication fork is the region of
active DNA synthesis, is the
place where the parental
strands are separated and are
synthesized two new daughter
strands
Replication fork is the region of
active DNA synthesis, is the
place where the parental
strands are separated and are
synthesized two new daughter
strands
12. DNA 'replication fork' reconstituted for the
first time
To create his replication fork model,
researchers used enzymes from yeast.
Like human cells, yeast cells are
eukaryotic, meaning a membrane
encloses their nucleus
To create his replication fork model,
researchers used enzymes from yeast.
Like human cells, yeast cells are
eukaryotic, meaning a membrane
encloses their nucleus
Researchers at Rockefeller
University have built the first model
system about "replication fork" to
decipher what goes on here and
understanding the complete process
Researchers at Rockefeller
University have built the first model
system about "replication fork" to
decipher what goes on here and
understanding the complete process
13. They were able to purify and
reconstitute the central
components that propel the
eukaryotic replication fork
They were able to purify and
reconstitute the central
components that propel the
eukaryotic replication fork
That's why they said "for the first time
enables us to study the process and its
regulation by the cell in fine detail" and
it was presented as a research tool,
which could allow scientists to better
understand what occurs in DNA
replication and some disease states
That's why they said "for the first time
enables us to study the process and its
regulation by the cell in fine detail" and
it was presented as a research tool,
which could allow scientists to better
understand what occurs in DNA
replication and some disease states
DNA 'replication fork' reconstituted for the
first time
14. This model as a study tool allow researches and medical
people better understand the process of DNA replicaton and
what goes wrong in disease states
DNA 'replication fork' reconstituted for the
first time
STUDENT OBSERVATION
15. Understand the different biological processes,
compounds and pathways involved followed by
the genetic material are of great impotence to
understand both normal and abnormal
procedures that are held for proper operation or
pathological states
16. The discovery of the
enzyme PDC within the
nucleus and its possible
relationship to
epigenetic regulation is
a huge advance
understanding different
etiological processes or
to think of possible
medical interventions
17. Creating a model that outlines the replication fork
eukaryotic cell with its components and processes
serves as a research tool to study in more detail
the mechanisms involved, normal versus abnormal
operating states and develop a possible medical
treatment
18. The era of molecular biology and genetics with
broader developments, discoveries and study tools
have facilitated and improved medical work to
contribute their knowledge in the diagnostic aids
and treatments developed
19. University of Alberta Faculty of Medicine & Dentistry. "Sweet
genes: New way found by which metabolism is linked to the
regulation of DNA." ScienceDaily.
www.sciencedaily.com/releases/2014/07/140703151821.htm
(accessed July 26, 2014).
Rockefeller University. "DNA 'replication fork' reconstituted for
the first time." ScienceDaily.
www.sciencedaily.com/releases/2014/07/140709100106.htm
(accessed July 25, 2014)
MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 7. ed.
Medellín: UPB. Fac. de Medicina, 2012.