Community Nursing Research Strategy Masterclass
13th September 2013
The WSPCR was requested to organise a research masterclass for the Directors of Nursing from all the Welsh Health Boards on Friday 11th Sept. It was funded by the Health Minister and attended by the CNO. It also included the Head of the NISCHR and the manager of AHSC. The masterclass included the presentation of the Welsh Community Nurse Research Strategy which aims to raise the quality and quantity of research in Community Nursing in Wales. The workshop also generated further areas for research activity/priority.
http://www.wspcr.ac.uk/crns-masterclass-sep-2013.php
Using system dynamics for ex-ante impact assessment of food safety policies i...ILRI
Presentation by Karl M. Rich, Nguyen Thi Thu Huyen, Duong Nam Ha, Nguyen Thi Duong Nga, Vu Khac Xuan, Ninh Xuan Trung, Tran Van Long, Pham Van Hung, Fred Unger, Kanar Hamza and Lucy Lapar at the Safe Pork conference, Porto, Portugal, 7-10 September 2015.
Talk to Heads of University Biological Sciences Departments WInter Meeting 10 November 2011.
http://www.societyofbiology.org/newsandevents/events/view/327
Community Nursing Research Strategy Masterclass
13th September 2013
The WSPCR was requested to organise a research masterclass for the Directors of Nursing from all the Welsh Health Boards on Friday 11th Sept. It was funded by the Health Minister and attended by the CNO. It also included the Head of the NISCHR and the manager of AHSC. The masterclass included the presentation of the Welsh Community Nurse Research Strategy which aims to raise the quality and quantity of research in Community Nursing in Wales. The workshop also generated further areas for research activity/priority.
http://www.wspcr.ac.uk/crns-masterclass-sep-2013.php
Using system dynamics for ex-ante impact assessment of food safety policies i...ILRI
Presentation by Karl M. Rich, Nguyen Thi Thu Huyen, Duong Nam Ha, Nguyen Thi Duong Nga, Vu Khac Xuan, Ninh Xuan Trung, Tran Van Long, Pham Van Hung, Fred Unger, Kanar Hamza and Lucy Lapar at the Safe Pork conference, Porto, Portugal, 7-10 September 2015.
Talk to Heads of University Biological Sciences Departments WInter Meeting 10 November 2011.
http://www.societyofbiology.org/newsandevents/events/view/327
Tripartite dimension of interaction of patients, regulators and industry (Jan...jangeissler
Tripartite dimension of interaction of patients, regulators and industry, presented by Jan Geissler as a scene-setting presentation at the EUPATI Workshop on the interaction of patients, regulators and industry on 20 July 2016 in Berlin
Update on local and national survivorship initiativesUCLPartners
Presentation by Gill Levitt of Great Ormond Street Hospital for Children NHS Foundation Trust at the London Cancer Children, Teenager and Young Adults Study Day, held on 25 July 2013.
Similarities and differences between Rare Cancers and Rare Diseasesjangeissler
Similarities and differences between Rare Cancers and Rare Diseases, presentation by Jan Geissler based on a table published by Kathy Oliver, Jan Geissler and Ariane Weinman here: http://www.eurordis.org/publication/rare-cancers-and-rare-diseases-similarities-and-differences
A presentation by Jimmy Whitworth as part of the Sustainability and Ownership panel discussion at the International Symposium on Cohort and Longitudinal Studies in Developing Contexts, UNICEF Office of Research - Innocenti, Florence, Italy 13-15 October 2014
25 January 2022: Webinar on Adverse Outcome Pathway co-operative activities b...OECD Environment
On 25 January 2022, the OECD held a webinar on Adverse Outcome Pathway (AOP) co-operative activities between Scientific journals and the OECD.
This webinar was organised primarily for Scientific Journal editors or publishers who are interested in reviewing/publishing AOPs and collaborating with the OECD in this activity.
The objective of the webinar was to present the basis for cooperation between scientific journals and the OECD and discuss the lessons learnt so far.
Dan Villeneuve (US EPA) presented the AOP framework and challenges being encountered.
Access the webinar replay at: https://oe.cd/testing-assessment-webinars
Presentation by Ann Phoenix, Co-Director of TCRU and Institute of Education (childhood and parenting and Harriet Ward, Co-Director of CCfR, Loughborough University
25 January 2022: Webinar on Adverse Outcome Pathway co-operative activities b...OECD Environment
On 25 January 2022, the OECD held a webinar on Adverse Outcome Pathway (AOP) co-operative activities between Scientific journals and the OECD.
This webinar was organised primarily for Scientific Journal editors or publishers who are interested in reviewing/publishing AOPs and collaborating with the OECD in this activity.
The objective of the webinar was to present the basis for cooperation between scientific journals and the OECD and discuss the lessons learnt so far.
Based on the outcome of a workshop recently held on ‘Science with impact in an era of information overload’, Clemens Wittwehr (EC Joint Research Centre) focused on the importance of an increased cooperation between all stakeholders in order to promote the application of the AOP framework.
Access the webinar replay at: https://oe.cd/testing-assessment-webinars
How to communicate scientific and medical information to patients, advocates ...jangeissler
How to communicate scientific and medical information to patients, advocates and caregivers, presented by Jan Geissler at the European Medical Writer's Symposium (EMWA) on 12 May 2016
Tripartite dimension of interaction of patients, regulators and industry (Jan...jangeissler
Tripartite dimension of interaction of patients, regulators and industry, presented by Jan Geissler as a scene-setting presentation at the EUPATI Workshop on the interaction of patients, regulators and industry on 20 July 2016 in Berlin
Update on local and national survivorship initiativesUCLPartners
Presentation by Gill Levitt of Great Ormond Street Hospital for Children NHS Foundation Trust at the London Cancer Children, Teenager and Young Adults Study Day, held on 25 July 2013.
Similarities and differences between Rare Cancers and Rare Diseasesjangeissler
Similarities and differences between Rare Cancers and Rare Diseases, presentation by Jan Geissler based on a table published by Kathy Oliver, Jan Geissler and Ariane Weinman here: http://www.eurordis.org/publication/rare-cancers-and-rare-diseases-similarities-and-differences
A presentation by Jimmy Whitworth as part of the Sustainability and Ownership panel discussion at the International Symposium on Cohort and Longitudinal Studies in Developing Contexts, UNICEF Office of Research - Innocenti, Florence, Italy 13-15 October 2014
25 January 2022: Webinar on Adverse Outcome Pathway co-operative activities b...OECD Environment
On 25 January 2022, the OECD held a webinar on Adverse Outcome Pathway (AOP) co-operative activities between Scientific journals and the OECD.
This webinar was organised primarily for Scientific Journal editors or publishers who are interested in reviewing/publishing AOPs and collaborating with the OECD in this activity.
The objective of the webinar was to present the basis for cooperation between scientific journals and the OECD and discuss the lessons learnt so far.
Dan Villeneuve (US EPA) presented the AOP framework and challenges being encountered.
Access the webinar replay at: https://oe.cd/testing-assessment-webinars
Presentation by Ann Phoenix, Co-Director of TCRU and Institute of Education (childhood and parenting and Harriet Ward, Co-Director of CCfR, Loughborough University
25 January 2022: Webinar on Adverse Outcome Pathway co-operative activities b...OECD Environment
On 25 January 2022, the OECD held a webinar on Adverse Outcome Pathway (AOP) co-operative activities between Scientific journals and the OECD.
This webinar was organised primarily for Scientific Journal editors or publishers who are interested in reviewing/publishing AOPs and collaborating with the OECD in this activity.
The objective of the webinar was to present the basis for cooperation between scientific journals and the OECD and discuss the lessons learnt so far.
Based on the outcome of a workshop recently held on ‘Science with impact in an era of information overload’, Clemens Wittwehr (EC Joint Research Centre) focused on the importance of an increased cooperation between all stakeholders in order to promote the application of the AOP framework.
Access the webinar replay at: https://oe.cd/testing-assessment-webinars
How to communicate scientific and medical information to patients, advocates ...jangeissler
How to communicate scientific and medical information to patients, advocates and caregivers, presented by Jan Geissler at the European Medical Writer's Symposium (EMWA) on 12 May 2016
Fast forward SMMI business collaborationAlan Scrase
Presenter – Kevin Forshaw from the SMMI will describe how it is supporting and promoting innovation in the marine sector through the use of the facilities, staff and students at the UofS. The SMMI is unique internationally recognised centre of excellence, bringing together the research, innovation and education communities from universities, research institutes, industry and governments.
A presentation delivered by IPPOSI CEO, Derick Mitchell at a conference organised by the Clinical Research Facility, St. James's Hospital, Dublin, May 2018
Academic Health Science Networks supporting strategic commissioningInnovation Agency
Dr Liz Mear, Chief Executive of the Innovation Agency, presented at NHS Confed 17 on Academic Health Science Networks (AHSNs) supporting strategic commissioning and bringing innovators, commissioners, clinicians and patients to together to develop closer collaboration and a demonstrably clearer understanding of NHS needs and opportunities.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
2. INTEGRATE AMR - Objectives
• Interdisciplinary Collaborations
• Follow-on Funding
• Promotion of Antimicrobial
Resistance area to EPS researchers
• Engagement with Industry and
Public Health
3. INTEGRATE AMR – Funding Available
Early Career
Fellowships
Visiting
Fellowships
Pump Prime
Fund
Conference
Travel
Away
Days
Workshops
Seminars Symposia
• Interdisciplinary Collaborations
• Follow-on Funding
• Promotion of Antimicrobial
Resistance area to EPS researchers
• Engagement with Industry and
Public Health
4. INTEGRATE AMR
+ Social Sciences
+ Education
+ Warwick Business School
+ UHCW RD&I
+ Clinical Research Network
+ Industry
+ PHE
Mathematics
Life Sciences
Engineering
Physics
Medicine
Chemistry
Pump Priming Fund:
1 page application
Monthly rolling deadline
(3/5 funded)
Infection in a Microfluidic Channel
Physics/Medicine Collaboration
5. INTEGRATE AMR
Promotion of AMR research to Early Career Researchers
Early Career Fellowships (x10)
Seminars
Summer School
6. INTEGRATE AMR
Joint events and match funding
UHCW Grand Round
EU FP7
Phage Conference
PHE Modelling
Challenge
CRN AMR Sandpit
ANTRUK ‘Tea Party’
7. INTEGRATE AMR – Find out more
www.warwick.ac.uk/wamic/
@Warwick_AMR
8. “Synthetic Chemistry”
“Natural Products”
“Biosynthetic
Pathways”
“Phage Therapy”
“Microfluidics”
“Bacterial Motility and
Attachment”
“Biofilms”
“Predictive Modeling”
“Epidemiology”
“Hospital-acquired
Infections”
“Behaviour Change”
“Control and
Pharmacokinetics”
“Cell Wall and Protein
Biosynthesis”
“Structural Studies”
Thank you
