This document summarizes presentations from symposiums on vulnerable plaque and atherothrombosis. It discusses the role of plaque disruption, blood thrombogenicity, and patient vulnerability in acute coronary events. Specifically, it examines how risk factors like diabetes, smoking, and hyperlipidemia can increase blood thrombogenicity by enhancing tissue factor activity and other prothrombotic mechanisms. Targeting the tissue factor pathway with inhibitors is proposed as a promising new approach to antithrombotic therapy.