Heredity is the passing on of characteristics from one generation to the next. It is the reason why offspring look like their parents. It also explains why cats always give birth to kittens and never puppies. The process of heredity occurs among all living things including animals, plants, bacteria, protists and fungi. The study of heredity is called genetics and scientists that study heredity are called geneticists.
Through heredity, living things inherit traits from their parents. Traits are physical characteristics. You resemble your parents because you inherited your hair and skin color, nose shape, height, and other traits from them.
Cells are the basic unit of structure and function of all living things. Tiny biochemical structures inside each cell called genes carry traits from one generation to the next. Genes are made of a chemical called DNA (deoxyribonucleic acid). Genes are strung together to form long chains of DNA in structures known as chromosomes. Genes are like blueprints for building a house, except that they carry the plans for building cells, tissues, organs, and bodies. They have the instructions for making the thousands of chemical building blocks in the body. These building blocks are called proteins. Proteins are made of smaller units called amino acids. Differences in genes cause the building of different amino acids and proteins. These differences cause individuals to have different traits such as hair color or blood types.
A gene gives only the potential for the development of a trait. How this potential is achieved depends partly on the interaction of the gene with other genes. But it also depends partly on the environment. For example, a person may have a genetic tendency toward being overweight. But the person's actual weight will depend on such environmental factors as how what kinds of food the person eats and how much exercise that person does.
Heredity is the passing on of characteristics from one generation to the next. It is the reason why offspring look like their parents. It also explains why cats always give birth to kittens and never puppies. The process of heredity occurs among all living things including animals, plants, bacteria, protists and fungi. The study of heredity is called genetics and scientists that study heredity are called geneticists.
Through heredity, living things inherit traits from their parents. Traits are physical characteristics. You resemble your parents because you inherited your hair and skin color, nose shape, height, and other traits from them.
Cells are the basic unit of structure and function of all living things. Tiny biochemical structures inside each cell called genes carry traits from one generation to the next. Genes are made of a chemical called DNA (deoxyribonucleic acid). Genes are strung together to form long chains of DNA in structures known as chromosomes. Genes are like blueprints for building a house, except that they carry the plans for building cells, tissues, organs, and bodies. They have the instructions for making the thousands of chemical building blocks in the body. These building blocks are called proteins. Proteins are made of smaller units called amino acids. Differences in genes cause the building of different amino acids and proteins. These differences cause individuals to have different traits such as hair color or blood types.
A gene gives only the potential for the development of a trait. How this potential is achieved depends partly on the interaction of the gene with other genes. But it also depends partly on the environment. For example, a person may have a genetic tendency toward being overweight. But the person's actual weight will depend on such environmental factors as how what kinds of food the person eats and how much exercise that person does.
Chapter 15: Chromosomal Basis of InheritanceAngel Vega
KEY CONCEPTS
15.1 Morgan showed that Mendelian inheritance has its physical
basis in the behavior of chromosomes: Scientific inquiry
15.2 Sex-linked genes exhibit unique patterns of inheritance
15.3 Linked genes tend to be inherited together because they are located near each other on the same chromosome
15.4 Alterations of chromosome number or structure cause
some genetic disorders
15.5 Some inheritance patterns are exceptions to standard
Mendelian inheritance
Heredity or Hereditary is the process of passing the traits and characteristics from parents to offsprings.
The offspring cells get their features and characteristics aka genetic information from their mother and father.
Chapter 15: Chromosomal Basis of InheritanceAngel Vega
KEY CONCEPTS
15.1 Morgan showed that Mendelian inheritance has its physical
basis in the behavior of chromosomes: Scientific inquiry
15.2 Sex-linked genes exhibit unique patterns of inheritance
15.3 Linked genes tend to be inherited together because they are located near each other on the same chromosome
15.4 Alterations of chromosome number or structure cause
some genetic disorders
15.5 Some inheritance patterns are exceptions to standard
Mendelian inheritance
Heredity or Hereditary is the process of passing the traits and characteristics from parents to offsprings.
The offspring cells get their features and characteristics aka genetic information from their mother and father.
When chromosomes are duplicated, each chromosome has two copies of the allele, one on each sister chromatid. However, Gregor Mendel’s “hereditary factors” were purely an abstract concept when he proposed their existence in 1860. Using improved techniques of microscopy, cytology and genetics were converged as biologists began to see parallels between the behavior of Mendel’s proposed hereditary factors during sexual life cycles and the behavior of chromosomes which later began to be developed into “the chromosome theory of inheritance”. According to this theory, Mendelian genes have specific loci (positions) along chromosomes, and it is the chromosomes that undergo segregation and independent assortment.
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وقتی کروموزومها کپی میشوند، هر کروموزوم دارای دو نسخه از یک آلل است که هر کدام بر روی هر کروماتید خواهری قرار دارد. با این حال، اصل "عوامل وراثتی" مندل، هنگامی که وی در سال 1860 وجود آنها را مطرح کرد، یک مفهوم کاملاً انتزاعی بود. با استفاده از تکنیکهای بهبود یافته میکروسکوپی، سیتولوژی و ژنتیک همگرا شدند، زیرا زیست شناسان رفتارهای موازی بین عوامل وراثتی مندل در طول چرخههای جنسی را مشاهده کردند که بعدها این رفتارهای کروموزومی به "نظریه کروموزومی وراثت " تبدیل شد. براساس این نظریه، ژنهای مندلی دارای موقعیتهای (موقعیت) خاصی در امتداد کروموزومها هستند و این کروموزومها هستند که تحت جداسازی و طبقه بندی مستقل قرار میگیرند.
B4FA 2012 Nigeria: Principles of Genetics - Charles Amadib4fa
Presentation by Dr Charles Amadi, National Root Crops Research Centre, Umudike, Nigeria
Delivered at the B4FA Media Dialogue Workshop, Ibadan, Nigeria - September 2012
www.b4fa.org
JMeter webinar - integration with InfluxDB and GrafanaRTTS
Watch this recorded webinar about real-time monitoring of application performance. See how to integrate Apache JMeter, the open-source leader in performance testing, with InfluxDB, the open-source time-series database, and Grafana, the open-source analytics and visualization application.
In this webinar, we will review the benefits of leveraging InfluxDB and Grafana when executing load tests and demonstrate how these tools are used to visualize performance metrics.
Length: 30 minutes
Session Overview
-------------------------------------------
During this webinar, we will cover the following topics while demonstrating the integrations of JMeter, InfluxDB and Grafana:
- What out-of-the-box solutions are available for real-time monitoring JMeter tests?
- What are the benefits of integrating InfluxDB and Grafana into the load testing stack?
- Which features are provided by Grafana?
- Demonstration of InfluxDB and Grafana using a practice web application
To view the webinar recording, go to:
https://www.rttsweb.com/jmeter-integration-webinar
Key Trends Shaping the Future of Infrastructure.pdfCheryl Hung
Keynote at DIGIT West Expo, Glasgow on 29 May 2024.
Cheryl Hung, ochery.com
Sr Director, Infrastructure Ecosystem, Arm.
The key trends across hardware, cloud and open-source; exploring how these areas are likely to mature and develop over the short and long-term, and then considering how organisations can position themselves to adapt and thrive.
Transcript: Selling digital books in 2024: Insights from industry leaders - T...BookNet Canada
The publishing industry has been selling digital audiobooks and ebooks for over a decade and has found its groove. What’s changed? What has stayed the same? Where do we go from here? Join a group of leading sales peers from across the industry for a conversation about the lessons learned since the popularization of digital books, best practices, digital book supply chain management, and more.
Link to video recording: https://bnctechforum.ca/sessions/selling-digital-books-in-2024-insights-from-industry-leaders/
Presented by BookNet Canada on May 28, 2024, with support from the Department of Canadian Heritage.
Securing your Kubernetes cluster_ a step-by-step guide to success !KatiaHIMEUR1
Today, after several years of existence, an extremely active community and an ultra-dynamic ecosystem, Kubernetes has established itself as the de facto standard in container orchestration. Thanks to a wide range of managed services, it has never been so easy to set up a ready-to-use Kubernetes cluster.
However, this ease of use means that the subject of security in Kubernetes is often left for later, or even neglected. This exposes companies to significant risks.
In this talk, I'll show you step-by-step how to secure your Kubernetes cluster for greater peace of mind and reliability.
Neuro-symbolic is not enough, we need neuro-*semantic*Frank van Harmelen
Neuro-symbolic (NeSy) AI is on the rise. However, simply machine learning on just any symbolic structure is not sufficient to really harvest the gains of NeSy. These will only be gained when the symbolic structures have an actual semantics. I give an operational definition of semantics as “predictable inference”.
All of this illustrated with link prediction over knowledge graphs, but the argument is general.
Kubernetes & AI - Beauty and the Beast !?! @KCD Istanbul 2024Tobias Schneck
As AI technology is pushing into IT I was wondering myself, as an “infrastructure container kubernetes guy”, how get this fancy AI technology get managed from an infrastructure operational view? Is it possible to apply our lovely cloud native principals as well? What benefit’s both technologies could bring to each other?
Let me take this questions and provide you a short journey through existing deployment models and use cases for AI software. On practical examples, we discuss what cloud/on-premise strategy we may need for applying it to our own infrastructure to get it to work from an enterprise perspective. I want to give an overview about infrastructure requirements and technologies, what could be beneficial or limiting your AI use cases in an enterprise environment. An interactive Demo will give you some insides, what approaches I got already working for real.
Accelerate your Kubernetes clusters with Varnish CachingThijs Feryn
A presentation about the usage and availability of Varnish on Kubernetes. This talk explores the capabilities of Varnish caching and shows how to use the Varnish Helm chart to deploy it to Kubernetes.
This presentation was delivered at K8SUG Singapore. See https://feryn.eu/presentations/accelerate-your-kubernetes-clusters-with-varnish-caching-k8sug-singapore-28-2024 for more details.
State of ICS and IoT Cyber Threat Landscape Report 2024 previewPrayukth K V
The IoT and OT threat landscape report has been prepared by the Threat Research Team at Sectrio using data from Sectrio, cyber threat intelligence farming facilities spread across over 85 cities around the world. In addition, Sectrio also runs AI-based advanced threat and payload engagement facilities that serve as sinks to attract and engage sophisticated threat actors, and newer malware including new variants and latent threats that are at an earlier stage of development.
The latest edition of the OT/ICS and IoT security Threat Landscape Report 2024 also covers:
State of global ICS asset and network exposure
Sectoral targets and attacks as well as the cost of ransom
Global APT activity, AI usage, actor and tactic profiles, and implications
Rise in volumes of AI-powered cyberattacks
Major cyber events in 2024
Malware and malicious payload trends
Cyberattack types and targets
Vulnerability exploit attempts on CVEs
Attacks on counties – USA
Expansion of bot farms – how, where, and why
In-depth analysis of the cyber threat landscape across North America, South America, Europe, APAC, and the Middle East
Why are attacks on smart factories rising?
Cyber risk predictions
Axis of attacks – Europe
Systemic attacks in the Middle East
Download the full report from here:
https://sectrio.com/resources/ot-threat-landscape-reports/sectrio-releases-ot-ics-and-iot-security-threat-landscape-report-2024/
UiPath Test Automation using UiPath Test Suite series, part 3DianaGray10
Welcome to UiPath Test Automation using UiPath Test Suite series part 3. In this session, we will cover desktop automation along with UI automation.
Topics covered:
UI automation Introduction,
UI automation Sample
Desktop automation flow
Pradeep Chinnala, Senior Consultant Automation Developer @WonderBotz and UiPath MVP
Deepak Rai, Automation Practice Lead, Boundaryless Group and UiPath MVP
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After immersing yourself in the blue book and its red counterpart, attending DDD-focused conferences, and applying tactical patterns, you're left with a crucial question: How do I ensure my design is effective? Tactical patterns within Domain-Driven Design (DDD) serve as guiding principles for creating clear and manageable domain models. However, achieving success with these patterns requires additional guidance. Interestingly, we've observed that a set of constraints initially designed for training purposes remarkably aligns with effective pattern implementation, offering a more ‘mechanical’ approach. Let's explore together how Object Calisthenics can elevate the design of your tactical DDD patterns, offering concrete help for those venturing into DDD for the first time!
3. Chromosome Theory
of Inheritance
• The work of scientists in the early
1900s
• Says 2 things:
1. Genes occupy specific loci (positions on
chromosomes)
2. Chromosomes undergo segregation and
independent assortment during meiosis
4. Thomas Hunt Morgan
and his fruit flies
• The first solid evidence associating a specific
gene with a a specific chromosome came from
Thomas Hunt Morgan, an embryologist
• Morgan’s experiments with fruit flies provided
convincing evidence that chromosomes are the
location of Mendel’s heritable factors
5. Fruit flies were a good
choice…
• They breed at a high rate
• A generation can be bred
every two weeks
• They have only four pairs
of chromosomes
6. What Morgan did…
• He spent a year looking
for variant individuals,
those that differed from
the normal, or “wild”
phenotype
• Traits alternative to the
wild type are called
mutant phenotypes
7. He found a
white eyed
male…
• He mated it to a “wild” type red eyed female and got
all red eyed offspring in the F1 generation
• What does that tell us?
• He let the F1s mate, and got the classic 3:1 ratio of
red:white eyes, but only in males
• What does that tell us?
• Morgan figured out that the gene for eye color was on
the X chromosome
• His work supported the chromosome theory of
inheritance
8.
9. Morgan’s other work
• Each chromosome has
hundreds or thousands of
genes
• Genes located on the same
chromosome that tend to be
inherited together are called
linked genes
10. Morgan experimented to see
inheritance of two traits
• Morgan crossed
flies that differed
in traits of body
color and wing
size
11. What he found…
• He found that the
body color and wing
size traits were
usually inherited
together and the
offspring looked like
the parents, mostly…
12. What he found…
• Some of the offspring had phenotypes different from
the parents, but in lower ratios than expected
• Offsrping with phenotypes like the parents called
parental types
• Offspring with new phenotype combos called
recombinant types
• 50% frequency of recombination = genes on 2
different chromosomes
Gametes from yellow-round
heterozygous parent (YyRr)
Gametes from greenwrinkled homozygous
recessive parent (yyrr)
Parental-type
offspring
Recombinant
offspring
13. What he
found…
• He discovered that some genes can be linked, but
there is a process that can break their connection:
crossing over
• This led to the development of genetic maps that
determine the location of each gene on a chromosome
based on the frequency of recombination
• Distance between genes expressed as map units
• 1 map unit = 1% recombination frequency
14. Sex-linked
genes
• An organism’s sex is
an inherited
phenotypic character
determined by the
presence or absence
of certain
chromosomes
• Mammals like humans
have an XX or XY
system of inheritance
• Other organisms have
other systems
15. Genes on the sex
chromosomes are called
sex-linked genes
• Some diseases on the X
chromosome:
• Color blindness
• Rare in females, mild disease
• Duchenne muscular dystrophy
• 1 in 3500 males in US gets it
• Lack the gene for the muscle protein
dystrophin
• Muscles get weaker and lose
coordination
• Usually don’t live past 20s
• Hemophilia
• Lack the protein to cause clotting
• Don’t clot normally
16. Barr bodies
• In mammalian females, 1 of the 2 X chromosomes
is inactivated during embryonic development
• The inactive X condenses into what is called a
Barr body (we can see it under the microscope)
• If she is heterozygous for a sex-linked trait, she
will be a mosaic for that trait
17. • Some cells have the
maternal X
inactivated
• These cells have the
orange color
• Some cells have the
paternal X
inactivated
• These cells have the
black color
• All cells in the
ovaries have active
X chromosomes
18. Chromosomal mutations
• In nondisjunction, pairs
of homologous
chromosomes do not
separate normally
during meiosis
• As a result, one
gamete receives two of
the same type of
chromosome, and
another gamete
receives no copy
19. What results…
• Aneuploidy - a zygote
produced from a normal
gamete and a gamete
produced by
nondisjunction
• Offspring with this condition
have an abnormal number
of a particular chromosome
20. Very rare among
animals
Common in plants,
some fish, some
amphibians
What results…
• Trisomy - having 3 copies of a particular
chromosome
• Monosomy - having just one copy of a particular
chromosome
• Polyploidy is a condition in which an organism has
more than two complete sets of chromosomes
Recent research
has shown that
this Chilean
rodent is a
tetraploid
21. Chromosomal breakage
• Breakage of a chromosome can lead to
four types of changes in chromosome
structure:
• Deletion removes a chromosomal segment
29. Down syndrome
• Trisomy 21 - 3
number 21
chromosomes
• 1 in 700 children in
US
• Frequency increases
with age of mother
30. Trisomy 18 – Edward’s syndrome
low birth weight, mental
retardation, extra fingers and toes
31. • Klinefelter
syndrome is the
result of an extra
chromosome in a
male, producing
XXY individuals
Trisomy of sex
chromosomes
• Monosomy X, called
Turner syndrome,
produces X0 females, who
are sterile; it is the only
known viable monosomy
in humans