Serotonin is synthesized from tryptophan and is found in high concentrations in the gastrointestinal tract, blood platelets, and central nervous system. It functions as both a neurotransmitter and hormone. Serotonin mediates a variety of effects through multiple receptor subtypes, including smooth muscle contraction, vasoconstriction, platelet aggregation, gastrointestinal motility, mood, appetite, and sleep. Dysregulation of serotonin signaling has been implicated in conditions like migraine, depression, anxiety, and carcinoid syndrome, a tumor that secretes excess serotonin. A number of drugs target specific serotonin receptors to treat associated symptoms.
Introduction to the endocrine system
Growth hormone: Mechanism of Action, secretion, regulation.
Prolactin
Sex hormones
Oral contraceptives
Corticosteroids
This document describes an experiment to estimate the unknown concentration of an acetylcholine solution using a bracketing bioassay with hen's ileum tissue. The experiment involves determining the dose-response curve for a standard acetylcholine solution and then bracketing responses to the unknown solution with responses to the standard. Close bracketing of the unknown response between two standard responses allows the concentration of the unknown to be accurately calculated using the formula provided. The aim is to present the methodology for using a bracketing bioassay to estimate an unknown drug concentration.
Autacoids - pharmacological actions and drugs related to them. SIVASWAROOP YARASI
Autacoids or "autocoids" are biological factors which act like local hormones, have a brief duration, and act near the site of synthesis. The word autacoids comes from the Greek "autos" (self) and "acos" (relief, i.e. drug).
Serotonin is a monoamine neurotransmitter synthesized from tryptophan. It is found extensively in the gastrointestinal tract and in serotonergic neurons in the central nervous system. Serotonin receptors include 5-HT1-7 and are involved in various physiological functions like mood, appetite, sleep, and pain perception. Imbalances in the serotonergic system are associated with disorders like depression, anxiety, schizophrenia, and impulse control disorders. Drugs that affect the serotonergic system include SSRIs, SNRIs, triptans, 5-HT3 antagonists, buspirone, and MAOIs.
Opioids are psychoactive chemicals that bind to opioid receptors in the central nervous system, peripheral nervous system, and gastrointestinal tract. Opioid receptors are classified into μ, κ, and δ types. Opioids can function as agonists, partial agonists, or antagonists at these receptors. Opioids are classified based on their origin, such as natural, semisynthetic, or synthetic, and based on their strength and function, such as pure agonists, partial agonists, agonist-antagonists, or pure antagonists. The pharmacological actions of opioids include analgesia, respiratory depression, sedation, myosis, and decreased blood pressure through effects on the central nervous system, eyes,
Seretonin (5HT) and Its Antagonists PharmacologyPranatiChavan
Serotonin is a chemical that has a wide variety of functions in the human body. It is sometimes called the happy chemical, because it contributes to wellbeing and happiness.
The scientific name for serotonin is 5-hydroxytryptamine, or 5-HT. It is mainly found in the brain, bowels, and blood platelets.
Serotonin is used to transmit messages between nerve cells, it is thought to be active in constricting smooth muscles, and it contributes to wellbeing and happiness, among other things. As the precursor for melatonin, it helps regulate the body’s sleep-wake cycles and the internal clock.
It is thought to play a role in appetite, the emotions, and motor, cognitive, and autonomic functions. However, it is not known exactly if serotonin affects these directly, or if it has an overall role in co-ordinating the nervous system.
Introduction to Physiological and pathological role of serotonin
Autocoids, Classification, synthesis ,Serotonergic receptors, Physiological actions, Pathophysiological role
Presented by
K.Firdous banu
Department of Pharmacology
Introduction to the endocrine system
Growth hormone: Mechanism of Action, secretion, regulation.
Prolactin
Sex hormones
Oral contraceptives
Corticosteroids
This document describes an experiment to estimate the unknown concentration of an acetylcholine solution using a bracketing bioassay with hen's ileum tissue. The experiment involves determining the dose-response curve for a standard acetylcholine solution and then bracketing responses to the unknown solution with responses to the standard. Close bracketing of the unknown response between two standard responses allows the concentration of the unknown to be accurately calculated using the formula provided. The aim is to present the methodology for using a bracketing bioassay to estimate an unknown drug concentration.
Autacoids - pharmacological actions and drugs related to them. SIVASWAROOP YARASI
Autacoids or "autocoids" are biological factors which act like local hormones, have a brief duration, and act near the site of synthesis. The word autacoids comes from the Greek "autos" (self) and "acos" (relief, i.e. drug).
Serotonin is a monoamine neurotransmitter synthesized from tryptophan. It is found extensively in the gastrointestinal tract and in serotonergic neurons in the central nervous system. Serotonin receptors include 5-HT1-7 and are involved in various physiological functions like mood, appetite, sleep, and pain perception. Imbalances in the serotonergic system are associated with disorders like depression, anxiety, schizophrenia, and impulse control disorders. Drugs that affect the serotonergic system include SSRIs, SNRIs, triptans, 5-HT3 antagonists, buspirone, and MAOIs.
Opioids are psychoactive chemicals that bind to opioid receptors in the central nervous system, peripheral nervous system, and gastrointestinal tract. Opioid receptors are classified into μ, κ, and δ types. Opioids can function as agonists, partial agonists, or antagonists at these receptors. Opioids are classified based on their origin, such as natural, semisynthetic, or synthetic, and based on their strength and function, such as pure agonists, partial agonists, agonist-antagonists, or pure antagonists. The pharmacological actions of opioids include analgesia, respiratory depression, sedation, myosis, and decreased blood pressure through effects on the central nervous system, eyes,
Seretonin (5HT) and Its Antagonists PharmacologyPranatiChavan
Serotonin is a chemical that has a wide variety of functions in the human body. It is sometimes called the happy chemical, because it contributes to wellbeing and happiness.
The scientific name for serotonin is 5-hydroxytryptamine, or 5-HT. It is mainly found in the brain, bowels, and blood platelets.
Serotonin is used to transmit messages between nerve cells, it is thought to be active in constricting smooth muscles, and it contributes to wellbeing and happiness, among other things. As the precursor for melatonin, it helps regulate the body’s sleep-wake cycles and the internal clock.
It is thought to play a role in appetite, the emotions, and motor, cognitive, and autonomic functions. However, it is not known exactly if serotonin affects these directly, or if it has an overall role in co-ordinating the nervous system.
Introduction to Physiological and pathological role of serotonin
Autocoids, Classification, synthesis ,Serotonergic receptors, Physiological actions, Pathophysiological role
Presented by
K.Firdous banu
Department of Pharmacology
Expt. 9 Effect of atropine on DRC of acetylcholine using rat ileumVISHALJADHAV100
Objective
Principle
Requirements
Experimental specifications (conditions)
Preparation of ACh and Atropine stock and std. solutions
Preparation of Tyrode solution (PSS)
Procedure
Kymograph recording of contractions
Observation table
Calculation
Graphical presentation of CRC/ DRC
Result and interpretation
Neurohumoral transmission in CNS-
The term neurohumoral transmission designates the transfer of a nerve impulse from a presynaptic to a postsynaptic neuron by means of a humoral agent e.g. a biogenic amine, an amino acid or a peptide.
Expt. 1 Introduction to in vitro pharmacology and physiological salt solutionsVISHALJADHAV100
This document provides an overview of in-vitro pharmacology experiments using isolated tissues and physiological salt solutions (PSS). It defines pharmacology and drugs, describes the aims of experimental pharmacology as finding therapeutic agents, studying toxicity and mechanisms of action. It also discusses types of experiments, equipment like organ baths and levers for recording tissue responses, and PSS compositions and roles. PSS are artificial solutions that maintain isolated tissues by resembling extracellular fluid composition. Selection of the appropriate PSS depends on the tissue being studied.
The document describes the hot plate test, which is used to assess analgesic (pain-relieving) properties of drugs. It involves placing rodents on a heated surface and measuring the time until they react to the heat. A longer reaction time indicates stronger analgesia. The hot plate test apparatus consists of a temperature-controlled plate, timer, and safety features. It is used to screen analgesic drugs by comparing an animal's reaction time before and after administering a test compound. If the reaction time increases after administration, it suggests the compound has analgesic effects.
This document provides information about autacoids, which are local hormones that include histamine and serotonin. It focuses on histamine, discussing its sources from mast cells and basophils, mechanisms of release, effects on organ systems, and use of antihistamines to treat allergic reactions. Serotonin is also discussed, including its role in mood, appetite, sleep, and vasoconstriction. The document summarizes the different types of serotonin receptors and their functions.
This document summarizes a seminar on sympathomimetic drugs presented by Mohd Fahad and guided by Mohd. Khushtar. It discusses different types of adrenergic drugs including direct, indirect, and mixed acting sympathomimetics. It describes the actions of adrenergic drugs on various organs mediated by alpha and beta receptors. Important drugs are discussed in detail including their uses, doses, preparations, and adverse effects. The document provides an overview of adrenergic pharmacology and the therapeutic uses of sympathomimetic drugs.
Histamine is a biogenic amine present in many animal and plant tissues. It is implicated as a mediator in hypersensitivity and tissue injury reactions. Histamine is present and stored in mast cells, especially in the skin, lungs, and gastrointestinal mucosa. It is synthesized from the amino acid histidine and acts on H1, H2, and H3 receptors to cause various pharmacological effects like vasodilation, increased capillary permeability, smooth muscle contraction, and increased gastric acid secretion. Serotonin is another amine present in enterochromaffin cells of the gastrointestinal tract. It is synthesized from tryptophan and acts on multiple 5-HT receptor subtypes to cause vasoconstriction, intestinal per
This document discusses the uses of corticosteroids in various medical conditions. It begins with an overview of steroid biosynthesis and transport in the blood. It then covers the mechanisms of action including transactivation and transrepression. The rest of the document details the pharmacological actions and specific uses of corticosteroids in conditions like adrenal insufficiency, arthritis, immunosuppression, lung diseases, infections, skin diseases, intestinal diseases, and more.
This document discusses several biochemical mediators involved in inflammation including renin, angiotensins, kinins, prostaglandins, leukotrienes, cytokines, and platelet-activating factor (PAF). It describes where these mediators are synthesized, their receptors, actions on various organ systems, and physiological roles. Key points include that kinins are potent vasodilators, prostaglandins can cause fever by acting on the hypothalamus, leukotrienes recruit immune cells and cause bronchoconstriction, and cytokines coordinate the immune response and cellular functions.
Histamine is an amine autocoid that is synthesized and stored in mast cells and basophils. It is released during allergic reactions and inflammation and acts both locally and systemically via four G protein-coupled receptors, H1-H4. The H1 receptor mediates smooth muscle contraction and increased capillary permeability. The H2 receptor increases gastric acid secretion and relaxes smooth muscles. Histamine plays an important role in allergic reactions, inflammation, gastric acid secretion, and neuronal signaling. It is involved in various physiological and pathological processes.
pA2 determination involves measuring drug antagonism through various methods. Sir Heinz Otto Schild developed the pA2 measure in 1947 to quantify antagonism using the dose ratio and affinity constant. The most common methods to determine pA2 values are Schild's plot, which analyzes log dose ratios against antagonist concentrations, and measuring shifts in dose response curves. Higher pA2 values indicate more specific antagonism on the pA scale. The pA2 value is defined as the negative log of the molar antagonist concentration required to double the agonist dose to produce the same effect.
Expt 11 Effect of drugs on locomotor activity using actophotometerMirza Anwar Baig
This document describes an experiment to evaluate the effects of drugs on locomotor activity using an actophotometer. Rats or mice are injected with either a saline control, the antipsychotic drug chlorpromazine at 3 mg/kg, or caffeine at 3 mg/kg. Their movement is then measured in the actophotometer before and after drug administration. Chlorpromazine is expected to reduce locomotor activity as a CNS depressant, while caffeine may increase it as a CNS stimulant. The results are presented as locomotor activity scores showing that chlorpromazine decreased activity and caffeine increased it, demonstrating their respective CNS effects.
The autonomic nervous system regulates involuntary bodily functions and is divided into the sympathetic and parasympathetic divisions. The sympathetic division is responsible for the "fight or flight" response and increases heart rate and blood pressure. The parasympathetic division acts to slow the heart and aid digestion. Most organs receive dual innervation from both divisions to allow dynamic regulation of functions. Neurotransmission within the autonomic nervous system uses acetylcholine or norepinephrine/epinephrine as neurotransmitters. Postsynaptic responses are mediated through direct ion channel coupling or via second messenger systems to regulate various cellular processes.
1. basics of experimental pharmacologyMBBS IMS MSU
Experimental pharmacology involves studying the effects of pharmacological agents on different animal species. The aims are to identify suitable therapeutic agents for human use, study drug toxicity and mechanisms of action. Common laboratory animals used include mice, rats, guinea pigs and rabbits. Rats are commonly used due to their small size and low drug requirements. Wistar rats are a commonly used strain. Mice are also used for toxicology and drug screening studies due to their small size. Guinea pigs are sensitive to histamine and antibiotics, making them useful for studies in these areas. Rabbits are docile and used for pyrogen testing and studies of drugs affecting capillary permeability. Frogs are commonly used for isolated tissue studies and studies of drugs acting on
This document summarizes 5 major categories of transducer mechanisms:
1) G-protein coupled receptors which activate downstream effectors like adenylyl cyclase or phospholipase C.
2) Ion channel receptors which directly open or close ion channels.
3) Transmembrane enzyme-linked receptors which activate intracellular protein kinases.
4) Transmembrane JAK-STAT binding receptors which activate the JAK/STAT signaling pathway.
5) Receptors regulating gene expression which bind intracellularly to directly regulate gene transcription.
This presentation is about the neurotransmitter 5-HT (serotonin), we focused on its definition, biosynthesis, storage and destruction, with mentioning its both central and peripheral effects, and lastly the serotonin receptors in the human body, as well as their agonist and antagonists.
This document discusses serotonin (5-HT), its receptors, synthesis, actions, roles, and drugs that affect the 5-HT system. Some key points:
- 5-HT is a neurotransmitter found mainly in the intestines, platelets, and brain. It acts on several receptor subtypes to regulate various functions.
- 5-HT receptors include 5-HT1-7, with 5-HT1 regulating neurotransmission and 5-HT2/3 mediating various actions like smooth muscle contraction.
- 5-HT has diverse roles like regulating gastrointestinal motility, platelet aggregation, and mood/behavior via effects in the brain and periphery. Imbalances in the 5-HT system
Expt. 9 Effect of atropine on DRC of acetylcholine using rat ileumVISHALJADHAV100
Objective
Principle
Requirements
Experimental specifications (conditions)
Preparation of ACh and Atropine stock and std. solutions
Preparation of Tyrode solution (PSS)
Procedure
Kymograph recording of contractions
Observation table
Calculation
Graphical presentation of CRC/ DRC
Result and interpretation
Neurohumoral transmission in CNS-
The term neurohumoral transmission designates the transfer of a nerve impulse from a presynaptic to a postsynaptic neuron by means of a humoral agent e.g. a biogenic amine, an amino acid or a peptide.
Expt. 1 Introduction to in vitro pharmacology and physiological salt solutionsVISHALJADHAV100
This document provides an overview of in-vitro pharmacology experiments using isolated tissues and physiological salt solutions (PSS). It defines pharmacology and drugs, describes the aims of experimental pharmacology as finding therapeutic agents, studying toxicity and mechanisms of action. It also discusses types of experiments, equipment like organ baths and levers for recording tissue responses, and PSS compositions and roles. PSS are artificial solutions that maintain isolated tissues by resembling extracellular fluid composition. Selection of the appropriate PSS depends on the tissue being studied.
The document describes the hot plate test, which is used to assess analgesic (pain-relieving) properties of drugs. It involves placing rodents on a heated surface and measuring the time until they react to the heat. A longer reaction time indicates stronger analgesia. The hot plate test apparatus consists of a temperature-controlled plate, timer, and safety features. It is used to screen analgesic drugs by comparing an animal's reaction time before and after administering a test compound. If the reaction time increases after administration, it suggests the compound has analgesic effects.
This document provides information about autacoids, which are local hormones that include histamine and serotonin. It focuses on histamine, discussing its sources from mast cells and basophils, mechanisms of release, effects on organ systems, and use of antihistamines to treat allergic reactions. Serotonin is also discussed, including its role in mood, appetite, sleep, and vasoconstriction. The document summarizes the different types of serotonin receptors and their functions.
This document summarizes a seminar on sympathomimetic drugs presented by Mohd Fahad and guided by Mohd. Khushtar. It discusses different types of adrenergic drugs including direct, indirect, and mixed acting sympathomimetics. It describes the actions of adrenergic drugs on various organs mediated by alpha and beta receptors. Important drugs are discussed in detail including their uses, doses, preparations, and adverse effects. The document provides an overview of adrenergic pharmacology and the therapeutic uses of sympathomimetic drugs.
Histamine is a biogenic amine present in many animal and plant tissues. It is implicated as a mediator in hypersensitivity and tissue injury reactions. Histamine is present and stored in mast cells, especially in the skin, lungs, and gastrointestinal mucosa. It is synthesized from the amino acid histidine and acts on H1, H2, and H3 receptors to cause various pharmacological effects like vasodilation, increased capillary permeability, smooth muscle contraction, and increased gastric acid secretion. Serotonin is another amine present in enterochromaffin cells of the gastrointestinal tract. It is synthesized from tryptophan and acts on multiple 5-HT receptor subtypes to cause vasoconstriction, intestinal per
This document discusses the uses of corticosteroids in various medical conditions. It begins with an overview of steroid biosynthesis and transport in the blood. It then covers the mechanisms of action including transactivation and transrepression. The rest of the document details the pharmacological actions and specific uses of corticosteroids in conditions like adrenal insufficiency, arthritis, immunosuppression, lung diseases, infections, skin diseases, intestinal diseases, and more.
This document discusses several biochemical mediators involved in inflammation including renin, angiotensins, kinins, prostaglandins, leukotrienes, cytokines, and platelet-activating factor (PAF). It describes where these mediators are synthesized, their receptors, actions on various organ systems, and physiological roles. Key points include that kinins are potent vasodilators, prostaglandins can cause fever by acting on the hypothalamus, leukotrienes recruit immune cells and cause bronchoconstriction, and cytokines coordinate the immune response and cellular functions.
Histamine is an amine autocoid that is synthesized and stored in mast cells and basophils. It is released during allergic reactions and inflammation and acts both locally and systemically via four G protein-coupled receptors, H1-H4. The H1 receptor mediates smooth muscle contraction and increased capillary permeability. The H2 receptor increases gastric acid secretion and relaxes smooth muscles. Histamine plays an important role in allergic reactions, inflammation, gastric acid secretion, and neuronal signaling. It is involved in various physiological and pathological processes.
pA2 determination involves measuring drug antagonism through various methods. Sir Heinz Otto Schild developed the pA2 measure in 1947 to quantify antagonism using the dose ratio and affinity constant. The most common methods to determine pA2 values are Schild's plot, which analyzes log dose ratios against antagonist concentrations, and measuring shifts in dose response curves. Higher pA2 values indicate more specific antagonism on the pA scale. The pA2 value is defined as the negative log of the molar antagonist concentration required to double the agonist dose to produce the same effect.
Expt 11 Effect of drugs on locomotor activity using actophotometerMirza Anwar Baig
This document describes an experiment to evaluate the effects of drugs on locomotor activity using an actophotometer. Rats or mice are injected with either a saline control, the antipsychotic drug chlorpromazine at 3 mg/kg, or caffeine at 3 mg/kg. Their movement is then measured in the actophotometer before and after drug administration. Chlorpromazine is expected to reduce locomotor activity as a CNS depressant, while caffeine may increase it as a CNS stimulant. The results are presented as locomotor activity scores showing that chlorpromazine decreased activity and caffeine increased it, demonstrating their respective CNS effects.
The autonomic nervous system regulates involuntary bodily functions and is divided into the sympathetic and parasympathetic divisions. The sympathetic division is responsible for the "fight or flight" response and increases heart rate and blood pressure. The parasympathetic division acts to slow the heart and aid digestion. Most organs receive dual innervation from both divisions to allow dynamic regulation of functions. Neurotransmission within the autonomic nervous system uses acetylcholine or norepinephrine/epinephrine as neurotransmitters. Postsynaptic responses are mediated through direct ion channel coupling or via second messenger systems to regulate various cellular processes.
1. basics of experimental pharmacologyMBBS IMS MSU
Experimental pharmacology involves studying the effects of pharmacological agents on different animal species. The aims are to identify suitable therapeutic agents for human use, study drug toxicity and mechanisms of action. Common laboratory animals used include mice, rats, guinea pigs and rabbits. Rats are commonly used due to their small size and low drug requirements. Wistar rats are a commonly used strain. Mice are also used for toxicology and drug screening studies due to their small size. Guinea pigs are sensitive to histamine and antibiotics, making them useful for studies in these areas. Rabbits are docile and used for pyrogen testing and studies of drugs affecting capillary permeability. Frogs are commonly used for isolated tissue studies and studies of drugs acting on
This document summarizes 5 major categories of transducer mechanisms:
1) G-protein coupled receptors which activate downstream effectors like adenylyl cyclase or phospholipase C.
2) Ion channel receptors which directly open or close ion channels.
3) Transmembrane enzyme-linked receptors which activate intracellular protein kinases.
4) Transmembrane JAK-STAT binding receptors which activate the JAK/STAT signaling pathway.
5) Receptors regulating gene expression which bind intracellularly to directly regulate gene transcription.
This presentation is about the neurotransmitter 5-HT (serotonin), we focused on its definition, biosynthesis, storage and destruction, with mentioning its both central and peripheral effects, and lastly the serotonin receptors in the human body, as well as their agonist and antagonists.
This document discusses serotonin (5-HT), its receptors, synthesis, actions, roles, and drugs that affect the 5-HT system. Some key points:
- 5-HT is a neurotransmitter found mainly in the intestines, platelets, and brain. It acts on several receptor subtypes to regulate various functions.
- 5-HT receptors include 5-HT1-7, with 5-HT1 regulating neurotransmission and 5-HT2/3 mediating various actions like smooth muscle contraction.
- 5-HT has diverse roles like regulating gastrointestinal motility, platelet aggregation, and mood/behavior via effects in the brain and periphery. Imbalances in the 5-HT system
This document presents information on serotonin (5-HT) from its biosynthesis and pathways in the brain to its functions and clinical applications. Serotonin is a neurotransmitter synthesized from tryptophan and localized mainly in the intestines and brain. It regulates various functions like mood, vascular activity, and gastrointestinal motility. Serotonin pathways originate from raphe nuclei and project throughout the brain and spinal cord. There are multiple 5-HT receptor subtypes classified into families based on their structure and function. Serotonin has both central and peripheral roles and drugs like SSRIs, SNRIs, TCAs impact serotonergic neurotransmission. Serotonin agonists and antagonists have clinical uses for conditions like depression, migraines,
This document discusses serotonin (5-HT), its pharmacological actions, and drugs that affect the serotonin system. Serotonin acts on various systems in the body like the cardiovascular, respiratory, and gastrointestinal systems. Drugs can affect serotonin by inhibiting or enhancing its synthesis, reuptake, storage, or degradation. Some drugs are serotonin receptor agonists or antagonists that target specific receptor subtypes. Serotonin receptor antagonists are used to treat conditions like migraines, nausea/vomiting, and schizophrenia.
Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter synthesized from tryptophan. It is present mainly in the gastrointestinal tract and blood platelets, with some in the central nervous system. Serotonin acts through multiple receptor subtypes and has diverse physiological effects including regulation of mood, appetite, sleep, and cardiovascular and gastrointestinal functions. Antagonists of serotonin receptors are used to treat conditions like migraine, hypertension, nausea/vomiting, and carcinoid syndrome. Common antagonists include cyproheptadine, ketanserin, ondansetron, and ergot alkaloids.
Serotonin (5-HT) is a monoamine neurotransmitter that has diverse functions including mood, cognition, and physiological processes. It is found widely in nature, especially in the gastrointestinal tract, blood platelets, and central nervous system. 5-HT is synthesized from tryptophan and stored in neurons and chromaffin cells. It is released and acts on several receptor subtypes to exert its effects before being reuptaken or metabolized. Key 5-HT receptors include 5-HT1 receptors which inhibit adenylate cyclase, and 5-HT2 receptors which stimulate phospholipase C. Agonists and antagonists that target these receptors are used to treat various conditions like anxiety, migraine, and hypertension.
This document discusses the pharmacology of serotonin (5-HT). It begins by describing the historical identification of 5-HT and its role as a neurotransmitter and hormone. It then discusses the distribution, biosynthesis, metabolism, and receptors of 5-HT. The major receptors discussed are 5-HT1-5HT4 receptors, and their roles in the CNS and periphery. The effects of 5-HT at different receptors, such as its effects on blood vessels, platelets, and smooth muscle are summarized. Finally, the mechanisms and uses of serotonergic drugs like SSRIs and ergot alkaloids are discussed.
This slideshare is about what is autocoid,and differences between harmone and autocoid and had expalined about an example which is an autocoid and also an chemical messenger.and it is also known as happy harmone.
5HT widely distributed in:
GIT enterochromaffin cells (90%)
myenteric plexus where it serves as a prokinetic agent
As a neurotransmitter in CNS
platelets where it diffuses inside from plasma by active transport, and is released at the site of damage after platelet aggregation,
In lungs, bone marrow, pineal gland (as a precursor of melatonin)
5- HT is then stored in 5-HT containing cells such as enterochromaffin cells and neurons as co-transmitter together with various peptide hormones such as somatostatin, vasoactive intestinal peptide and substance P
5-HT is stored within storage vesicles, and its uptake at the vesicular membrane by vesicular monoamine transporter (VMAT-2) is inhibited by reserpine.
Degradation occurs through oxidative deamination by MAO, to 5-hydroxyindole acetaldehyde followed by its oxidation to 5-hydroxyindole acetic acid (5-HIAA)
5- HIAA is excreted in urine
Gaddum and Picarelli (1957) classified 5-HT receptors into musculotropic (D type) and neurotropic (M type) on the basis of their blockade by Dibenzyline (phenoxybenzamine) and Morphine.
5- HT Receptors: there are seven main types (5-HT1, to 5- HT7) of serotonin receptors. Of these, 5-HT1, and 5- HT2, are subdivided further. With a total of 14 (types plus subtypes) receptors.
5-HT Receptors Location:5-HT, receptors are located mainly in CNS. They function as inhibitory presynaptic receptors (auto receptor) and belong to the family of G-protein coupled receptors linked to adenylate cyclase
5-HT1 : Auto receptors; inhibit serotonergic neural activity in brain.
5-HT1A—present in raphe nuclei and hippocampus; buspirone (antianxiety) may act through these receptors.
5-HT1D/1B—Constricts cranial blood vessels and inhibits release of inflammatory neuropeptides in them; sumatriptan (antimigraine) acts through these receptors.
5-HT2A : Previously D type receptor; most important post junctional receptor mediating direct actions of 5-HT like vascular and visceral smooth muscle contraction, platelet aggregation, neuronal activation in brain; ketanserin blocks these receptors.
5-HT3 : Previously M type receptor; depolarizes neurones by gating cation channels; elicits reflex effects of 5-HT—emesis, gut peristalsis, bradycardia, transient hypotension, apnoea, pain, itch; ondansetron (antiemetic) acts by blocking these receptors.
5-HT4 : Mediate intestinal secretion, augmentation of peristalsis. Renzapride (prokinetic) is a selective 5-HT4 agonist.Central Nervous System :5-HT is an important neurotransmitter in CNS
5-HT is involved in the regulation of mood, behaviour, sleep, depression, pain perception, sexual activity, thermoregulation
in the hypothalamic control of the release of pituitary hormones.
Serotonin is a monoamine neurotransmitter synthesized from tryptophan. It is found primarily in enterochromaffin cells in the GI tract, platelets, and the central nervous system. Serotonin acts through multiple receptor subtypes and has diverse physiological effects including regulation of mood, appetite, sleep, cognition, cardiovascular function, platelet aggregation, and intestinal motility. Imbalances in the serotonin system have been implicated in psychiatric conditions like depression and anxiety. Drugs that affect serotonin synthesis, reuptake, and receptor activity are used to treat mood disorders, migraine, nausea/vomiting, and other clinical conditions.
This document discusses histamines, antihistamines, and 5-hydroxytryptamine (5-HT, serotonin) and their antagonists. It describes how histamines are synthesized and stored in mast cells and basophils and released during allergic reactions. The pharmacological actions of histamines are also explained. Antihistamines are described as drugs that block the actions of histamine by competing for H1 receptors. The document also covers the synthesis, receptors, pharmacological actions and functions of 5-HT as well as some 5-HT antagonists and their clinical uses.
Serotonin receptors, also known as 5-hydroxytryptamine receptors, are found in the gastrointestinal tract, platelets, and central nervous system. There are 7 main classes of serotonin receptors (5-HT1 to 5-HT7) with multiple subtypes. The receptors have various functions like regulating mood, appetite, sleep, intestinal movements, vasoconstriction, and hemostasis. The biosynthesis of serotonin begins with the amino acid tryptophan being converted into 5-hydroxytryptamine in serotonergic neurons. Future research aims to better understand the specific roles of the different serotonin receptor subtypes to help develop more targeted drugs.
The document discusses the synthesis, receptors, pathways and functions of the neurotransmitter serotonin in both the peripheral and central nervous systems. It also outlines several disorders associated with abnormalities in the serotonergic system such as depression, anxiety, and schizophrenia. Finally, it reviews several classes of drugs that act on serotonin receptors or serotonin reuptake to treat these disorders.
The patient is presenting with symptoms consistent with migraine including severe unilateral headache, nausea, and flashing lights. The probable diagnosis is migraine. For acute treatment, medications like NSAIDs, triptans like sumatriptan, and ergot alkaloids like ergotamine may be used. Prophylactic treatments include beta blockers, TCAs, calcium channel blockers, and anticonvulsants.
5-HT (serotonin) is a neurotransmitter found in the brain and periphery that plays an important role in platelet function and various disorders. It is synthesized from tryptophan via tryptophan hydroxylase and stored in platelets and neurons. Degradation occurs via monoamine oxidase A. There are multiple 5-HT receptor subtypes located throughout the body. 5-HT is involved in gastrointestinal motility, smooth muscle contraction, vascular effects, platelet aggregation, and various central nervous system functions. Disorders related to abnormal 5-HT include migraine, carcinoid syndrome, and pulmonary hypertension.
Serotonin is a monoamine neurotransmitter synthesized from tryptophan that is primarily found in the gastrointestinal tract and brain. It acts as a vasoconstrictor and plays important roles in mood, appetite, vomiting, and pain perception as a neurotransmitter. Serotonin signals through multiple receptor subtypes and has diverse physiological effects including cardiovascular, respiratory, gastrointestinal, and platelet functions. Dysregulation of the serotonin system contributes to conditions like migraine, hypertension, and nausea/vomiting. A variety of drugs have been developed that target specific serotonin receptors.
This document discusses serotonin (5-HT), including its synthesis from tryptophan, storage in platelets and the intestine, degradation by MAO, and actions. It notes the four main families of 5-HT receptors and describes 5-HT's effects on various systems like the cardiovascular system and gastrointestinal tract. The pathophysiological roles of 5-HT in conditions like migraine, Raynaud's phenomenon, and carcinoid syndrome are mentioned. Finally, the document outlines several drugs that affect 5-HT systems, such as SSRIs, triptans, LSD, and cisapride.
Serotonin (5-HT) is synthesized from tryptophan in enterochromaffin cells in the gut and neurons in the brain. It functions as a neurotransmitter and is involved in numerous physiological processes including mood, appetite, sensory perception, and gastrointestinal motility. There are seven families of serotonin receptors which mediate its diverse effects. Serotonin reuptake inhibitors and receptor agonists/antagonists are used clinically to treat conditions like depression, anxiety, migraine, and nausea.
Serotonin & drugs acing on serotonin receptorsJeenaJoy10
This document discusses serotonin (5-HT), its sources, synthesis, receptors, physiological actions, and pathological roles. It also discusses several drugs that act on 5-HT receptors. Serotonin is synthesized from tryptophan in the brain and gastrointestinal tract. It acts as a neurotransmitter and regulates various physiological functions via 7 families of G protein-coupled receptors and ligand-gated ion channels. Alterations in the serotonergic system are implicated in several disorders, including depression, migraines, and carcinoid syndrome. Several drugs have been developed that target specific 5-HT receptors to treat conditions like nausea, vomiting, hypertension, and migraines.
Aprepitant is an NK1 receptor antagonist approved for preventing chemotherapy-induced nausea and vomiting. It works by blocking substance P in the brain, which is involved in the final common pathway leading to vomiting. Aprepitant significantly increases the effectiveness of 5-HT3 receptor antagonists and corticosteroids for CINV prevention. It has a good safety profile but requires monitoring for potential drug interactions due to being metabolized by CYP3A4.
LAND USE LAND COVER AND NDVI OF MIRZAPUR DISTRICT, UPRAHUL
This Dissertation explores the particular circumstances of Mirzapur, a region located in the
core of India. Mirzapur, with its varied terrains and abundant biodiversity, offers an optimal
environment for investigating the changes in vegetation cover dynamics. Our study utilizes
advanced technologies such as GIS (Geographic Information Systems) and Remote sensing to
analyze the transformations that have taken place over the course of a decade.
The complex relationship between human activities and the environment has been the focus
of extensive research and worry. As the global community grapples with swift urbanization,
population expansion, and economic progress, the effects on natural ecosystems are becoming
more evident. A crucial element of this impact is the alteration of vegetation cover, which plays a
significant role in maintaining the ecological equilibrium of our planet.Land serves as the foundation for all human activities and provides the necessary materials for
these activities. As the most crucial natural resource, its utilization by humans results in different
'Land uses,' which are determined by both human activities and the physical characteristics of the
land.
The utilization of land is impacted by human needs and environmental factors. In countries
like India, rapid population growth and the emphasis on extensive resource exploitation can lead
to significant land degradation, adversely affecting the region's land cover.
Therefore, human intervention has significantly influenced land use patterns over many
centuries, evolving its structure over time and space. In the present era, these changes have
accelerated due to factors such as agriculture and urbanization. Information regarding land use and
cover is essential for various planning and management tasks related to the Earth's surface,
providing crucial environmental data for scientific, resource management, policy purposes, and
diverse human activities.
Accurate understanding of land use and cover is imperative for the development planning
of any area. Consequently, a wide range of professionals, including earth system scientists, land
and water managers, and urban planners, are interested in obtaining data on land use and cover
changes, conversion trends, and other related patterns. The spatial dimensions of land use and
cover support policymakers and scientists in making well-informed decisions, as alterations in
these patterns indicate shifts in economic and social conditions. Monitoring such changes with the
help of Advanced technologies like Remote Sensing and Geographic Information Systems is
crucial for coordinated efforts across different administrative levels. Advanced technologies like
Remote Sensing and Geographic Information Systems
9
Changes in vegetation cover refer to variations in the distribution, composition, and overall
structure of plant communities across different temporal and spatial scales. These changes can
occur natural.
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This slide is special for master students (MIBS & MIFB) in UUM. Also useful for readers who are interested in the topic of contemporary Islamic banking.
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An import error occurs when a program fails to import a module or library, disrupting its execution. In languages like Python, this issue arises when the specified module cannot be found or accessed, hindering the program's functionality. Resolving import errors is crucial for maintaining smooth software operation and uninterrupted development processes.
2. Serotonin
was the name given to an unknown vasoconstrictor substance found in
the serum after blood had clotted. It was identified chemically as 5-
hydroxytryptamine in 1948 and shown to originate from platelets. It
was subsequently found in the gastrointestinal tract and central nervous
system (CNS), and shown to function both as a neurotransmitter and as
a local hormone in the peripheral vascular system
Serotonin is available in:
-plants like (banana)
-animal tissues
- venoms and stings
Serotonin is present in diet , but most is metabolized before entering
the blood
Biosynthesis and metabolism of 5-HT:
4. 5-HT is formed from dietary tryptophan, which is converted to 5-hydroxytryptophan
(in chromaffin cells and neurons, but not in platelets) by tryptophan hydroxylase,
then to 5-HT by a non-specific decarboxylase
5-HT is often stored in neurons and chromaffin cells as a cotransmitter together with
various peptide hormones, such as somatostatin, substance P or vasoactive intestinal
polypeptide.
Distribution
5-HT occurs in the highest concentrations in three organs
1- In the wall of the intestine:. Over 90% of the total amount in the body is present in
the enterochromaffin cells in the gut .
2- In blood. 5-HT: is present in high concentrations in platelets, which accumulate it
from the plasma by an active transport system and release it when they aggregate at
sites of tissue damage.
3-In the CNS: 5-HT is a transmitter in the CNS and is present in high concentrations in
localised regions of the midbrain.
5-HT is transported into cells by a specific transport system
Transformation of serotonin into melatonin is carried out primarily in the pineal
gland. The concentration of melatonin in the pineal gland presents circadian
variations: it follows the variations of N-acetyl transferase activity, increasing during
the night and decreasing during the day, darkness and light playing a regulatory role.
Light inhibits melatonin biosynthesis
5. Degradation occurs mainly by monoamine oxidase, with the
formation of an aldehyde intermediate. This is followed by
0xidation to 5-hydroxyindoleacetic acid (5-HIAA), which is
excreted in urine.
The level of 5-HIAA is significantly increased in CARCINOID
SYNDROME.
Carinoid Syndrome:
Is a malignant tumor of chromaffin cells, which usually
arising in small intestine and metastasizing to the liver. This
tumor secretes excessive amount of 5-HT , prostaglandins
and bradykinins.
Symptoms of carcinoid tumor or syndrome:
1- diarrhea
2- intestinal colic.
3- bronchoconstriction.
4- 20 fold increase in the urinary excretion of 5-HIAA
6. Family Type Mechanism Action
5-HT1 Gi/Go-protein coupled.
Decreasing cellular levels
of cAMP.
Inhibitory
5-HT2 Gq/G11-protein coupled.
Increasing cellular levels
of IP3 and DAG.
Excitatory
5-HT3
Ligand-
gated Na+ and K+ cation
channel.
Depolarizing plasma
membrane.
Excitatory
5-HT4 Gs-protein coupled.
Increasing cellular levels
of cAMP.
Excitatory
5-HT5 Gi/Go-protein coupled.[6] Decreasing cellular levels
of cAMP.
Inhibitory
5-HT6 Gs-protein coupled.
Increasing cellular levels
of cAMP.
Excitatory
5-HT7 Gs-protein coupled.
Increasing cellular levels
of cAMP.
Excitatory
Serotonin receptors subtypes
10. Pharmacological actions of serotonin:
Serotonin has profound effects on the gastrointestinal, cardiovascular ,respiratory ,
and peripheral and central nervous system function
1-On smooth muscle:
-serotonin causes contraction of the smooth muscles of→ stomach, intestine, uterus,
and bronchial smooth muscles mainly via 5-HT2 receptor activation(++ of
phospholipase C/Ip3 system).
2- Cardiovascular system:
-Vasoconstriction of renal, placental,uterine,umbilical, and pulmonary blood
vessels.(N.B large blood vessels, both arteries and veins are usually constricted by 5-
HT and this is mainly through direct effect on 5-HT2A receptors)
-Vasoconstriction of the large intracranial blood vessels (5-HT1-stimulation.
- Vasodiltation of skeletal muscle beds.
-Action on heart:
Serotonin has a positive initropic and chronotropic action by 5-HT4 receptor
stimulation and could take part in the genesis of certain rhythm disorders. It has a
positive inotropic effect.
-Action on blood pressure:
It is complex, according to experimental conditions, serotonin gives either
hypotension, or hypertension, or no modification
11.
12. 3-Digestive effects:
•Serotonin has an emetic effect by stimulation of 5-HT3 receptors. These receptors
are located particularly on the vagal terminations in the digestive tract and in area
postrema (chemoreceptor trigger zone), which is accessible to peripheral circulating
serotonin. Their stimulation elicits nausea and vomiting, and 5-HT3 antagonists are
used to avoid vomiting induced by antineoplastic treatments. 5-HT has an ulcerative
action, its administration to animals in high doses induces gastric.
NB:LOS=The lower oesophageal sphincter
13. •Serotonin increases intestinal motility, probably by stimulation of 5-
HT4 and 5-HT3 receptors: in human beings, injected by intravenous
route, it increases duodenum and small intestine motility. This effect
explains diarrhea observed in patients with carcinoid syndrome.
4-Migraine:
Migraine is a disease characterized by repeated accesses of headache
in which vasomotor phenomena and serotonin play a determining
part. In the first prodromic phase, there is a vasoconstriction, and in
the second painful phase, a vasodilation. This vasodilation is reduced
by vasoconstrictive drugs.
5-Myocardial ischemia:
Serotonin released from platelets seems to worsen the myocardial
ischemia by vasoconstriction.
15. 7-Central effects:
•Effects of serotonin on the central nervous system are numerous,
complex and difficult to systematize, but of considerable importance
from a pharmacological point of view because many drugs act by its
intermediary.
•Serotonin is involved in the regulation of sleep, mood
(antidepressant action), temperature, appetite (appetite suppressant
effect).
Over stimulation of 5-HT2 receptors could induce productive
and negative symptoms of psychotic disorders. LSD or
lysergide, agonist of 5-HT2 receptors and also of D1 and D2
dopaminergic receptors, has hallucinogenic properties
8-Other actions:
-Stimulation of catecholamine from adrenal gland
-Stimulation of the sensory nerves, which contribute to pain
response
-Regulation of the release of ACTH, groth hormones,
prolactin, leutilizing hormone, FSH, and TSH
16. 5-HT Agonists:
•Buspirone:
It is a partial agonist for 5-HT1A and Used as anxiolytic
•Sumatriptan:
Is a selective 5-TH1D and 5-HT1B agonist. These receptors are found in cerebral and
meningeal and mediate vasoconstriction.
Bioavailability of sumatriptan is about 15% but other triptans e.g natratriptan,
elemotriptan, rizatriptan and almotriptan have 40-80% bioavailability.
The t1/2 of sumatriptan, almotriptan, eletriptan , rizatriptan and zolmatriptan is
about 2-3 hours whereas the t1/2 of natratriptan is 6 hrs
Sumatriptan is poorly absorbed therefore it is given by subcutaneous or nasal
administration.
Uses of triptans:
In treatment of migraine
Adverse effects of sumatriptan:
1- injection site reaction 2-unpleasant taste with nasal adminitration
Chest pressure (resolved within 30 min)
3- weakness, drowsiness, dizzines and fatigue.
ContraIndications: Hypertension, and pregnancy
17. Tegaserod, a newer 5-HT4 partial agonist, is used for irritable bowel syndrome
with constipation
Cisapride, a 5-HT4 agonist, was used in the treatment of gastroesophageal
reflux and motility
Ergot Alkaloids: are 5-HT1B/1D agonists
Are derivatives of lysergic acid
They are 2 types: a. Amino acid alkaloids: e.g ergotamine ,ergotoxine
and b. Amine alkaloids. E.g ergometrine
1- Ergotamine:
-has also partial α-receptor agonist activity.
-is poorly absorbed and caffeine increases its absorption
- contracts smooth muscle of uterus(oxytotic action)
Uses:
In acute attack of migraine
Adverse effects:
Nausea, vomiting, anginal pain, and abortion
in case of pregnant women.
Contraindications:
-Peripheral vascular disease -coronary heart disease - hypertension
- Pregnancy - liver and kidney disease
18. 2- Ergometrine:
It is a partial 5-HT receptor agonist
Has no α-adrenergic effect
Has potent oxytocic action.
Used for prevension and treatment of postpartum hemorrhage
5-HT receptors Antagonists:
1-Ketanserin:
-Is A 5-HT2A antagonist and has α1-receptor antagonistic activities
Ketanserin lowers blood pressure in patients with hypertension, causing a reduction
comparable to that seen with b adrenergic-receptor antagonists or diuretics
-Ketanserin inhibits 5-HT-induced platelet aggregation
2-Ritanserin, another 5-HT2 antagonist, has little or no a-blocking action. It has
been reported to alter bleeding time and to reduce thromboxane formation,
presumably by altering platelet function
3-Ondansetron is the prototypical 5-HT3 antagonist. This drug and its analogs are
very important in the prevention of nausea and vomiting associated with surgery and
cancer chemotherapy