This document discusses three approaches for modeling the power consumption of an RF subsystem: multivariate polynomial fitting, neural networks, and homotopy continuation. It presents a case study where measurements of an RF subsystem's power consumption were taken under varying conditions of transmitter power, signal bandwidth, carrier frequency, and ambient temperature. The document aims to compare the accuracy of the three modeling approaches for capturing the power consumption across the varying conditions while accounting for measurement uncertainty. Polynomial fitting and neural networks are described as existing approaches, while homotopy continuation is proposed as a new technique for this application.