2. INTRODUCTION
It is a condition progressive enlargement of
prostate gland, resulting from an increase in the
number of size of epithelial cells and stromal
tissue.
3.
4. ETIOLOGY
1. Ageing
2. Excessive accumulation of prostatic androgen
3. Family history
4. Diet increase animal fat and saturated faty
acids
5. Reduced exercise and alcohol consumption
5. CONTINUE..
Recent studies have identified smoking (both
current and former smoking), heavy alcohol
consumption, hypotension, heart disease and
diabetes mellitus as risk factors associated with
BPH.
6. PATHOPHYSILOGY
The cause of BPH is uncertain, but studies suggest
that estradiol levels may have a relationship to
prostate size among men with testosterone levels
above the median.
7. The hypertrophied lobes of prostate may obstruct the
vesical neck or prostatic urethra, causing incomplete
emptying of the bladder and urinary retention.
As a result. A gradual dilation of the ureters
(hyroureter) and kidneys (hydronephrosis) can occur.
10. Inflammation and infection
sensation that the bladder has not been completely
emptied.
Generalized symptoms include
Fatigue
Anorexia
Nausea and vomiting
Epigastric discomfort
13. MEDICAL MANAGEMENT
The main goals of medical management:
•Restore bladder function
•Relive signs and symptoms and prevent and treat
complications.
14. PHARMACOLOGIC THERAPY
Pharmacologic therapy include:
•Alpha adrenergic blocker and 5-alpha reductase
inhibitors this type of medications relax the
smooth muscle of the bladder neck and prostate.
The smooth muscle blockade improves urine flow
and relives BPH symptoms.
