The document describes the electrocardiogram (ECG or EKG), which measures electrical activity of the heart. It notes that the ECG waveform consists of P waves from atrial depolarization, QRS complex from ventricular depolarization, and T waves from ventricular repolarization. It explains that the ECG represents both depolarization and repolarization waves generated by the heart during each heartbeat. It provides details on normal ECG intervals and how to analyze ECG rhythms.
Ventricular tachycardia (VT) is a broad complex tachycardia originating from a ventricular ectopic focus. It is defined as three or more ventricular extrasystoles in succession at a rate of more than 120 beats per minute (bpm). Accelerated idioventricular rhythm refers to ventricular rhythms with rates of 100-120 bpm
Ventricular tachycardia (VT) is a broad complex tachycardia originating from a ventricular ectopic focus. It is defined as three or more ventricular extrasystoles in succession at a rate of more than 120 beats per minute (bpm). Accelerated idioventricular rhythm refers to ventricular rhythms with rates of 100-120 bpm
Electrocardiography: is the recording of the electrical impulses that are generated in the heart. These impulses initiate the contraction of cardiac muscles.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
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Basic ekg
1. The electrocardiogram
ECG or EKG
The ECG is a measurement of the sum total of
electrical activity generated by the heart
measured from the surface of the body
An electrical record of the heart’s activity
It is one of the most valuable diagnostic tools for
the recognition of a large variety of cardiac
disorders
2. Characteristics of the normal electrocardiogram
The normal electrocardiogram is composed
of:
P wave: is caused by electrical potentials
generated when the atria depolarize before
atrial contraction begins
QRS complex: is caused by potentials
generated when the ventricles depolarize
before contraction
The P wave and the components of the QRS
complex are depolarization waves
3. T wave: is caused by potentials generated as
the ventricles recover from the state of
depolarization. the T wave is known as a
repolarization wave
The electrocardiogram is composed of both
depolarization and repolarization waves.
4. The atrial repolarization wave, known as the
atrial T wave, is usually obscured by the much
larger QRS complex. For this reason, an atrial T
wave seldom is observed in the
electrocardiogram
5. The “PQRST”
P wave - Atrial
depolarization
• QRS - Ventricular
depolarization
• T wave - Ventricular
repolarization
6. Depolarization Waves Versus Repolarization Waves
In figure (A) depolarization,
The first half of the fiber has
already depolarized, while
the remaining half is still
polarized
The left electrode on the
outside of the fiber is in an
area of negativity, and the
right electrode is in an area
of positivity, this causes the
meter to record positive
When depolarization has
reached half way mark the
record risen to maximum
positive value
7. Depolarization Waves Versus Repolarization Waves
In figure (B) depolarization
has extended over the entire
muscle fiber, and the
recording to the right has
returned to the zero baseline
because both electrodes are
now in areas of equal
negativity. The completed
wave is a depolarization wave
because it results from spread
of depolarization along the
muscle fiber membrane
8. Depolarization Waves Versus Repolarization Waves
In figure (C) shows halfway
repolarization of the same
muscle fiber, with positivity
returning to the outside of
the fiber. At this point, the
left electrode is in an area
of positivity, and the right
electrode is in an area of
negativity
Consequently, the
recording, as shown to the
right, becomes negative
9. Depolarization Waves Versus Repolarization Waves
In figure (D) the muscle
fiber has completely
repolarized, and both
electrodes are now in areas
of positivity, so that no
potential difference is
recorded between them
This completed negative
wave is a repolarization
wave because it results
from spread of
repolarization along the
muscle fiber membrane
10. Relation of ventricle action potential to the
QRS and T waves in the electrocardiogram
No potential is recorded in the
electrocardiogram when the
ventricular muscle is either
completely polarized or completely
depolarized
Only when the muscle is partly
polarized and partly depolarized
does current flow from one part
of the ventricles to another
part, and therefore current also
flows to the surface of the body
to produce the electrocardiogram
11. The time of the onset of the P wave to the onset
of the QRS complex is termed as PR interval. It
represent the conduction time from the atrial to
the ventricle
The time from the beginning of the Q wave to
the end of the S wave is called the QRS interval.
It indicates the time taken by the impulse to
separate to the two ventricles
12. The time from the beginning of the Q wave to
the end of T wave is called the QT interval. It
represent the total electrical activity of
ventricles
The line between the QRS complex and T wave
is called ST segment. It represent the time
between completion of depolarization and onset
of repolarization
13. The time interval from the apex of one R
wave to the next R wave is called R-R interval
R-R interval is related to the heart rate or rate
of ventricular contraction
The time interval from the beginning of one P
wave to the beginning of the next P wave is
called P-P interval
14. Vertical Axis = Voltage
Vertical axis represents voltage on the EKG
One small box (1 mm) represents 0.10 mV
15. Horizontal Axis = Time
1 small (1 mm) box = 0.04 seconds (40 ms)
1 large (5 mm) box = 0.20 seconds (200 ms)
5 large (5 mm) boxes = 1 second (1000 ms)
15 large (5 mm) boxes = 3 seconds and is
marked on EKG paper
16. The ECG Paper
Horizontally
One small box - 0.04 s
One large box - 0.20 s
Vertically
One large box - 0.5 mV
17. The ECG Paper
3 sec 3 sec
Every 3 seconds (15 large boxes) is marked by
a vertical line.
This helps when calculating the heart rate.
NOTE: the following strips are not marked
but all are 6 seconds long.
19. Step 1: Calculate Rate
3 sec 3 sec
Option 1
Count the # of R waves in a 6 second rhythm
strip, then multiply by 10.
Interpretation?
9 x 10 = 90 bpm
20. Step 1: Calculate Rate
R wave
Option 2
Find a R wave that lands on a bold line.
Count the # of large boxes to the next R wave. If
the second R wave is 1 large box away the rate is
300, 2 boxes - 150, 3 boxes - 100, 4 boxes - 75, etc.
(cont)
24. Step 2 : Determine Regularity
Regular: If the difference between the longest
R-R interval in the ECG and the shortest R-R
interval is less than 0.12 second
Irregular: If the difference between the
longest R-R interval in the ECG and the
shortest R-R interval is greater than 0.12
second
25. Step 2: Determine regularity
R R
Look at the R-R distances (using a caliper or
markings on a pen or paper).
Interpretation?
Regular
26. Step 3: Assess the P waves
Are there P waves?
Do the P waves all look alike?
Do the P waves occur at a regular rate?
Is there one P wave before each QRS?
Interpretation?
Normal P waves with 1 P
wave for every QRS