AUTACOIDS.pdf
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This document defines autacoids as organic substances produced in one part of the body and transported to another part where they exert physiological effects. It discusses the main types of autacoids - amines, lipids, peptides - and provides details on histamine and serotonin, including their synthesis, receptors, pharmacology, therapeutic uses, and adverse effects. Prostaglandins and leukotrienes are also covered, outlining their actions, uses, and risks.
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Autacoids ppt
This document provides an overview of autacoids and their types. It discusses that autacoids are organic substances produced in one part of the body and transported via blood or lymph to exert physiological effects elsewhere. The main types discussed are amines like histamine and serotonin, lipids like prostaglandins and leukotrienes, and peptides like bradykinin. It then goes into further detail on the synthesis, pharmacology, therapeutic uses, and receptors of histamine, serotonin, prostaglandins, leukotrienes.
AUTOCOIDS.pptx
This document discusses different types of autacoids including amines, lipids, peptides, histamine, serotonin, prostaglandins, and leukotrienes. It provides details on their synthesis, pharmacology, therapeutic uses, and examples of agonists and antagonists. The key points are:
- Autacoids are organic substances produced in one part of the body and transported to another part where they exert physiological effects.
- Types discussed include histamine, serotonin, prostaglandins, leukotrienes, and others.
- Their effects are mediated via different receptors and second messenger systems.
- Therapeutic uses include treatment of allergies, asthma, inflammation, and other conditions
Autacoid drug prsu raipur
This document discusses autacoids, which are diverse substances produced locally in the body that have intense biological activity near their site of synthesis and release. It focuses on two specific autacoids - histamine and 5-hydroxytryptamine (serotonin). Histamine is produced by mast cells and acts through H1 and H2 receptors to cause vasodilation, increased heart rate, bronchoconstriction and increased gastric secretion. Serotonin is produced mainly in the intestines and platelets and acts through 5HT receptors to constrict blood vessels, stimulate cardiac output, induce gut peristalsis and inhibit gastric secretion. Both histamine and serotonin play important roles in various physiological and pathophysiological processes.
Pharmacology of AUTOCOIDS : HISTAMINE & ITS SYNTHETIC ANALOGUES
Histamine is a chemical messenger that mediates allergic and inflammatory responses. It acts through four receptor subtypes: H1, H2, H3, and H4. H1 receptors mediate smooth muscle contraction and increased capillary permeability. H2 receptors increase gastric acid secretion. Synthetic analogues that act as agonists or antagonists at specific receptor subtypes have therapeutic uses. Betahistine is an H1 agonist used for vertigo, while betazole and impromidine are H2 agonists that stimulate gastric acid secretion. Clozapine is an H4 agonist antipsychotic primarily used for treatment-resistant schizophrenia.
Autocoids.pptx
Autocoids are the self treating substance and local hormones . which is create changes in body Phisiology on the situation of to admine poisonous as well as foreign substance.
in this ppt gives Physiology of 5HT , Prostaglandin, and Histamine with their clinical use and adverse effect.
Also discussed about anti histamine , 5 HT antagonist with suitable examples.
16.THE PHARMACOLOGY OF SEROTONIN (5-HT).ppt
This document discusses the pharmacology of serotonin (5-HT). It begins by describing the historical identification of 5-HT and its role as a neurotransmitter and hormone. It then discusses the distribution, biosynthesis, metabolism, and receptors of 5-HT. The major receptors discussed are 5-HT1-5HT4 receptors, and their roles in the CNS and periphery. The effects of 5-HT at different receptors, such as its effects on blood vessels, platelets, and smooth muscle are summarized. Finally, the mechanisms and uses of serotonergic drugs like SSRIs and ergot alkaloids are discussed.
Serotonin
Serotonin is synthesized from tryptophan and is found in high concentrations in the gastrointestinal tract, blood platelets, and central nervous system. It functions as both a neurotransmitter and hormone. Serotonin mediates a variety of effects through multiple receptor subtypes, including smooth muscle contraction, vasoconstriction, platelet aggregation, gastrointestinal motility, mood, appetite, and sleep. Dysregulation of serotonin signaling has been implicated in conditions like migraine, depression, anxiety, and carcinoid syndrome, a tumor that secretes excess serotonin. A number of drugs target specific serotonin receptors to treat associated symptoms.
Serotonin, agonists and antagonists
This document discusses serotonin (5-HT), its receptors, synthesis, actions, roles, and drugs that affect the 5-HT system. Some key points:
- 5-HT is a neurotransmitter found mainly in the intestines, platelets, and brain. It acts on several receptor subtypes to regulate various functions.
- 5-HT receptors include 5-HT1-7, with 5-HT1 regulating neurotransmission and 5-HT2/3 mediating various actions like smooth muscle contraction.
- 5-HT has diverse roles like regulating gastrointestinal motility, platelet aggregation, and mood/behavior via effects in the brain and periphery. Imbalances in the 5-HT system
Recommended
Autacoids ppt
This document provides an overview of autacoids and their types. It discusses that autacoids are organic substances produced in one part of the body and transported via blood or lymph to exert physiological effects elsewhere. The main types discussed are amines like histamine and serotonin, lipids like prostaglandins and leukotrienes, and peptides like bradykinin. It then goes into further detail on the synthesis, pharmacology, therapeutic uses, and receptors of histamine, serotonin, prostaglandins, leukotrienes.
AUTOCOIDS.pptx
This document discusses different types of autacoids including amines, lipids, peptides, histamine, serotonin, prostaglandins, and leukotrienes. It provides details on their synthesis, pharmacology, therapeutic uses, and examples of agonists and antagonists. The key points are:
- Autacoids are organic substances produced in one part of the body and transported to another part where they exert physiological effects.
- Types discussed include histamine, serotonin, prostaglandins, leukotrienes, and others.
- Their effects are mediated via different receptors and second messenger systems.
- Therapeutic uses include treatment of allergies, asthma, inflammation, and other conditions
Autacoid drug prsu raipur
This document discusses autacoids, which are diverse substances produced locally in the body that have intense biological activity near their site of synthesis and release. It focuses on two specific autacoids - histamine and 5-hydroxytryptamine (serotonin). Histamine is produced by mast cells and acts through H1 and H2 receptors to cause vasodilation, increased heart rate, bronchoconstriction and increased gastric secretion. Serotonin is produced mainly in the intestines and platelets and acts through 5HT receptors to constrict blood vessels, stimulate cardiac output, induce gut peristalsis and inhibit gastric secretion. Both histamine and serotonin play important roles in various physiological and pathophysiological processes.
Pharmacology of AUTOCOIDS : HISTAMINE & ITS SYNTHETIC ANALOGUES
Histamine is a chemical messenger that mediates allergic and inflammatory responses. It acts through four receptor subtypes: H1, H2, H3, and H4. H1 receptors mediate smooth muscle contraction and increased capillary permeability. H2 receptors increase gastric acid secretion. Synthetic analogues that act as agonists or antagonists at specific receptor subtypes have therapeutic uses. Betahistine is an H1 agonist used for vertigo, while betazole and impromidine are H2 agonists that stimulate gastric acid secretion. Clozapine is an H4 agonist antipsychotic primarily used for treatment-resistant schizophrenia.
Autocoids.pptx
Autocoids are the self treating substance and local hormones . which is create changes in body Phisiology on the situation of to admine poisonous as well as foreign substance.
in this ppt gives Physiology of 5HT , Prostaglandin, and Histamine with their clinical use and adverse effect.
Also discussed about anti histamine , 5 HT antagonist with suitable examples.
16.THE PHARMACOLOGY OF SEROTONIN (5-HT).ppt
This document discusses the pharmacology of serotonin (5-HT). It begins by describing the historical identification of 5-HT and its role as a neurotransmitter and hormone. It then discusses the distribution, biosynthesis, metabolism, and receptors of 5-HT. The major receptors discussed are 5-HT1-5HT4 receptors, and their roles in the CNS and periphery. The effects of 5-HT at different receptors, such as its effects on blood vessels, platelets, and smooth muscle are summarized. Finally, the mechanisms and uses of serotonergic drugs like SSRIs and ergot alkaloids are discussed.
Serotonin
Serotonin is synthesized from tryptophan and is found in high concentrations in the gastrointestinal tract, blood platelets, and central nervous system. It functions as both a neurotransmitter and hormone. Serotonin mediates a variety of effects through multiple receptor subtypes, including smooth muscle contraction, vasoconstriction, platelet aggregation, gastrointestinal motility, mood, appetite, and sleep. Dysregulation of serotonin signaling has been implicated in conditions like migraine, depression, anxiety, and carcinoid syndrome, a tumor that secretes excess serotonin. A number of drugs target specific serotonin receptors to treat associated symptoms.
Serotonin, agonists and antagonists
This document discusses serotonin (5-HT), its receptors, synthesis, actions, roles, and drugs that affect the 5-HT system. Some key points:
- 5-HT is a neurotransmitter found mainly in the intestines, platelets, and brain. It acts on several receptor subtypes to regulate various functions.
- 5-HT receptors include 5-HT1-7, with 5-HT1 regulating neurotransmission and 5-HT2/3 mediating various actions like smooth muscle contraction.
- 5-HT has diverse roles like regulating gastrointestinal motility, platelet aggregation, and mood/behavior via effects in the brain and periphery. Imbalances in the 5-HT system
pharmacology of Histamines , Serotonin and its antagonist
Histamine and serotonin are classical autacoids that act as local hormones. Histamine is involved in allergic reactions and is found in mast cells and basophils. It acts on H1, H2, H3 and H4 receptors. H1 receptor antagonists like cetirizine and loratadine are used to treat allergic disorders. Serotonin acts as a neurotransmitter and regulates gastrointestinal motility, blood pressure, and platelet aggregation via 5HT receptors. 5HT receptor antagonists like ondansetron, ketanserin and methysergide are used for conditions like migraine and nausea/vomiting.
5-HT Pharmacology - drdhriti
Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter synthesized from tryptophan. It is present mainly in the gastrointestinal tract and blood platelets, with some in the central nervous system. Serotonin acts through multiple receptor subtypes and has diverse physiological effects including regulation of mood, appetite, sleep, and cardiovascular and gastrointestinal functions. Antagonists of serotonin receptors are used to treat conditions like migraine, hypertension, nausea/vomiting, and carcinoid syndrome. Common antagonists include cyproheptadine, ketanserin, ondansetron, and ergot alkaloids.
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Autacoids....With Slide No
The document discusses several autacoids including histamine, bradykinin, 5-hydroxytryptamine (5HT), eicosanoids, and platelet activating factor (PAF). It describes their synthesis, mechanisms of action, functions, and pharmacological properties. Histamine is involved in allergic responses and acts on H1 and H2 receptors. Bradykinin causes pain and vasodilation. 5HT is involved in platelet aggregation and gastrointestinal motility. Eicosanoids like prostaglandins are lipid-derived autacoids formed from arachidonic acid. PAF causes potent vasodilation and increases vascular permeability.
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This document discusses histamines, antihistamines, and 5-hydroxytryptamine (5-HT, serotonin) and their antagonists. It describes how histamines are synthesized and stored in mast cells and basophils and released during allergic reactions. The pharmacological actions of histamines are also explained. Antihistamines are described as drugs that block the actions of histamine by competing for H1 receptors. The document also covers the synthesis, receptors, pharmacological actions and functions of 5-HT as well as some 5-HT antagonists and their clinical uses.
Autocoids
This document discusses various autacoids, including histamine, serotonin, prostaglandins, and thromboxanes. It provides details on their classification, synthesis, mechanisms of action, pharmacological effects, clinical uses, and antagonists. Histamine and serotonin are classified as amine autacoids derived from amino acids and act as inflammatory mediators. Prostaglandins and thromboxanes are eicosanoids derived from arachidonic acid that play important roles in inflammation and platelet aggregation. The document outlines the physiological roles and clinical applications of agonists and antagonists that target histamine, serotonin, and prostaglandin receptors.
5 HT [seratonin]
5-HT (serotonin) is a neurotransmitter found in the brain and periphery that plays an important role in platelet function and various disorders. It is synthesized from tryptophan via tryptophan hydroxylase and stored in platelets and neurons. Degradation occurs via monoamine oxidase A. There are multiple 5-HT receptor subtypes located throughout the body. 5-HT is involved in gastrointestinal motility, smooth muscle contraction, vascular effects, platelet aggregation, and various central nervous system functions. Disorders related to abnormal 5-HT include migraine, carcinoid syndrome, and pulmonary hypertension.
(Autocoids) Histamine Pharmacology ppt
Histamine, meaning ‘tissue amine’ (histos—tissue) is almost ubiquitously present in animal tissues and in certain plants, e.g. stinging nettle. Its pharmacology was studied in detail by Dale in the beginning of the 20th century when close parallelism was noted between its actions and the manifestations of certain allergic reactions. It was implicated as a mediator of hypersensitivity phenomena and tissue injury reactions. It is now known to play important physiological roles.
AUTOCOIDS MEDIATORS OF INFLAMMATION (1).pdf
Ggggggggggggggggggggggggggggghhhhhhhhhhhhhhhhhhhhhhhjjjjj ggggggggggggggggggggggggggggghhhhhhhhhhhhhhhhhhhhhhhjjjjj
Seretonin (5HT) and Its Antagonists Pharmacology
Serotonin is a chemical that has a wide variety of functions in the human body. It is sometimes called the happy chemical, because it contributes to wellbeing and happiness.
The scientific name for serotonin is 5-hydroxytryptamine, or 5-HT. It is mainly found in the brain, bowels, and blood platelets.
Serotonin is used to transmit messages between nerve cells, it is thought to be active in constricting smooth muscles, and it contributes to wellbeing and happiness, among other things. As the precursor for melatonin, it helps regulate the body’s sleep-wake cycles and the internal clock.
It is thought to play a role in appetite, the emotions, and motor, cognitive, and autonomic functions. However, it is not known exactly if serotonin affects these directly, or if it has an overall role in co-ordinating the nervous system.
Histamines and Antihistamines
This document discusses histamine and antihistamines. It covers the topics of histamine synthesis, storage, release and receptors. Histamine causes vasodilation, increased permeability and smooth muscle contraction through H1 receptors. Antihistamines such as fexofenadine and loratadine are second generation drugs that selectively block H1 receptors without crossing the blood brain barrier, thereby reducing sedation. H2 receptor antagonists such as cimetidine and ranitidine are used to suppress gastric acid secretion by blocking histamine and other stimuli at the parietal cell.
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HISTAMINE AND THEIR ANTAGONISTS
Histamine is an endogenous substance that is amine synthesized, stored and released by the various cells of the body: (a) Mast cells, which are abundant in the skin, GI, and the respiratory tract,
(b) Basophils in the blood, and (c) Some neurons in the CNS and peripheral NS.
It is an “Autocoid” that is secreted locally and regulate the activity of various near lying cells and neurons.
Pharmacology of Histamine and antihistaminics
This document discusses histamine, antihistamines, and their mechanisms of action. It provides details on histamine biosynthesis, storage, release, receptors, and pharmacological actions. It describes the classification and effects of first and second generation antihistamines. The therapeutic uses of H1 and H2 receptor antagonists for allergic disorders, pruritus, cough, and more are outlined. Pharmacokinetics including absorption, distribution, metabolism, and excretion of antihistamines are covered. Finally, the document reviews the adverse effects of antihistamines such as sedation, dry mouth, and fatigue.
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The document provides an overview of histamine and antihistamines. It discusses how histamine is synthesized and stored in mast cells and basophils. Histamine is released through immunologic and non-immunologic mechanisms to produce local inflammatory responses. It acts through four G-protein coupled receptors (H1-H4) and has effects on blood vessels, heart, lungs, gastric acid secretion, and the central nervous system. Antihistamines like diphenhydramine and cetirizine are H1 receptor antagonists used to treat allergic conditions by blocking the effects of histamine. First generation antihistamines have anticholinergic effects while second generation drugs have fewer side effects.
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PHARMACOLOGY (HISTAMINE ITS ANTAGONISTS) pptx
This document discusses autacoids and histamine and antihistamines. It defines autacoids as locally acting substances produced by cells that have intense biological activity. Histamine is described as an autacoid mediator that is widely distributed and involved in allergic reactions. The document outlines the synthesis, release, mechanisms of action, effects and clinical uses of histamine. It also discusses antihistamines, describing first and second-generation H1 receptor antagonists, their mechanisms of action, uses in allergies and motion sickness, and potential adverse effects.
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pharmacology of Histamines , Serotonin and its antagonist
Histamine and serotonin are classical autacoids that act as local hormones. Histamine is involved in allergic reactions and is found in mast cells and basophils. It acts on H1, H2, H3 and H4 receptors. H1 receptor antagonists like cetirizine and loratadine are used to treat allergic disorders. Serotonin acts as a neurotransmitter and regulates gastrointestinal motility, blood pressure, and platelet aggregation via 5HT receptors. 5HT receptor antagonists like ondansetron, ketanserin and methysergide are used for conditions like migraine and nausea/vomiting.
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The document discusses several autacoids including histamine, bradykinin, 5-hydroxytryptamine (5HT), eicosanoids, and platelet activating factor (PAF). It describes their synthesis, mechanisms of action, functions, and pharmacological properties. Histamine is involved in allergic responses and acts on H1 and H2 receptors. Bradykinin causes pain and vasodilation. 5HT is involved in platelet aggregation and gastrointestinal motility. Eicosanoids like prostaglandins are lipid-derived autacoids formed from arachidonic acid. PAF causes potent vasodilation and increases vascular permeability.
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This document discusses histamines, antihistamines, and 5-hydroxytryptamine (5-HT, serotonin) and their antagonists. It describes how histamines are synthesized and stored in mast cells and basophils and released during allergic reactions. The pharmacological actions of histamines are also explained. Antihistamines are described as drugs that block the actions of histamine by competing for H1 receptors. The document also covers the synthesis, receptors, pharmacological actions and functions of 5-HT as well as some 5-HT antagonists and their clinical uses.
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This document discusses various autacoids, including histamine, serotonin, prostaglandins, and thromboxanes. It provides details on their classification, synthesis, mechanisms of action, pharmacological effects, clinical uses, and antagonists. Histamine and serotonin are classified as amine autacoids derived from amino acids and act as inflammatory mediators. Prostaglandins and thromboxanes are eicosanoids derived from arachidonic acid that play important roles in inflammation and platelet aggregation. The document outlines the physiological roles and clinical applications of agonists and antagonists that target histamine, serotonin, and prostaglandin receptors.
5 HT [seratonin]
5-HT (serotonin) is a neurotransmitter found in the brain and periphery that plays an important role in platelet function and various disorders. It is synthesized from tryptophan via tryptophan hydroxylase and stored in platelets and neurons. Degradation occurs via monoamine oxidase A. There are multiple 5-HT receptor subtypes located throughout the body. 5-HT is involved in gastrointestinal motility, smooth muscle contraction, vascular effects, platelet aggregation, and various central nervous system functions. Disorders related to abnormal 5-HT include migraine, carcinoid syndrome, and pulmonary hypertension.
(Autocoids) Histamine Pharmacology ppt
Histamine, meaning ‘tissue amine’ (histos—tissue) is almost ubiquitously present in animal tissues and in certain plants, e.g. stinging nettle. Its pharmacology was studied in detail by Dale in the beginning of the 20th century when close parallelism was noted between its actions and the manifestations of certain allergic reactions. It was implicated as a mediator of hypersensitivity phenomena and tissue injury reactions. It is now known to play important physiological roles.
AUTOCOIDS MEDIATORS OF INFLAMMATION (1).pdf
Ggggggggggggggggggggggggggggghhhhhhhhhhhhhhhhhhhhhhhjjjjj ggggggggggggggggggggggggggggghhhhhhhhhhhhhhhhhhhhhhhjjjjj
Seretonin (5HT) and Its Antagonists Pharmacology
Serotonin is a chemical that has a wide variety of functions in the human body. It is sometimes called the happy chemical, because it contributes to wellbeing and happiness.
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Serotonin is used to transmit messages between nerve cells, it is thought to be active in constricting smooth muscles, and it contributes to wellbeing and happiness, among other things. As the precursor for melatonin, it helps regulate the body’s sleep-wake cycles and the internal clock.
It is thought to play a role in appetite, the emotions, and motor, cognitive, and autonomic functions. However, it is not known exactly if serotonin affects these directly, or if it has an overall role in co-ordinating the nervous system.
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This document discusses histamine and antihistamines. It covers the topics of histamine synthesis, storage, release and receptors. Histamine causes vasodilation, increased permeability and smooth muscle contraction through H1 receptors. Antihistamines such as fexofenadine and loratadine are second generation drugs that selectively block H1 receptors without crossing the blood brain barrier, thereby reducing sedation. H2 receptor antagonists such as cimetidine and ranitidine are used to suppress gastric acid secretion by blocking histamine and other stimuli at the parietal cell.
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The document summarizes the key aspects of the endocrine system. It discusses the two main control systems - the nervous system and the endocrine system. It then focuses on the endocrine system, describing the endocrine glands and hormones. The mechanisms of hormone action and classifications of hormones are explained. Finally, it provides overviews of specific endocrine glands including the pituitary gland, thyroid gland, parathyroid glands, and adrenal glands.
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The document summarizes key aspects of the endocrine system. It describes the major endocrine glands including the adrenal gland, pancreas, thyroid gland, parathyroid glands, pineal gland, thymus gland, testes and ovaries. It also discusses the hormones produced by each gland and their functions in regulating processes like stress response, metabolism, growth, and reproduction. Additionally, it provides a brief comparison of the endocrine and nervous systems, noting examples of neuroendocrine organs that have aspects of both systems.
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Histamine is an endogenous substance that is amine synthesized, stored and released by the various cells of the body: (a) Mast cells, which are abundant in the skin, GI, and the respiratory tract,
(b) Basophils in the blood, and (c) Some neurons in the CNS and peripheral NS.
It is an “Autocoid” that is secreted locally and regulate the activity of various near lying cells and neurons.
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This document discusses histamine, antihistamines, and their mechanisms of action. It provides details on histamine biosynthesis, storage, release, receptors, and pharmacological actions. It describes the classification and effects of first and second generation antihistamines. The therapeutic uses of H1 and H2 receptor antagonists for allergic disorders, pruritus, cough, and more are outlined. Pharmacokinetics including absorption, distribution, metabolism, and excretion of antihistamines are covered. Finally, the document reviews the adverse effects of antihistamines such as sedation, dry mouth, and fatigue.
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The document summarizes the hypothalamic control of the pituitary gland and the hormones produced by its anterior and posterior lobes. The posterior lobe produces ADH and oxytocin, which regulate water balance and labor, respectively. The anterior lobe produces GH, PRL, ACTH, MSH, TSH, LH, FSH, and beta-LPH, which regulate growth, lactation, skin pigmentation, and reproduction. The hypothalamus controls pituitary function through releasing and inhibiting hormones.
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This document discusses autacoids and histamine and antihistamines. It defines autacoids as locally acting substances produced by cells that have intense biological activity. Histamine is described as an autacoid mediator that is widely distributed and involved in allergic reactions. The document outlines the synthesis, release, mechanisms of action, effects and clinical uses of histamine. It also discusses antihistamines, describing first and second-generation H1 receptor antagonists, their mechanisms of action, uses in allergies and motion sickness, and potential adverse effects.
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A furuncle is a skin infection of a single hair follicle, usually caused by Staphylococcus aureus. It presents as a red, painful nodule with a central punctum that can become fluctuant with pus. Risk factors include diabetes, HIV/AIDS, steroid use, and other immunosuppressive conditions. Treatment involves incision and drainage to remove pus, followed by antibiotics such as flucloxacillin or erythromycin. Without treatment, furuncles may burst and drain spontaneously, healing slowly with scarring.
Behavioral Science.ppt
This document provides an overview of sociology and anthropology concepts for a healthcare module. It defines sociology as the scientific study of human social life, social change, and the social causes and consequences of human behavior. Anthropology is defined as the study of human societies and cultures, both past and present. Key figures in the development of sociology are discussed, including Auguste Comte, Karl Marx, Max Weber, and Emile Durkheim. Core concepts covered include socialization, social norms, roles, values, and social stratification. The importance and various applications of sociology within the healthcare sector are also outlined.
INTRODUCTION TO IMCNI. updated.pptx
This document provides an introduction to the Integrated Management of Childhood Illness (IMCNI) strategy. The objectives of IMCNI case management are to improve quality of care for children under five and reduce childhood mortality. IMCNI takes an integrated approach by addressing the overlapping signs and symptoms of multiple diseases threatening child health, including pneumonia, diarrhea, measles, malaria, malnutrition and HIV/AIDS. The strategy combines treatment and prevention of major childhood illnesses with aspects of nutrition, immunization and important community practices to improve child growth, development and survival.
2. Assess & Classify age 2 months upto 5 yrs.pptx
The main modes of transmission of diarrhoea include:
- Water contamination: Drinking water contaminated with human or animal feces which contain disease-causing organisms. This occurs when water sources are located near latrines or open defecation areas.
- Food contamination: Eating food contaminated during preparation or storage with human or animal feces which contain disease-causing organisms. This can occur if food handlers do not wash hands properly after defecating.
- Person-to-person: Spread of disease-causing organisms from the stool of an infected person through hands to the mouth of another person. This occurs due to lack of proper handwashing, especially after defecating and before handling food or eating
CHEST INJURY GROUP FOUR.pptx
The document discusses pneumothorax and its management. It defines pneumothorax as the presence of air in the pleural cavity, causing partial or full lung collapse. It describes the classification, causes, clinical presentation and investigations of pneumothorax. Needle decompression or chest drain insertion are the initial management steps, while VATS or open thoracostomy may be needed for persistent or traumatic cases. Complications can include respiratory failure, cardiac arrest or hemopneumothorax.
CHEST CONDITION-DCM 2021.pptx
1. Airway obstruction occurs when air cannot freely flow in or out of the lungs due to a partial or complete blockage. It is a common cause of emergency department visits and is often caused by inflammation, infection, trauma, or foreign bodies like food.
2. Airway obstruction can occur in the upper or lower airways and can be partial or complete, acute or chronic. Common causes include inhaled objects, tumors, injuries, infections, and certain medical conditions.
3. Symptoms include choking, difficulty breathing, coughing, wheezing, and cyanosis. Diagnosis involves imaging tests like chest x-rays and bronchoscopy. Management depends on the severity and cause but may include removing ob
HYPERTENSION.pptx
Beyond mountains there are mountains (Haitian Proverb)
The document discusses guidelines for diagnosing and treating hypertension from the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7). It outlines classifications for normal blood pressure and stages of hypertension based on systolic and diastolic readings. It also provides recommendations on lifestyle modifications, drug therapies, treatment goals, and monitoring for hypertensive patients.
Behavioral Science (2).ppt
Sociology and anthropology are behavioral sciences concerned with the study of human social life and culture. Sociology involves the scientific study of social patterns, institutions, and changes within societies, while anthropology primarily focuses on the classification and analysis of humans and their societies from cultural, historical, and physical perspectives. The document provides background on influential thinkers in sociology like Auguste Comte, Karl Marx, Max Weber, and Emile Durkheim. It also defines key concepts in sociology and anthropology and discusses how knowledge of these disciplines can be applied in healthcare settings.
PEDIATRIC HISTORY.ppt
The document provides guidance on taking a pediatric history, including focusing the history on the chief complaint, birth and medical history, developmental milestones, vaccinations, family history, and social factors. It also outlines the approach to performing a physical examination of children, with tips on techniques for different age groups and examining individual body systems in a sensitive manner. The goal is to obtain relevant information to identify health issues while maintaining the comfort, safety and dignity of pediatric patients.
Surface anatomy areas.pptx
The document describes several anatomical spaces and structures. It begins by describing the axilla region, including its borders and contents such as nerves, vessels and lymph nodes. It then discusses the cubital fossa and its clinical relevance for measuring blood pressure and performing venepuncture. Finally, it examines the carpal tunnel and its importance in carpal tunnel syndrome, as well as the anatomical snuffbox and its relationship to scaphoid fractures.
CVS lssn 2.pptx
Cardiac failure, also known as heart failure, results from any structural or functional disorder that impairs the heart's ability to fill with or eject blood. The causes include pump failure, pressure overload, volume overload, and multifactorial causes. The main types are left ventricular failure, right ventricular failure, and chronic heart failure. Signs and symptoms include dyspnea, orthopnea, edema, and fatigue. Diagnosis involves physical exam, chest x-ray, electrocardiogram, and echocardiogram.
antihistamine presentation-khall.ppt
Antihistamines are drugs that reduce or eliminate the effects of histamine, which is released during allergic reactions. There are several classes of antihistamines including first generation, second generation, and third generation. First generation antihistamines are effective but cause more side effects like sedation due to their ability to cross the blood brain barrier. Newer generations have been developed with greater selectivity for peripheral histamine receptors, resulting in fewer side effects. Research continues on developing more selective antihistamines and exploring the anti-inflammatory properties and potential for new treatments.
Lecture 4(0).pdf
This document provides an overview of the peripheral nervous system, with a focus on receptors, sensation, pain, vision, and hearing. It discusses:
1) The divisions of the peripheral nervous system into afferent (sensory) and efferent (motor) divisions. The afferent division includes somatic sensation, proprioception, and the special senses.
2) Receptor physiology, including the types of receptors, transduction of stimuli into electrical signals, adaptation, and generation of receptor or action potentials.
3) Characteristics of pain, including nociceptors and pain neurotransmitters.
4) Anatomy and physiology of the eye, including accommodation, the retina, photore
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官方认证美国旧金山州立大学毕业证学位证书案例原版一模一样
原版一模一样【微信：741003700 】【美国旧金山州立大学毕业证学位证书】【微信：741003700 】学位证，留信认证（真实可查，永久存档）offer、雅思、外壳等材料/诚信可靠,可直接看成品样本，帮您解决无法毕业带来的各种难题！外壳，原版制作，诚信可靠，可直接看成品样本。行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备。十五年致力于帮助留学生解决难题，包您满意。
本公司拥有海外各大学样板无数，能完美还原海外各大学 Bachelor Diploma degree, Master Degree Diploma
1:1完美还原海外各大学毕业材料上的工艺：水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠。文字图案浮雕、激光镭射、紫外荧光、温感、复印防伪等防伪工艺。材料咨询办理、认证咨询办理请加学历顾问Q/微741003700
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
All Of My Java Codes With A Sample Output.docx
Contains All of the Java Programs from Beginning to the Advanced Concepts that I had Practiced While Learning Java
一比一原版美国西北大学毕业证(NWU毕业证书)学历如何办理
原版办理【微信号:BYZS866】【美国西北大学毕业证(NWU毕业证书)】【微信号:BYZS866】《成绩单、外壳、雅思、offer、真实留信官方学历认证（永久存档/真实可查）》采用学校原版纸张、特殊工艺完全按照原版一比一制作（包括：隐形水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠，文字图案浮雕，激光镭射，紫外荧光，温感，复印防伪）行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备，十五年致力于帮助留学生解决难题，业务范围有加拿大、英国、澳洲、韩国、美国、新加坡，新西兰等学历材料，包您满意。
【我们承诺采用的是学校原版纸张（纸质、底色、纹路）我们拥有全套进口原装设备，特殊工艺都是采用不同机器制作，仿真度基本可以达到100%，所有工艺效果都可提前给客户展示，不满意可以根据客户要求进行调整，直到满意为止！】
【业务选择办理准则】
一、工作未确定，回国需先给父母、亲戚朋友看下文凭的情况，办理一份就读学校的毕业证【微信号BYZS866】文凭即可
二、回国进私企、外企、自己做生意的情况，这些单位是不查询毕业证真伪的，而且国内没有渠道去查询国外文凭的真假，也不需要提供真实教育部认证。鉴于此，办理一份毕业证【微信号BYZS866】即可
三、进国企，银行，事业单位，考公务员等等，这些单位是必需要提供真实教育部认证的，办理教育部认证所需资料众多且烦琐，所有材料您都必须提供原件，我们凭借丰富的经验，快捷的绿色通道帮您快速整合材料，让您少走弯路。
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
留信网服务项目：
1、留学生专业人才库服务（留信分析）
2、国（境）学习人员提供就业推荐信服务
3、留学人员区块链存储服务
【关于价格问题（保证一手价格）】
我们所定的价格是非常合理的，而且我们现在做得单子大多数都是代理和回头客户介绍的所以一般现在有新的单子 我给客户的都是第一手的代理价格，因为我想坦诚对待大家 不想跟大家在价格方面浪费时间
对于老客户或者被老客户介绍过来的朋友，我们都会适当给一些优惠。
选择实体注册公司办理，更放心，更安全！我们的承诺：客户在留信官方认证查询网站查询到认证通过结果后付款，不成功不收费！
按照学校原版(UofT文凭证书)多伦多大学毕业证快速办理
快速办理【(UofT毕业证书)多伦多大学毕业证】【176555708微信号】硕士毕业证成绩单、外壳、offer、留信学历认证（永久存档真实可查）采用学校原版纸张、特殊工艺完全按照原版一比一制作（包括：隐形水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠，文字图案浮雕，激光镭射，紫外荧光，温感，复印防伪）行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备，十五年致力于帮助留学生解决难题，业务范围有加拿大、英国、澳洲、韩国、美国、新加坡，新西兰等学历材料，包您满意。
【我们承诺采用的是学校原版纸张（纸质、底色、纹路），我们拥有全套进口原装设备，特殊工艺都是采用不同机器制作，仿真度基本可以达到100%，所有工艺效果都可提前给客户展示，不满意可以根据客户要求进行调整，直到满意为止！】
【业务选择办理准则】
一、工作未确定，回国需先给父母、亲戚朋友看下文凭的情况，办理一份就读学校的毕业证【微信176555708】文凭即可
二、回国进私企、外企、自己做生意的情况，这些单位是不查询毕业证真伪的，而且国内没有渠道去查询国外文凭的真假，也不需要提供真实教育部认证。鉴于此，办理一份毕业证【微信176555708】即可
三、进国企，银行，事业单位，考公务员等等，这些单位是必需要提供真实教育部认证的，办理教育部认证所需资料众多且烦琐，所有材料您都必须提供原件，我们凭借丰富的经验，快捷的绿色通道帮您快速整合材料，让您少走弯路。
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
留信网服务项目：
1、留学生专业人才库服务（留信分析）
2、国（境）学习人员提供就业推荐信服务
3、留学人员区块链存储服务
→ 【关于价格问题（保证一手价格）】
我们所定的价格是非常合理的，而且我们现在做得单子大多数都是代理和回头客户介绍的所以一般现在有新的单子 我给客户的都是第一手的代理价格，因为我想坦诚对待大家 不想跟大家在价格方面浪费时间
对于老客户或者被老客户介绍过来的朋友，我们都会适当给一些优惠。
选择实体注册公司办理，更放心，更安全！我们的承诺：客户在留信官方认证查询网站查询到认证通过结果后付款，不成功不收费！
Community Skills Building Workshop | PMI Silver Spring Chapter | June 12, 2024
Community Skills Building Workshop | PMI Silver Spring Chapter | June 12, 2024Hector Del Castillo, CPM, CPMM
We recently hosted the much-anticipated Community Skill Builders Workshop during our June online meeting. This event was a culmination of six months of listening to your feedback and crafting solutions to better support your PMI journey. Here’s a look back at what happened and the exciting developments that emerged from our collaborative efforts.
A Gathering of Minds
We were thrilled to see a diverse group of attendees, including local certified PMI trainers and both new and experienced members eager to contribute their perspectives. The workshop was structured into three dynamic discussion sessions, each led by our dedicated membership advocates.
Key Takeaways and Future Directions
The insights and feedback gathered from these discussions were invaluable. Here are some of the key takeaways and the steps we are taking to address them:
• Enhanced Resource Accessibility: We are working on a new, user-friendly resource page that will make it easier for members to access training materials and real-world application guides.
• Structured Mentorship Program: Plans are underway to launch a mentorship program that will connect members with experienced professionals for guidance and support.
• Increased Networking Opportunities: Expect to see more frequent and varied networking events, both virtual and in-person, to help you build connections and foster a sense of community.
Moving Forward
We are committed to turning your feedback into actionable solutions that enhance your PMI journey. This workshop was just the beginning. By actively participating and sharing your experiences, you have helped shape the future of our Chapter’s offerings.
Thank you to everyone who attended and contributed to the success of the Community Skill Builders Workshop. Your engagement and enthusiasm are what make our Chapter strong and vibrant. Stay tuned for updates on the new initiatives and opportunities to get involved. Together, we are building a community that supports and empowers each other on our PMI journeys.
Stay connected, stay engaged, and let’s continue to grow together!
About PMI Silver Spring Chapter
We are a branch of the Project Management Institute. We offer a platform for project management professionals in Silver Spring, MD, and the DC/Baltimore metro area. Monthly meetings facilitate networking, knowledge sharing, and professional development. For more, visit pmissc.org.A Guide to a Winning Interview June 2024
This webinar is an in-depth review of the interview process. Preparation is a key element to acing an interview. Learn the best approaches from the initial phone screen to the face-to-face meeting with the hiring manager. You will hear great answers to several standard questions, including the dreaded “Tell Me About Yourself”.
Gabrielle M. A. Sinaga Portfolio, Film Student (2024)
My portfolio as a highly motivated film student pursuing a career in Yogyakarta.
How to overcome obstacles in the way of success.pdf
Success is often not achievable without facing and overcoming obstacles along the way. To reach our goals and achieve success, it is important to understand and resolve the obstacles that come in our way.
In this article, we will discuss the various obstacles that hinder success, strategies to overcome them, and examples of individuals who have successfully surmounted their obstacles.
在线制作加拿大萨省大学毕业证文凭证书实拍图原版一模一样
原版一模一样【微信：741003700 】【加拿大萨省大学毕业证文凭证书】【微信：741003700 】学位证，留信认证（真实可查，永久存档）offer、雅思、外壳等材料/诚信可靠,可直接看成品样本，帮您解决无法毕业带来的各种难题！外壳，原版制作，诚信可靠，可直接看成品样本。行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备。十五年致力于帮助留学生解决难题，包您满意。
本公司拥有海外各大学样板无数，能完美还原海外各大学 Bachelor Diploma degree, Master Degree Diploma
1:1完美还原海外各大学毕业材料上的工艺：水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠。文字图案浮雕、激光镭射、紫外荧光、温感、复印防伪等防伪工艺。材料咨询办理、认证咨询办理请加学历顾问Q/微741003700
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
按照学校原版(ArtEZ文凭证书)ArtEZ艺术学院毕业证快速办理
官方原版办理【(ArtEZ毕业证书)ArtEZ艺术学院毕业证】【176555708微信号】海外认证成绩单、外壳、offer、留信学历认证（永久存档真实可查）采用学校原版纸张、特殊工艺完全按照原版一比一制作（包括：隐形水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠，文字图案浮雕，激光镭射，紫外荧光，温感，复印防伪）行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备，十五年致力于帮助留学生解决难题，业务范围有加拿大、英国、澳洲、韩国、美国、新加坡，新西兰等学历材料，包您满意。
【我们承诺采用的是学校原版纸张（纸质、底色、纹路），我们拥有全套进口原装设备，特殊工艺都是采用不同机器制作，仿真度基本可以达到100%，所有工艺效果都可提前给客户展示，不满意可以根据客户要求进行调整，直到满意为止！】
【业务选择办理准则】
一、工作未确定，回国需先给父母、亲戚朋友看下文凭的情况，办理一份就读学校的毕业证【微信176555708】文凭即可
二、回国进私企、外企、自己做生意的情况，这些单位是不查询毕业证真伪的，而且国内没有渠道去查询国外文凭的真假，也不需要提供真实教育部认证。鉴于此，办理一份毕业证【微信176555708】即可
三、进国企，银行，事业单位，考公务员等等，这些单位是必需要提供真实教育部认证的，办理教育部认证所需资料众多且烦琐，所有材料您都必须提供原件，我们凭借丰富的经验，快捷的绿色通道帮您快速整合材料，让您少走弯路。
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
留信网服务项目：
1、留学生专业人才库服务（留信分析）
2、国（境）学习人员提供就业推荐信服务
3、留学人员区块链存储服务
→ 【关于价格问题（保证一手价格）】
我们所定的价格是非常合理的，而且我们现在做得单子大多数都是代理和回头客户介绍的所以一般现在有新的单子 我给客户的都是第一手的代理价格，因为我想坦诚对待大家 不想跟大家在价格方面浪费时间
对于老客户或者被老客户介绍过来的朋友，我们都会适当给一些优惠。
选择实体注册公司办理，更放心，更安全！我们的承诺：客户在留信官方认证查询网站查询到认证通过结果后付款，不成功不收费！
一比一原版(EUR毕业证)鹿特丹伊拉斯姆斯大学毕业证如何办理
原件一模一样【微信：95270640】【鹿特丹伊拉斯姆斯大学毕业证EUR学位证成绩单】【微信：95270640】（留信学历认证永久存档查询）采用学校原版纸张、特殊工艺完全按照原版一比一制作（包括：隐形水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠，文字图案浮雕，激光镭射，紫外荧光，温感，复印防伪）行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备，十五年致力于帮助留学生解决难题，业务范围有加拿大、英国、澳洲、韩国、美国、新加坡，新西兰等学历材料，包您满意。
【业务选择办理准则】
一、工作未确定，回国需先给父母、亲戚朋友看下文凭的情况，办理一份就读学校的毕业证【微信：95270640】文凭即可
二、回国进私企、外企、自己做生意的情况，这些单位是不查询毕业证真伪的，而且国内没有渠道去查询国外文凭的真假，也不需要提供真实教育部认证。鉴于此，办理一份毕业证【微信：95270640】即可
三、进国企，银行，事业单位，考公务员等等，这些单位是必需要提供真实教育部认证的，办理教育部认证所需资料众多且烦琐，所有材料您都必须提供原件，我们凭借丰富的经验，快捷的绿色通道帮您快速整合材料，让您少走弯路。
留信网认证的作用:
1:该专业认证可证明留学生真实身份【微信：95270640】
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
→ 【关于价格问题（保证一手价格）
我们所定的价格是非常合理的，而且我们现在做得单子大多数都是代理和回头客户介绍的所以一般现在有新的单子 我给客户的都是第一手的代理价格，因为我想坦诚对待大家 不想跟大家在价格方面浪费时间
对于老客户或者被老客户介绍过来的朋友，我们都会适当给一些优惠。
选择实体注册公司办理，更放心，更安全！我们的承诺：可来公司面谈，可签订合同，会陪同客户一起到教育部认证窗口递交认证材料，客户在教育部官方认证查询网站查询到认证通过结果后付款，不成功不收费！
办理鹿特丹伊拉斯姆斯大学毕业证毕业证offerEUR学位证【微信：95270640 】外观非常精致，由特殊纸质材料制成，上面印有校徽、校名、毕业生姓名、专业等信息。
办理鹿特丹伊拉斯姆斯大学毕业证EUR学位证毕业证offer【微信：95270640 】格式相对统一，各专业都有相应的模板。通常包括以下部分：
校徽：象征着学校的荣誉和传承。
校名:学校英文全称
授予学位：本部分将注明获得的具体学位名称。
毕业生姓名：这是最重要的信息之一，标志着该证书是由特定人员获得的。
颁发日期：这是毕业正式生效的时间，也代表着毕业生学业的结束。
其他信息：根据不同的专业和学位，可能会有一些特定的信息或章节。
办理鹿特丹伊拉斯姆斯大学毕业证毕业证offerEUR学位证【微信：95270640 】价值很高，需要妥善保管。一般来说，应放置在安全、干燥、防潮的地方，避免长时间暴露在阳光下。如需使用，最好使用复印件而不是原件，以免丢失。
综上所述，办理鹿特丹伊拉斯姆斯大学毕业证毕业证offerEUR学位证【微信：95270640 】是证明身份和学历的高价值文件。外观简单庄重，格式统一，包括重要的个人信息和发布日期。对持有人来说，妥善保管是非常重要的。
体育博彩论坛-十大体育博彩论坛-体育博彩论坛|【网址🎉ac55.net🎉】
在体育博彩论坛，你会发现数之不尽的在线博彩机会，包括世界各地的精彩体育赛事以及绝佳的赔率。此外，体育博彩论坛还会为你提供诸如赌场、宾果和扑克等在线游戏以及各种各样的奖金优惠，包括体育博彩论坛的免费投注。无论你是忠实的足球迷，或者是二十一点的专业玩家，在这里都可以找到你最感兴趣的投注市场或游戏。
在线办理(UOIT毕业证书)安大略省理工大学毕业证在读证明一模一样
原件一模一样【微信：bwp0011】《(UOIT毕业证书)安大略省理工大学毕业证》【微信：bwp0011】学位证，留信认证（真实可查，永久存档）原件一模一样纸张工艺/offer、雅思、外壳等材料/诚信可靠,可直接看成品样本，帮您解决无法毕业带来的各种难题！外壳，原版制作，诚信可靠，可直接看成品样本。行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备。十五年致力于帮助留学生解决难题，包您满意。
本公司拥有海外各大学样板无数，能完美还原。
1:1完美还原海外各大学毕业材料上的工艺：水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠。文字图案浮雕、激光镭射、紫外荧光、温感、复印防伪等防伪工艺。材料咨询办理、认证咨询办理请加学历顾问微bwp0011
【主营项目】
一.毕业证【微bwp0011】成绩单、使馆认证、教育部认证、雅思托福成绩单、学生卡等！
二.真实使馆公证(即留学回国人员证明,不成功不收费)
三.真实教育部学历学位认证（教育部存档！教育部留服网站永久可查）
四.办理各国各大学文凭(一对一专业服务,可全程监控跟踪进度)
如果您处于以下几种情况：
◇在校期间，因各种原因未能顺利毕业……拿不到官方毕业证【微bwp0011】
◇面对父母的压力，希望尽快拿到；
◇不清楚认证流程以及材料该如何准备；
◇回国时间很长，忘记办理；
◇回国马上就要找工作，办给用人单位看；
◇企事业单位必须要求办理的
◇需要报考公务员、购买免税车、落转户口
◇申请留学生创业基金
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
一比一原版(surrey毕业证书)英国萨里大学毕业证成绩单修改如何办理
原版定制【微信:741003700】《(surrey毕业证书)英国萨里大学毕业证学位证成绩单》【微信:741003700】成绩单 、雅思、外壳、留信学历认证永久存档查询，采用学校原版纸张、特殊工艺完全按照原版一比一制作（包括：隐形水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠，文字图案浮雕，激光镭射，紫外荧光，温感，复印防伪）行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备，十五年致力于帮助留学生解决难题，业务范围有加拿大、英国、澳洲、韩国、美国、新加坡，新西兰等学历材料，包您满意。
【业务选择办理准则】
一、工作未确定，回国需先给父母、亲戚朋友看下文凭的情况，办理一份毕业证【Q微信741003700】文凭即可
二、回国进私企、外企、自己做生意的情况，这些单位是不查询毕业证真伪的，而且国内没有渠道去查询国外文凭的真假，也不需要提供真实教育部认证。鉴于此，办理一份毕业证【Q微信741003700】即可
三、进国企，银行，事业单位，考公务员等等，这些单位是必需要提供真实教育部认证的，办理教育部认证所需资料众多且烦琐，所有材料您都必须提供原件，我们凭借丰富的经验，快捷的绿色通道帮您快速整合材料，让您少走弯路。
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
【关于价格问题（保证一手价格）】
我们所定的价格是非常合理的，而且我们现在做得单子大多数都是代理和回头客户介绍的所以一般现在有新的单子 我给客户的都是第一手的代理价格，因为我想坦诚对待大家 不想跟大家在价格方面浪费时间
对于老客户或者被老客户介绍过来的朋友，我们都会适当给一些优惠。
一比一原版布拉德福德大学毕业证（bradford毕业证）如何办理
一模一样【微信：A575476】【布拉德福德大学毕业证（bradford毕业证）成绩单Offer】【微信：A575476】（留信学历认证永久存档查询）采用学校原版纸张、特殊工艺完全按照原版一比一制作（包括：隐形水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠，文字图案浮雕，激光镭射，紫外荧光，温感，复印防伪）行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备，十五年致力于帮助留学生解决难题，业务范围有加拿大、英国、澳洲、韩国、美国、新加坡，新西兰等学历材料，包您满意。
【业务选择办理准则】
一、工作未确定，回国需先给父母、亲戚朋友看下文凭的情况，办理一份就读学校的毕业证【微信：A575476】文凭即可
二、回国进私企、外企、自己做生意的情况，这些单位是不查询毕业证真伪的，而且国内没有渠道去查询国外文凭的真假，也不需要提供真实教育部认证。鉴于此，办理一份毕业证【微信：A575476】即可
三、进国企，银行，事业单位，考公务员等等，这些单位是必需要提供真实教育部认证的，办理教育部认证所需资料众多且烦琐，所有材料您都必须提供原件，我们凭借丰富的经验，快捷的绿色通道帮您快速整合材料，让您少走弯路。
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
→ 【关于价格问题（保证一手价格）
我们所定的价格是非常合理的，而且我们现在做得单子大多数都是代理和回头客户介绍的所以一般现在有新的单子 我给客户的都是第一手的代理价格，因为我想坦诚对待大家 不想跟大家在价格方面浪费时间
对于老客户或者被老客户介绍过来的朋友，我们都会适当给一些优惠。
选择实体注册公司办理，更放心，更安全！我们的承诺：可来公司面谈，可签订合同，会陪同客户一起到教育部认证窗口递交认证材料，客户在教育部官方认证查询网站查询到认证通过结果后付款，不成功不收费！
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Are you interested to know what actions help in a job search? This webinar is the summary of several individuals who discussed their job search journey for others to follow. You will learn there are common actions that helped them succeed in their quest for gainful employment.
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AUTACOIDS.pdf
- 2. DEFINITION An organic substance, such as a hormone, produced in one part of organism and transported by the blood or lymph to another part of the organism where it exerts a physiologic effect on that part.
- 3. TYPES OF AUTACOIDS: ´ Amines : Histamine,5-Hydroxytryptamine. ´ Lipids : Prostaglandins, Leukotriens, ´ Platelet activating factor. ´ Peptide : Bradykinin , angiotensin.
- 4. HISTAMINE ´ SYNTHESIS AND DEGRADATION OF HISTAMINE Histidine decarboxylase Histamine Imadazole acetic acid N-methyl transferase N-methyl histamine oxidase Methyl imidazole acetic acid
- 5. PHARMACOLOGY H1 H2 H3 S.M - contraction Gastric gland-acid secretions Brain- inhibition of histamine release- sedation B.V – vaso dilation B.V-dilation B.V - vaso dilatation Afferent nerve ending - stimulation Heart-postive inotropy Skin , gastric, mucosa- decrease histamine release Ganglionic cell- stimulation Uterus - relaxation Lungs , spleen – decrease histamine release Adrenal medulla-release of CAs Brain - transmitte
- 6. CLASSIFICATION H1 H2 H3 SELECTIVE AGONISTS 2- methylhistamine,2- pyridylethylamine,2- thiazolyl ethylamine 4-methy histamine, Dimaprit, impromidine ἀ-methyl histamine SELECTIVE ANTAGONISTS Mepyramine, chlorpheniramine Cimetidine, ranitidine Thioperamide, impromidine RECEPTOR TYPE G-Protein coupled G-P G-P EFFECTOR PATHWAY IP3/DAG Ca+ release C-AMP inc Ca+ infulx ,K+ channel activation, cAMP dec
- 7. THERAPEUTIC INDICATION ´ Common cold ´ Motion sickess ´ Duodenal ulcer(Zollinger - ellision syndrome) ´ Parkinsonism ´ Allergic disorders ´ Sedative and hypnotic , Anxiolytic ADR: CNS depression, fatigue, gynecomastia in men, galactorrhea women.
- 8. SEROTONIN ´ Sertonin (vasoconstrictor) appeared serum . SYNTHESIS TRYPTOPHAN hydroxylase 5-Hydroxytryptophan decarboxylase 5-HT (MAO) 5-Hydroxy indole acetic acid dehydrogenase 5-Hydroxy tryptohol
- 9. TYPES RECEPTOR LOCATION MAIN EFFECTS SECOND MESSENGER AGONISTS ANTAGONIST S 1A CNS Neuronal inhibition, Behavioural effects cAMP 5-CT 8-OH-DPAT Buspirone Spiperone, Methiothepin, Ergotamine 1B CNS VASCULAR- S.M Pulmonary vasoconstrion cAMP 5-CT Ergotamine Methiothepin 1D CNS B.V Cerebral vaso constriction, locomotion cAMP 5-CT Sumatriptan Methiothepin Ergotamine 2A CNS PNS S.M PLATELETS s.m contraction IP3/DAG ἀ-Me-5-HT LSD(CNS) LSD(Peripher y) KETANSERIN, cyproheptadi ne 2B GASTRIC FUNDUS contraction IP3/DAG ἀ-Me-5-HT - 2C CNS Cerebrospinal IP3/DAG ἀ-Me-5-HT Methysergide
- 10. RECEPTOR LOCATION MAIN EFFECTS SECOND MESSENGE R AGONISTS ANTAGONI STS 5-HT3 PNS CNS Neuronal excitation, emesis ligand-gated cation channel 2-Me-5-HT, Chlorophenyl biguanide Ondansetr on,tropiset ron 5-HT4 PNS CNS Gi motility cAMP 5-methoxy- tryptamine, metochlopromide Various exp.comp 5-HT5 CNS Not known Not known Not known Not known 5-HT6 CNS Not known Not known Not known Not known 5-HT7 CNS, GI TRACT, B.V Not known cAMP 5-CT,LSD Various 5- HT2
- 11. PHARMACOLOGY ´ CVS : Arteries are constricted as well as dilated by direct action of 5-HT. ´ S.M : Stimualtor of GIT. ´ GLANDS : It inhibits gastric secretion. It ulcer protective property. ´ RESPIRATION: Hyperventilation ´ PLATELETS : 5-HT cause change in shape of platelets and is a weak aggregator.
- 12. THERAPEUTIC USES ´ 5-HT AGONISTS : Anxiolytics ( Buspirone), Depression( Fluoxetine) Migraine(Ergot alkaloids) ´ 5-HT ANTAGONISTS: Nausea, emesis, antineoplastic therapy (Ondansetron, Granisetron, Dolasetron) ADR: Abdominal pain, Muscle cramps, Chest pain.
- 14. PHARMACOLOGICAL ACTIONS ORGAN PGE2 PGF2ἀ PGI2 TXA2 B.V Vaso dilatation Vaso dilatation Vaso dilatation Vaso constriction HEART Weak inotropic, cardiac stimulation Weak inotropic _ _ PLATELETS Variable effect _ Anti aggregatory aggregation UTERUS contraction contraction _ _ BRONCHI Dilatation, inhibits histamine constriction Dilatation, inhibits histamine constriction STOMACH Acid secretion(dec), Mucous production(inc) _ Acid secretion(dec), Mucous production(inc) _ INTESTINE Contracts spasmogenic Weak Weak
- 15. THERAPEUTIC USES ™ PGE1 : CHF (Alprostadil) NSAID-induced GI ulcer (misoprostol) ™ PGF2ἀ : Topically to lower intraocular pressure in glaucoma. ™ PGI : pulmonary hypertension.(Flolan) ADR : Diarrhea , Hypotension, Flushing, Cardiac Arrest , Anemia, Menstrual irregularities , Abortion Decreased renal function.
- 16. LEUKOTRIENES ´ PHARMACOLOGY : ´ CNS : fall in B.P ´ S.M : Bronchoconstrictors and spastic contraction of GIT at low concentration ´ AFFERENT : Carrying pain impulses and tenderness to inflammation.
- 17. THERPEUTIC USES ´ TREATMENT OF ASTHMA (Zileuton) ´ Reduced bronchospasm ´ ADR : ´ GI upset , ´ liver dysfunction