This document discusses the importance of methodology in scientific research papers that aim to apply science and technology to address millennium challenges. It defines methodology as the framework and methods used in a research study. The document examines key components of methodology, including research design, study population, variables, sampling techniques, sample size determination, data collection methods, and data analysis. It provides examples for how to determine these methodological components and stresses that applying the appropriate methodology is essential for producing valid, high-quality research that can help solve important problems.