This document discusses quinolones, a class of synthetic antimicrobial compounds. It begins by introducing nalidixic acid, the first quinolone, and describes its mechanism of action by inhibiting bacterial DNA gyrase. The document then discusses the development of more potent fluoroquinolones in the 1980s, which have additional fluorine substitutions. Various generations of fluoroquinolones are classified based on their chemical structure. The mechanism of action, pharmacokinetics, adverse effects, interactions and therapeutic uses of fluoroquinolones are summarized.