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Antimicrobials 1 Lec

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BETA LACTAM & OTHER CELL WALL- & MEMBRANE ACTIVE ANTIBIOTICS MA. LENY ALDA G. JUSAYAN, MD DEPARTMENT OF PHARMACOLOGY
Introduction ,[object Object]
History ,[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Structure ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
Chemical Properties of Penicillins ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Chemical Properties of Penicillins ,[object Object],[object Object],[object Object]
 
 
thiazolidine ring (A) connected to a b-lactam ring (B), to which is attached a side chain (R).
[object Object],[object Object]
Cell Wall production ,[object Object],[object Object],[object Object]
[object Object]
[object Object],[object Object],[object Object]
[object Object]
[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
 
 
 
Beta Lactam Antibiotics & Other Cell Wall Synthesis Inhibitors ,[object Object],[object Object],[object Object],[object Object],[object Object]
Classification ,[object Object],[object Object],[object Object]
PENICILLINS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
PENICILLINS ,[object Object],[object Object],[object Object],[object Object]
Penicillinase Susceptible ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Penicillinase Susceptible ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Penicillinase Susceptible ,[object Object],[object Object],[object Object]
Mechanisms of Action: ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
Mechanisms of Drug Actions by Enzyme Inhibition: ,[object Object]
:Mechanisms of Resistance: ,[object Object],[object Object],[object Object],[object Object]
 
Resistance to β-Lactams – Gram pos.
PHARMACOKINETICS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
[object Object]
Parenteral Administration of Penicillin G ,[object Object],[object Object]
[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
PHARMACOKINETICS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
ADVERSE EFFECTS: ,[object Object],[object Object],[object Object],[object Object]
ADVERSE EFFECTS: ,[object Object],[object Object],[object Object],[object Object]
Specific toxicities ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Specific toxicities ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Unitage of Penicillin ,[object Object],[object Object],[object Object]
Penicillin G ,[object Object],[object Object]
Penicillin G ,[object Object],[object Object],[object Object]
B. Procaine Penicillin G – IM ,[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
D. Penicillin V ,[object Object],[object Object],[object Object],[object Object],[object Object]
E. Ampicillin and Amoxicillin ,[object Object],[object Object],[object Object],[object Object]
E. Ampicillin and Amoxicillin ,[object Object],[object Object],[object Object],[object Object],[object Object]
Ampicillin doses: ,[object Object],[object Object],[object Object],[object Object]
F. ESTERS OF AMPICILLIN ,[object Object],[object Object]
G. CARBOXYPENICILLINS and UREIDOPENICILLINS ,[object Object],[object Object],[object Object],[object Object],[object Object]
H. PENICILLINASE RESISTANT ,[object Object],[object Object],[object Object],[object Object]
H. PENICILLINASE RESISTANT ,[object Object],[object Object],[object Object],[object Object]
Drug-drug Interactions ,[object Object],[object Object]
Classification of the Penicillins and Summary of Their Pharmacological Properties ,[object Object]
[object Object]
[object Object]
Cephalosporins   First Generation        Second Generation     Third Generation       Fourth Generation                      * Oral Agent Cefadroxil *   Cefaclor * Cefdinir Cefepime   Cefazolin    Cefamandole  Cefoperaxone    Cefpirome   Cefelixin *   Cefonicid  Cefotaxime     Cephalothin    Ceforanide Ceftazidime     Cephaprin    Cefotetan Ceftibuten     Cephradine *   Cefoxitin  Ceftizoxime       Cefuroxime moxalactam Ceftriaxone
CEPHALOSPORINS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
CEPHALOSPORINS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cephalosporins ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
CEPHALOSPORINS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
GENERAL PROPERTIES OF CEPHALOSPORINS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
GENERAL PROPERTIES OF CEPHALOSPORINS ,[object Object],[object Object],[object Object]
CEPHALOSPORINS ,[object Object],[object Object],[object Object],[object Object]
CEPHALOSPORINS ,[object Object],[object Object],[object Object],[object Object]
CEPHALOSPORINS ,[object Object],[object Object],[object Object],[object Object]
CEPHALOSPORINS ,[object Object],[object Object],[object Object],[object Object]
CEPHALOSPORINS ,[object Object],[object Object]
CEPHALOSPORINS ,[object Object],[object Object],[object Object]
THIRD GENERATION ,[object Object],[object Object],[object Object]
THIRD GENERATION ,[object Object],[object Object],[object Object],[object Object]
THIRD GENERATION ,[object Object],[object Object],[object Object],[object Object]
THIRD GENERATION ,[object Object],[object Object],[object Object]
CEPHALOSPORINS ,[object Object],[object Object],[object Object]
CEPHALOSPORINS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
ADVERSE EFFECTS of Cephalosporins ,[object Object],[object Object],[object Object],[object Object]
ADVERSE EFFECTS of Cephalosporins ,[object Object],[object Object],[object Object]
MONOBACTAMS ,[object Object],[object Object],[object Object]
Monobactam ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object]
MONOBACTAMS ,[object Object],[object Object]
BETA LACTAMASE INHIBITORS ,[object Object],[object Object],[object Object]
BETA LACTAMASE INHIBITORS ,[object Object],[object Object],[object Object],[object Object]
Carbapenems ,[object Object],[object Object],[object Object],[object Object]
Imipenem: ,[object Object],[object Object]
[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
Meropenem ,[object Object],[object Object],[object Object]
CARBAPENEMS ,[object Object],[object Object],[object Object],[object Object]
CARBAPENEMS ,[object Object],[object Object],[object Object],[object Object],[object Object]
A. VANCOMYCIN ,[object Object],[object Object],[object Object]
A. VANCOMYCIN ,[object Object],[object Object],[object Object]
A. VANCOMYCIN ,[object Object],[object Object],[object Object],[object Object]
B. FOSFOMYCIN ,[object Object],[object Object]
B. FOSFOMYCIN ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
C. BACITRACIN ,[object Object],[object Object],[object Object],[object Object],[object Object]
D. CYCLOSERINE ,[object Object],[object Object],[object Object],[object Object]
 
POST-TEST ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]

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Antimicrobials 1 Lec

  • 1. BETA LACTAM & OTHER CELL WALL- & MEMBRANE ACTIVE ANTIBIOTICS MA. LENY ALDA G. JUSAYAN, MD DEPARTMENT OF PHARMACOLOGY
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  • 11. thiazolidine ring (A) connected to a b-lactam ring (B), to which is attached a side chain (R).
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  • 35. Resistance to β-Lactams – Gram pos.
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  • 64. Cephalosporins   First Generation        Second Generation     Third Generation       Fourth Generation                      * Oral Agent Cefadroxil *   Cefaclor * Cefdinir Cefepime   Cefazolin    Cefamandole  Cefoperaxone    Cefpirome   Cefelixin *   Cefonicid  Cefotaxime     Cephalothin    Ceforanide Ceftazidime     Cephaprin    Cefotetan Ceftibuten     Cephradine *   Cefoxitin  Ceftizoxime       Cefuroxime moxalactam Ceftriaxone
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