Potentiometry, Electrochemical cell, construction and working of indicator an...Vandana Devesh Sharma
Potentiometry - Electrochemical cell -Construction and working of reference (Standard hydrogen, silver chloride electrode and calomel electrode)
Indicator electrodes (metal electrodes and glass electrode)
Methods to determine end point of potentiometric titration
and applications
Potentiometry is the method to find the concentration of solute in
A given solution by measuring the potential between two Electrodes
(reference and Indicator electrode) . Potentiometric titration involves
the measurement of the potential of the indicator electrode and
reference electrode.
In potentiometric titration reference and indicator electrodes are
immersed in the solution of particular analyte (titrand) and
potential of indicator electrode is measured with relation to
reference electrode.
Titrant is added in analyte (Titrand) and change in potential is noted
down.
At the end point there is sharp change in potential on indicator
electrode.
Graph is plotted between the indicator electrode potential and
volume of titrant added.
This method is used for determination of sharp end point.
Types of Potentiometric Titration
1. Acid-base titration 2. Redox Titration 3.Complexometric titration 4. Precipitation Titration
ESTIMATION OF THE RATE OF REACTION WILL BE DONE BASED ON THE POTENTIAL DIFFERENCE BETWEEN REFERENCE AND INDICATOR ELECTRODE. THE POTENTIAL OF THE REFERENCE ELECTRODE IS STABLE WHERE AS THE POTENTIAL OF THE INDICATOR ELECTRODE VARIES WITH THE POTENTIAL OF THE SOLUTION IN WHICH IT IS PLACED
Potentiometry, Electrochemical cell, construction and working of indicator an...Vandana Devesh Sharma
Potentiometry - Electrochemical cell -Construction and working of reference (Standard hydrogen, silver chloride electrode and calomel electrode)
Indicator electrodes (metal electrodes and glass electrode)
Methods to determine end point of potentiometric titration
and applications
Potentiometry is the method to find the concentration of solute in
A given solution by measuring the potential between two Electrodes
(reference and Indicator electrode) . Potentiometric titration involves
the measurement of the potential of the indicator electrode and
reference electrode.
In potentiometric titration reference and indicator electrodes are
immersed in the solution of particular analyte (titrand) and
potential of indicator electrode is measured with relation to
reference electrode.
Titrant is added in analyte (Titrand) and change in potential is noted
down.
At the end point there is sharp change in potential on indicator
electrode.
Graph is plotted between the indicator electrode potential and
volume of titrant added.
This method is used for determination of sharp end point.
Types of Potentiometric Titration
1. Acid-base titration 2. Redox Titration 3.Complexometric titration 4. Precipitation Titration
ESTIMATION OF THE RATE OF REACTION WILL BE DONE BASED ON THE POTENTIAL DIFFERENCE BETWEEN REFERENCE AND INDICATOR ELECTRODE. THE POTENTIAL OF THE REFERENCE ELECTRODE IS STABLE WHERE AS THE POTENTIAL OF THE INDICATOR ELECTRODE VARIES WITH THE POTENTIAL OF THE SOLUTION IN WHICH IT IS PLACED
Potentiometry passively measures the potential of a solution between two electrodes, affecting the solution very little in the process. One electrode is called the reference electrode and has a constant potential, while the other one is an indicator electrode whose potential changes with the composition of the sample. Therefore, the difference of potential between the two electrodes gives an assessment of the composition of the sample. Potentiometry usually uses indicator electrodes made selectively sensitive to the ion of interest, such as fluoride in fluoride selective electrodes, so that the potential solely depends on the activity of this ion of interest.
Potentiometry is one of the methods of electroanalytical chemistry. It is usually employed to find the concentration of a solute in solution. In potentiometric measurements, the potential between two electrodes is measured using a high impedance voltmeter An ion-selective electrode (ISE), also known as a specific ion electrode (SIE), is a transducer (or sensor) that converts the activity of a specific ion dissolved in a solution into an electrical potential. There are four main types of ion-selective membrane used in ion-selective electrodes (ISEs): glass, solid state, liquid based, and compound electrode.
Potentiometry: Electrical potential, electrochemical cell, reference electrodes, indicator
electrodes, measurement of potential and Ph, construction and working of electrodes,
Potentiometric titrations, methods of detecting end point, Karl Fischer titration.
Potentiometry passively measures the potential of a solution between two electrodes, affecting the solution very little in the process. One electrode is called the reference electrode and has a constant potential, while the other one is an indicator electrode whose potential changes with the composition of the sample. Therefore, the difference of potential between the two electrodes gives an assessment of the composition of the sample. Potentiometry usually uses indicator electrodes made selectively sensitive to the ion of interest, such as fluoride in fluoride selective electrodes, so that the potential solely depends on the activity of this ion of interest.
Potentiometry is one of the methods of electroanalytical chemistry. It is usually employed to find the concentration of a solute in solution. In potentiometric measurements, the potential between two electrodes is measured using a high impedance voltmeter An ion-selective electrode (ISE), also known as a specific ion electrode (SIE), is a transducer (or sensor) that converts the activity of a specific ion dissolved in a solution into an electrical potential. There are four main types of ion-selective membrane used in ion-selective electrodes (ISEs): glass, solid state, liquid based, and compound electrode.
Potentiometry: Electrical potential, electrochemical cell, reference electrodes, indicator
electrodes, measurement of potential and Ph, construction and working of electrodes,
Potentiometric titrations, methods of detecting end point, Karl Fischer titration.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
1. POTENTIOMETRIC TITRATION
Submitted To:
DR. C. SREEDHAR
PROFESSOR AND HOD
DEPT. OF PHARMACEUTICAL
ANALYSIS
KARNATAKA COLLEGE OF PHARMACY
BANGALORE
SUBMITTED BY:
S.GOKULRAJ
M PHARM 1ST SEMESTER
DEPT.OF PHARMACEUTICAL
ANALYSIS
KARNATAKA COLLEGE OF
PHARMACY
KARNATAKA COLLEGE OF PHARMACY
1
SUBJECT: APA
2. content
Introduction
Principle
Nernst equation
Components of potentiometric cell
Types of electrode
Potentiometric titration
Instrumentation
Types of potentiometric titration
Advantages of potentiometri titration
Application of potentiometric titration
KARNATAKA COLLEGE OF PHARMACY
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3. INTRODUCTION
It is consists of measuring the potential or emf of a
solution using set of indicator and reference
electrode.
It is based on potential measurement of
electrochemical cells without any appreciable current.
The use of electrodes to measure voltages from
chemical reactions.
The potential of a solution depends on the nature and
concentration of the ions of the drug absorption.
The potential is measured in mV using a
potentiometer.
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4. PRICIPLE
The principle is based on the fact that the potential of the
given sample is directly proportional to the concentration
of its electroactive ions.
In the potentiometry is when the pair of electrode is
placed in the sample solution it shows the potential
differences by the addition of the titrant.
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5. NERNST EQUATION
The potential (E) of a metal electrode at 25°C
Immersed into a solution of it’s own ions is given by,
E=E°+(0.0592/n) log c
Where,
• E- potential
• E°-standard potential of the metal
• n- valency of ions
• C-concentration of ions
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6. Components of potentiometric cell:
They are four type of components are used they are,
1. Reference electrode
2. Salt bridge
3. Analyte
4. Indicator electrode
E cell = E reference +E junction + E indicator
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7. TYPES OF ELECTRODE
The electrodes are mainly used to measure the voltages.
They are two different types of electrodes used they are,
1. Reference electrode
2. Indicator electrode
1. Reference electrode:
It is the one which has a standard potential on its own and it’s
potential does not change to whichever solution it is dipped into.
Different types of reference electrodes used they are,
1. Hydrogen electrode
2. Saturated calomel electrode
3. Silver-silver chloride electrode
4. Mercury-mercurous sulphate electrode
5. Mercury-Mercuric Oxide Electrode:
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8. 1. Hydrogen electrode:
It will be used as indicator as well as reference
electrode.
It consists of platinum foil coated with platinum black and
has wire contact through the mercury.
This assembly is enclosed in a glass covering through
which hydrogen is passed at 1 atmospheric pressure
continuously and dipped into the solution of standard
acid or unknown solution.
KARNATAKA COLLEGE OF PHARMACY
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9. 2. Saturated calomel electrode:
It consists of an inner jacket and outer
sleeve.
The inner tube has wire contact with
mercury and plugged with a mixture of
calomel and KCL.
This is surrounded by an outer sleeve
and the tip is filled with crystals of KCL
and porous plug of asbestos.
The space between the inner jacket and
outer sleeve is filled with either saturated
KCL or 1N KCL or 0.1N KCL, on the
potential of the electrode depends upon.
The potential of the half cell depends
upon
Concentration of the potassium chloride
used.
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10. 3.Silver-silver chloride electrode:
It is simply a silver wire coated electrolyticaly with silver
chloride and dipped into potassium chloride.
The potential of this half cell also depends upon
temperature as well as concentration of potassium
chloride used.
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11. 2.Indicator electrode:
It is responds to changes in emf or pH of a solution.
It is used to indicate the emf or potential or pH of a
solution.
Different types of indicator electrodes used they are,
1. Antimony –antimony oxide electrode
2. Hydrogen electrode
3. Glass electrode
1.Hydrogen electrode:
It is used as indicator electrode when dipped into a
unknown
Solution whose potential or pH has to be determined.
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12. 2.Antimony-antimony oxide electrode:
It consists of a antimony rod dipped into a solution,
whose potential or PH has to be determined.
The antimony react with water to form antimony oxide
and release the electrons.
Sb+H2O SBO+2H+3e
KARNATAKA COLLEGE OF PHARMACY
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13. 3.Glass electrode:
It is the most widely used in the indicator electrode.
It is selective and response to change in the concentration of
hydrogen ion.
The glass electrode consists of the glass tube with a thin PH
sensitive glass bulb at its tip.
It has a silver-silver chloride wire at the center of the tube and the
lower tip of the wire immerses into the 0.1N HCL filled in the glass
tube.
This assembly act as an indicator electrode and is dipped into a
solution whose PH or potential to be known.
The potential of the glass electrode is given by,
E=K+0.0592(PH1-PH2)at 25C
KARNATAKA COLLEGE OF PHARMACY
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14. Potentiometric titration
These are the titration in which the end point of
titration can be determined by measuring the
potential or changes in the potential of a solution
caused by the addition of titrant.
Alternatively the PH can also be monitored during
the titration to detect end point.
In a titration, the addition of titrant cause changes
in the concentration or activity of ions in solution.
KARNATAKA COLLEGE OF PHARMACY
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15. Instrumentation
Titration can be done manually or under
automation.
When it is done manually, a beaker with a stirrer
and a pipette are sufficient.
Incase of automatic models,a sample cell which
can hold a pair of electrode,inlet for titrant and a
stirrer for mixing a solution are essential.
The pair of reference and indicator electrode
depends on the type of titration.
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16. A= reference
electrode
B= indicator electrode
C=burette
D=PH meter with a
mV scale
E=magnetic stirrer
with variable speed
F= magnetic guide
Process of instrumentation:
KARNATAKA COLLEGE OF PHARMACY
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17. Types of potentiometric titrations
They are different types,
1. Acid - base titrations
2. Redox titrations
3. Diazotisation titrations
4. Complexometric titrations
5. Precipitation titrations
6. Non aquous titrations
KARNATAKA COLLEGE OF PHARMACY
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18. 1. Acid – Base titrations:
The acid – base titrations can be done in aqueous as
well as by non-aqueous medium.
Reference electrode : Saturated calomel electrode
Indicator electrode : Glass electrode
Examples:
Titration of HCL vs NAOH
Titration of HCL vs NH4OH
Titration of CH3COOH vs NH4OH
Titration of CH3COOH vs NAOH
Titration of (CH3COOH+HCL )vs NAOH
Titration of (NH4OH+NAOH )vs HCL etc….
KARNATAKA COLLEGE OF PHARMACY
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19. 2.Redox titration:
In this titration will be an a oxidation and reduction
process is happened.
Reference electrode: saturated calomel electrode (or)
silver- silver chloride
electrode.
Indicator electrode: platinum wire or foil
Exampls:
Ferrous ammonium sulphate in dil.H2SO4 (VS) KMNO4
Ferrous ammonium sulphate in dil.H2SO4 (VS) K2Cr2O7
Ferrous sulphate in 6N H2SO4 (VS) cerric ammonium
sulphate
Ce+4 + Fe+2 → Ce+3 + Fe+3
KARNATAKA COLLEGE OF PHARMACY
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20. 3.Complexometric titration:
In this method of titration used to determine the metal
ions by using a potentiometric titration method.
Reference electrode: saturated calomel electrode
Indicator electrode: silver-silver chloride electrode (or)
mercury electrode
Examples
Divalent ions,trivalent ions,CN etc… (vs) EDTA.
Ag+ + 2 CN- → [Ag(CN)2]- (chemically stable )
KARNATAKA COLLEGE OF PHARMACY
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21. 4.Precipitation titration:
For the quantitative determination of several ions or
elements,precipitating agents are used as titrants and the
end point is determined by potentiometric method.
Reference electrode: saturated calomel electrode (or)
silver-silver chloride
electrode(or)
hydrogen electrode
Indicator electrode: silver wire electrode
Examples:
Determination of halogen by using silver nitrate.
The titrant mixture of Cl and Br and I with AgNO3.
AgN03 + KCl → AgCl ↓ + KNO3
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22. 5.DIAZOTATION TITRATION:
The formation of diazonium salt is called as a diazotation
titration.
It is detect by two methods they are,
1. One method is detect by using starch iodide paper
(external indicator method).
2. The other method, better than the external indicator
method is by potentiometric method of determining end
point.
Reference electrode: Saturated calomel electrode
Indicator electrode: Glass electrode
Examples:
Alkaloids,amines,sulpha drugs and other drugs which
contain aromatic primary amino group can be titrated
against 0.1N sodium nitrate in HCL.
KARNATAKA COLLEGE OF PHARMACY
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23. Assay of nitrazepam
Material required:
0.25g of nitrazepam,25ml of acetic anhydride,250ml of 0.1M perchloric acid,a
potentiometer,a magnatic stirrer,burette.
Theory:
It is weakly basic compound and hence,it may be titrated conveniently by means
of a non-aqueous titration technique and determining the end point potentiometrically.
Procedure:
weigh accurately 0.25g of nitrazepam and dissolve in 25ml of acetic anhydride.titrate
with 0.1M perchloric acid placed in a burette and adding it carefully into the beaker
kept on a magnetic stirrer potentiometrically.
Each ml of 0.1M perchloric acid is equvalent to 28.13 mg of C15H11N3O3
KARNATAKA COLLEGE OF PHARMACY
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24. TITRATION
Potentiometric titrations is employed for acid-base,
redox, neutralization, precipitation,diazotation
titration and complexometric reactions.
The method can be used for coloured solution.
Apparatus are not more expensive and It is freely
available.
There is no need of external indicator for redox
titrations.
It is employed for the analysis of dilute solutions with
high degree of accuracy.
The technique is applicable even in non-aqueous
media.
Rapid analysis method.
Possibility of automation of titration processes.
High sensitivity.
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25. APPLICATIONS
Clinical chemistry:
Ion selective electrodes are present sensors for clinical samples
because of their selectivity for analyte in complex matrices.
The most common analytes are electrolytes such as Na, k,Ca,H, and Cl
and dissolved gases such as CO₂
Environmental chemistry:
For analysis of CN,NH, NO, F, in water and waste water.
Potentiometric titrations:
For determining the equivalence point of an acid base titration.
possible for redox, precipitation, acid-base, complexation as well as for
all titrations in aqueous n non aqueous solvents.
Agriculture:
NO3,NH4,I,Ca, K,CN, Cl in soils, plant materials, feed stuffs,
fertilizers.
Detergent manufacturing:
Ca, Ba, F for studying effects in water quality.
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26. Food processing:
Salt content of meat fish dairy products fruit juices brewing
solutions
Ca in dairy products and beer
K in fruit juice and wine making
Corrosive effects of NO3 in canned foods
F in drinking water and other drinks
NO3 and NO2 in meat preservatives
It is widely used electro-analytical method.
Potentiometric principle is useful in checking the pH of the
official buffers & different test solutions.
Assay of bisacodyl suppositories and assay of sulpha drugs
can be estimated potentiometrically.
A no. of drugs official in pharmacopoeia are assayed by this
procedure, some of them are Caffeine, Phenobarbitol,
Tetrahydrazine HCl, Amoxyllin sodium, Disulfuram,
Hydrallazine HCl, Metaclopramide HCl, Propranolol HCI,
Nalixidic acid, Lomustine,etc…
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27. Reference
Text book of PHARMACEUTICAL ANALYSIS 4th
edition Dr. Ravi Sankar.
Text book of pharmaceutical drug analysis 3rd
edition Dr. ASHUTOSH KAR
Instrumental method of chemical analysis
Dr. R.Chatwal
KARNATAKA COLLEGE OF PHARMACY
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