This document discusses anti-HIV drugs, their mechanisms of action, and treatment regimens. It describes established drug targets for anti-HIV drugs like CCR5 coreceptors and reverse transcriptase. It provides details on first line treatment regimens including two NRTIs with an NNRTI or PI/r. It also discusses treatment failure, adverse effects, special populations, and co-infections.
Antiviral Drugs – A Brief (Classification & Mechanism of Actions)Parth Thosani
This presentation gives you an overview of antiviral agents (both retro and non-retro viruses), focusing on the sites of actions, classification and class-wise mechanism of actions.
Medical Undergraduate Lecture slides on Pharmacotherapy of HIV-AIDS. These slides include life cycle of HIV. Classification of available drugs based on target site. Individual Drugs with Mechanism of action, PK, AE and drug interactions. Treatment principles and guidelines for HIV-AIDS based on NACO(National Aids Control Organisation, India) Guidelines.
Hello friends. In this PPT I am talking about Anti-viral drugs drugs. If you like it, please do let me know in the comments section. A single word of appreciation from you will encourage me to make more of such videos. Thanks. Enjoy and welcome to the beautiful world of pharmacology where pharmacology comes to life. This video is intended for MBBS, BDS, paramedical and any person who wishes to have a basic understanding of the subject in the simplest way.
Antiviral Drugs – A Brief (Classification & Mechanism of Actions)Parth Thosani
This presentation gives you an overview of antiviral agents (both retro and non-retro viruses), focusing on the sites of actions, classification and class-wise mechanism of actions.
Medical Undergraduate Lecture slides on Pharmacotherapy of HIV-AIDS. These slides include life cycle of HIV. Classification of available drugs based on target site. Individual Drugs with Mechanism of action, PK, AE and drug interactions. Treatment principles and guidelines for HIV-AIDS based on NACO(National Aids Control Organisation, India) Guidelines.
Hello friends. In this PPT I am talking about Anti-viral drugs drugs. If you like it, please do let me know in the comments section. A single word of appreciation from you will encourage me to make more of such videos. Thanks. Enjoy and welcome to the beautiful world of pharmacology where pharmacology comes to life. This video is intended for MBBS, BDS, paramedical and any person who wishes to have a basic understanding of the subject in the simplest way.
This PPT covers Drug therapy for Viral Infection or disease. It includes Viral replication cycle, classification of antiviral drugs, Anti-Herpes drug, Anti Influenza drugs, Anti hepatitis drugs and anti retroviral drugs
Antiviral drugs are a class of medication used specifically for treating viral infections rather than bacterial ones. Most antivirals are used for specific viral infections, while a broad-spectrum antiviral is effective against a wide range of viruses.
Types of HIV Virus Anti-HIV drugs, classification, mechanism of action, pharmacological action, pharmacokinetics, adverse drug reactions, drug interactions, contraindications and therapeutic uses
This PPT covers Drug therapy for Viral Infection or disease. It includes Viral replication cycle, classification of antiviral drugs, Anti-Herpes drug, Anti Influenza drugs, Anti hepatitis drugs and anti retroviral drugs
Antiviral drugs are a class of medication used specifically for treating viral infections rather than bacterial ones. Most antivirals are used for specific viral infections, while a broad-spectrum antiviral is effective against a wide range of viruses.
Types of HIV Virus Anti-HIV drugs, classification, mechanism of action, pharmacological action, pharmacokinetics, adverse drug reactions, drug interactions, contraindications and therapeutic uses
MANAGEMENT OF HIV FALLS UNDER THREE MAJOR CATEGORIES
1.POST EXPOSURE PROPHYLAXIS(P.E.P)
2.TREATMENT/MANAGEMENT OF HIV-AIDS
3.TREATMENT OF ADJOINING CONDITIONS
eg-
-Fungal Infections
-Bacterial infections
-Viral infections
-NEOPLASIAS
-misc.( recurrent apthos ulcers, xerostomia,salivary G. enlargement)
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
3. Established targets for anti-HIV drugs:
1. Chemokine coreceptor (CCR5) on host cells : provide
anchorage for the surface proteins of the virus.
2. Fusion of viral envelope with plasma membrane of CD4
cells: through which HIV- RNA enters the cell.
3. HIV reverse transcriptase: Which transcripts HIV-
RNA into proviral DNA.
4. HIV-integrase: Viral enzyme which integrates the
proviral DNA into host DNA.
5. HIV protease: Which cleaves the large virus directed
polyprotein into functional viral proteins.
6. • Nucleoside analogs (NRTI) act as competitive inhibitors or
chain terminators at the substrate binding site of RT.
• The first anti-HIV drug approved was the NRTI known as
AZT or Zidovudine (1987).
7. • Thymidine analogue (azido- thymidine, AZT), the
prototype NRTI
• Phosphorylation in the host cell—zidovudine
triphosphate selectively inhibits viral reverse
transcriptase in preference to cellular DNA polymerase
Single-stranded viral RNA
Virus directed reverse transcriptase
(inhibited by zidovudine triphosphate)
Double-stranded proviral DNA
•Resistance : point mutations
8. Pharmacokinetics:
• The oral absorption is rapid, bioavailability is ~65%
• It is quickly cleared by hepatic glucuronidation (t1⁄2 =1 hr);
15–20% of the unchanged drug along with the metabolite is
excreted in urine.
• CSF level is ~50% of that in plasma
• It crosses placenta and is found in milk.
• AZT also reduces neurological manifestations of AIDS and
new Kaposi’s lesions do not appear while on treatment with
this.
9. Adverse effects:
• Anaemia, neutropenia.
• Nausea, anorexia, abdominal pain, headache,
insomnia and myalgia are common at the start of
therapy, diminish later.
• Myopathy, pigmentation of nails, lactic acidosis,
hepatomegaly, convulsions and encephalopathy -infrequent
10. • Inhibits HIV reverse transcriptase as well as HBV DNA
polymerase
• Oral bioavailability is high and plasma t1⁄2 longer (6–8
hours).
• Synergizes with most other NRTIs for HIV & is an
essential component of all first line triple drug NACO
regimens.
• Side effects are few—fatigue, rashes, abdominal pain
• Pancreatitis and neuropathy are rare
• Hematological toxicity does not occur
11. • A guanosine nucleoside analogue.
• Indicated for the therapy of HIV-1 infection in adults and
children.
Adverse effects:
• Anorexia, nausea, vomiting, malaise, headache, and
insomnia.
• A potentially fatal hypersensitivity reaction (approx 5% of
patients).
12. • Is the only nucleotide analogue, relatively newer.
• It is also active against HBV
• Due to good tolerability profile, it is now included in first
line regimens.
• Renal toxicity is to be watched.
13. • Nucleoside unrelated compounds which directly inhibit HIV
reverse transcriptase
• No need for intracellular phosphorylation.
• Bind at the allosteric non-bonding site of RT, causing a
conformational change of the active site.
• More potent than AZT on HIV-1, but do not inhibit HIV-2.
• Resistance : point mutations
• General ADR’s: Rashes including Stevens Johnson syndrome,
elevated liver enzymes.
14. • Either NVP or EFV is included in the first line triple drug
regimen used by NACO.
• Cross- resistance between NVP and EFV is common.
• Enzyme inducers and Inhibitors
15. NEVIRAPINE
• Rashes are the commonest, followed by nausea and
headache. Occasionally severe skin reaction. Potentially
hepatotoxic.
EFAVIRENZ
• Side effects are headache, rashes, dizziness, insomnia
and a variety of neuropsychiatric symptoms.
• Because of its longer plasma t1⁄2, occasional missed doses
of EFV are less damaging.
• Teratogenic on animals.
16. • Acts at a late step in HIV replication.
• Bind to the active site of protease molecule, interfere with
its cleaving function.
• More effective viral inhibitors than AZT.
• Effective in both newly as well as chronically infected cells.
• Nelfinavir, lopinavir and ritonavir induce their own metabolism,
• Ritonavir used in booster dose.
• Also metabolism of PIs is induced by rifampicin and other
enzyme inducers rendering them ineffective.
17. • Most prominent adverse effects of PIs are gastrointestinal
intolerance, asthenia, headache, dizziness, limb and facial
tingling, numbness and rashes.
• Lipodystrophy, dyslipidaemia and insulin resistance are of
particular concern.
• Diabetes may be exacerbated.
• Indinavir crystallizes in urine and increases risk of urinary
calculi.
18. Ritonavir (RTV)
• Drug interactions.
• More commonly employed as a booster drug in a low dose.
• Nausea, diarrhoea, paresthesias, fatigue and lipid
abnormalities are prominent.
19. • Binds to HIV 1 envelope transmembrane glycoprotein (gp41)
involved in fusion of viral and cellular membranes
entry of virus into host cell is blocked
• Not active against HIV 2
Pharmacokinetics:
• Administered s.c twice daily
• Used as add on drug in earlier regimens
Adverse reactions:
• Local nodule/ cyst at injection site, rash, pneumonia like sym.
20. • Targets the host cell chemokine -CCR5 receptor and blocks it
attachment and entry of virus is inhibited
• Used in highly treatment experienced patients
Adverse reactions:
• Impaired immune surveillance
• Increased risk of infection/malignancy
• Hepatotoxicity
• Skin rashes
21. • HIV Integrase nicks the host chromosomal DNA and
integrates the proviral DNA with it
• Active against both HIV 1 and 2 and causes improved
CD4 cell count
Uses:
• As a component of drug regimen along with other
drugs in treatment experienced patients
• Adverse effect: myopathy
22. • Greater the suppression of viral replication, lesser is the
chance of emergence of drug resistant virus.
• Monotherapy is contraindicated.
• HAART: highly active antiretroviral therapy with a
combination of 3 or more drugs is indicated.
• The current NACO guidelines (2017) on when to start
ART: All persons diagnosed with HIV infection should
be initiated on ART regardless of the CD4 count or
WHO Clinical Staging or age group or population sub-
groups.
• Proper counselling.
23. • Regimen should have 2 NRTI+ 1NNRTI and treatment is
life long.
• Efavirenz is indicated for patient with hepatic dysfunction and
concurrently taking rifampicin. It is contraindicated in
pregnancy.
• PI containing regimen: 2NRTI+PI or NRTI+NNRTI +PI (low
dose ritonavir boosted PIs are used)
• Development of drug toxicity: no dose reduction
Either entire regimen should be interrupted
Or the offending drug should be changed
24.
25. An ART regimen is considered to have failed when:
• Plasma HIV-RNA count is not rendered undectable
(<50 copies/μl) with in 6 months therapy.
• Repeated detection of virus in plasma after initial
supression to undectable levels despite continuation of
drug regimen.
• Clinical deterioration,fall in CD4 cell count, serious
opportunistic infection while continuing drug therapy.
26. • Drugs with known overlapping viral resistance should not be
used.
1. Indinavir should not be substituted for nelfinavir or
saquinavir
2. Efavirenz should not be replaced by nevirapine
• Viral resistance testing is recommended for selecting the
salvage regimen.
• A boosted PI is nearly always included.
28. Third-line regimens should include new drugs with
minimal risk of cross-resistance to previously used
regimens such as Integrase inhibitors and second-
generation NNRTIs and PIs.
Accordingly, such a regimen is Raltegravir (400 mg) +
Darunavir (600 mg) + Ritonavir (100 mg); one tablet
each twice daily.
30. For adults and adolescents
Preferred 2 NRTI Tenofovir 300mg daily ±
Emtricitabine 200mg daily ±
Preferred PI Lopinavir/r (400+ 100mg) or
Atazanavir/r (300+ 100mg) daily
Alternative 3rd drug Darunavir/r or Raltegravir or
Efavirenz
For children ≤ 10 yrs
Preferred 2 NRTI Zidovudine + lamivudine
Preferred PI Lopinavir/r
Alternative 3rd drug Atazanavir/r or Darunavir/r or
Raltegravir or Efavirenz
31. Drug regimen
Tenofovir 300mg daily ± Emtricitabine 200mg daily
Key risk groups
Homosexual men
Sex workers
Injection drug users
Transgender
Uninfected partner of a heterosexual serodiscordant couples
32. • Vertical transmission: Highest rate of transmission (2/3rd)
through placenta, during delivery or breast feeding.
• All HIV positive pregnant women including those presenting
in labour and breast feeding should be initiated on a triple
drug ART and continue lifelong ART.
• Nevirapine prophylaxis to HIV exposed infant: minimum 6
weeks and extended to 12 weeks, if the duration of ART in
pregnant mother falls less than 4 weeks before delivery.
• Drugs safe in pregnancy: Zidovudine, Lamivudine,
Nevirapine, Nelfinavir, Saquinavir
33. • ART should be initiated as soon as possible in all HIV/TB-
co-infected patients with active TB.
• If an NNRTI-based regimen is used, EFV would be the
preferred drug.
• Except for SQV/r, PIs are not recommended during TB
treatment with Rifampicin, even then Rifampicin
should be substituted with Rifabutin.