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Lund
May 7, 2014
Shalini Andersson, CVMD
Mikael Varga, RIA
Per-Erik Strömstedt, Discovery Sciences
Magnus Klarqvist, RIA
AstraZeneca R&D Mölndal
Our commitment to making a meaningful difference in
healthcare is founded on our innovative science. The
pursuit of scientific excellence that addresses unmet
patient need guides everything we do.
Pascal Soriot
CEO
Mission: To push the boundaries of science to
deliver life-changing medicines
Om AstraZeneca
With three strategic priorities
Achieve
Scientific
Leadership
Be a great
place to work
Return
to growth
Our strategy is focused on innovation
Increase proximity to bioscience clusters
and co-locate around three strategic sites
4
Proximity to NIH,
Johns Hopkins
New site in Cambridge with close proximity
to University of Cambridge and world class
UK bioscience community
Connections to Karolinska
Institute & Medicon Valley
Gaithersburg MölndalCambridge
Leverage historical strength
Respiratory and CV/Met
Co-locate around
biologics/specialty care
Co-locate R&D in world-class
science cluster
Our research and development
To deliver the next generation
Biologics
Small
Molecules
Immuno -
therapies
Protein
engineering
Neuroscience
Infection
& Vaccines
CV-
Metabolism
Respiratory,
Inflammation
& Autoimmunity
Oncology
Core Therapy Areas Opportunity-focused
• Two iMeds - RIA and CVMD
• Safety and Discovery Sciences
• A large Development organisation
• Several centers of excellence, eg inhalation technologies and transgenics
• Proximity to academic centers and Europes largest hospital
AstraZeneca R&D Mölndal
A strong heritage to build on
6
2,300 dedicated colleagues in Mölndal...
901 in Research – 2 iMeds
1,004 in Development - GMD
60 % women
40 % men
1,570 have an academic degree
570 have a PhD
>30 professorers
>30 post-docs
…including >250 scientists from 30 countries
who bring new insights, expertise and energy!
Our current focus in RIA
• Respiratory, Inflammation & Autoimmunity (RIA)
 Asthma
 COPD (Chronic obstructive pulmonary disease)
 Idiopathic Pulmonary Fibrosis
 Rheumatology
 Autoimmune disorders
COPD
10
AZ has a strong and continuing presence in front line COPD care
based on bronchodilator/anti-inflammatory therapy
What’s next?
Hallmarks of COPD
COPD is mixed disease with both airway
obstructions and loss of functional lung
Breathlessness in COPD is
more than airflow obstruction
Our current focus in CVMD
• Cardiovascular and Metabolic diseases (CVMD)
 Diabetic Nephropathy
 Cardiac Regeneration
 Islet Health and Metabolism
Cardiac Regeneration
Diabetic Nephropathy
Islet Cell Health (Diabetes)
Cardiac Regeneration
Goal
To identify and develop small or large molecules that enhance endogenous
regenerative capacity of the heart for the treatment of post-MI cardiac dysfunction
and heart failure.
Vision
To launch a new therapy which will offer an entirely new treatment paradigm for
patients who are dying of heart failure today.
Induction of proliferation of
existing cardiomyocytes
Direct reprogramming of cardiac
fibroblasts into cardiomyocytes
or cardiac progenitors
Activation of resident cardiac
progenitor cells in the heart:
Epicardial progenitor cells
(EPDC) or cardiac stem cells
(CSC)
Discovery Sciences
14 Per-Erik Strömstedt | May 7, 2014 | Discovery Sciences
• Compound
management
• Biobanks
(clinical samples)
• Hit generation
• SAR screening
• Ion channel centre
of excellence
• Crystallography; first
structures, iterative structures
• NMR and other biophysical
techniques
• Fragment Chemistry
• Chemical Biology
• Computational biology
• Cheminformatics
• Predictive Chemistry
• Compound collection
enhancement
• Proteins
• Cells
• Transgenics
• Antibodies
DS
• Project support
• Statistical qualification
Discovery Sciences (DS) provides centralised, state-of-the art support for hit finding,
lead optimization and target validation for all therapeutic research areas with AZ.
• Assay development
• High content biology assays
Partnering, collaborations and open
innovation remain key to pushing the
boundaries of science
We are driving
science through
collaborations…
…more than 90
partnerships in the
last three years
To deliver the next
generation of medicines
we must continue to find
ways to combine our
science with the best
science that’s happening
elsewhere
Challenging ourselves to
find new ways to break
through the barriers and
work more openly with
scientists in other
organisations who share
our passion for patients
and who can bring
different perspectives to
innovative research
Accessible through an Open Innovation
Website
http://openinnovation.astrazeneca.com
• Summerworker
• Master’s thesis
• Graduate programme
• Post-Doc programme
Opportunities at AZ Mölndal
21 Author | 00 Month Year Set area descriptor | Sub level 1
60 Summer workers 2013
22 Master’s thesis students
6 Graduate students
33 Post-Docs
With the ambition to increase …
AstraZeneca Post-Doc Programme
Investing in innovative science
The next generation of scientific minds
AstraZeneca Post-Doc Programme gives post-doctoral scientists the chance
to undertake high-quality, innovative research in a cross-discipline scientific
environment within the pharmaceutical industry.
AstraZeneca post-doctoral scientists:
• Conduct independent, cutting-edge research in state-of-the-art facilities
• Collaborate with AstraZeneca scientists in discovery and drug
development teams
• Work alongside a world-leading academic advisor
• Publish their work in high-quality scientific journals and communicate research
findings at international scientific conferences.
Each scientist receives a tailored training and development programme, aligned with the established
AstraZeneca approach to personal development. This includes core training on drug discovery and
development, as well as on key skills, such as presentation delivery and publication writing.
AstraZeneca Internal
Post-doc Program
Post-doc proposal selection based on
• Scientific Novelty
• Feasability (Scientific, Technical and 2 yr time frame)
• Availability of academic collaborator
For more information on the opportunities of the programme,
visit:
http://www.astrazeneca.com/Research/capabilities/AstraZeneca-
expandspostdoc-program
For the latest vacancies, visit:
http://www.astrazenecacareers.com/students-all/postdoc-
program2/
http://www.candidatecare.com/srccsh/RTI.home?r=2000032721810&c=11&d=astrazeneca.
candidatecare.com&_dissimuloSSO=XTZ23XJ29Jg:66k7sC-1j79cH6WaCOhgu4K8OQE
Graduate vacancies for AZ Sweden are now live with a
closing date of the 19th May 2013.
AstraZeneca R&D Mölndal
To push the boundaries of
science to deliver life-changing
medicines
and discussion
questions
??
25
Topushtheboundariesofsciencetodeliverlife-changingmedicines
>20 Clinical ready
compounds
>40 Mechanistic
tool compounds
up to $100K grants
Potential to partner
your molecules
Prizes for solutions
to R&D challenges
Partnerships
New clinically validated
projects
New lead optimization projects
New targets/hit ID projects
Access to novel molecules
Novel solutions
Clinical Compound
Bank
Pharmacology
Toolbox
Target Innovation
New Molecule
Profiling
R&D Challenges
Suggestion Box
Ideas for future
partnerships
Academics
Why is it Attractive?
AZ
GenerationofNoveldataforpublicationsandadvancemedicalscience
A global business
50,000 employees.
Research across 3 continents.
$4.2 billion invested in R&D in 2013.
Manufacturing in 17 countries.
Sales in 100 countries.
$25.7 billion sales in 2013.
AstraZeneca Mölndal
2 150
900
1 100
>250
employees
in Innovative Medicines
in Global Medicines Development
colleagues from 30 countries
1 614 with academic degree
574 PhDs
3

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AstraZeneca, Lund, May 7 2014

  • 1. Lund May 7, 2014 Shalini Andersson, CVMD Mikael Varga, RIA Per-Erik Strömstedt, Discovery Sciences Magnus Klarqvist, RIA AstraZeneca R&D Mölndal
  • 2. Our commitment to making a meaningful difference in healthcare is founded on our innovative science. The pursuit of scientific excellence that addresses unmet patient need guides everything we do. Pascal Soriot CEO Mission: To push the boundaries of science to deliver life-changing medicines
  • 3. Om AstraZeneca With three strategic priorities Achieve Scientific Leadership Be a great place to work Return to growth Our strategy is focused on innovation
  • 4. Increase proximity to bioscience clusters and co-locate around three strategic sites 4 Proximity to NIH, Johns Hopkins New site in Cambridge with close proximity to University of Cambridge and world class UK bioscience community Connections to Karolinska Institute & Medicon Valley Gaithersburg MölndalCambridge Leverage historical strength Respiratory and CV/Met Co-locate around biologics/specialty care Co-locate R&D in world-class science cluster
  • 5. Our research and development To deliver the next generation Biologics Small Molecules Immuno - therapies Protein engineering Neuroscience Infection & Vaccines CV- Metabolism Respiratory, Inflammation & Autoimmunity Oncology Core Therapy Areas Opportunity-focused
  • 6. • Two iMeds - RIA and CVMD • Safety and Discovery Sciences • A large Development organisation • Several centers of excellence, eg inhalation technologies and transgenics • Proximity to academic centers and Europes largest hospital AstraZeneca R&D Mölndal
  • 7. A strong heritage to build on 6
  • 8. 2,300 dedicated colleagues in Mölndal... 901 in Research – 2 iMeds 1,004 in Development - GMD 60 % women 40 % men 1,570 have an academic degree 570 have a PhD >30 professorers >30 post-docs …including >250 scientists from 30 countries who bring new insights, expertise and energy!
  • 9. Our current focus in RIA • Respiratory, Inflammation & Autoimmunity (RIA)  Asthma  COPD (Chronic obstructive pulmonary disease)  Idiopathic Pulmonary Fibrosis  Rheumatology  Autoimmune disorders
  • 10. COPD 10 AZ has a strong and continuing presence in front line COPD care based on bronchodilator/anti-inflammatory therapy What’s next? Hallmarks of COPD COPD is mixed disease with both airway obstructions and loss of functional lung Breathlessness in COPD is more than airflow obstruction
  • 11. Our current focus in CVMD • Cardiovascular and Metabolic diseases (CVMD)  Diabetic Nephropathy  Cardiac Regeneration  Islet Health and Metabolism
  • 13. Cardiac Regeneration Goal To identify and develop small or large molecules that enhance endogenous regenerative capacity of the heart for the treatment of post-MI cardiac dysfunction and heart failure. Vision To launch a new therapy which will offer an entirely new treatment paradigm for patients who are dying of heart failure today. Induction of proliferation of existing cardiomyocytes Direct reprogramming of cardiac fibroblasts into cardiomyocytes or cardiac progenitors Activation of resident cardiac progenitor cells in the heart: Epicardial progenitor cells (EPDC) or cardiac stem cells (CSC)
  • 14. Discovery Sciences 14 Per-Erik Strömstedt | May 7, 2014 | Discovery Sciences • Compound management • Biobanks (clinical samples) • Hit generation • SAR screening • Ion channel centre of excellence • Crystallography; first structures, iterative structures • NMR and other biophysical techniques • Fragment Chemistry • Chemical Biology • Computational biology • Cheminformatics • Predictive Chemistry • Compound collection enhancement • Proteins • Cells • Transgenics • Antibodies DS • Project support • Statistical qualification Discovery Sciences (DS) provides centralised, state-of-the art support for hit finding, lead optimization and target validation for all therapeutic research areas with AZ. • Assay development • High content biology assays
  • 15. Partnering, collaborations and open innovation remain key to pushing the boundaries of science
  • 16. We are driving science through collaborations… …more than 90 partnerships in the last three years
  • 17. To deliver the next generation of medicines we must continue to find ways to combine our science with the best science that’s happening elsewhere Challenging ourselves to find new ways to break through the barriers and work more openly with scientists in other organisations who share our passion for patients and who can bring different perspectives to innovative research
  • 18. Accessible through an Open Innovation Website http://openinnovation.astrazeneca.com
  • 19. • Summerworker • Master’s thesis • Graduate programme • Post-Doc programme
  • 20. Opportunities at AZ Mölndal 21 Author | 00 Month Year Set area descriptor | Sub level 1 60 Summer workers 2013 22 Master’s thesis students 6 Graduate students 33 Post-Docs With the ambition to increase …
  • 21. AstraZeneca Post-Doc Programme Investing in innovative science The next generation of scientific minds AstraZeneca Post-Doc Programme gives post-doctoral scientists the chance to undertake high-quality, innovative research in a cross-discipline scientific environment within the pharmaceutical industry. AstraZeneca post-doctoral scientists: • Conduct independent, cutting-edge research in state-of-the-art facilities • Collaborate with AstraZeneca scientists in discovery and drug development teams • Work alongside a world-leading academic advisor • Publish their work in high-quality scientific journals and communicate research findings at international scientific conferences. Each scientist receives a tailored training and development programme, aligned with the established AstraZeneca approach to personal development. This includes core training on drug discovery and development, as well as on key skills, such as presentation delivery and publication writing.
  • 22. AstraZeneca Internal Post-doc Program Post-doc proposal selection based on • Scientific Novelty • Feasability (Scientific, Technical and 2 yr time frame) • Availability of academic collaborator For more information on the opportunities of the programme, visit: http://www.astrazeneca.com/Research/capabilities/AstraZeneca- expandspostdoc-program For the latest vacancies, visit: http://www.astrazenecacareers.com/students-all/postdoc- program2/
  • 23. http://www.candidatecare.com/srccsh/RTI.home?r=2000032721810&c=11&d=astrazeneca. candidatecare.com&_dissimuloSSO=XTZ23XJ29Jg:66k7sC-1j79cH6WaCOhgu4K8OQE Graduate vacancies for AZ Sweden are now live with a closing date of the 19th May 2013. AstraZeneca R&D Mölndal To push the boundaries of science to deliver life-changing medicines
  • 25. Topushtheboundariesofsciencetodeliverlife-changingmedicines >20 Clinical ready compounds >40 Mechanistic tool compounds up to $100K grants Potential to partner your molecules Prizes for solutions to R&D challenges Partnerships New clinically validated projects New lead optimization projects New targets/hit ID projects Access to novel molecules Novel solutions Clinical Compound Bank Pharmacology Toolbox Target Innovation New Molecule Profiling R&D Challenges Suggestion Box Ideas for future partnerships Academics Why is it Attractive? AZ GenerationofNoveldataforpublicationsandadvancemedicalscience
  • 26. A global business 50,000 employees. Research across 3 continents. $4.2 billion invested in R&D in 2013. Manufacturing in 17 countries. Sales in 100 countries. $25.7 billion sales in 2013.
  • 27. AstraZeneca Mölndal 2 150 900 1 100 >250 employees in Innovative Medicines in Global Medicines Development colleagues from 30 countries 1 614 with academic degree 574 PhDs 3